Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17848589 | 2007 | Cell line : - Source : Tumor Bank Network established at the Centro Nacional de Investigaciones Oncologicas (CNIO) Sample Type : - No. of Sample : - Stage : - | Antibody Microarrays,Protein Labeling and Microarray Assay,Tissue Microarray Design and Immunohistochemistry | Up-regulation | 1.622 | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Intermediate filaments type I, keratins (acidic) |
| Description | The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq, Jul 2008] |
| Chromosome | 17 |
| Location | 17q21.2 |
| Start | 41500981 |
| End | 41505613 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 4633 |
| OMIM ID | 148065 |
| HGNC ID | HGNC:6415 |
| Unigene ID | Hs.654550 |
| Ensembl ID | ENSG00000171401 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_002274.3 |
|---|---|
| Exon | join(1..558,1889..1971,2171..2327,2516..2677,2802..2927, 3020..3240,4252..4633) | mRNA Sequence | Download Select all |
| Length | 1719 |
CDS Information
| Location | join(64..558,1889..1971,2171..2327,2516..2677,2802..2927, 3020..3240,3870..3895,4252..4358) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS11396.1 |
Protein Information
| Protein ID | NP_705694.2 |
|---|---|
| Protein Name | Keratin 13 |
| Molecular Wt. (Da) | 49427 |
| Protein Sequence | Download Select all |
| Length | 458 |
| Uniprot ID | P16070 |
| Ensembl Protein ID | ENSP00000263398 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 425;- |
| S | Phosphorylation | 427;- |
| T | Phosphorylation | 327 |
| S | Phosphorylation | 337 |
| T | Phosphorylation | 327 |
| S | Phosphorylation | 337 |
| S | Phosphorylation | 422 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3855 | KRT7 | 1014 | NP_005547.3 | in vivo | 11591653 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00038 | 103-415 | Filament |
| TIGR02168 | 191-416 | SMC_prok_B |
| TIGR02168 | 103-377 | SMC_prok_B |
| TIGR02168 | 155-415 | SMC_prok_B |
| COG1196 | 118-427 | Smc |
| TIGR02169 | 202-415 | SMC_prok_A |
| COG1196 | 159-416 | Smc |
| TIGR02168 | 120-412 | SMC_prok_B |
| COG1196 | 108-416 | Smc |
| pfam13514 | 229-403 | AAA_27 |
| PHA02562 | 164-405 | 46 |
| TIGR02169 | 203-403 | SMC_prok_A |
| COG1196 | 108-347 | Smc |
| smart00787 | 210-328 | Spc7 |
| TIGR02169 | 144-415 | SMC_prok_A |
| COG0419 | 111-400 | SbcC |
| TIGR03007 | 180-400 | pepcterm_ChnLen |
| COG1196 | 192-417 | Smc |
| COG2433 | 115-279 | COG2433 |
| pfam07888 | 150-404 | CALCOCO1 |
| TIGR02169 | 103-324 | SMC_prok_A |
Ontology Information
| HPRD ID | 1093 |
|---|---|
| Molecular Class | Structural protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.