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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| KRT5 | 3852 | Keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types) | 12 | K5; CK5; DDD; EBS2; KRT5A |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22564821 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 5 CRC samples with 5 normal tissue Stage : - | Immunoblotting, Western blotting, immunohistochemistry and Heat map analysis | Up-regulation | - | KRT5, JUP, TUBB, and COL6A1 coded proteins are shown differential expressionand these proteins gave specific network information for CRC, and yielded a panel of novel markers and potential targets for treatmen. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Intermediate filaments type II, keratins (basic) |
| Description | The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008] |
| Chromosome | 12 |
| Location | 12q13.13 |
| Start | 52514575 |
| End | 52520459 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 5885 |
| OMIM ID | 148040 |
| HGNC ID | HGNC:6442 |
| Unigene ID | Hs.433845 |
| Ensembl ID | ENSG00000186081 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_000424.3 |
|---|---|
| Exon | join(1..718,1300..1514,2297..2357,2468..2563,2706..2870, 3228..3353,3603..3823,4628..4662,5220..5885) | mRNA Sequence | Download Select all |
| Length | 2320 |
CDS Information
| Location | join(164..718,1300..1514,2297..2357,2468..2563,2706..2870, 3228..3353,3603..3823,4628..4662,5220..5518) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS8830.1 |
Protein Information
| Protein ID | NP_000415.2 |
|---|---|
| Protein Name | Keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types) |
| Molecular Wt. (Da) | 62247 |
| Protein Sequence | Download Select all |
| Length | 590 |
| Uniprot ID | P29965 |
| Ensembl Protein ID | ENSP00000359663 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 60;- |
| Y | Phosphorylation | 66;- |
| S | Phosphorylation | 359 |
| Y | Phosphorylation | 361 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3848 | KRT1 | 763 | NP_006112.3 | in vivo | 11591653 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam06810 | 375-486 | Phage_GP20 |
| cl21593 | 375-486 | Phage_GP20 superfamily |
| pfam03961 | 388-470 | DUF342 |
| cl19219 | 388-470 | DUF342 superfamily |
| pfam05957 | 393-453 | DUF883 |
| cl01888 | 393-453 | DUF883 superfamily |
| pfam00038 | 167-480 | Filament |
| TIGR02168 | 164-491 | SMC_prok_B |
| COG1196 | 210-478 | Smc |
| COG1196 | 223-475 | Smc |
| COG1196 | 167-475 | Smc |
| COG1196 | 211-475 | Smc |
| TIGR02168 | 335-472 | SMC_prok_B |
| TIGR02169 | 156-482 | SMC_prok_A |
| PRK09039 | 308-456 | PRK09039 |
| PRK01156 | 157-478 | PRK01156 |
| TIGR02169 | 226-482 | SMC_prok_A |
| TIGR02168 | 196-456 | SMC_prok_B |
| pfam01576 | 219-455 | Myosin_tail_1 |
| TIGR01612 | 184-441 | 235kDa-fam |
| TIGR02169 | 228-490 | SMC_prok_A |
| COG0419 | 218-482 | SbcC |
| PHA02562 | 184-452 | 46 |
| pfam12128 | 159-449 | DUF3584 |
| PLN03229 | 196-484 | PLN03229 |
| TIGR01612 | 161-449 | 235kDa-fam |
| TIGR02168 | 212-475 | SMC_prok_B |
| COG1579 | 291-460 | COG1579 |
| COG1579 | 366-484 | COG1579 |
| TIGR04523 | 160-475 | Mplasa_alph_rch |
| pfam09728 | 162-454 | Taxilin |
| TIGR04523 | 150-473 | Mplasa_alph_rch |
| PRK12704 | 340-455 | PRK12704 |
| PRK03918 | 165-475 | PRK03918 |
| TIGR03545 | 347-454 | TIGR03545 |
| COG1196 | 153-406 | Smc |
| TIGR02680 | 316-475 | TIGR02680 |
| PRK02224 | 223-457 | PRK02224 |
| pfam04111 | 389-472 | APG6 |
| pfam13514 | 220-475 | AAA_27 |
| COG3883 | 220-442 | CwlO1 |
| pfam13514 | 221-471 | AAA_27 |
| pfam02994 | 332-491 | Transposase_22 |
| PRK11281 | 340-447 | PRK11281 |
| smart00787 | 345-481 | Spc7 |
| pfam05667 | 206-456 | DUF812 |
| pfam05483 | 229-460 | SCP-1 |
| PRK03918 | 238-449 | PRK03918 |
| TIGR02169 | 352-486 | SMC_prok_A |
| pfam05483 | 165-446 | SCP-1 |
| TIGR04523 | 165-403 | Mplasa_alph_rch |
| COG1196 | 361-482 | Smc |
| TIGR02169 | 386-482 | SMC_prok_A |
| PRK10636 | 361-449 | PRK10636 |
| TIGR01843 | 334-472 | type_I_hlyD |
| pfam13514 | 219-449 | AAA_27 |
Ontology Information
| HPRD ID | 1081 |
|---|---|
| Molecular Class | Structural protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.