CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
22968445	2012	Cell line : - Source : Department of Pathology of Wrocaw Medical University. Sample Type : - No. of Sample : - Stage : -	Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation.	Up-regulation	-	-

Gene Details

Chromosome: 17; NC_000017.10 (66031848..66042970)
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Gene Type	protein coding
Gene Family	Importins, Armadillo repeat containing
Description	The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq, Jul 2008]
Chromosome	17
Location	17q24.2
Start	68035732
End	68046854
Strand	+
Gene Sequence	>gi\|568815581:68035732-68046854 Homo sapiens chromosome 17, GRCh38.p2 Primary Assembly GCCACACGGTCTTTGAGCTGAGTCGAGGTGGACCCTTTGAACGCAGTCGCCCTACAGCCGCTGATTCCCC CCGCATCGCCTCCCGTGGAAGCCCAGGCCCGCTTCGCAGGTACAGACTCAGGCGGCGGCCCGGCCCGAGC GCTAACGGCTTGCCCGTGGGCGGCGTTCGCCTTTTGGGTTGGGGGAGGGAGGCCCCGGGTCCACGCCGAG CCTGGCTCTGCCTCCCGCGTTGACTAGGCCTCGGGGGCGACGTTCATTGACCAGGCGGCTGAGTTTCGCG GGGTCTGCGGGTTTAGGGCGCCGACGCTCTGCAAACGGCAGCGGAGGCCTTAACGCGTCGCGGCCGGGAG AATCGGAGCGAGCCAGGCTTGAGGGCGAATGTCCCGGGAGGACTTGTGGCGGCCCTGGTTTCGCCTCCTC CTTTCTCGTTGCATCTTCCCCGGCGTGGGGGCAGGGGCTGGGGGTGGCAGTTGGGAGCACCGTCTCTGAC ACCTAGGCCCCGGGGGTGGCTCTGCCACCAAGTCGTAGGCGAGCGTAATGAAAGCAAAGATAGCAAATTG TAAGGAGGGCTTTGACTTTTGTCATCTTCTGAATGACGCACAGCTGATGTCATCCTAATTAAGCGCATTC ACTCCTAGTCTCTGGAAATGCAAATCAAATATGCGAGATGCGGCACTGCATTTTTAATGTTGACCATAAT GTAATGATGAAGCAAATTTTTATTTAATTTTCGAGTCTGCACCTATTTTGGCCAAGTAAAGACAGTAAAA TAGGGAGAGCCTCCTGAGGATCTGAATTTATTGCCCTGGCACATAATTTTTAGCTGTAAGTTGACTTGGT TCCCCTACTTTGTCTTGAATTAACTATTAGGGACTCTGGAGTATCGAACTAGGCTGTCAGAAACGGTGGA TACATGTGGCTAGTCCAAATTGAAATACGCTGTAAGCTTAAAGTACACAAAAGATTTCAAAGATGGAGTA TGGAAAAAGAATGTAGAAGATGTCAGTTATTTTATATATTGATAACACGTTGAAATACTATTTGGATATG TTGGGTTAAGTAAAATACATTATTAAAATTAGTTTCACTTGTTTCTTTTCTCCTTTTTAAAAATATGGCT ACTAGGAAGTTTCAATTTATATAGCTTGCATTCTATTTCTGATGGAGAGCCCTCTCCAGGAAGTCTCAGC CCTTTAGAGGGAAGGGGGACACTTCCCCTTTGGGTAAAGCTATTTCATAGTGCCGAAAACATGATGATCC CCCCTCTAGTATACAGGTGTGGATTCAGTAGATGCTTGATAATTCAGTTCTTATTTGGTACTATTATTGA CAAAGGAAAATGATAAAGGAAATATTTTTCTCTTCCCCCATCTTTTAGCTTTCTCCCTTTGTCTCATAAC CATGTCCACCAACGAGAATGCTAATACACCAGCTGCCCGTCTTCACAGATTCAAGAACAAGGGAAAAGAC AGTACAGTGAGTACCTTCTGTTGCTTTCCTGTGGTGGTATTTAAATGGGAAGACATTTGGAAAGGGGTGA AAACTGAGGTATTTAAAAAAAAAATGCCCTCACTTAGCAACAAAAACTGGTGTGATAGGTGAAACGGCAT GTTATCTTTTCTCAAGGAAATGAGGCGTCGCAGAATAGAGGTCAATGTGGAGCTGAGGAAAGCTAAGAAG GATGACCAGATGCTGAAGAGGAGAAATGTAAGCTCATTTCCTGATGATGCTACTTCTCCGCTGCAGGAAA ACCGCAACAACCAGGTAAAAAATGTATTTTAGTTTATGAGTTACGTGAAATCCAGAAAATCAGTAGGGAC TTTTCTTAGAAATTCAAGTAAACTTAACATTTCTAGTCTTAACGGTTTTAACTATCTGTGAACATCTTTT TCTCTGTTTGCAATTAGTAATTGTCTTCTTTCCTGCCTTCTGTAATCCACTGAAGCTGATTTAGGATCTT CCTTTAGCTCTGACCTTCCTTCAGACTTCCCTGCATTTCTAGCTACTAGCTGGGTACCTTGGCCTGACCA GTGTGTCCAGAGCCAGCCAGTTTCTGGTTTATTTCTTCTTTTTTTTTTTTTTCCCCCGAGATGGAGTCTT GCTCTGTTGCTCAGGCTGGAGTGCAGCAGCACAATCGGCTCACTGCAACCTCTGCCTCATGGGTTCAAGC AATTCTCCTGCCACAGCCTCCTGAGTAGCTGGGATTATGGGTGCGCATCACCACGCTTGGCTAGTTTTTG TATTTTTTTGTTTTTGTTTCTTTGAGACAGAGTTTTGCTCTGTCGCCCAGGCTAGCGTGCAGTGGTGCGA TCTCCGCTCACTGCAAGCTCCATCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTAAGTAGCTGG GACTACAGGCGCCCGCACCCTGTCTGGCTAATTTTTTGTATTTTTAGTAGAGACGGTGTTTCAACATGTT AGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACA GGCGTGAGCCACTGCCCGGCCTGTTTTTGTATTTTTAGTAGAGGCGGGGTTTCACCATGTTGGCCAGGCT AGTCTTGAACTCATGACCTCGTGATATGCCTGCCTTGGTCTCCAGAAGTGCTGGGATTACAAGCGTGAGC CACCAGGCCCTTCCCGTTTTTGGTTTATTTCTGCCTTTTTTGGTATTCTCTATGTTTTTGTATTTGTCAC CAGCTTTGTTCAGGACTTTCCTTCTGAAATATTTACAGTAGCCTCCTAATTTATCATATCCTTCTTTATG CCATATACTATTTTCCTGAAATTTTTCCTGAAGTACTGCTTTAGACCTGTGTTTTCGCTCCTTAAAATCC ATACTCCAAATTGCTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCATTGCACTCCAGC CTGTGCAACAAGAGTGAAACTCCGTCTCAAGGAAAAAAATAAAAATAAAATAAATCCATACTCCAGCTGG GCATGGTGGTTCATGCCTGTAATTCCAACACTTTGGGAAGCTGAAATGGGAGGATCACTGGAGGCCAGGA GTTTGAGCCCAGCCTAGGCAACATAGGAAGACCTCGTCTCTATAAAAAGTAAAGTTAGCTGGGTGTGGTG GCGCCGGCCTTTAGTCCTAGGTATTCAGGGGGCTGAGACAGAAGAATCACTTGAGCCCGGGATTTTGAGG CTGCAGTGAGCTGTGATTGCACCACTGCACCCCATGCTGGGTGACAGTGAGACCCTGTCTCTAAGAAATC CCTACTCTATGAAGGCCTTCCATAAAGTAGACTTAACTTAGATTTTCAAATTTATCTTTCATCTGGGCCC TTTCCTACATGTTTTTCTCACAATATGCTTCCTTTTTTTTTTGTTTTGAGACAAAACCTTGGTTTGTTGC CCAGGCTGGAGTGCAGTGGTACGATCTTGGCTGACTGCAGCCTCCGTCTCCTGGGTTCAAGTGACTCTCC TGCCTCAGCCTCCCAAGTAGCTGGGATCACAGGGGATCACCACGATGTCTAGCTAATTTTTGCATTTTTA GTAGACACGGGGATTCACCGTGTTTCCCAGTCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCT CGGCCTCCCAAAGTGCTGGGATTACAGGCGCGAGCCACTTCGCCCAGCCAAACATAAACCATTTATATTT GCAGCAACACTTAACCGTGGAAATATGTAGATTATAAAATTAGATATGAAAATCCTCGGCCGGGTGTGGT GGCTCACACCTGTAATCCCATTACTTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCGGGAGTTTGAG ACCAGCCTGACCAACATGGAGAAACTCCATCTCTACTAAAAATACAAAATTAGCTGGGCATCGTGGCGCA TGCCTGTAATCCCAGCTACTCAGGAGGCTGTGGCAGGAGAATCGCTTGAACCCGGGAGGTGGAGGCGGTG GTGAGCCGAGATCACGCCATTGCACTCCAGCCTGGGCAAGAAGAGCAAAACTCTGTCTCCAAAAAAAAAA GTCGGGCATGGTAGCTCATGCCTGTAATTCCAGCACTTTGGGAGGCTGAGGCAGGTGGATCACCTGAGGT TGGCAGTTCGAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAAAAAAAAAAT TAGCCAGGCATGGTGGCGCATGCCTATAATCTCAGGTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAA CCCAGGAGGCGGAGGTGGTGGTGAGCCAAGATCATGCCACTGCACTCCAGCCTGGGGATTGAGTGAAACT CCGTCTCAAAAAAAAAAAGAAAAGAAAATCCTCAGAACGTTGCCTATGACTTCATGTCTTTCTCCCTCAA AGTATATCTGAATGCAAGTGATTGAGACTAACGTAGAAATAATCTTCAGTCTGCTCTGATTCTTGATTTT TGAGACAAGGTCTTGTATGGCGACAGGCAAACACCACCATGCCTGGATATTTTTTTTTTTTTTTTTTTTT TGTTGGGAGGTCTCACTGTGTTGCTCAGGCTGGTCTCACCTGAGCTCAAGCCATCCTCCCTCCTGAGCCT CCCAAAGTGCTAGGCTTACAGGTGTGAGCCACCATGCCTGTCCTTCTCGTTCATTTTTTAAAATTGTTCA AAGCTGCCTTTTTTAGCGACAAAACACTTGGATACTCCATAACTTGAGACTCCAGTGAGTCCATGACAAC AAGTTTGGAAACTGTTCTACATATAAAATAATGAATATTTAACAGGCAAAATTAAATGTAGGGCTAAATA TTTAGTAGCTGGCTATAAGCCTAACGATGTTTACACTTGCCTTCACAAGTAAGTGTGGATTTTATTGTTT GTATTTAATCTTAATGATAATGTGCAAACTTTCACTTTTCTTCTAGGGCACTGTAAATTGGTCTGTTGAT GACATTGTCAAAGGCATAAATAGCAGCAATGTGGAAAATCAGCTCCAAGCTACTCAAGCTGCCAGGTAAG TCTTGTCTGCGATAGCATGGGTAGCCTAAGAAATTTGTGTTTTTAGATTTTTTTTTGGGGGGTGGGGCAG GAAGGGACAGACAGATAGTACAAGGAAAGATTAGGCCAGCCAGCCATAAGCCAAATAGTATTTTTTATTT ATTAATTTTTTTGAGAGGGGAGGCCTTGCTATTTTGCCCAGGCTGGCCTGGAATGCCTGGGTTCAAGCAG TCCTCTGACCTCAGCCTCCTGAAGTGCTGGGATCACAGGTGTGTGCCATTGCACCTGCCCATAAAGTTTT TACCAAAGTAATGTTTCAAGTCACTGGCAGGGGAAGGAAGAAATAAATAGTAAGTGGGATTGAGACATGC ATTTAGAATGATAGATCCATTTAGGAGATAAGTATAATTTGACCTTTACCTCCCACTATACGTGGATATT TATGATATAATAGAAAGGATTAATAAGTTCTATAGCTTGACAGTGTGCAGAAGAAAAATTTCAATGGTAA ATTATCATTAAAAAGTTCTAGGCTGGGTGCTGTGGCTCATTCCTGTAATCCCAGCACTTTGGGAGGCCAA GGGGTCGGTTACTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAACATGGTGAGAGCCAGTTTCTACAAA AGAAATTATTAGCTGGGTGTGGTGGCACATGCCTGTAATCTCACGTGTTTGGGAGGCTCAGGCACAATAA TCACTTGAACCCAGCAGGCGGAGGTTGCAGTGAGCTGAGATCTTGCCACTGCATTCCAGCATGGCGACAG AGCAAGACTCTGTCTCAAAAAATAAATAAATAAAATAACTTGGGTGTGGCGGTGCACACTTGTCGTCCCA GCTACTAAGGAGGCTGAGGTGGGAGGATCACTTGAGCCCAGGAGGTCGAGGCTGCAGTGAGCTGTGATCG TGGCACTGCACTCTAGCCTGAGTGGAGTGAGATCCTATTTCAAAAAAACAAAATGTGCTTAACCACAACT ATCAGAACAAATTCAGTGAGAGTATAACCCTGTCAGAATGTGAAAAGTTTTTTTAAAAAGTGACAAGATC TGGAGTAGATTTCTGCAGGGATGGAAAGGAGGGTAATCTACATTAATTTCTGGAAAAATGGTAGTTAATT ATACCGCATACATAGCACCATACAAGTAATCTGTTCAGCTTCTCTTAGGTTCCAGAATGTCTCAGCATTT AGTGATTTACTTAAAAGGTTGTCTGAAGTTCTAAACTCTTGAATTGCATTTTATATTGGTTTTTACACAA ACTCCTTTTGTTAATCACTGTCAACTTTTATTTCTCTTTTTGTTCCCCTTTAGGAAACTACTTTCCAGAG AAAAACAGCCCCCCATAGACAACATAATCCGGGCTGGTTTGATTCCGAAATTTGTGTCCTTCTTGGGCAG AACTGATTGTAGTCCCATTCAGTTTGAATCTGCTTGGGCACTCACTAACATTGCTTCTGGGACATCAGAA CAAACCAAGGCTGTGGTAGATGGAGGTGCCATCCCAGCATTCATTTCTCTGTTGGCATCTCCCCATGCTC ACATCAGTGAACAAGCTGTCTGGGCTCTAGGAAACATTGCAGGTACTTGGACTTGAAGTTCTTTTGACTG AATGTATCTAATCGTAATTAGTTGGAAGAAAGGCCTTGTTATAAGTAATAGTGACTTTGTCAAGTTTTGA GCTTGCTTTCAAGCCCTTATTAGGAATGAAAGTGTCGTCTTTACAAAGGCAGCAGAGGGCCATCTAAGTA AGTTTGGGAGTTTTTGCTGGTGCATTCAGTCACTGAAAATTGATGGTGTTGGACAAGGTAATAAAATTAA TCTTGCCTCGGCCGGGCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCAGAGGCGGGTGGAT CATGAGGTCAGGAGATTGAGACCATCCTGGCTAACACAGTGAAACCCCACCTCTACTAAAAATACAAAAA ATTAGCCGGGCGTGGCGGCGGGCGCCTGAGGCTGAGGCAGGAGAATGGCTTGAACCCAGGAGGCGGAGCT TGCAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGAGAAACTCCGTCTCAAAAAAAA AAAAAAAAAAATTAATCTTGCCTTTTTTTTCAGGTGATGGCTCAGTGTTCCGAGACTTGGTTATTAAGTA CGGTGCAGTTGACCCACTGTTGGCTCTCCTTGCAGTTCCTGATATGTCATCTTTAGCAGTAAGTTACTAA CATGAGTAAAGTTACTCACTTCTTCATTCTAATTTCCCCCATCTTCTCAAAAGACAGAACCTCTCATTGC CTATTTTTTTTCCCCCAGTGTGGCTACTTACGTAATCTTACCTGGACACTTTCTAATCTTTGCCGCAACA AGAATCCTGCACCCCCGATAGATGCTGTTGAGCAGATTCTTCCTACCTTAGTTCGGCTCCTGCATCATGA TGATCCAGAAGTATTAGCAGATACCTGCTGGGCTATTTCCTACCTTACTGATGGTCCAAATGAACGAATT GGCATGGTGGTGAAAACAGGAGTTGTGCCCCAACTTGTGAAGCTTCTAGGAGCTTCTGAATTGCCAATTG TGGTAAGTTATTTACTTGTAGATTAGGACATAAGTATAAGAAGCATGATCAGGGCTGGGCGTGGTAGTGG TGGCTCACACCTGTGTAATCCCAGCACTTTGGGAGACCAAGGCAGGTGGATCACCTGAGGTCAGGAGTTC GAGACCAGCCTGGCCAACATTGTGAAAGCCCATCTCTACTAAAAATACAAAGAAATTATCTGGACATGGT GGCACGTGTCTGTAATCTCAACTACTCGGGAGGCTAAGGCAGGAGAATTGCTTGAATCTGGGAGGCAGAG GCTGCAGTGACCCGAAATCGTGCCATTATACTCCAGTCTCTCAAAAAAAAAAAAAAAAGCATAATCAGTT GATAGTAATATTGAAATATTGCCTATTTCAGGCCATGATGGGCCTCTTGTTAAAACTTTTAGGGTATAGA ATTTCTAAAGTGCTGGGGAAAAAATAACCAGCATCAACATATTTTTTTTTTTTCAGACTCCTGCCCTAAG AGCCATAGGGAATATTGTCACTGGTACAGATGAACAGACTCAGGTTGTGATTGATGCAGGAGCACTCGCC GTCTTTCCCAGCCTGCTCACCAACCCCAAAACTAACATTCAGAAGGAAGCTACGTGGACAATGTCAAACA TCACAGCCGGCCGCCAGGACCAGATACAGCAAGTTGTGAATCATGGATTAGTCCCATTCCTTGTCAGTGT TCTCTCTAAGGTAACGAAGTCTTAGGATTTAATCAAGTCATTTTTAGTATTTATAGAAAGCTGTGCTTGA TAAGCTTCTTCACGTGCAAGAATCTTGGGTTCTACTAGGAGTCCTTTGCTGAACAATACCCAGTAACCCC TTTTACTTAAGGTTGGATAGAACCTTGGTACTTTCAGTCATTGTTTTTGTGAAAAAGTACTCTTGGAATC TTATTTGTGCAACTGTTCTGAAATAAAACCATTTCCTTATGTTTAATAGGCAGATTTTAAGACACAAAAG GAAGCTGTGTGGGCCGTGACCAACTATACCAGTGGTGGAACAGTTGAACAGATTGTGTACCTTGTTCACT GTGGCATAATAGAACCGTTGATGAACCTCTTAACTGCAAAAGATACCAAGATTATTCTGGTTATCCTGGA TGCCATTTCAAATATCTTTCAGGTAAGTCCTATCAAGGTGGCTTTGTTTGAATTTGGACTTGATAATAAT CAGTTTACTATTTAGACTTGGGGGAGGGCAGCTGTAAGTTTACTCACTAGTAAGCCACAGAATCAGAAAG CCTGTTTATGTGGCCACCCCTTTGATTAAAAATGAGGCAGGCATTATAAAAGATACAAAAGAGACGACAA GTGGATGGTGTGACCTGAATCGGAGTCAGGCGCTTATGTGGACTCATCACACCTGTTTACTTGGTTGATT TAATTTCCCAATTTCATACCGATTTTTGGTGACATTAAATTTGAATGACTTGGCCAGGCACGGTGGCTCA TGCCTGTAATCACAGCACTTTGGAAGTCCGAGGTGGGTGGATCACCTGAGGTCAAGAGTTCGAGACCAGC CTGGCCAACATGGCGAAACCCTGTCTCTGCTAAAAATGCAAGAATTAGCCATGTGTGGTGGTGGGCGCCT ATAATCCCAGCTACTCAGAAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAAGCGGAAGTTGCAGTGAG CCAAGTTTGTGTTATTGCACTCCAGCTTGGGCAAGAGTGAAACTGTCTTAAAAAAAAAAAAAAAAAAAGT TGAGCCTTCAATAATGGATGCTAGCGTATCTGTTACTGTGTATAAATAATTTGTCAGTATGTGGCCAGTA TTTCTTCTTCCCCTCATCTAATCCCCTAAGTTATTTTGAAGCAAATCTGTTTTTTTCATCTATAGATATT TATGTATCTCTTTAAGGTTGAAAATTTAAAGGAAAACTAACCTACATACCATTCCATATGTCCAGTAAAT CCTTAATACCAACACACATTCTGTTTGGGGACGTTTAGTTTAGCACTCCATAGGCCATCTTTGCCCTTAG ACACCTTGACTACACCTTGTGATGACATAGGATGCTTTATGAAACAATACACCCCTGTTCCCATAGCAGA CCAGTTGAACTGGAATGTAGTGTTGTTTTAAAAGTTGCCCGCATGATTTTGATACATAGAAAAGGTTGGG AGCTACTACTGATTGTAAGATCTTTGGCTCCAGTTGAAGTAGTGCTAAAAGCAGGTACAGATCCAATCAC ATTGAGTGTCAACAAAATATAAAATGGACATAAAACTATGATAGGCTTGATGAAGGAATTGTTAGGTGCT TATTTCTGCCTGACGTATCAATATTCAAATTATTGATGTTTTCTTCATTAAAATAAAACCAGAGTATATG CCAGTAAACTTGGATTTTTTTTTTTTTTAGGCTGCTGAGAAACTAGGTGAAACTGAGAAACTTAGTATAA TGATTGAAGAATGTGGAGGCTTAGACAAAATTGAAGCTCTACAAAACCATGAAAATGAGTCTGTGTATAA GGCTTCGTTAAGCTTAATTGAGAAGTATTTCTCTGTAGAGGTGAGTAATGGATGGTAATATTAATAACAA CTTGGAAACATAAAGTCAAGGCCATAAGCCTTTTTTTCCCTTTTAAAAATAAGTGTCATATCTTTGTTAA ATATAGTAAAATATCAGTGTGCATGGGACATAATGTACTTATTTGCCCCTCTAGTTTGGCTTGATGGTAA TAAAATCTTTTTAAACTGAGATTTTAAAAGCCACCAGATTAGTTTCAAATGAACAACCTTGAGAATCTTA GAATATCTTGAGGGTAAGTTAACGGGTGTCATTGTAGGAGGTGATAGAGAAGTAGGCCAAACTCATCACC ATGCTCTGGGCCTAATACAGTCTTTTCCTATTGAAAAGTGACGGTTGGGGAAGAAAAAAATCTCGGCCTG TTTGTGTTACTGTAGTAGCTAGCATTTATGAATTGGCAAAGTTTCAGAGACCCTCCCTCCTCTATGTCAA ATACTATAATATCATACAGGATTAAAGGTGTAATATGCAGATCAAGACCTAGAGATTAAATACAGACTTC AGGTAGGCTGCTGCTTGGAATACTTATATCATTTTTATACTTATTTTTTAATATATTTCCAGGAAGAGGA AGATCAAAACGTTGTACCAGAAACTACCTCTGAAGGCTACACTTTCCAAGTTCAGGATGGGGCTCCTGGG ACCTTTAACTTTTAGATCATGTAGCTGAGACATAAATTTGTTGTGTACTACGTTTGGTATTTTGTCTTAT TGTTTCTCTACTAAGAACTCTTTCTTAAATGTGGTTTGTTACTGTAGCACTTTTTACACTGAAACTATAC TTGAACAGTTCCAACTGTACATACATACTGTATGAAGCTTGTCCTCTGACTAGGTTTCTAATTTCTATGT GGAATTTCCTATCTTGCAGCATCCTGTAAATAAACATTCAAGTCCACCCTTTTCTTGACTTCA Download Select all
Length	11123
OMIM ID	600685
HGNC ID	HGNC:6395
Unigene ID	Hs.594238
Ensembl ID	ENSG00000182481
PharmGKB ID	-

mRNA Information

mRNA ID	NM_002266.2
Exon	join(1..109,1379..1476,1627..1764,4947..5035,6354..6622, 7174..7268,7369..7632,8107..8340,8590..8772,10041..10190, 10773..11123)
mRNA Sequence	>3838 GCCACACGGTCTTTGAGCTGAGTCGAGGTGGACCCTTTGAACGCAGTCGCCCTACAGCCGCTGA TTCCCCCCGCATCGCCTCCCGTGGAAGCCCAGGCCCGCTTCGCAGCTTTCTCCCTTTGTCTCAT AACCATGTCCACCAACGAGAATGCTAATACACCAGCTGCCCGTCTTCACAGATTCAAGAACAAG GGAAAAGACAGTACAGAAATGAGGCGTCGCAGAATAGAGGTCAATGTGGAGCTGAGGAAAGCTA AGAAGGATGACCAGATGCTGAAGAGGAGAAATGTAAGCTCATTTCCTGATGATGCTACTTCTCC GCTGCAGGAAAACCGCAACAACCAGGGCACTGTAAATTGGTCTGTTGATGACATTGTCAAAGGC ATAAATAGCAGCAATGTGGAAAATCAGCTCCAAGCTACTCAAGCTGCCAGGAAACTACTTTCCA GAGAAAAACAGCCCCCCATAGACAACATAATCCGGGCTGGTTTGATTCCGAAATTTGTGTCCTT CTTGGGCAGAACTGATTGTAGTCCCATTCAGTTTGAATCTGCTTGGGCACTCACTAACATTGCT TCTGGGACATCAGAACAAACCAAGGCTGTGGTAGATGGAGGTGCCATCCCAGCATTCATTTCTC TGTTGGCATCTCCCCATGCTCACATCAGTGAACAAGCTGTCTGGGCTCTAGGAAACATTGCAGG TGATGGCTCAGTGTTCCGAGACTTGGTTATTAAGTACGGTGCAGTTGACCCACTGTTGGCTCTC CTTGCAGTTCCTGATATGTCATCTTTAGCATGTGGCTACTTACGTAATCTTACCTGGACACTTT CTAATCTTTGCCGCAACAAGAATCCTGCACCCCCGATAGATGCTGTTGAGCAGATTCTTCCTAC CTTAGTTCGGCTCCTGCATCATGATGATCCAGAAGTATTAGCAGATACCTGCTGGGCTATTTCC TACCTTACTGATGGTCCAAATGAACGAATTGGCATGGTGGTGAAAACAGGAGTTGTGCCCCAAC TTGTGAAGCTTCTAGGAGCTTCTGAATTGCCAATTGTGACTCCTGCCCTAAGAGCCATAGGGAA TATTGTCACTGGTACAGATGAACAGACTCAGGTTGTGATTGATGCAGGAGCACTCGCCGTCTTT CCCAGCCTGCTCACCAACCCCAAAACTAACATTCAGAAGGAAGCTACGTGGACAATGTCAAACA TCACAGCCGGCCGCCAGGACCAGATACAGCAAGTTGTGAATCATGGATTAGTCCCATTCCTTGT CAGTGTTCTCTCTAAGGCAGATTTTAAGACACAAAAGGAAGCTGTGTGGGCCGTGACCAACTAT ACCAGTGGTGGAACAGTTGAACAGATTGTGTACCTTGTTCACTGTGGCATAATAGAACCGTTGA TGAACCTCTTAACTGCAAAAGATACCAAGATTATTCTGGTTATCCTGGATGCCATTTCAAATAT CTTTCAGGCTGCTGAGAAACTAGGTGAAACTGAGAAACTTAGTATAATGATTGAAGAATGTGGA GGCTTAGACAAAATTGAAGCTCTACAAAACCATGAAAATGAGTCTGTGTATAAGGCTTCGTTAA GCTTAATTGAGAAGTATTTCTCTGTAGAGGAAGAGGAAGATCAAAACGTTGTACCAGAAACTAC CTCTGAAGGCTACACTTTCCAAGTTCAGGATGGGGCTCCTGGGACCTTTAACTTTTAGATCATG TAGCTGAGACATAAATTTGTTGTGTACTACGTTTGGTATTTTGTCTTATTGTTTCTCTACTAAG AACTCTTTCTTAAATGTGGTTTGTTACTGTAGCACTTTTTACACTGAAACTATACTTGAACAGT TCCAACTGTACATACATACTGTATGAAGCTTGTCCTCTGACTAGGTTTCTAATTTCTATGTGGA ATTTCCTATCTTGCAGCATCCTGTAAATAAACATTCAAGTCCACCCTTTTCTTGACTTCAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAA Download Select all
Length	2011

CDS Information

Location	join(1402..1476,1627..1764,4947..5035,6354..6622, 7174..7268,7369..7632,8107..8340,8590..8772,10041..10190, 10773..10865)
CDS Sequence	>gi\|62388891:133-1722 Homo sapiens karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (KPNA2), mRNA ATGTCCACCAACGAGAATGCTAATACACCAGCTGCCCGTCTTCACAGATTCAAGAACAAGGGAAAAGACA GTACAGAAATGAGGCGTCGCAGAATAGAGGTCAATGTGGAGCTGAGGAAAGCTAAGAAGGATGACCAGAT GCTGAAGAGGAGAAATGTAAGCTCATTTCCTGATGATGCTACTTCTCCGCTGCAGGAAAACCGCAACAAC CAGGGCACTGTAAATTGGTCTGTTGATGACATTGTCAAAGGCATAAATAGCAGCAATGTGGAAAATCAGC TCCAAGCTACTCAAGCTGCCAGGAAACTACTTTCCAGAGAAAAACAGCCCCCCATAGACAACATAATCCG GGCTGGTTTGATTCCGAAATTTGTGTCCTTCTTGGGCAGAACTGATTGTAGTCCCATTCAGTTTGAATCT GCTTGGGCACTCACTAACATTGCTTCTGGGACATCAGAACAAACCAAGGCTGTGGTAGATGGAGGTGCCA TCCCAGCATTCATTTCTCTGTTGGCATCTCCCCATGCTCACATCAGTGAACAAGCTGTCTGGGCTCTAGG AAACATTGCAGGTGATGGCTCAGTGTTCCGAGACTTGGTTATTAAGTACGGTGCAGTTGACCCACTGTTG GCTCTCCTTGCAGTTCCTGATATGTCATCTTTAGCATGTGGCTACTTACGTAATCTTACCTGGACACTTT CTAATCTTTGCCGCAACAAGAATCCTGCACCCCCGATAGATGCTGTTGAGCAGATTCTTCCTACCTTAGT TCGGCTCCTGCATCATGATGATCCAGAAGTATTAGCAGATACCTGCTGGGCTATTTCCTACCTTACTGAT GGTCCAAATGAACGAATTGGCATGGTGGTGAAAACAGGAGTTGTGCCCCAACTTGTGAAGCTTCTAGGAG CTTCTGAATTGCCAATTGTGACTCCTGCCCTAAGAGCCATAGGGAATATTGTCACTGGTACAGATGAACA GACTCAGGTTGTGATTGATGCAGGAGCACTCGCCGTCTTTCCCAGCCTGCTCACCAACCCCAAAACTAAC ATTCAGAAGGAAGCTACGTGGACAATGTCAAACATCACAGCCGGCCGCCAGGACCAGATACAGCAAGTTG TGAATCATGGATTAGTCCCATTCCTTGTCAGTGTTCTCTCTAAGGCAGATTTTAAGACACAAAAGGAAGC TGTGTGGGCCGTGACCAACTATACCAGTGGTGGAACAGTTGAACAGATTGTGTACCTTGTTCACTGTGGC ATAATAGAACCGTTGATGAACCTCTTAACTGCAAAAGATACCAAGATTATTCTGGTTATCCTGGATGCCA TTTCAAATATCTTTCAGGCTGCTGAGAAACTAGGTGAAACTGAGAAACTTAGTATAATGATTGAAGAATG TGGAGGCTTAGACAAAATTGAAGCTCTACAAAACCATGAAAATGAGTCTGTGTATAAGGCTTCGTTAAGC TTAATTGAGAAGTATTTCTCTGTAGAGGAAGAGGAAGATCAAAACGTTGTACCAGAAACTACCTCTGAAG GCTACACTTTCCAAGTTCAGGATGGGGCTCCTGGGACCTTTAACTTTTAG Download Select all
CCDS ID	CCDS32713.1

Protein Information

Protein ID	NP_002257.1
Protein Name	Karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
Molecular Wt. (Da)	57731
Protein Sequence	>3838 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPL QENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFL GRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGD GSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTL VRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNI VTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVS VLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIF QAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTS EGYTFQVQDGAPGTFNF Download Select all
Length	529
Uniprot ID	P33681
Ensembl Protein ID	ENSP00000264246

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
K	Acetylation	22
S	Phosphorylation	62
K	Acetylation	22
S	Phosphorylation	62;-
S	Phosphorylation	24;-
T	Phosphorylation	61;-
S	Phosphorylation	55;-
S	Phosphorylation	490
T	Phosphorylation	349
T	Phosphorylation	358
T	Phosphorylation	363
T	Phosphorylation	3
S	Acetylation	2
S	Phosphorylation	54
T	Phosphorylation	73
T	Phosphorylation	311
S	Phosphorylation	2

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
339	APOBEC1	2531	NP_001635.2	yeast 2-hybrid	12881431
672	BRCA1	218	NP_009231.2	in vitro;yeast 2-hybrid	9497340
835	CASP2	2800	NP_116764.2	in vitro	12477715
1452	CSNK1A1	2739	NP_001020276.1	in vitro	12062430
2035	EPB41	558	AAD42222.1	in vitro	10359596
2908	NR3C1	679	NP_001019265.1	in vivo	12933681
3005	H1F0	819	NP_005309.1	in vitro	10228156
3702	ITK	1746	NP_005537.3	in vitro;in vivo	11581171
4793	NFKBIB	7260	NP_002494.2	in vitro	14743216
5079	PAX5	1334	NP_057953.1	in vitro;yeast 2-hybrid	10748034
5757	PTMA	1778	NP_001092755.1	in vitro	11310559
5896	RAG1	1556	NP_000439.1	yeast 2-hybrid	8016130
5965	RECQL	2762	NP_002898.2	in vitro;yeast 2-hybrid	9168958
5970	RELA	1241	NP_068810.3	in vitro	12504098
5971	RELB	6886	NP_006500.2	in vitro;in vivo	14743216
6514	SLC2A2	685	NP_000331.1	in vitro;in vivo;yeast 2-hybrid	11988093
7157	TP53	1859	NP_000537.3	in vitro;in vivo;yeast 2-hybrid	10930427
10628	TXNIP	5964	NP_006463.3	in vitro;yeast 2-hybrid	15234975
28986	MAGEH1	6633	NP_054780.2	yeast 2-hybrid	15383276
51176	LEF1	1075	NP_057353.1	in vitro;in vivo;yeast 2-hybrid	8631802
84060	C7orf64	13173	NP_115496.2	in vitro	15383276

Pathway Information

Pathway Name	Pathway ID
Influenza A	hsa05164

Structure Information

PDB ID	1EFX
Resolution	3
Method	X-RAY DIFFRACTION
Chains	A
Molecule	HLA-CW3 (HEAVY CHAIN)
Model	View

Domain Information

ID	Location	Description
cd00020	113-238	ARM
cl22454	113-238	ARM superfamily
cd00020	252-364	ARM
cl22454	252-364	ARM superfamily
cd00020	329-449	ARM
cl22454	329-449	ARM superfamily
pfam01749	May-99	IBB
cl03339	May-99	IBB superfamily
cd00020	288-406	ARM
cd00020	198-322	ARM
cd00020	81-190	ARM
pfam00514	324-364	Arm
pfam00514	151-190	Arm
smart00185	151-190	ARM
smart00185	324-364	ARM
pfam13513	134-189	HEAT_EZ
smart00185	366-406	ARM
pfam00514	367-406	Arm
pfam00514	242-280	Arm
smart00185	242-280	ARM
pfam00514	409-447	Arm
pfam00514	109-149	Arm
smart00185	108-149	ARM
smart00185	282-321	ARM
smart00185	411-447	ARM
pfam00514	282-322	Arm
pfam13513	231-278	HEAT_EZ
pfam00514	197-238	Arm
COG5064	10-528	SRP1
PLN03200	78-191	PLN03200
PLN03200	95-365	PLN03200
pfam13646	121-217	HEAT_2

Ontology Information

HPRD ID	178
Molecular Class	Transport/cargo protein
Molecular Function	Receptor activity (GO:0004872)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report

CoReCG

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General Information

Evidence Information

Gene Details

mRNA Information

CDS Information

Protein Information

Post-translational Modification Information (Source : HPRD)

Enzyme Information

PPi Information

Pathway Information

Structure Information

Domain Information

Ontology Information

SNP Information

Drug Information

External Links

Important Information

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO