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General Information
- Evidence
- Gene
- mRNA
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22132820 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : - Stage : - | miRNA microarray, real time RT-PCR | Down-regulation | - | Study suggests that miR-17 plays an important role in CRC carcinogenesis by targeting�RND3�and may be a therapeutic agent for CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011] |
| Chromosome | 2 |
| Location | 2q23.3 |
| Start | 151324707 |
| End | 151344209 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 19503 |
| OMIM ID | 602924 |
| HGNC ID | HGNC:671 |
| Unigene ID | Hs.6838 |
| Ensembl ID | ENSG00000115963 |
| PharmGKB ID | PA24953 |
mRNA Information
| mRNA ID | NM_001254738.1 |
|---|---|
| Exon | join(1..428,915..1002,12712..12821,15935..16069, 17458..19503) | mRNA Sequence | Download Select all |
| Length | 2807 |
Protein Information
| Protein ID | NP_001241667.1 |
|---|---|
| Protein Name | Rho family GTPase 3 |
| Molecular Wt. (Da) | 27237 |
| Protein Sequence | Download Select all |
| Length | 244 |
| Uniprot ID | O15344 |
| Ensembl Protein ID | ENSP00000312678 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 394 | ARHGAP5 | 4060 | NP_001025226.1 | in vitro;in vivo;yeast 2-hybrid | 12842009 |
| 6093 | ROCK1 | 3414 | NP_005397.1 | in vitro;in vivo;yeast 2-hybrid | 12773565 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04172 | 19-200 | Rnd3_RhoE_Rho8 |
| cl21455 | 19-200 | P-loop_NTPase superfamily |
| cd04173 | 23-244 | Rnd2_Rho7 |
| cd04131 | 23-198 | Rnd |
| cd04174 | 1-244 | Rnd1_Rho6 |
| smart00174 | 26-200 | RHO |
| cd00157 | 24-196 | Rho |
| cd04132 | 21-212 | Rho4_like |
| cd01870 | 25-196 | RhoA_like |
| cd01875 | 20-207 | RhoG |
| cd04129 | 25-198 | Rho2 |
| cd01871 | 21-184 | Rac1_like |
| cd04130 | 22-196 | Wrch_1 |
| cd04134 | 25-190 | Rho3 |
| cd01874 | 22-196 | Cdc42 |
| cd04135 | 25-196 | Tc10 |
| cd00154 | 24-190 | Rab |
| cd04133 | 22-193 | Rop_like |
| smart00175 | 25-191 | RAB |
| cd01860 | 25-191 | Rab5_related |
| cd00876 | 25-191 | Ras |
| cd01868 | 24-191 | Rab11_like |
| cd04123 | 25-190 | Rab21 |
| cd01893 | 25-196 | Miro1 |
| cd04111 | 25-195 | Rab39 |
| cd01869 | 25-191 | Rab1_Ypt1 |
| cd01863 | 25-179 | Rab18 |
| smart00173 | 25-191 | RAS |
| cd01861 | 24-190 | Rab6 |
| smart00010 | 25-191 | small_GTPase |
| cd01864 | 25-190 | Rab19 |
| pfam08477 | 25-138 | Miro |
| cd01867 | 25-194 | Rab8_Rab10_Rab13_like |
| cd01873 | 25-140 | RhoBTB |
| cd04139 | 25-190 | RalA_RalB |
| cd04128 | 25-209 | Spg1 |
| cd04122 | 25-190 | Rab14 |
| cd00882 | 27-190 | Ras_like_GTPase |
| cd01862 | 25-196 | Rab7 |
| cd04110 | 25-138 | Rab35 |
| cd04107 | 25-140 | Rab32_Rab38 |
| cd04175 | 25-190 | Rap1 |
| cd04114 | 25-194 | Rab30 |
| cd04120 | 25-190 | Rab12 |
| cd04127 | 25-184 | Rab27A |
| cd04144 | 25-244 | Ras2 |
| cd04124 | 25-144 | RabL2 |
| cd04147 | 25-190 | Ras_dva |
| cd04145 | 25-191 | M_R_Ras_like |
| cd01865 | 25-190 | Rab3 |
| cd04119 | 25-191 | RJL |
| cd04115 | 25-197 | Rab33B_Rab33A |
| cd01866 | 25-190 | Rab2 |
| cd04140 | 25-191 | ARHI_like |
| cd04137 | 25-192 | RheB |
| cd00877 | 25-159 | Ran |
| cd04108 | 25-196 | Rab36_Rab34 |
| cd04177 | 25-190 | RSR1 |
| cd04117 | 25-195 | Rab15 |
| cd04146 | 25-193 | RERG_RasL11_like |
| cd04136 | 25-190 | Rap_like |
| cd04112 | 25-179 | Rab26 |
| cd04106 | 25-139 | Rab23_like |
| cd04116 | 25-193 | Rab9 |
| cd04109 | 25-244 | Rab28 |
| cd04113 | 25-190 | Rab4 |
| cd04138 | 25-191 | H_N_K_Ras_like |
| cd04176 | 25-190 | Rap2 |
| cd04143 | 25-196 | Rhes_like |
| cd04141 | 25-191 | Rit_Rin_Ric |
| cd04121 | 25-208 | Rab40 |
| cd04118 | 25-139 | Rab24 |
| cd04101 | 25-191 | RabL4 |
| PLN00023 | 25-123 | PLN00023 |
| cd09914 | 23-156 | RocCOR |
| cd04142 | 25-179 | RRP22 |
| cd00878 | 25-157 | Arf_Arl |
| cd04126 | 25-169 | Rab20 |
| cd04102 | 25-123 | RabL3 |
| pfam00025 | 6-153 | Arf |
| cd01892 | 22-139 | Miro2 |
| cd04164 | 95-158 | trmE |
| COG4225 | 75-171 | YesR |
| cl04955 | 75-171 | LanC_like superfamily |
| cd04159 | 26-139 | Arl10_like |
| pfam00071 | 25-194 | Ras |
| COG1100 | 21-217 | Gem1 |
| TIGR00231 | 25-177 | small_GTP |
| PLN03118 | 10-184 | PLN03118 |
| PLN03110 | 25-192 | PLN03110 |
| PLN03108 | 25-190 | PLN03108 |
| PTZ00132 | 25-140 | PTZ00132 |
| PLN03071 | 18-159 | PLN03071 |
| PTZ00369 | 25-216 | PTZ00369 |
| smart00176 | 29-159 | RAN |
| PTZ00099 | 46-204 | PTZ00099 |
Ontology Information
| HPRD ID | 1091 |
|---|---|
| Molecular Class | G protein |
| Molecular Function | Cytokine activity (GO:0005125) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.