Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| RHOB | 388 | Ras homolog gene family, member B | 2 | ARH6; ARHB; RHOH6; MST081; MSTP081 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21872591 | 2011 | Cell line : SW1116,colo 320 Source : - Sample Type : - No. of Sample : - Stage : - | Luciferase assay, Cell growth assay, In vitro apoptosis assay, Matrigel invasion assay, Quantitative | Down-regulation | - | RhoB protein is relatively short-lived in cells and its protein expression is readily inducible upon exposure to a wide-variety of biological stimuli including growth factors such as PDGF, EGF andTGF-Beta RhoB was shown to be down-regulated in head and neck carcinoma and lung cancer but over-expressed in breast cancer. In gastric cancer tissue and cell lines, RhoB expression is significantly suppressed, and is regulated by histone deacetylation, not by DNA methylation, at the epigenetic level. RhoB may be a useful target in exploring the potential therapeutic benefits of miR-21 mediated tumor cell behaviors in colorectal cancer. |
| 16909123 | 2007 | Cell line : - Source : Cork Teaching Hospitals. Sample Type : - No. of Sample : - Stage : - | Western blotting, Chromatin immunohistochemistry and RT-PCR and real time PCR | Unknown | - | RhoB suppresses EGFR-, ErbB2-, Ras- and Akt-mediated malignant transformation and metastasis. Antitumor agents farnesyltransferase inhibitors (FTIs) and geranylgeranyltransferase I inhibitors (GGTIs) upregulate RhoB expression in a wide spectrum of human cancer cells. Promoter acetylation is a novel mechanism by which RhoB expression levels are regulated after treatment with FTI-277 and GGTI298. FTI-277 and GGTI-298 induce the transcription of RhoB by inducing HDAC1 dissociation and promoting histone acetylation of the RhoB promoter. |
| 20683666 | 2010 | Cell line : - Source : Department of Pathology of Wroc$aw Medical University Sample Type : - No. of Sample : - Stage : TNM Stage II | Western blotting, RT-PCR, and RhoB-promoter luciferase reporter assays | Unknown | - | - |
| 19401702 | 2009 | Cell line : HT 29 Source : - Sample Type : - No. of Sample : - Stage : - | FACS, Affymetrix oligonucleotide microarrays. | Up-regulation | - | RHOB mediate apoptosis in neoplastic cells, and are targets for novel antitumour agents.
|
| 22968445 | 2012 | Cell line : HCT 116 Source : Sample Type : - No. of Sample : - Stage : - | LC-MS/MS analysis | Up-regulation | 4.1 | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | - |
| Chromosome | 2 |
| Location | 2p24 |
| Start | 20447071 |
| End | 20449445 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 2375 |
| OMIM ID | 165370 |
| HGNC ID | HGNC:668 |
| Unigene ID | Hs.502876 |
| Ensembl ID | ENSG00000143878 |
| PharmGKB ID | - |
Protein Information
| Protein ID | NP_004031.1 |
|---|---|
| Protein Name | Ras homolog gene family, member B |
| Molecular Wt. (Da) | 21783 |
| Protein Sequence | Download Select all |
| Length | 196 |
| Uniprot ID | P09874 |
| Ensembl Protein ID | ENSP00000355759 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| C | Palmitoylation | 189 |
| C | Palmitoylation | 192 |
| C | Prenylation | 193 |
| C | Prenylation | 193 |
Enzyme Information
| EC | 3.6.5.2 |
|---|---|
| Name | small monomeric GTPase |
| Class | Hydrolases; Acting on acid anhydrides; Acting on GTP to facilitate cellular and subcellular movement |
| Sysname | GTP phosphohydrolase (cell-regulating) |
| Substrate | GTP [CPD:C00044]; H2O |
| Product | GDP [CPD:C00035]; phosphate |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 2FV8 |
|---|---|
| Resolution | 1.9 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | Rho-related GTP-binding protein RhoB |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01870 | 5-179 | RhoA_like |
| cl21455 | 5-179 | P-loop_NTPase superfamily |
| smart00174 | 8-181 | RHO |
| cd00157 | 7-177 | Rho |
| cd04132 | 4-182 | Rho4_like |
| cd04129 | 5-193 | Rho2 |
| cd01875 | 7-179 | RhoG |
| cd04131 | 5-179 | Rnd |
| cd01871 | 7-177 | Rac1_like |
| cd04134 | 6-190 | Rho3 |
| cd04172 | 4-181 | Rnd3_RhoE_Rho8 |
| cd01874 | 7-179 | Cdc42 |
| cd04130 | 7-178 | Wrch_1 |
| cd04173 | 5-181 | Rnd2_Rho7 |
| cd04135 | 7-179 | Tc10 |
| cd04174 | 2-181 | Rnd1_Rho6 |
| cd04133 | 7-179 | Rop_like |
| cd00154 | 7-176 | Rab |
| smart00175 | 7-181 | RAB |
| cd00876 | 7-176 | Ras |
| smart00010 | 7-178 | small_GTPase |
| smart00173 | 7-176 | RAS |
| cd01860 | 7-177 | Rab5_related |
| cd01873 | 7-178 | RhoBTB |
| cd00882 | 9-173 | Ras_like_GTPase |
| cd01863 | 7-172 | Rab18 |
| cd01869 | 7-177 | Rab1_Ypt1 |
| cd04123 | 7-177 | Rab21 |
| cd04139 | 7-176 | RalA_RalB |
| cd01867 | 7-181 | Rab8_Rab10_Rab13_like |
| cd04144 | 7-186 | Ras2 |
| cd01868 | 7-173 | Rab11_like |
| cd01861 | 6-172 | Rab6 |
| cd04145 | 7-177 | M_R_Ras_like |
| cd01862 | 7-182 | Rab7 |
| cd04177 | 7-176 | RSR1 |
| cd04138 | 7-176 | H_N_K_Ras_like |
| cd01893 | 7-179 | Miro1 |
| cd04111 | 7-182 | Rab39 |
| cd04175 | 7-176 | Rap1 |
| cd04176 | 7-176 | Rap2 |
| cd04106 | 7-172 | Rab23_like |
| cd01866 | 7-181 | Rab2 |
| cd04117 | 7-180 | Rab15 |
| cd04113 | 7-176 | Rab4 |
| cd04116 | 7-176 | Rab9 |
| cd04110 | 7-182 | Rab35 |
| cd04137 | 6-173 | RheB |
| cd01864 | 7-172 | Rab19 |
| cd04136 | 7-176 | Rap_like |
| cd04115 | 7-134 | Rab33B_Rab33A |
| cd04114 | 7-172 | Rab30 |
| cd04119 | 7-173 | RJL |
| cd04147 | 7-178 | Ras_dva |
| pfam08477 | 7-120 | Miro |
| cd04124 | 7-121 | RabL2 |
| cd01865 | 7-172 | Rab3 |
| cd04112 | 7-186 | Rab26 |
| cd09914 | 5-177 | RocCOR |
| cd00877 | 7-124 | Ran |
| cd04146 | 7-180 | RERG_RasL11_like |
| cd04108 | 7-171 | Rab36_Rab34 |
| cd04140 | 7-172 | ARHI_like |
| cd04122 | 7-181 | Rab14 |
| cd04120 | 7-171 | Rab12 |
| cd04101 | 7-177 | RabL4 |
| cd04141 | 7-181 | Rit_Rin_Ric |
| cd04107 | 7-171 | Rab32_Rab38 |
| cd04127 | 7-173 | Rab27A |
| cd04143 | 7-173 | Rhes_like |
| cd00878 | 7-172 | Arf_Arl |
| cd04109 | 7-178 | Rab28 |
| cd04118 | 7-173 | Rab24 |
| cd04148 | 7-176 | RGK |
| cd04128 | 7-121 | Spg1 |
| cd04121 | 7-195 | Rab40 |
| cd04126 | 7-173 | Rab20 |
| pfam00025 | 7-172 | Arf |
| cd04160 | 9-169 | Arfrp1 |
| cd04142 | 7-182 | RRP22 |
| cd04152 | 8-123 | Arl4_Arl7 |
| cd04156 | 7-171 | ARLTS1 |
| cd04155 | 17-169 | Arl3 |
| cd01892 | 10-121 | Miro2 |
| cd04159 | 8-135 | Arl10_like |
| cd04153 | 7-169 | Arl5_Arl8 |
| cd04162 | 8-172 | Arl9_Arfrp2_like |
| cd04150 | 7-122 | Arf1_5_like |
| PTZ00133 | Jul-90 | PTZ00133 |
| cd00879 | 7-172 | Sar1 |
| cd01897 | 109-179 | NOG |
| cd04149 | 7-138 | Arf6 |
| PLN00223 | Jul-91 | PLN00223 |
| cd01878 | 107-172 | HflX |
| cd04164 | 78-167 | trmE |
| cd04163 | 73-173 | Era |
| cd00880 | 109-173 | Era_like |
| cd01854 | 109-182 | YjeQ_EngC |
| pfam00071 | 7-180 | Ras |
| TIGR00231 | 5-159 | small_GTP |
| COG1100 | 4-181 | Gem1 |
| PLN03118 | 7-172 | PLN03118 |
| PTZ00132 | 7-129 | PTZ00132 |
| PLN03108 | 7-181 | PLN03108 |
| PLN03110 | 7-173 | PLN03110 |
| PTZ00369 | 1-176 | PTZ00369 |
| PLN03071 | 7-123 | PLN03071 |
| smart00176 | 11-130 | RAN |
| PTZ00099 | 28-141 | PTZ00099 |
| COG0486 | 44-188 | MnmE |
| TIGR03918 | 77-182 | GTP_HydF |
| PRK13796 | 99-173 | PRK13796 |
| TIGR03596 | 101-181 | GTPase_YlqF |
| COG2262 | 109-172 | HflX |
| PRK05291 | 78-188 | trmE |
| PRK00093 | 111-182 | PRK00093 |
Ontology Information
| HPRD ID | 1435 |
|---|---|
| Molecular Class | GTPase |
| Molecular Function | Catalytic activity (GO:0003824) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P62745 | DB00083 | Botulinum Toxin Type A | BiotechDrug |