Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GSTK1 | 373156 | Glutathione S-transferase kappa 1 | 7 | GST; GST13; hGSTK1; GSTK1-1; GST13-13; GST 13-13 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23189274 | 2012 | Cell line : - Source : Clinic of Oncological and Reconstructive Surgery of the Maria Sklodowska Curie Memorial Cancer Center & Institute of Oncology in Gliwice. Sample Type : CRC tumor and normal tissue No. of Sample : 47 Stage : - | Homogenisation,Enzyme activity assay,Histopathology. | Down-regulation | - | Activity of GST decreased significantly in tumour as compared with normal mucosa. |
| 21711092 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | PCR-RLFP | Polymorhpism | - | This study suggests that the GSTP1 I105V polymorphism may modulate CRC risk in the Kashmiri population. A case-control study in which 86 CRC cases were studied for GSTP1 I105V polymorphism against 160 controls taken from the general population. |
| 21803734 | 2011 | Cell line : - Source : India (Kashmiri population) Sample Type : - No. of Sample : - Stage : - | GSTM1, T1 and P1 genotyping. | Polymorhpism | - | These findings suggest that GST gene polymorphisms influence interindividual susceptibility to smoking-associated colorectal cancer. Incident cases of colorectal cancer (n = 480) and matched controls (n = 1167) were selected from the Singapore Chinese Health Study. |
| 22126490 | 2011 | Cell line : - Source : Singapore Chinese Health Study Sample Type : Case control study No. of Sample : 86 CRC case and 160 control Stage : - | real time Rt-PCR , Chi-squared test | Polymorhpism | - | GSTM1 null genotype may contribute to colorectal cancer development in people over 60 years old. |
| 22697302 | 2012 | Cell line : - Source : Isfahan province, Iran. Sample Type : Blood sample No. of Sample : 140 CRC patients and 90 healthy individuals Stage : - | PCR-RFLP,RT-PCR. | Polymorhpism | - | GSTP1 the heterozygote genotype Ile105Val was associated with decreased risk of CRC. |
| 22269287 | 2012 | Cell line : - Source : Czech Central European population. Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Glutathione S-transferases / Mitochondrial (kappa) |
| Description | This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009] |
| Chromosome | 7 |
| Location | 7q34 |
| Start | 143263429 |
| End | 143269129 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 5701 |
| OMIM ID | 602321 |
| HGNC ID | HGNC:16906 |
| Unigene ID | Hs.390667 |
| Ensembl ID | ENSG00000197448 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001143679.1 |
|---|---|
| Exon | join(1..157,658..739,1120..1248,1564..1868,4189..4305, 4663..4756,5360..5701) | mRNA Sequence | Download Select all |
| Length | 1226 |
CDS Information
| Location | join(86..157,658..739,1120..1248,1564..1868,4189..4305, 4663..4756,5360..5409) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS47730.1 |
Protein Information
| Protein ID | NP_057001.1 |
|---|---|
| Protein Name | Glutathione S-transferase kappa 1 |
| Molecular Wt. (Da) | 25366 |
| Protein Sequence | Download Select all |
| Length | 226 |
| Uniprot ID | P04406 |
| Ensembl Protein ID | ENSP00000229239 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 98 |
| T | Phosphorylation | 104 |
| S | Phosphorylation | 98 |
| T | Phosphorylation | 104 |
| K | Acetylation | 94 |
| K | Acetylation | 94 |
| K | Acetylation | 71 |
| K | Acetylation | 71 |
| K | Acetylation | 225 |
| K | Acetylation | 169 |
| S | Phosphorylation | 96 |
| S | Phosphorylation | 96 |
Enzyme Information
No matching records could be found.
PPi Information
No STRING Network could be found.
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemical carcinogenesis | hsa05204 |
| Drug metabolism - cytochrome P450 | hsa00982 |
| Glutathione metabolism | hsa00480 |
| Metabolism of xenobiotics by cytochrome P450 | hsa00980 |
| Peroxisome | hsa04146 |
Structure Information
| PDB ID | 1YZX |
|---|---|
| Resolution | 1.93 |
| Method | X-RAY DIFFRACTION |
| Chains | A,B |
| Molecule | Glutathione S-transferase kappa 1 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03021 | 6-211 | DsbA_GSTK |
| cl00388 | 6-211 | Thioredoxin_like superfamily |
| pfam01323 | 7-211 | DSBA |
| cd03022 | 8-210 | DsbA_HCCA_Iso |
| COG3917 | 5-212 | NahD |
| COG2761 | 7-184 | FrnE |
| cd02972 | Aug-49 | DsbA_family |
Ontology Information
| HPRD ID | 9043 |
|---|---|
| Molecular Class | Enzyme: Glutathione transferase |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q9Y2Q3 | DB00143 | Glutathione | SmallMoleculeDrug |