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General Information
- Evidence
- Gene
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25110434 | 2014 | Cell line : HCT116, SW1116, SW480, VOLO Source : Cell bank at the Chinese Academy of Sciences. First Affiliated Hospital of Fujian Medical University. Sample Type : CRC tumor and normal tissue No. of Sample : 126 CRC 142 normal tissues Stage : - | Methylation-specific PCR, real-time RT-PCR, Western blotting | Methylation | - | These data suggest that KISS1 is down-regulated in cancer tissues via promoter hypermethylation and therefore may represent a candidate target for treating metastatic CRC. |
| 26010933 | 2015 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 111 Stage : - | Immunohistochemistry | Up-regulation | - | Larger and advanced colorectal cancers express more KISS1, without reaching the former normal levels, and increased KISS1 levels are associated with worse prognosis. KISS1 levels were higher in larger tumors, in stage III and IV cancers. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq, Mar 2012] |
| Chromosome | 1 |
| Location | 1q32 |
| Start | 204159469 |
| End | 204165619 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 6151 |
| OMIM ID | 603286 |
| HGNC ID | HGNC:6341 |
| Unigene ID | Hs.95008 |
| Ensembl ID | ENSG00000170498 |
| PharmGKB ID | PA30127 |
mRNA Information
| mRNA ID | NM_002256.3 |
|---|---|
| Exon | join(1..116,3578..3718,5695..6151) | mRNA Sequence | Download Select all |
| Length | 731 |
Protein Information
| Protein ID | NP_002247.3 |
|---|---|
| Protein Name | KiSS-1 metastasis-suppressor |
| Molecular Wt. (Da) | 107120 |
| Protein Sequence | Download Select all |
| Length | 138 |
| Uniprot ID | Q13586 |
| Ensembl Protein ID | ENSP00000300737 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 112 |
| G | Proteolytic Cleavage | 118 |
| G | Proteolytic Cleavage | 118 |
| G | Proteolytic Cleavage | 118 |
| G | Proteolytic Cleavage | 118 |
| G | Proteolytic Cleavage | 118 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam15152 | 45-122 | Kisspeptin |
| cl21019 | 45-122 | Kisspeptin superfamily |
Ontology Information
| HPRD ID | 3740 |
|---|---|
| Molecular Class | Ligand |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.