CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
20089989	2010	Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : -	Biochemical isolation to nano-LC-MS/MS analysis	Up-regulation	-	This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue.

Gene Details

Chromosome: 17; NC_000017.10 (39679869..39684641, complement)
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Gene Type	protein coding
Gene Family	Intermediate filaments type I, keratins (acidic)
Description	The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]
Chromosome	17
Location	17q21.2
Start	41523617
End	41528389
Strand	-
Gene Sequence	>gi\|568815581:c41528389-41523617 Homo sapiens chromosome 17, GRCh38.p2 Primary Assembly AGATATCCGCCCCTGACACCATTCCTCCCTTCCCCCCTCCACCGGCCGCGGGCATAAAAGGCGCCAGGTG AGGGCCTCGCCGCTCCTCCCGCGAATCGCAGCTTCTGAGACCAGGGTTGCTCCGTCCGTGCTCCGCCTCG CCATGACTTCCTACAGCTATCGCCAGTCGTCGGCCACGTCGTCCTTCGGAGGCCTGGGCGGCGGCTCCGT GCGTTTTGGGCCGGGGGTCGCCTTTCGCGCGCCCAGCATTCACGGGGGCTCCGGCGGCCGCGGCGTATCC GTGTCCTCCGCCCGCTTTGTGTCCTCGTCCTCCTCGGGGGCCTACGGCGGCGGCTACGGCGGCGTCCTGA CCGCGTCCGACGGGCTGCTGGCGGGCAACGAGAAGCTAACCATGCAGAACCTCAACGACCGCCTGGCCTC CTACCTGGACAAGGTGCGCGCCCTGGAGGCGGCCAACGGCGAGCTAGAGGTGAAGATCCGCGACTGGTAC CAGAAGCAGGGGCCTGGGCCCTCCCGCGACTACAGCCACTACTACACGACCATCCAGGACCTGCGGGACA AGGTGGGCGGAGGCCCGGCCGCGGGAAGTGCAGTGCACCTGCCGCGGAAACCCAGCCCCGCGGGCCGGGC GAGGTTCCAGGCGGGGCGGCGGGCAGGAGCCCGTTAGGACGTGGGAAGGTCCACAGGTGGGGCCGAGTAA AGGGGGACAGGAGACGTGCGGGGCAGGACCTCGGGGCTGGATGCAGAGGCCGGGGTGGTGGAAAGGGGAG GAGAACTGGGCAGGGCAGATAAGTGGGTGGGGCCTCTGGAGGTGGCGGGGGCAAGGTTGGAGCCCCGGGA CGAAGAAGGGACGCGGGTCAGCGAGGCCTGAAGAGTGGGAGGAGATGGGACCCGGCTGTAGAGTGCCCAG AGGTCTAGGCCAGGGGCCGCGCTGCCGCAGGAAGATGCGAGAGTTTGGCTTTGGTGATCTGGTCCACCCG GGGCCAGTCTTGCCCCCTCTGCCACCGCAGCGTAGGGCCTCCTGCATTCCGTTTCTCTGGCCGGAAGGGT CTAGTGTTCATCCCTCTCAGGCTTTGGCCTCCTCCCACTCTCCCGCCCTGGGGCCCATTCGTTTAGGAAG AATGGGAGAGCCGGTCGTGGCCCCTGGGCGGGGTAAAGGAGGGAGGCTTGGTAAACCTCTGCTGGGGAGG ACCCAGTACAGTGGCAGCTCCTTGTCGGGGAAAGAACGGATCTGCGTCACACGCTCTTACAGGGGAACCC TAAGGGGCCTGAGGGGTAGGGCTTGGTCTCCACCCAGAGGGAAGGAGAAATTTTTCGAGTCGTAAAGAAA TGTATCAGAAGCCATGGAACATTTACAGCCGCACACGCTGGGTCTCCCAACAAACAGATCCCCAAAATAT TTTCCAGTGCTGTACTCGTGGCATAGACCCAGACCCACAGACCAGGAGGAAGCGCTAGAGATGTCAACAG CCAACAAAAACAGTGCTTTACACACTTGTAAAATTGTGACCTACAGGGGCTGGGCACTGTGGCTCACGCC TGTAACCCCAGCACTTTGGGTGGCCAAGGTGGGAGGATTGCTTGAGCCCCAGGAGTTCGAGATCAGCCTG GCAAACATGGTAAAATCCTGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGCATGCCTGTA ATCCCAGCTACCTGGGAGGCTGAGGCAGGAGAATTGCTGGAACCCAAGAGGCGGAGGCTGCAGTGAGCCG AGATTGCGCCATTGCACTTCAGTCTCGGCCACAGAGCGAGAGTCCGTCTCAAAAAAAAAAAAAAAAAAAA AAAAAAAGGAATTAGCTTGGCATGGTGGCGTGTGCCTTGCAGCGAGCTGTACGTGATCAGTGCCACTGCA CTCCAGCCTGGGGCAACACAGCGAGACCCTGTATCAAAAAAAAAAAAAAATTGCGACAATAAGTACATTT TACTACGCACCCTTACGCATTCTTTTTCTCACCTCTGTGTGTGTGTGTGCGTGCACATGCACACACACAA ATGGGTGACACAATTCTCACCATACTAAGAGAAATCCCCTCTGATATTTTGTAGCCTATTCTGTTGCATT AAAAAACTACACAATCGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCGGAGGCG GGCGGATCACGAGGTCAGGAGATCCAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAAT ACAAAAAAAAATTAGCTGGGCGTGGTGGAGGGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGA GAATGGCGTGAACCCGGGAGGCGGGGCTTGCAGTGAGCCGAGATCGCGACGCTGCACTCCAGCCTGGGTG ACAGAGCGAGACTCTGTCTCAAAAAAACCCCAAAAAACAAAACCAAAAAACCCCCCCAAAACACAAAACT ATACAATCACCACCTGGTGCCTTGACTAATGAGTGATGACCTGCTCTTTGAAAAACAGAACACAATTACC TTATTCAATGATAAGCTGGCTGTTGTGAATGCGCCTCTTAGGTCAGTAAGACCTCAGGTTGGGGTGAACT TGGATGAGGCATCATCCTAAACTTTAGTTTCCACCTCTGTAAGATAGGAGTACCCACTGACCTAGCAGTG AGGTTCCAGAAGCTATAAAAGATGAGATTCAAAGTGCCTGGCACATAATTGATACTCAACAAATGGGATT CTCTTCCCTGGGGGCAAAATATGCTTCGCATAGTGGGGGGGGCAGGTATAGACAAAATCTACCCCCCATC TGGTTTATAGACCCCCTTCAGGCCATTTAGAGTTTCATTGCACACAGGTCTCAGAGATTTCCTCCCCAGG CTTGCCTTCCTGCCCTCCCCCACCCAAGTCCCCCTGGCTCCAGTTTTCTTCCTGCCCCAGCTTCTGGGCA TGGACTGTTTGCAAGGCCTCCCAGAGAGCGGGCCAATGGGCGGCAGATGCTGGCTAGGGCTTTGGTCTCT AGGGTGCCGGGGTATATTCATTTGCTCCCCTCTCTCTTCTGGGAAGAAAGTGAGTGGGCAGTGCCTGTGT GTTGAACTGGTACCAACCTCTGCCTCTGCCTTCCAGATTCTTGGTGCCACCATTGAGAACTCCAGGATTG TCCTGCAGATCGACAATGCCCGTCTGGCTGCAGATGACTTCCGAACCAAGTGAGTGTCTCTGTCCTGGGG GCTGCAGAAGCCAGGACTGGGGTAGGGGTTGGGGGGTTTAGAATCTGCCCTCACCTAGCCTAGATGGCCT GAAGCTAACCCCCCTATGGACTCCTGAACTCTGGGGAGGTAGGGAAGTCTTCAGAGATGCTGAGGAAGCT CTGCCTGGCTGCAACTATTTCCTTTGAAAGGTTTGAGACGGAACAGGCTCTGCGCATGAGCGTGGAGGCC GACATCAACGGCCTGCGCAGGGTGCTGGATGAGCTGACCCTGGCCAGGACCGACCTGGAGATGCAGATCG AAGGCCTGAAGGAAGAGCTGGCCTACCTGAAGAAGAACCATGAGGAGGTGGGTTTGAAGCTGGGCCTTTC TTCCATCCTTCCCTAACCTCCCAGGGCTGAAGACTCTTTTATTCTGTATTCTCTGACCGTGGTAACACTT GGTGCACCCTCACCATGGCCCTGGGTGTGGGATCATGGATCCCAGGGTTCCAAGAGGAATCAGTGATGAC CCAGTCTGTCCCCCAGTGCTAGTTACTAGGCCTGCACCTGAAAACTAAGCCCCTTTAGCCTGAAGGGTGG GGAAGTGACCTGGGCCAGGCCCAGTGGGGTCTGGGCCCTGACATGCCCATCTCTGCTGTATCTTTACAGG AAATCAGTACGCTGAGGGGCCAAGTGGGAGGCCAGGTCAGTGTGGAGGTGGATTCCGCTCCGGGCACCGA TCTCGCCAAGATCCTGAGTGACATGCGAAGCCAATATGAGGTCATGGCCGAGCAGAACCGGAAGGATGCT GAAGCCTGGTTCACCAGCCGGGTAGGTAGAGGGAAGCAGGCACCCTTTGGGGGTTAGGAAGGGGAGGGCT TTGTGTTCCCTACGCGAAGGTCTGACTCAATGCTTATTCCCTCTTCTTCCTCTCTCTGCAGACTGAAGAA TTGAACCGGGAGGTCGCTGGCCACACGGAGCAGCTCCAGATGAGCAGGTCCGAGGTTACTGACCTGCGGC GCACCCTTCAGGGTCTTGAGATTGAGCTGCAGTCACAGCTGAGCATGGTATGTGTCCCCCCACCGCCGCC GCTTCCCTGTGCAATTCACACTTATACCCTTGCAGCCTAGGGCAGCCTGGCCGGTGGCTGTGCCCATGCC CTCTCCGGGAACCAGGCTCTGCTGAGTCACAACCCCCTCTCCCTATCCTCAGAAAGCTGCCTTGGAAGAC ACACTGGCAGAAACGGAGGCGCGCTTTGGAGCCCAGCTGGCGCATATCCAGGCGCTGATCAGCGGTATTG AAGCCCAGCTGGGCGATGTGCGAGCTGATAGTGAGCGGCAGAATCAGGAGTACCAGCGGCTCATGGACAT CAAGTCGCGGCTGGAGCAGGAGATTGCCACCTACCGCAGCCTGCTCGAGGGACAGGAAGATCACTACAAC AATTTGTCTGCCTCCAAGGTCCTCTGAGGCAGCAGGCTCTGGGGCTTCTGCTGTCCTTTGGAGGGTGTCT TCTGGGTAGAGGGATGGGAAGGAAGGGACCCTTACCCCCGGCTCTTCTCCTGACCTGCCAATAAAAATTT ATGGTCCAAGGGA Download Select all
Length	4773
OMIM ID	148020
HGNC ID	HGNC:6436
Unigene ID	Hs.654568
Ensembl ID	ENSG00000171345
PharmGKB ID	-

mRNA Information

mRNA ID	NM_002276.4
Exon	join(1..562,3117..3199,3391..3547,3850..4011,4122..4247, 4393..4773)
mRNA Sequence	>3880 AGATATCCGCCCCTGACACCATTCCTCCCTTCCCCCCTCCACCGGCCGCGGGCATAAAAGGCGC CAGGTGAGGGCCTCGCCGCTCCTCCCGCGAATCGCAGCTTCTGAGACCAGGGTTGCTCCGTCCG TGCTCCGCCTCGCCATGACTTCCTACAGCTATCGCCAGTCGTCGGCCACGTCGTCCTTCGGAGG CCTGGGCGGCGGCTCCGTGCGTTTTGGGCCGGGGGTCGCCTTTCGCGCGCCCAGCATTCACGGG GGCTCCGGCGGCCGCGGCGTATCCGTGTCCTCCGCCCGCTTTGTGTCCTCGTCCTCCTCGGGGG CCTACGGCGGCGGCTACGGCGGCGTCCTGACCGCGTCCGACGGGCTGCTGGCGGGCAACGAGAA GCTAACCATGCAGAACCTCAACGACCGCCTGGCCTCCTACCTGGACAAGGTGCGCGCCCTGGAG GCGGCCAACGGCGAGCTAGAGGTGAAGATCCGCGACTGGTACCAGAAGCAGGGGCCTGGGCCCT CCCGCGACTACAGCCACTACTACACGACCATCCAGGACCTGCGGGACAAGATTCTTGGTGCCAC CATTGAGAACTCCAGGATTGTCCTGCAGATCGACAATGCCCGTCTGGCTGCAGATGACTTCCGA ACCAAGTTTGAGACGGAACAGGCTCTGCGCATGAGCGTGGAGGCCGACATCAACGGCCTGCGCA GGGTGCTGGATGAGCTGACCCTGGCCAGGACCGACCTGGAGATGCAGATCGAAGGCCTGAAGGA AGAGCTGGCCTACCTGAAGAAGAACCATGAGGAGGAAATCAGTACGCTGAGGGGCCAAGTGGGA GGCCAGGTCAGTGTGGAGGTGGATTCCGCTCCGGGCACCGATCTCGCCAAGATCCTGAGTGACA TGCGAAGCCAATATGAGGTCATGGCCGAGCAGAACCGGAAGGATGCTGAAGCCTGGTTCACCAG CCGGACTGAAGAATTGAACCGGGAGGTCGCTGGCCACACGGAGCAGCTCCAGATGAGCAGGTCC GAGGTTACTGACCTGCGGCGCACCCTTCAGGGTCTTGAGATTGAGCTGCAGTCACAGCTGAGCA TGAAAGCTGCCTTGGAAGACACACTGGCAGAAACGGAGGCGCGCTTTGGAGCCCAGCTGGCGCA TATCCAGGCGCTGATCAGCGGTATTGAAGCCCAGCTGGGCGATGTGCGAGCTGATAGTGAGCGG CAGAATCAGGAGTACCAGCGGCTCATGGACATCAAGTCGCGGCTGGAGCAGGAGATTGCCACCT ACCGCAGCCTGCTCGAGGGACAGGAAGATCACTACAACAATTTGTCTGCCTCCAAGGTCCTCTG AGGCAGCAGGCTCTGGGGCTTCTGCTGTCCTTTGGAGGGTGTCTTCTGGGTAGAGGGATGGGAA GGAAGGGACCCTTACCCCCGGCTCTTCTCCTGACCTGCCAATAAAAATTTATGGTCCAAGGGAA AAAAAAAAAAAAAAAAAA Download Select all
Length	1490

CDS Information

Location	join(143..562,3117..3199,3391..3547,3850..4011,4122..4247, 4393..4647)
CDS Sequence	>gi\|131412244:143-1345 Homo sapiens keratin 19 (KRT19), mRNA ATGACTTCCTACAGCTATCGCCAGTCGTCGGCCACGTCGTCCTTCGGAGGCCTGGGCGGCGGCTCCGTGC GTTTTGGGCCGGGGGTCGCCTTTCGCGCGCCCAGCATTCACGGGGGCTCCGGCGGCCGCGGCGTATCCGT GTCCTCCGCCCGCTTTGTGTCCTCGTCCTCCTCGGGGGCCTACGGCGGCGGCTACGGCGGCGTCCTGACC GCGTCCGACGGGCTGCTGGCGGGCAACGAGAAGCTAACCATGCAGAACCTCAACGACCGCCTGGCCTCCT ACCTGGACAAGGTGCGCGCCCTGGAGGCGGCCAACGGCGAGCTAGAGGTGAAGATCCGCGACTGGTACCA GAAGCAGGGGCCTGGGCCCTCCCGCGACTACAGCCACTACTACACGACCATCCAGGACCTGCGGGACAAG ATTCTTGGTGCCACCATTGAGAACTCCAGGATTGTCCTGCAGATCGACAATGCCCGTCTGGCTGCAGATG ACTTCCGAACCAAGTTTGAGACGGAACAGGCTCTGCGCATGAGCGTGGAGGCCGACATCAACGGCCTGCG CAGGGTGCTGGATGAGCTGACCCTGGCCAGGACCGACCTGGAGATGCAGATCGAAGGCCTGAAGGAAGAG CTGGCCTACCTGAAGAAGAACCATGAGGAGGAAATCAGTACGCTGAGGGGCCAAGTGGGAGGCCAGGTCA GTGTGGAGGTGGATTCCGCTCCGGGCACCGATCTCGCCAAGATCCTGAGTGACATGCGAAGCCAATATGA GGTCATGGCCGAGCAGAACCGGAAGGATGCTGAAGCCTGGTTCACCAGCCGGACTGAAGAATTGAACCGG GAGGTCGCTGGCCACACGGAGCAGCTCCAGATGAGCAGGTCCGAGGTTACTGACCTGCGGCGCACCCTTC AGGGTCTTGAGATTGAGCTGCAGTCACAGCTGAGCATGAAAGCTGCCTTGGAAGACACACTGGCAGAAAC GGAGGCGCGCTTTGGAGCCCAGCTGGCGCATATCCAGGCGCTGATCAGCGGTATTGAAGCCCAGCTGGGC GATGTGCGAGCTGATAGTGAGCGGCAGAATCAGGAGTACCAGCGGCTCATGGACATCAAGTCGCGGCTGG AGCAGGAGATTGCCACCTACCGCAGCCTGCTCGAGGGACAGGAAGATCACTACAACAATTTGTCTGCCTC CAAGGTCCTCTGA Download Select all
CCDS ID	CCDS11399.1

Protein Information

Protein ID	NP_002267.2
Protein Name	Keratin 19
Molecular Wt. (Da)	43975
Protein Sequence	>3880 MTSYSYRQSSATSSFGGLGGGSVRFGPGVAFRAPSIHGGSGGRGVSVSSARFVSSSSSGAYGGG YGGVLTASDGLLAGNEKLTMQNLNDRLASYLDKVRALEAANGELEVKIRDWYQKQGPGPSRDYS HYYTTIQDLRDKILGATIENSRIVLQIDNARLAADDFRTKFETEQALRMSVEADINGLRRVLDE LTLARTDLEMQIEGLKEELAYLKKNHEEEISTLRGQVGGQVSVEVDSAPGTDLAKILSDMRSQY EVMAEQNRKDAEAWFTSRTEELNREVAGHTEQLQMSRSEVTDLRRTLQGLEIELQSQLSMKAAL EDTLAETEARFGAQLAHIQALISGIEAQLGDVRADSERQNQEYQRLMDIKSRLEQEIATYRSLL EGQEDHYNNLSASKVL Download Select all
Length	400
Uniprot ID	P19256
Ensembl Protein ID	ENSP00000358501

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	10
S	Phosphorylation	35
S	Phosphorylation	46
Y	Phosphorylation	130;-
S	Phosphorylation	40
S	Phosphorylation	22
T	Phosphorylation	302
S	Phosphorylation	312

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
2189	FANCG	4262	NP_004620.1	yeast 2-hybrid	16189514
3854	KRT6B	1012	NP_005546.2	yeast 2-hybrid	16189514
3866	KRT15	1009	NP_002266.2	yeast 2-hybrid	16189514
5108	PCM1	2624	AAA60120.1	yeast 2-hybrid	16189514
7283	TUBG1	1853	NP_001061.2	in vivo	10444072
9146	HGS	5085	NP_004703.1	yeast 2-hybrid	16189514
9814	SFI1	11550	NP_001007468.1	yeast 2-hybrid	16189514
10152	ABI2	7338	AAF70308.1	yeast 2-hybrid	16189514
11067	C10orf10	12558	NP_008952.1	yeast 2-hybrid	16189514
11170	FAM107A	9753	NP_009108.1	yeast 2-hybrid	16189514
27332	ZNF638	11736	NP_055312.2	yeast 2-hybrid	16189514
83878	USHBP1	18276	NP_114147.2	yeast 2-hybrid	16189514
85359	DGCR6L	16800	NP_150282.1	yeast 2-hybrid	16189514
149371	EXOC8	9943	NP_787072.2	yeast 2-hybrid	16189514

Pathway Information

No matching records could be found.

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
pfam00038	79-388	Filament
TIGR02168	130-395	SMC_prok_B
TIGR02168	169-385	SMC_prok_B
COG1196	147-385	Smc
TIGR02168	134-386	SMC_prok_B
COG1196	84-389	Smc
TIGR02168	132-387	SMC_prok_B
COG1196	134-396	Smc
PRK09039	276-389	PRK09039
COG1196	84-351	Smc
TIGR02168	181-399	SMC_prok_B
TIGR02169	178-389	SMC_prok_A
COG1196	196-398	Smc
pfam04156	273-385	IncA
COG1196	180-385	Smc
PHA02562	137-380	46
TIGR02169	244-394	SMC_prok_A
TIGR03007	87-311	pepcterm_ChnLen
smart00787	197-331	Spc7
TIGR02169	151-354	SMC_prok_A
TIGR02169	137-390	SMC_prok_A
PRK11281	273-373	PRK11281

Ontology Information

HPRD ID	3763
Molecular Class	Cytoskeletal protein
Molecular Function	Receptor activity (GO:0004872)
Biological Process	Cell communication (GO:0007154); Cell motility (GO:0006928)

SNP Information

View SNP Geneview Report

CoReCG

Search results:

General Information

Evidence Information

Gene Details

mRNA Information

CDS Information

Protein Information

Post-translational Modification Information (Source : HPRD)

Enzyme Information

PPi Information

Pathway Information

Structure Information

Domain Information

Ontology Information

SNP Information

Drug Information

External Links

Important Information

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO