Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| RHOA | 387 | ras homolog family member A | 3 | RhoA, Rho12, RHOH12 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22750095 | 2012 | Cell line : DLD 1, LS174T, HT 29, HEK293T Source : - Sample Type : - No. of Sample : - Stage : - | si RNA and transfection,shRNA Transfection,Immunoprecipitation,Immunofluorescence,Adhesion assay,Cell migration assay, immunohistochemistry, Invasion assay, Cell proliferation Assay | Activation | - | GCF2 plays an important role in colorectal cancer metastasis by regulating RhoA-induced cell adhesion, migration, and invasion. |
| 23649168 | 2013 | Cell line : HT 29 , AZ 97 Source : - Sample Type : - No. of Sample : - Stage : - | real time RT-PCR , Flow cytometry,ELISA, G-LISA assays, Migration assays,Cell proliferation assay | Activation | - | RHOA involves in cell migration in colon cancer. |
| 24582560 | 2014 | Cell line : HT 29 Source : - Sample Type : - No. of Sample : - Stage : - | Migration assays, proliferation assay, annexin V assay, G-LISA assay | Activation | - | - |
| 24958816 | 2014 | Cell line : Caco 2, HT 29 Source : - Sample Type : - No. of Sample : - Stage : - | Western Blotting, RhoA GTPase Pull-Down Assay,GST-RhoAG17A Pull-Down Assay, Cell Migration Assays | Activation | - | GRP stimulation activates RhoApredominantly through G13 heterotrimeric G-protein signaling resulting cancer cell migration. |
| 25413277 | 2014 | Cell line : SW837, SW480/ADH, HEK293T, MDA MB 231, L cells Source : Medical institutions in Spain, Finland and Australia Sample Type : - No. of Sample : - Stage : - | RHOA activity assay, Proliferation, migration, invasion, soft-agar assays, Enzymatic activity assays, immunohistochemistry, Microarray, Luciferase reporter assays, Western blotting, Immunoprecipitation, Polarization assay, real time RT-PCR | Inactivation | - | RHOA a novel tumour suppressor in colorectal cancer. Primary colorectal tumor samples were used in this study. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015] |
| Chromosome | 3 |
| Location | 3p21.3 |
| Start | 49396569 |
| End | 49449526 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 52958 |
| OMIM ID | 165390 |
| HGNC ID | HGNC:667 |
| Unigene ID | Hs.247077 |
| Ensembl ID | ENSG00000067560 |
| PharmGKB ID | PA134865095 |
mRNA Information
| mRNA ID | XM_011533695.1 |
|---|---|
| Exon | join(579..771,36503..36660,43546..43666,49468..49598, 51712..52958) | mRNA Sequence | Download Select all |
| Length | 1850 |
Protein Information
| Protein ID | XP_011531997.1 |
|---|---|
| Protein Name | ras homolog family member A |
| Molecular Wt. (Da) | 21637 |
| Protein Sequence | Download Select all |
| Length | 193 |
| Uniprot ID | P10620 |
| Ensembl Protein ID | ENSP00000010404 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 188 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 394 | ARHGAP5 | 4060 | NP_001025226.1 | in vitro | 9407060 |
| 1729 | DIAPH1 | 3670 | NP_005210.3 | in vitro | 1 610 948 115 864 300 |
| 1856 | DVL2 | 3690 | NP_004413.1 | in vivo | 12533515 |
| 3303 | HSPA1A | 774 | NP_005336.3 | in vivo | 12490434 |
| 3708 | ITPR1 | 925 | Q14643 | in vitro;in vivo | 12766172 |
| 5590 | PRKCZ | 1504 | NP_002735.3 | in vivo | 15210811 |
| 7046 | TGFBR1 | 1822 | NP_004603.1 | in vivo | 15761153 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Adherens junction | hsa04520 |
| Axon guidance | hsa04360 |
| Bacterial invasion of epithelial cells | hsa05100 |
| cAMP signaling pathway | hsa04024 |
| cGMP-PKG signaling pathway | hsa04022 |
| Chemokine signaling pathway | hsa04062 |
| Colorectal cancer | hsa05210 |
| Endocytosis | hsa04144 |
| Focal adhesion | hsa04510 |
| Leukocyte transendothelial migration | hsa04670 |
| MicroRNAs in cancer | hsa05206 |
| Neurotrophin signaling pathway | hsa04722 |
| Oxytocin signaling pathway | hsa04921 |
| Pancreatic secretion | hsa04972 |
| Pathogenic Escherichia coli infection | hsa05130 |
| Pathways in cancer | hsa05200 |
| Pertussis | hsa05133 |
| Phospholipase D signaling pathway | hsa04072 |
| Platelet activation | hsa04611 |
| Proteoglycans in cancer | hsa05205 |
| Rap1 signaling pathway | hsa04015 |
| Ras signaling pathway | hsa04014 |
| Regulation of actin cytoskeleton | hsa04810 |
| Sphingolipid signaling pathway | hsa04071 |
| T cell receptor signaling pathway | hsa04660 |
| TGF-beta signaling pathway | hsa04350 |
| Tight junction | hsa04530 |
| Tuberculosis | hsa05152 |
| Vascular smooth muscle contraction | hsa04270 |
| Viral carcinogenesis | hsa05203 |
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01870 | 5-179 | RhoA_like |
| cl21455 | 5-179 | P-loop_NTPase superfamily |
| smart00174 | 8-181 | RHO |
| cd00157 | 7-177 | Rho |
| cd04132 | 4-193 | Rho4_like |
| cd04129 | 5-193 | Rho2 |
| cd01875 | 7-193 | RhoG |
| cd04131 | 5-179 | Rnd |
| cd01871 | 7-177 | Rac1_like |
| cd04134 | 6-192 | Rho3 |
| cd01874 | 7-179 | Cdc42 |
| cd04172 | 4-179 | Rnd3_RhoE_Rho8 |
| cd04173 | 5-188 | Rnd2_Rho7 |
| cd04130 | 7-178 | Wrch_1 |
| cd04135 | 7-179 | Tc10 |
| cd04174 | 2-179 | Rnd1_Rho6 |
| cd04133 | 7-179 | Rop_like |
| cd00154 | 7-176 | Rab |
| smart00175 | 7-180 | RAB |
| cd00876 | 7-176 | Ras |
| cd01873 | 7-178 | RhoBTB |
| smart00173 | 7-172 | RAS |
| smart00010 | 7-172 | small_GTPase |
| cd01860 | 7-177 | Rab5_related |
| cd01863 | 7-172 | Rab18 |
| cd04123 | 7-172 | Rab21 |
| cd01861 | 6-173 | Rab6 |
| cd01869 | 7-177 | Rab1_Ypt1 |
| cd01867 | 7-180 | Rab8_Rab10_Rab13_like |
| cd04139 | 7-171 | RalA_RalB |
| cd00882 | 9-173 | Ras_like_GTPase |
| cd04144 | 7-193 | Ras2 |
| cd04177 | 7-176 | RSR1 |
| cd04145 | 7-177 | M_R_Ras_like |
| cd01868 | 7-173 | Rab11_like |
| cd04111 | 7-176 | Rab39 |
| cd04138 | 7-171 | H_N_K_Ras_like |
| cd04137 | 6-192 | RheB |
| cd01866 | 7-171 | Rab2 |
| cd01864 | 7-175 | Rab19 |
| cd01862 | 7-180 | Rab7 |
| cd04136 | 7-171 | Rap_like |
| cd04175 | 7-171 | Rap1 |
| cd01893 | 7-179 | Miro1 |
| cd04117 | 7-181 | Rab15 |
| cd04176 | 7-176 | Rap2 |
| cd04116 | 7-176 | Rab9 |
| cd04113 | 7-176 | Rab4 |
| cd04106 | 7-172 | Rab23_like |
| cd04110 | 7-183 | Rab35 |
| cd04114 | 7-176 | Rab30 |
| cd01865 | 7-172 | Rab3 |
| cd04146 | 7-180 | RERG_RasL11_like |
| cd04112 | 7-187 | Rab26 |
| cd04115 | 7-134 | Rab33B_Rab33A |
| cd04147 | 7-182 | Ras_dva |
| cd04120 | 7-171 | Rab12 |
| cd04122 | 7-180 | Rab14 |
| cd04124 | 7-121 | RabL2 |
| pfam08477 | 7-120 | Miro |
| cd04140 | 7-173 | ARHI_like |
| cd00877 | 7-171 | Ran |
| cd04119 | 7-172 | RJL |
| cd04141 | 7-176 | Rit_Rin_Ric |
| cd04108 | 7-171 | Rab36_Rab34 |
| cd09914 | 5-169 | RocCOR |
| cd04107 | 7-171 | Rab32_Rab38 |
| cd04118 | 7-172 | Rab24 |
| cd04101 | 7-177 | RabL4 |
| cd04127 | 7-172 | Rab27A |
| cd04109 | 7-174 | Rab28 |
| cd00878 | 7-173 | Arf_Arl |
| cd04143 | 7-179 | Rhes_like |
| cd04128 | 7-121 | Spg1 |
| cd04142 | 7-191 | RRP22 |
| cd04121 | 7-185 | Rab40 |
| cd04148 | 7-187 | RGK |
| cd04126 | 7-172 | Rab20 |
| cd04160 | 9-169 | Arfrp1 |
| cd04152 | 8-123 | Arl4_Arl7 |
| pfam00025 | 7-172 | Arf |
| cd01892 | 10-180 | Miro2 |
| cd04156 | 7-134 | ARLTS1 |
| cd04159 | 8-123 | Arl10_like |
| cd04155 | 7-169 | Arl3 |
| cd04153 | 7-176 | Arl5_Arl8 |
| PTZ00133 | Jul-90 | PTZ00133 |
| cd00879 | 7-172 | Sar1 |
| cd04150 | 7-123 | Arf1_5_like |
| cd04149 | 7-141 | Arf6 |
| cd04164 | 78-167 | trmE |
| pfam00071 | 7-180 | Ras |
| TIGR00231 | 5-159 | small_GTP |
| COG1100 | 4-181 | Gem1 |
| PLN03118 | 7-172 | PLN03118 |
| PLN03108 | 7-171 | PLN03108 |
| PTZ00369 | 1-193 | PTZ00369 |
| PTZ00132 | 7-123 | PTZ00132 |
| PLN03071 | 7-123 | PLN03071 |
| PLN03110 | 7-189 | PLN03110 |
| smart00176 | 11-123 | RAN |
| PTZ00099 | 28-172 | PTZ00099 |
| PRK00089 | 76-172 | era |
| TIGR03596 | 101-188 | GTPase_YlqF |
Ontology Information
| HPRD ID | 3436 |
|---|---|
| Molecular Class | GTPase |
| Molecular Function | Glutathione transferase activity (GO:0004364) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.