Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| KIT | 3815 | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 4 | CD117, SCFR, C-Kit |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26026391 | 2015 | Cell line : DLD1, HT29, LS174T, COLO320 Source : - Sample Type : CRC tumor and adjecent normal tissue No. of Sample : 137 Stage : - | real time RT-PCR, single-cell gene expression analysis, flow cytometry, and immunohistochemistry, immunoblotting | Up-regulation | - | KIT and KITLG are expressed by a subset of human colon tumors. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, "Immunoglobulin superfamily / Immunoglobulin-like domain containing" |
| Description | This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Chromosome | 4 |
| Location | 4q12 |
| Start | 55524095 |
| End | 55606881 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 82787 |
| OMIM ID | 164920 |
| HGNC ID | HGNC:6342 |
| Unigene ID | Hs.479754 |
| Ensembl ID | ENSG00000157404 |
| PharmGKB ID | PA30128 |
mRNA Information
| mRNA ID | NM_000222.2 |
|---|---|
| Exon | join(1..154,37585..37854,40357..40638,41703..41839, 45797..45965,49171..49360,51497..51612,65657..65771, 67930..68123,69291..69397,69489..69615,69896..70000, 70084..70194,71408..71558,73401..73492,73944..74071, 75143..75265,78571..78682,78794..78893,79248..79353, 80502..82788) | mRNA Sequence | Download Select all |
| Length | 5190 |
Protein Information
| Protein ID | NP_000213.1 |
|---|---|
| Protein Name | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
| Molecular Wt. (Da) | 53573 |
| Protein Sequence | Download Select all |
| Length | 976 |
| Uniprot ID | O14965 |
| Ensembl Protein ID | ENSP00000321591 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 545 |
| Y | Phosphorylation | 547 |
| Y | Phosphorylation | 553 |
| Y | Phosphorylation | 730 |
| Y | Phosphorylation | 747 |
| Y | Phosphorylation | 568 |
| Y | Phosphorylation | 570 |
| Y | Phosphorylation | 703 |
| Y | Phosphorylation | 936 |
| Y | Dephosphorylation | 570 |
| S | Phosphorylation | 741 |
| S | Phosphorylation | 746 |
| S | Phosphorylation | 821 |
| S | Phosphorylation | 959 |
| Y | Phosphorylation | 900 |
| Y | Phosphorylation | 721 |
| Y | Phosphorylation | 932;- |
| T | Phosphorylation | 354 |
| Y | Phosphorylation | 362 |
| T | Phosphorylation | 354 |
| Y | Phosphorylation | 362 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 25 | ABL1 | 1809 | NP_009297.2 | in vitro;in vivo | 12374739 |
| 695 | BTK | 2248 | NP_000052.1 | in vivo | 15007095 |
| 867 | CBL | 1320 | NP_005179.2 | in vivo | 8950973 |
| 868 | CBLB | 5136 | NP_733762.2 | in vivo | 15315962 |
| 928 | CD9 | 880 | NP_001760.1 | in vivo | 12036870 |
| 1154 | CISH | 3897 | NP_037456.5 | in vivo | 14707129 |
| 1213 | CLTC | 350 | NP_004850.1 | in vivo | 10477727 |
| 2057 | EPOR | 587 | NP_000112.1 | in vivo | 11124255 |
| 2885 | GRB2 | 150 | NP_002077.1 | in vitro;in vivo | 10377264 |
| 3635 | INPP5D | 9033 | NP_001017915.1 | in vitro | 11071635 |
| 3717 | JAK2 | 993 | NP_004963.1 | in vitro;in vivo | 935 573 786 116 937 000 000 |
| 3932 | LCK | 1080 | NP_005347.3 | in vitro | 9788619 |
| 5294 | PIK3CG | 3135 | NP_002640.2 | in vitro;in vivo | 7520444 |
| 5579 | PRKCB | 1499 | NP_002729.2 | in vitro | 7693453 |
| 6772 | STAT1 | 2777 | NP_009330.1 | in vivo | 9355737 |
| 6776 | STAT5A | 3301 | NP_003143.2 | in vivo | 10358045 |
| 6777 | STAT5B | 5037 | NP_036580.2 | in vivo | 10358045 |
| 9306 | SOCS6 | 5491 | NP_004223.2 | in vitro;in vivo;yeast 2-hybrid | 14707129 |
| 9655 | SOCS5 | 6159 | NP_054730.1 | in vivo | 14707129 |
| 10076 | PTPRU | 3908 | NP_005695.3 | in vitro;in vivo | 10397721 |
| 51196 | PLCE1 | 7087 | NP_057425.3 | in vitro | 12878163 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Acute myeloid leukemia | hsa05221 |
| Central carbon metabolism in cancer | hsa05230 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Endocytosis | hsa04144 |
| Hematopoietic cell lineage | hsa04640 |
| Melanogenesis | hsa04916 |
| Pathways in cancer | hsa05200 |
| Phospholipase D signaling pathway | hsa04072 |
| PI3K-Akt signaling pathway | hsa04151 |
| Rap1 signaling pathway | hsa04015 |
| Ras signaling pathway | hsa04014 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05104 | 553-928 | PTKc_Kit |
| cl21453 | 553-928 | PKc_like superfamily |
| cd05860 | 311-411 | Ig4_SCFR |
| cl11960 | 311-411 | Ig superfamily |
| cd00096 | 230-304 | Ig |
| cl11960 | 230-304 | Ig superfamily |
| cd00096 | 426-505 | Ig |
| cl11960 | 426-505 | Ig superfamily |
| cd05055 | 553-928 | PTKc_PDGFR |
| cd05106 | 550-928 | PTKc_CSF-1R |
| cd05105 | 553-925 | PTKc_PDGFR_alpha |
| cd05107 | 553-926 | PTKc_PDGFR_beta |
| cd05054 | 581-924 | PTKc_VEGFR |
| cd05102 | 581-924 | PTKc_VEGFR3 |
| cd05103 | 581-922 | PTKc_VEGFR2 |
| cd14207 | 581-922 | PTKc_VEGFR1 |
| cd05053 | 576-929 | PTKc_FGFR |
| cd00192 | 593-925 | PTKc |
| cd05099 | 576-930 | PTKc_FGFR4 |
| cd05101 | 575-933 | PTKc_FGFR2 |
| cd05098 | 575-934 | PTKc_FGFR1 |
| cd05100 | 576-940 | PTKc_FGFR3 |
| cd05045 | 588-931 | PTKc_RET |
| cd05032 | 582-925 | PTKc_InsR_like |
| cd05050 | 583-926 | PTKc_Musk |
| cd05039 | 582-922 | PTKc_Csk_like |
| cd05034 | 593-917 | PTKc_Src_like |
| cd05048 | 583-920 | PTKc_Ror |
| cd05068 | 581-917 | PTKc_Frk_like |
| cd05041 | 595-922 | PTKc_Fes_like |
| cd05047 | 595-923 | PTKc_Tie |
| cd05036 | 583-926 | PTKc_ALK_LTK |
| cd05061 | 582-931 | PTKc_InsR |
| cd05089 | 582-923 | PTKc_Tie1 |
| cd05044 | 593-925 | PTKc_c-ros |
| cd05049 | 583-926 | PTKc_Trk |
| cd05052 | 582-925 | PTKc_Abl |
| cd13999 | 595-924 | STKc_MAP3K-like |
| cd05060 | 593-924 | PTKc_Syk_like |
| cd05038 | 584-925 | PTKc_Jak_rpt2 |
| cd05051 | 583-920 | PTKc_DDR |
| cd05148 | 582-918 | PTKc_Srm_Brk |
| cd05085 | 592-920 | PTKc_Fer |
| cd05072 | 582-925 | PTKc_Lyn |
| cd05088 | 587-939 | PTKc_Tie2 |
| cd05059 | 589-924 | PTKc_Tec_like |
| cd05033 | 593-928 | PTKc_EphR |
| cd05058 | 595-930 | PTKc_Met_Ron |
| cd05083 | 582-927 | PTKc_Chk |
| cd05067 | 581-925 | PTKc_Lck_Blk |
| cd05092 | 581-920 | PTKc_TrkA |
| cd05057 | 583-921 | PTKc_EGFR_like |
| cd05046 | 584-926 | PTK_CCK4 |
| cd05097 | 583-924 | PTKc_DDR_like |
| cd05056 | 582-925 | PTKc_FAK |
| cd04975 | 311-411 | Ig4_SCFR_like |
| cd05040 | 593-924 | PTKc_Ack_like |
| cd05073 | 582-925 | PTKc_Hck |
| cd05062 | 582-926 | PTKc_IGF-1R |
| cd05035 | 589-926 | PTKc_TAM |
| cd05084 | 592-922 | PTKc_Fes |
| cd05082 | 582-925 | PTKc_Csk |
| cd05091 | 591-920 | PTKc_Ror2 |
| cd05095 | 583-926 | PTKc_DDR2 |
| cd14204 | 586-931 | PTKc_Mer |
| cd14203 | 593-925 | PTKc_Src_Fyn_like |
| cd00180 | 595-922 | PKc |
| cd05075 | 588-926 | PTKc_Axl |
| cd05090 | 583-920 | PTKc_Ror1 |
| cd05094 | 586-924 | PTKc_TrkC |
| cd05113 | 586-925 | PTKc_Btk_Bmx |
| cd05069 | 582-925 | PTKc_Yes |
| cd05096 | 583-924 | PTKc_DDR1 |
| cd05063 | 593-928 | PTKc_EphR_A2 |
| cd05070 | 582-925 | PTKc_Fyn |
| cd05116 | 774-917 | PTKc_Syk |
| cd05043 | 598-922 | PTK_Ryk |
| cd05093 | 586-944 | PTKc_TrkB |
| cd05066 | 587-928 | PTKc_EphR_A |
| cd05071 | 582-931 | PTKc_Src |
| cd05074 | 585-925 | PTKc_Tyro3 |
| cd05108 | 593-959 | PTKc_EGFR |
| cd05112 | 587-921 | PTKc_Itk |
| cd14058 | 595-927 | STKc_TAK1 |
| cd05065 | 593-928 | PTKc_EphR_B |
| cd05115 | 595-924 | PTKc_Zap-70 |
| cd05109 | 593-921 | PTKc_HER2 |
| cd05114 | 589-924 | PTKc_Tec_Rlk |
| cd05079 | 584-928 | PTKc_Jak1_rpt2 |
| cd14205 | 584-926 | PTKc_Jak2_rpt2 |
| cd05081 | 772-925 | PTKc_Jak3_rpt2 |
| cd05080 | 584-925 | PTKc_Tyk2_rpt2 |
| cd05111 | 584-920 | PTK_HER3 |
| cd05064 | 593-928 | PTKc_EphR_A10 |
| cd14059 | 595-925 | STKc_MAP3K12_13 |
| cd05110 | 775-920 | PTKc_HER4 |
| cd14061 | 775-926 | STKc_MLK |
| cd06606 | 592-916 | STKc_MAPKKK |
| cd14206 | 595-920 | PTKc_Aatyk3 |
| cd14060 | 596-925 | STKc_MLTK |
| cd14062 | 595-925 | STKc_Raf |
| cd05042 | 593-916 | PTKc_Aatyk |
| cd14146 | 595-922 | STKc_MLK4 |
| cd05122 | 590-922 | PKc_STE |
| cd06627 | 588-919 | STKc_Cdc7_like |
| cd14147 | 771-925 | STKc_MLK3 |
| cd05087 | 593-920 | PTKc_Aatyk1 |
| cd13978 | 595-917 | STKc_RIP |
| cd14148 | 771-925 | STKc_MLK2 |
| cd14063 | 589-926 | PK_KSR |
| cd14150 | 593-925 | STKc_A-Raf |
| cd14145 | 771-921 | STKc_MLK1 |
| cd14151 | 582-925 | STKc_B-Raf |
| cd14065 | 595-922 | PKc_LIMK_like |
| cd14003 | 591-920 | STKc_AMPK-like |
| cd06608 | 585-922 | STKc_myosinIII_N_like |
| cd14027 | 772-920 | STKc_RIP1 |
| cd14221 | 771-925 | STKc_LIMK1 |
| cd08215 | 593-924 | STKc_Nek |
| cd14007 | 591-922 | STKc_Aurora |
| cd06629 | 771-916 | STKc_Bck1_like |
| cd14014 | 775-916 | STKc_PknB_like |
| cd14066 | 595-926 | STKc_IRAK |
| cd06614 | 775-922 | STKc_PAK |
| cd05086 | 595-924 | PTKc_Aatyk2 |
| cd06632 | 592-920 | STKc_MEKK1_plant |
| cd05117 | 591-919 | STKc_CAMK |
| cd05118 | 771-922 | STKc_CMGC |
| cd06605 | 773-922 | PKc_MAPKK |
| cd14137 | 593-916 | STKc_GSK3 |
| cd14064 | 595-925 | PKc_TNNI3K |
| cd14121 | 595-919 | STKc_ULK3 |
| cd06628 | 771-921 | STKc_Byr2_like |
| cd06612 | 774-922 | STKc_MST1_2 |
| cd14149 | 775-925 | STKc_C-Raf |
| cd14000 | 774-924 | STKc_LRRK |
| cd13992 | 771-926 | PK_GC |
| cd05581 | 587-916 | STKc_PDK1 |
| cd06611 | 595-922 | STKc_SLK_like |
| cd05123 | 775-914 | STKc_AGC |
| cd14156 | 776-925 | PKc_LIMK_like_unk |
| cd14154 | 771-920 | STKc_LIMK |
| cd13979 | 588-916 | STKc_Mos |
| cd14158 | 592-925 | STKc_IRAK4 |
| cd06623 | 773-922 | PKc_MAPKK_plant_like |
| cd14099 | 772-922 | STKc_PLK |
| cd08530 | 593-922 | STKc_CNK2-like |
| cd14155 | 773-925 | PKc_TESK |
| cd07833 | 594-922 | STKc_CDKL |
| cd06621 | 776-922 | PKc_Pek1_like |
| cd08225 | 593-922 | STKc_Nek5 |
| cd06622 | 773-922 | PKc_PBS2_like |
| cd14186 | 771-921 | STKc_PLK4 |
| cd08223 | 775-922 | STKc_Nek4 |
| cd06917 | 780-914 | STKc_NAK1_like |
| cd06631 | 772-922 | STKc_YSK4 |
| cd07829 | 595-922 | STKc_CDK_like |
| cd14002 | 771-870 | STKc_STK36 |
| cd06609 | 774-922 | STKc_MST3_like |
| cd06642 | 775-922 | STKc_STK25 |
| cd05037 | 775-921 | PTK_Jak_rpt1 |
| cd13996 | 595-920 | STKc_EIF2AK |
| cd13997 | 595-921 | PKc_Wee1_like |
| cd14202 | 581-892 | STKc_ULK1 |
| cd08217 | 789-923 | STKc_Nek2 |
| cd14222 | 771-920 | STKc_LIMK2 |
| cd07830 | 771-922 | STKc_MAK_like |
| cd07834 | 772-863 | STKc_MAPK |
| cd14008 | 774-920 | STKc_LKB1_CaMKK |
| cd06620 | 773-921 | PKc_Byr1_like |
| cd07858 | 772-872 | STKc_TEY_MAPK |
| cd05859 | 311-410 | Ig4_PDGFR-alpha |
| cd06644 | 775-922 | STKc_STK10 |
| cd14079 | 592-922 | STKc_AMPK_alpha |
| cd14011 | 774-924 | PK_SCY1_like |
| cd08224 | 774-922 | STKc_Nek6_7 |
| cd06626 | 772-916 | STKc_MEKK4 |
| cd14044 | 771-926 | PK_GC-C |
| cd06610 | 775-916 | STKc_OSR1_SPAK |
| cd14081 | 772-922 | STKc_BRSK1_2 |
| cd05620 | 772-920 | STKc_nPKC_delta |
| cd14131 | 786-922 | PKc_Mps1 |
| cd14025 | 774-920 | STKc_RIP4_like |
| cd07840 | 771-872 | STKc_CDK9_like |
| cd13994 | 595-921 | STKc_HAL4_like |
| cd07846 | 774-922 | STKc_CDKL2_3 |
| cd06619 | 776-871 | PKc_MKK5 |
| cd08222 | 775-922 | STKc_Nek11 |
| cd07852 | 774-872 | STKc_MAPK15-like |
| cd08529 | 592-923 | STKc_FA2-like |
| cd08228 | 775-928 | STKc_Nek6 |
| cd08220 | 593-920 | STKc_Nek8 |
| cd05078 | 773-922 | PTK_Jak2_rpt1 |
| cd06617 | 776-922 | PKc_MKK3_6 |
| cd07857 | 771-869 | STKc_MPK1 |
| cd13975 | 776-925 | PKc_Dusty |
| cd14119 | 775-920 | STKc_LKB1 |
| cd14009 | 595-872 | STKc_ATG1_ULK_like |
| cd07849 | 772-872 | STKc_ERK1_2_like |
| cd14067 | 773-927 | STKc_LRRK1 |
| cd14045 | 771-926 | PK_GC_unk |
| cd14080 | 591-922 | STKc_TSSK-like |
| cd06641 | 775-922 | STKc_MST3 |
| cd14047 | 774-920 | STKc_EIF2AK2_PKR |
| cd06613 | 775-922 | STKc_MAP4K3_like |
| cd06607 | 775-922 | STKc_TAO |
| cd07838 | 773-865 | STKc_CDK4_6_like |
| cd14057 | 771-926 | PK_ILK |
| cd07847 | 774-922 | STKc_CDKL1_4 |
| cd06648 | 775-922 | STKc_PAK_II |
| cd06639 | 593-922 | STKc_myosinIIIB_N |
| cd06640 | 775-922 | STKc_MST4 |
| cd14043 | 778-920 | PK_GC-2D |
| cd14052 | 593-861 | PTKc_Wee1_fungi |
| cd07841 | 771-919 | STKc_CDK7 |
| cd07848 | 771-872 | STKc_CDKL5 |
| cd14120 | 595-870 | STKc_ULK1_2-like |
| cd05579 | 772-923 | STKc_MAST_like |
| cd13998 | 776-930 | STKc_TGFbR-like |
| cd06616 | 787-920 | PKc_MKK4 |
| cd07845 | 775-863 | STKc_CDK10 |
| cd06618 | 773-922 | PKc_MKK7 |
| cd05578 | 776-914 | STKc_Yank1 |
| cd08229 | 775-915 | STKc_Nek7 |
| cd06654 | 778-922 | STKc_PAK1 |
| cd07859 | 772-875 | STKc_TDY_MAPK |
| cd14133 | 771-922 | PKc_DYRK_like |
| cd14010 | 771-922 | STKc_ULK4 |
| cd05077 | 775-924 | PTK_Jak1_rpt1 |
| cd14153 | 775-926 | PK_KSR2 |
| cd06659 | 776-870 | STKc_PAK6 |
| cd14001 | 773-926 | PKc_TOPK |
| cd13982 | 774-920 | STKc_IRE1 |
| cd14152 | 775-926 | STKc_KSR1 |
| cd14054 | 776-916 | STKc_BMPR2_AMHR2 |
| cd07839 | 771-884 | STKc_CDK5 |
| cd14006 | 595-916 | STKc_MLCK-like |
| cd08221 | 774-921 | STKc_Nek9 |
| cd14084 | 772-922 | STKc_Chk2 |
| cd05570 | 776-914 | STKc_PKC |
| cd14187 | 775-921 | STKc_PLK1 |
| cd06638 | 779-922 | STKc_myosinIIIA_N |
| cd14050 | 778-923 | PKc_Myt1 |
| cd14185 | 778-922 | STKc_DCKL3 |
| cd14201 | 772-903 | STKc_ULK2 |
| cd06634 | 778-916 | STKc_TAO2 |
| cd13993 | 588-924 | STKc_Pat1_like |
| cd05630 | 772-920 | STKc_GRK6 |
| cd05592 | 779-914 | STKc_nPKC_theta_like |
| cd14103 | 772-872 | STKc_MLCK |
| cd06643 | 775-922 | STKc_SLK |
| cd14098 | 775-922 | STKc_Rad53_Cds1 |
| cd14106 | 775-922 | STKc_DRAK |
| cd06656 | 778-922 | STKc_PAK3 |
| cd14663 | 775-922 | STKc_SnRK3 |
| cd07853 | 772-864 | STKc_NLK |
| cd14069 | 592-922 | STKc_Chk1 |
| cd14664 | 595-925 | STK_BAK1_like |
| cd14056 | 772-916 | STKc_TGFbR_I |
| cd14004 | 775-922 | STKc_PASK |
| cd07832 | 771-872 | STKc_CCRK |
| cd14068 | 775-924 | STKc_LRRK2 |
| cd08219 | 775-921 | STKc_Nek3 |
| cd14042 | 620-920 | PK_GC-A_B |
| cd05580 | 591-914 | STKc_PKA_like |
| cd05605 | 775-870 | STKc_GRK4_like |
| cd07862 | 774-863 | STKc_CDK6 |
| cd05572 | 775-904 | STKc_cGK |
| cd07856 | 772-872 | STKc_Sty1_Hog1 |
| cd07877 | 774-872 | STKc_p38alpha |
| cd07843 | 774-858 | STKc_CDC2L1 |
| cd06635 | 771-922 | STKc_TAO1 |
| cd08218 | 775-922 | STKc_Nek1 |
| cd06625 | 772-916 | STKc_MEKK3_like |
| cd06636 | 775-922 | STKc_MAP4K4_6_N |
| cd08528 | 786-924 | STKc_Nek10 |
| cd06630 | 771-922 | STKc_MEKK1 |
| cd14208 | 589-922 | PTK_Jak3_rpt1 |
| cd06657 | 776-922 | STKc_PAK4 |
| cd14048 | 775-862 | STKc_EIF2AK3_PERK |
| cd06647 | 775-922 | STKc_PAK_I |
| cd06633 | 778-922 | STKc_TAO3 |
| cd07878 | 582-944 | STKc_p38beta |
| cd05616 | 772-914 | STKc_cPKC_beta |
| cd06655 | 778-922 | STKc_PAK2 |
| cd06650 | 773-878 | PKc_MEK1 |
| cd06624 | 595-922 | STKc_ASK |
| cd05619 | 772-914 | STKc_nPKC_theta |
| cd07864 | 771-922 | STKc_CDK12 |
| cd13977 | 771-862 | STKc_PDIK1L |
| cd14175 | 774-922 | STKc_RSK1_C |
| cd07863 | 775-863 | STKc_CDK4 |
| cd06649 | 773-878 | PKc_MEK2 |
| cd06615 | 773-883 | PKc_MEK |
| cd07866 | 774-863 | STKc_BUR1 |
| cd07831 | 771-922 | STKc_MOK |
| cd14209 | 775-914 | STKc_PKA |
| cd07850 | 774-872 | STKc_JNK |
| cd07854 | 772-872 | STKc_MAPK4_6 |
| cd14135 | 771-894 | STKc_PRP4 |
| cd07851 | 774-872 | STKc_p38 |
| cd13989 | 776-870 | STKc_IKK |
| cd14073 | 588-922 | STKc_NUAK |
| cd14087 | 740-896 | STKc_PSKH1 |
| cd05076 | 775-922 | PTK_Tyk2_rpt1 |
| cd14072 | 775-922 | STKc_MARK |
| cd06637 | 775-922 | STKc_TNIK |
| cd07880 | 774-864 | STKc_p38gamma |
| cd05577 | 772-870 | STKc_GRK |
| cd14012 | 771-920 | PK_eIF2AK_GCN2_rpt1 |
| cd14173 | 776-872 | STKc_Mnk2 |
| cd07873 | 772-890 | STKc_PCTAIRE1 |
| cd07872 | 772-898 | STKc_PCTAIRE2 |
| cd06658 | 776-874 | STKc_PAK5 |
| cd14192 | 772-872 | STKc_MLCK3 |
| cd05582 | 775-893 | STKc_RSK_N |
| cd14086 | 774-922 | STKc_CaMKII |
| cd14090 | 776-872 | STKc_Mnk |
| cd14078 | 772-921 | STKc_MELK |
| cd14094 | 775-919 | STKc_CASK |
| cd14097 | 776-921 | STKc_STK33 |
| cd14142 | 790-926 | STKc_ACVR1_ALK1 |
| cd14091 | 776-922 | STKc_RSK_C |
| cd14197 | 775-872 | STKc_DRAK1 |
| cd14177 | 774-922 | STKc_RSK4_C |
| cd14077 | 771-921 | STKc_Kin1_2 |
| cd14194 | 772-922 | STKc_DAPK1 |
| cd07836 | 771-872 | STKc_Pho85 |
| cd14190 | 772-872 | STKc_MLCK2 |
| cd05590 | 593-914 | STKc_nPKC_eta |
| cd06646 | 775-921 | STKc_MAP4K5 |
| cd14164 | 775-920 | STKc_TSSK6-like |
| cd07871 | 772-890 | STKc_PCTAIRE3 |
| cd05632 | 772-872 | STKc_GRK5 |
| cd14105 | 771-872 | STKc_DAPK |
| cd14046 | 775-922 | STKc_EIF2AK4_GCN2_rpt2 |
| cd07870 | 772-873 | STKc_PFTAIRE2 |
| cd05631 | 772-870 | STKc_GRK4 |
| cd05585 | 783-914 | STKc_YPK1_like |
| cd06653 | 772-922 | STKc_MEKK3_like_u1 |
| cd05608 | 772-918 | STKc_GRK1 |
| cd14210 | 771-863 | PKc_DYRK |
| cd14143 | 773-916 | STKc_TGFbR1_ACVR1b_ACVR1c |
| cd14114 | 775-919 | STKc_Twitchin_like |
| cd14116 | 775-922 | STKc_Aurora-A |
| cd05615 | 772-914 | STKc_cPKC_alpha |
| cd14178 | 776-922 | STKc_RSK3_C |
| cd14189 | 775-922 | STKc_PLK3 |
| cd14093 | 775-922 | STKc_PhKG |
| cd07879 | 774-864 | STKc_p38delta |
| cd07860 | 771-890 | STKc_CDK2_3 |
| cd13987 | 773-882 | STKc_SBK1 |
| cd14176 | 774-922 | STKc_RSK2_C |
| cd07842 | 771-878 | STKc_CDK8_like |
| cd14191 | 775-872 | STKc_MLCK1 |
| cd13995 | 773-922 | STKc_MAP3K8 |
| cd14053 | 776-924 | STKc_ACVR2 |
| pfam00047 | 226-292 | ig |
| cd14107 | 775-916 | STKc_obscurin_rpt1 |
| cd14026 | 595-917 | STKc_RIP2 |
| cd07837 | 771-890 | STKc_CdkB_plant |
| cd14076 | 775-922 | STKc_Kin4 |
| cd14049 | 774-863 | STKc_EIF2AK1_HRI |
| cd07844 | 772-873 | STKc_PCTAIRE_like |
| cd07835 | 771-858 | STKc_CDK1_CdkB_like |
| cd14198 | 775-872 | STKc_DRAK2 |
| cd05611 | 775-914 | STKc_Rim15_like |
| cd07855 | 772-872 | STKc_ERK5 |
| cd14144 | 773-916 | STKc_BMPR1 |
| cd14196 | 771-872 | STKc_DAPK2 |
| cd14174 | 776-922 | STKc_Mnk1 |
| cd13968 | 595-812 | PKc_like |
| cd07876 | 774-885 | STKc_JNK2 |
| cd14104 | 771-872 | STKc_Titin |
| cd13985 | 593-927 | STKc_GAK_like |
| cd06652 | 772-917 | STKc_MEKK2 |
| cd14085 | 740-922 | STKc_CaMKIV |
| cd06645 | 773-922 | STKc_MAP4K3 |
| cd05587 | 772-879 | STKc_cPKC |
| cd14159 | 595-878 | STKc_IRAK1 |
| cd14181 | 778-922 | STKc_PhKG2 |
| cd06651 | 772-922 | STKc_MEKK3 |
| cd14162 | 592-907 | STKc_TSSK4-like |
| cd14188 | 775-922 | STKc_PLK2 |
| cd14220 | 790-926 | STKc_BMPR1a |
| cd14193 | 771-872 | STKc_MLCK4 |
| cd14165 | 774-885 | STKc_TSSK1_2-like |
| cd14195 | 772-872 | STKc_DAPK3 |
| cd14665 | 772-920 | STKc_SnRK2-3 |
| cd07875 | 774-885 | STKc_JNK1 |
| cd14036 | 774-925 | STKc_GAK |
| cd05595 | 772-914 | STKc_PKB_beta |
| pfam13927 | 212-294 | Ig_3 |
| cd14109 | 772-872 | PK_Unc-89_rpt1 |
| cd05573 | 788-870 | STKc_ROCK_NDR_like |
| cd13983 | 775-920 | STKc_WNK |
| cd14037 | 774-920 | STKc_NAK_like |
| cd05609 | 782-914 | STKc_MAST |
| cd07874 | 774-885 | STKc_JNK3 |
| cd14018 | 775-916 | STKc_PINK1 |
| cd13986 | 778-929 | STKc_16 |
| cd14199 | 772-920 | STKc_CaMKK2 |
| cd14167 | 740-922 | STKc_CaMKI_alpha |
| cd14170 | 776-957 | STKc_MAPKAPK2 |
| cd14039 | 776-861 | STKc_IKK_alpha |
| cd07861 | 771-862 | STKc_CDK1_euk |
| cd14111 | 771-870 | STKc_SPEG_rpt2 |
| cd14200 | 779-870 | STKc_CaMKK1 |
| cd14082 | 775-870 | STKc_PKD |
| cd14219 | 790-933 | STKc_BMPR1b |
| cd14070 | 775-919 | STKc_HUNK |
| cd14083 | 586-946 | STKc_CaMKI |
| cd05612 | 772-914 | STKc_PRKX_like |
| cd14038 | 776-870 | STKc_IKK_beta |
| cd14182 | 780-870 | STKc_PhKG1 |
| cd07869 | 772-873 | STKc_PFTAIRE1 |
| pfam13895 | 44-111 | Ig_2 |
| cl11960 | 44-111 | Ig superfamily |
| cd05617 | 772-914 | STKc_aPKC_zeta |
| cd14095 | 774-922 | STKc_DCKL |
| cd13991 | 775-854 | STKc_NIK |
| cd14033 | 772-922 | STKc_WNK4 |
| cd14166 | 745-919 | STKc_CaMKI_gamma |
| cd07865 | 775-862 | STKc_CDK9 |
| cd14161 | 586-883 | STKc_NUAK2 |
| cd14075 | 775-920 | STKc_NIM1 |
| cd14019 | 778-916 | STKc_Cdc7 |
| cd05613 | 789-914 | STKc_MSK1_N |
| cd14183 | 774-878 | STKc_DCKL1 |
| cd14101 | 772-922 | STKc_PIM2 |
| cd14662 | 772-920 | STKc_SnRK2 |
| cd05607 | 772-870 | STKc_GRK7 |
| cd14134 | 771-863 | PKc_CLK |
| cd14180 | 780-914 | STKc_MSK2_C |
| cd14031 | 771-921 | STKc_WNK3 |
| cd14136 | 773-862 | STKc_SRPK |
| cd05583 | 783-870 | STKc_MSK_N |
| cd14096 | 775-920 | STKc_RCK1-like |
| cd14071 | 774-922 | STKc_SIK |
| cd14108 | 771-872 | STKc_SPEG_rpt1 |
| cd14118 | 779-870 | STKc_CAMKK |
| cd00099 | 222-307 | IgV |
| cd05601 | 789-872 | STKc_CRIK |
| cd05604 | 772-967 | STKc_SGK3 |
| cd14110 | 774-922 | STKc_obscurin_rpt2 |
| cd14088 | 745-870 | STKc_CaMK_like |
| cd14092 | 775-934 | STKc_MSK_C |
| cd05618 | 772-914 | STKc_aPKC_iota |
| cd14229 | 775-872 | STKc_HIPK3 |
| cd05594 | 772-914 | STKc_PKB_alpha |
| cd14117 | 771-907 | STKc_Aurora-B_like |
| cd14089 | 774-922 | STKc_MAPKAPK |
| cd14074 | 775-922 | STKc_SNRK |
| cd14055 | 776-916 | STKc_TGFbR2_like |
| cd14179 | 789-914 | STKc_MSK1_C |
| cd14184 | 774-870 | STKc_DCKL2 |
| cd05593 | 772-914 | STKc_PKB_gamma |
| cd14032 | 771-906 | STKc_WNK2_like |
| cd14020 | 776-864 | STKc_KIS |
| cd05584 | 783-928 | STKc_p70S6K |
| cd14213 | 586-647 | PKc_CLK1_4 |
| cd05602 | 772-870 | STKc_SGK1 |
| cd05603 | 772-865 | STKc_SGK2 |
| cd05586 | 783-886 | STKc_Sck1_like |
| cd05598 | 789-910 | STKc_LATS |
| cd14130 | 775-925 | STKc_TTBK1 |
| cd14169 | 740-922 | STKc_CaMKI_beta |
| cd14113 | 787-870 | STKc_Trio_C |
| cd14005 | 775-922 | STKc_PIM |
| cd05588 | 772-870 | STKc_aPKC |
| cd14100 | 771-921 | STKc_PIM1 |
| cd14172 | 779-921 | STKc_MAPKAPK3 |
| cd14112 | 775-872 | STKc_Unc-89_rpt2 |
| cd04969 | 274-307 | Ig5_Contactin_like |
| cd05571 | 780-914 | STKc_PKB |
| cd05729 | 270-307 | Ig2_FGFR_like |
| cd14030 | 771-921 | STKc_WNK1 |
| cd05591 | 772-914 | STKc_nPKC_epsilon |
| smart00750 | 774-950 | KIND |
| cd14227 | 775-872 | STKc_HIPK2 |
| cd14228 | 775-872 | STKc_HIPK1 |
| cd05614 | 789-870 | STKc_MSK2_N |
| pfam13895 | 212-307 | Ig_2 |
| pfam07714 | 589-924 | Pkinase_Tyr |
| smart00410 | 220-307 | IG_like |
| smart00221 | 589-924 | STYKc |
| smart00219 | 589-924 | TyrKc |
| smart00220 | 591-922 | S_TKc |
| pfam00069 | 591-922 | Pkinase |
| COG0515 | 591-976 | SPS1 |
| PTZ00283 | 775-923 | PTZ00283 |
| smart00409 | 220-307 | IG |
| PTZ00267 | 774-951 | PTZ00267 |
| PLN00034 | 773-922 | PLN00034 |
| PTZ00036 | 772-902 | PTZ00036 |
| PTZ00426 | 589-914 | PTZ00426 |
| PTZ00263 | 772-963 | PTZ00263 |
| PTZ00024 | 775-945 | PTZ00024 |
| PHA02988 | 790-925 | PHA02988 |
| PHA03209 | 775-874 | PHA03209 |
| PLN00009 | 771-890 | PLN00009 |
| pfam07679 | 224-307 | I-set |
| PTZ00266 | 789-904 | PTZ00266 |
| PRK13184 | 775-925 | pknD |
| PHA03212 | 771-862 | PHA03212 |
| smart00408 | 225-297 | IGc2 |
| PHA03390 | 774-870 | pk1 |
Ontology Information
| HPRD ID | 4992 |
|---|---|
| Molecular Class | Receptor tyrosine kinase |
| Molecular Function | Cytoskeletal protein binding (GO:0008092) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P10721 | DB00398 | Sorafenib | SmallMoleculeDrug |
| P10721 | DB00619 | Imatinib | SmallMoleculeDrug |
| P10721 | DB01254 | Dasatinib | SmallMoleculeDrug |
| P10721 | DB01268 | Sunitinib | SmallMoleculeDrug |
| P10721 | DB04868 | Nilotinib | SmallMoleculeDrug |
| P10721 | DB06589 | Pazopanib | SmallMoleculeDrug |
| P10721 | DB08896 | Regorafenib | SmallMoleculeDrug |
| P10721 | DB08901 | Ponatinib | SmallMoleculeDrug |
| P10721 | DB09078 | Lenvatinib | SmallMoleculeDrug |