Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| KCNN4 | 3783 | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 | 19 | KCa3.1, hSK4, hKCa4, hIKCa1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23572150 | 2013 | Cell line : LoVo Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | These results implicated the up-regulation of KCNN4 channels in the PRL-3-mediated induction of EMT and promotion of cancer metastasis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Potassium channels, "Voltage-gated ion channels / Potassium channels, calcium-activated" |
| Description | The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008] |
| Chromosome | 19 |
| Location | 19q13.2 |
| Start | 44270685 |
| End | 44286269 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 15585 |
| OMIM ID | 602754 |
| HGNC ID | HGNC:6293 |
| Unigene ID | Hs.10082 |
| Ensembl ID | - |
| PharmGKB ID | PA222 |
mRNA Information
| mRNA ID | XM_005258882.2 |
|---|---|
| Exon | join(1..1437,7521..7948,10005..10140,12311..12421, 12580..12698,13108..13177,14433..14600,15051..15607) | mRNA Sequence | Download Select all |
| Length | 3026 |
Protein Information
| Protein ID | XP_005258939.1 |
|---|---|
| Protein Name | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 |
| Molecular Wt. (Da) | 74568 |
| Protein Sequence | Download Select all |
| Length | 395 |
| Uniprot ID | P42226 |
| Ensembl Protein ID | ENSP00000300134 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 801 | CALM1 | 241 | NP_008819.1 | in vitro;in vivo;yeast 2-hybrid | 10026195 |
| 5571 | PRKAG1 | 4118 | NP_002724.1 | in vivo;yeast 2-hybrid | 19052260 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Insulin secretion | hsa04911 |
| Protein digestion and absorption | hsa04974 |
| Salivary secretion | hsa04970 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam03530 | 11-129 | SK_channel |
| cl04138 | 11-129 | SK_channel superfamily |
| pfam02888 | 304-376 | CaMBD |
| cl03763 | 304-376 | CaMBD superfamily |
| smart01053 | 304-376 | CaMBD |
| pfam07885 | 237-286 | Ion_trans_2 |
| cl21560 | 237-286 | Ion_trans_2 superfamily |
Ontology Information
| HPRD ID | 3115 |
|---|---|
| Molecular Class | Intracellular ligand gated channel |
| Molecular Function | Calcium ion binding (GO:0005509) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| O15554 | DB00228 | Enflurane | SmallMoleculeDrug |
| O15554 | DB00257 | Clotrimazole | SmallMoleculeDrug |
| O15554 | DB00468 | Quinine | SmallMoleculeDrug |
| O15554 | DB00721 | Procaine | SmallMoleculeDrug |
| O15554 | DB01110 | Miconazole | SmallMoleculeDrug |
| O15554 | DB01159 | Halothane | SmallMoleculeDrug |