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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CD82 3732 CD82 molecule  11R2, IA4, TSPAN27 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23873015   2013Cell line : -

Source : -

Sample Type : CRC Tumor

No. of Sample : 70

Stage : Duke Stage C

Genotyping, DNA sequencing.Polymorhpism-Polymorphism in exon 3 (-29166 C>T) was observed to be associated with susceptibility of CRC.

11848527   2001Cell line : -

Source : Department of Gasterointerology, Afilieated Hospital of Binzhou Medical College.

Sample Type : CRC Tumor

No. of Sample : 356 CRC and 378 control

Stage : -

 ImmunohistochemistryUp-regulation-KAI1/CD82 expression closely correlates with clinicopathological factors for colorectal cancers. KAI1/CD82 expression appears to be a useful prognostic marker.

25247386   2014Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 19

Stage : -

-Up-regulation-PLOD2, DPEP1, SE1L1, CD82, PAR1, PLOD3, S12A2, LAMP3, OLFM4 were found to be up-regulated in the great majority of the cohort, and, interestingly, the association with colorectal cancer.


Gene Details



NC_000011.9 (44587141..44641339)

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Gene Type protein coding
Gene Family CD molecules, "Tetraspanins"
Description This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]  
Chromosome 11
Location 11p11.2
Start 44587141  
End 44641339  
Strand +  
Gene Sequence

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Length 54199  
OMIM ID 600623   
HGNC ID HGNC:6210   
Unigene ID Hs.527778   
Ensembl ID -   
PharmGKB ID PA142672155   

mRNA Information


mRNA ID XM_006718222.1
Exon join(1..76,23049..23130,30217..30299,35732..35804, 40632..40756,40929..41003,50846..50947,53736..53939, 54214..54297,54623..55937)  
mRNA Sequence

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Length 2219  



CDS Information


   
Location 56..982
CDS Sequence

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CCDS ID CCDS31469.1



Protein Information


      
Protein ID XP_006718285.1
Protein NameCD82 molecule
Molecular Wt. (Da)43898
Protein Sequence

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Length 308  
Uniprot IDP51692
Ensembl Protein ID ENSP00000293328  



Post-translational Modification Information (Source : HPRD)


Residue Type site
NGlycosylation129
NGlycosylation157
NGlycosylation198
NGlycosylation104
NGlycosylation132
NGlycosylation173

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
821CANX252NP_001737.1in vitro;in vivo11350933   
920CD41740NP_000607.1in vivo7636191   
930CD19113NP_001761.3in vivo9804823   
967CD631121NP_001771.1in vivo9759843   
1839HBEGF526NP_001936.1in vivo10749879   
1956EGFR579NP_005219.2in vitro;in vivo10985391   
2064ERBB21281NP_004439.2in vivo14576349   
2065ERBB31820NP_001973.2in vivo14576349   
3108HLA-DMA830NP_006111.2in vivo9759843   
3109HLA-DMB831NP_002109.1in vivo9759843   
3122HLA-DRA833NP_061984.2in vitro;in vivo9759843   
3655ITGA6945NP_001073286.1in vivo8757325   
3675ITGA35431NP_005492.1in vivo8757325   
3676ITGA41894NP_000876.3in vivo8757325   
3688ITGB1628NP_391987.1in vivo8757325   
3689ITGB22506NP_000202.2in vivo10602019   
4035LRP1138NP_002323.2in vitro;in vivo9804823   
4927NUP883974NP_002523.2yeast 2-hybrid16169070   
5738PTGFRN3124NP_065173.2in vitro;in vivo11278880   


Pathway Information


      
Pathway Name Pathway ID
p53 signaling pathway hsa04115


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd03160106-229  CD37_CD82_like_LEL
cl02781106-229  tetraspanin_LEL superfamily
cd03127107-228  tetraspanin_LEL
cd03165112-228  NET-5_like_LEL
cd03163107-226  TM4SF8_like_LEL
cd03155107-228  CD151_like_LEL
cd03158114-228  penumbra_like_LEL
cd03154130-228  TM4SF3_like_LEL
cd03161122-228  TM4SF2_6_like_LEL
cd03156113-227  uroplakin_I_like_LEL
cd03166107-228  CD63_LEL
cd03157136-225  TM4SF12_like_LEL
pfam0033524-256  Tetraspannin


Ontology Information


   
HPRD ID3302
Molecular ClassCell surface receptor
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO