Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22076435 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 4 Stage : - | 2D electrophoresis and MALDI-TOF/MS spectrometry, Western blotting, tissue microarray, immunohistochemistry | Up-regulation | - | KRT17 demonstrated a tendency of increased expression as pT stage advanced. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | -, "Intermediate filaments type I, keratins (acidic)" |
| Description | This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008] |
| Chromosome | 17 |
| Location | 17q21.2 |
| Start | 39775692 |
| End | 39780882 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 5191 |
| OMIM ID | 148069 |
| HGNC ID | HGNC:6427 |
| Unigene ID | Hs.2785 |
| Ensembl ID | ENSG00000128422 |
| PharmGKB ID | PA30214 |
mRNA Information
| mRNA ID | NM_000422.2 |
|---|---|
| Exon | join(1..553,1599..1681,2120..2276,2877..3038,3540..3665, 3752..3972,4073..4095,4943..5191) | mRNA Sequence | Download Select all |
| Length | 1574 |
Protein Information
| Protein ID | NP_000413.1 |
|---|---|
| Protein Name | keratin 17 |
| Molecular Wt. (Da) | 353460 |
| Protein Sequence | Download Select all |
| Length | 432 |
| Uniprot ID | O95425 |
| Ensembl Protein ID | ENSP00000348128 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 32;- |
| S | Phosphorylation | 10;- |
| S | Phosphorylation | 39;- |
| S | Phosphorylation | 28 |
| S | Phosphorylation | 24 |
| T | Phosphorylation | 410 |
| S | Phosphorylation | 12 |
| S | Phosphorylation | 13 |
| S | Phosphorylation | 17 |
| S | Phosphorylation | 18 |
| T | Phosphorylation | 171 |
| T | Phosphorylation | 175 |
| T | Phosphorylation | 27 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1956 | EGFR | 579 | NP_005219.2 | in vitro;in vivo | 12577067 |
| 3855 | KRT7 | 1014 | NP_005547.3 | in vivo | 11591653 |
| 11007 | CCDC85B | 16101 | NP_006839.2 | yeast 2-hybrid | 16189514 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| TIGR01882 | 215-296 | peptidase-T |
| cl14876 | 215-296 | Zinc_peptidase_like superfamily |
| PRK14145 | 350-403 | PRK14145 |
| cl03075 | 350-403 | GrpE superfamily |
| pfam00038 | 84-394 | Filament |
| TIGR02168 | 183-389 | SMC_prok_B |
| COG1196 | 129-389 | Smc |
| TIGR02168 | 138-383 | SMC_prok_B |
| COG1196 | 88-392 | Smc |
| TIGR02168 | 134-389 | SMC_prok_B |
| TIGR02169 | 172-401 | SMC_prok_A |
| TIGR02169 | 183-387 | SMC_prok_A |
| TIGR02168 | 139-353 | SMC_prok_B |
| COG1196 | 180-401 | Smc |
| COG5281 | 78-393 | COG5281 |
| pfam13514 | 183-414 | AAA_27 |
| COG1196 | 85-351 | Smc |
| COG1196 | 191-407 | Smc |
| pfam07888 | 174-403 | CALCOCO1 |
| COG1196 | 85-224 | Smc |
| pfam05483 | 156-416 | SCP-1 |
| COG0419 | 88-429 | SbcC |
| TIGR02169 | 138-416 | SMC_prok_A |
| COG1196 | 94-389 | Smc |
| TIGR02168 | 277-401 | SMC_prok_B |
Ontology Information
| HPRD ID | 8876 |
|---|---|
| Molecular Class | Cytoskeletal protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Signal transduction (GO:0007165); Regulation of immune response (GO:0050776) |
Drug Information
No matching records could be found.