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General Information
- Evidence
- Gene
- mRNA
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23894665 | 2013 | Cell line : - Source : Nanfang Hospital Sample Type : Serum sample No. of Sample : 35 healthy volunteers, 35 advanced colorectal adenoma , and 40 patients with CRC. Stage : - | MALDI-TOF-MS, ELISA, Immunohistochemistry | Up-regulation | - | kininogen-1 is a potential serum biomarker for the early detection of advanced colorectal adenoma and CRC. immunohistochemistry showed that expression of kininogen-1 was significantly higher in CRC and ACA tissues than in normal mucosa. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene. |
| Chromosome | 3 |
| Location | 3q27.3 |
| Start | 186717309 |
| End | 186744410 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 27102 |
| OMIM ID | 612358 |
| HGNC ID | HGNC:6383 |
| Unigene ID | Hs.77741 |
| Ensembl ID | ENSG00000113889 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_000893.3 |
|---|---|
| Exon | join(1..429,2797..2907,5129..5213,7780..7952,9929..10036, 14237..14321,15194..15366,21791..21898,22020..22106, 24214..24291,26397..27102) | mRNA Sequence | Download Select all |
| Length | 2143 |
CDS Information
| Location | join(235..429,2797..2907,5129..5213,7780..7952, 9929..10036,14237..14321,15194..15366,21791..21898, 22020..22106,24214..24291,26397..26477) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS3281.1 |
Protein Information
| Protein ID | NP_000884.1 |
|---|---|
| Protein Name | kininogen 1 |
| Molecular Wt. (Da) | 40625 |
| Protein Sequence | Download Select all |
| Length | 427 |
| Uniprot ID | P52789 |
| Ensembl Protein ID | ENSP00000290573 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| C | Disulfide Bridge | 107;126 |
| C | Disulfide Bridge | 142;145 |
| N | Glycosylation | 169 |
| C | Disulfide Bridge | 206;218 |
| C | Disulfide Bridge | 229;248 |
| C | Disulfide Bridge | 264;267 |
| N | Glycosylation | 294 |
| C | Disulfide Bridge | 328;340 |
| C | Disulfide Bridge | 351;370 |
| L | Proteolytic Cleavage | 378 |
| C | Disulfide Bridge | 83;94 |
| G | Proteolytic Cleavage | 384 |
| R | Proteolytic Cleavage | 389 |
| M | Proteolytic Cleavage | 379 |
| R | Proteolytic Cleavage | 389 |
| P | Proteolytic Cleavage | 387 |
| P | Proteolytic Cleavage | 383 |
| F | Proteolytic Cleavage | 385 |
| N | Glycosylation | 294 |
| N | Glycosylation | 205 |
| N | Glycosylation | 205 |
| N | Glycosylation | 48 |
| N | Glycosylation | 48 |
| N | Glycosylation | 169 |
| S | Phosphorylation | 332 |
| S | Phosphorylation | 332 |
| S | Phosphorylation | 329 |
| S | Phosphorylation | 329 |
| T | Phosphorylation | 326 |
| T | Phosphorylation | 326 |
| T | Phosphorylation | 327 |
| T | Phosphorylation | 327 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 183 | AGT | 106 | NP_000020.1 | in vivo | 11677365 |
| 351 | APP | 100 | NP_000475.1 | in vivo | 12090937 |
| 823 | CAPN1 | 253 | NP_005177.2 | in vitro | 30 381 698 253 784 |
| 824 | CAPN2 | 254 | NP_001739.2 | in vitro | 3038169 |
| 1511 | CTSG | 289 | NP_001902.1 | in vitro | 11920276 |
| 1514 | CTSL1 | 293 | NP_001903.1 | in vitro | 11517935 |
| 1520 | CTSS | 292 | NP_004070.3 | in vitro | 8706894 |
| 1991 | ELANE | 554 | NP_001963.1 | in vitro | 12887060 |
| 2147 | F2 | 1488 | NP_000497.1 | in vitro | 1652157 |
| 2512 | FTL | 616 | NP_000137.2 | in vitro | 12071855 |
| 3848 | KRT1 | 763 | NP_006112.3 | in vitro | 10066772 |
| 5329 | PLAUR | 1421 | NP_002650.1 | in vivo | 14764580 |
| 5340 | PLG | 1417 | NP_000292.1 | in vitro | 9428707 |
| 7057 | THBS1 | 1765 | NP_003237.2 | in vivo | 9459346 |
| 7448 | VTN | 1902 | NP_000629.3 | in vitro;in vivo | 10887113 |
| 22918 | CD93 | 396 | NP_036204.2 | in vitro | 122 133 298 710 908 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Complement and coagulation cascades | hsa04610 |
Structure Information
| PDB ID | 2WOK |
|---|---|
| Resolution | 1.7 |
| Method | X-RAY DIFFRACTION |
| Chains | B |
| Molecule | BRADYKININ |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00042 | 266-370 | CY |
| cl09238 | 266-370 | CY superfamily |
| cd00042 | 144-248 | CY |
| cl09238 | 144-248 | CY superfamily |
| cd00042 | 24-126 | CY |
| cl09238 | 24-126 | CY superfamily |
| smart00043 | 264-371 | CY |
| pfam00031 | 266-360 | Cystatin |
| pfam00031 | 144-237 | Cystatin |
| smart00043 | 142-249 | CY |
| pfam00031 | 24-114 | Cystatin |
| smart00043 | 24-127 | CY |
| PRK13263 | 423-469 | ureE |
| PRK13263 | 424-475 | ureE |
| PRK13263 | 420-466 | ureE |
Ontology Information
| HPRD ID | 834 |
|---|---|
| Molecular Class | Coagulation factor |
| Molecular Function | MHC class I receptor activity (GO:0030106); MHC class II receptor activity (GO:0045012) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.