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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
LAMA3 3909 laminin, alpha 3  18nicein-150kDa, kalinin-165kDa, BM600-150kDa, epiligrin 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25257191   2015Cell line : -

Source : Korean

Sample Type : CRC Tumor

No. of Sample : 139

Stage : TNM stage I-IV

SSCP, DNA sequencing,ImmunohistochemistryMutation-Frameshift mutations of LAMA1, LAMA3, LAMB1 and LAMB4, and loss of LAMB4 may be features of GC and CRC with MSI-H.


Gene Details



NC_000018.9 (21269562..21535030)

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Gene Type protein coding
Gene Family Laminins
Description The protein encoded by this gene belongs to the laminin family of secreted molecules. Laminins are heterotrimeric molecules that consist of alpha, beta, and gamma subunits that assemble through a coiled-coil domain. Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction. This gene encodes an alpha subunit and is responsive to several epithelial-mesenchymal regulators including keratinocyte growth factor, epidermal growth factor and insulin-like growth factor. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa and laryngoonychocutaneous syndrome. Alternative splicing and alternative promoter usage result in multiple transcript variants. [provided by RefSeq, Dec 2014]  
Chromosome 18
Location 18q11.2
Start 21269562  
End 21535030  
Strand +  
Gene Sequence

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Length 265469  
OMIM ID 600805   
HGNC ID HGNC:6483   
Unigene ID Hs.436367   
Ensembl ID ENSG00000053747   
PharmGKB ID PA30272   

mRNA Information


mRNA ID NM_198129.2
Exon join(1..535,24478..24630,58501..58618,59986..60104, 61476..61646,64279..64370,68954..69069,73963..74081, 84055..84145,86350..86481,88115..88177,94581..94715, 120924..121061,123615..123661,124961..125060, 125746..125798,126026..126131,126946..127045, 130399..130555,132810..132933,134981..135123, 137260..137357,137872..138025,144386..144546, 147539..147647,149339..149436,150343..150487, 152953..153079,153169..153308,155567..155682, 156855..157066,158022..158226,168402..168546, 169247..169387,172204..172365,175343..175441, 178392..178475,181989..182219,186852..186965, 192494..192603,195331..195411,200569..200675, 204856..204906,205465..205616,209296..209406, 209512..209623,209846..210013,211685..211  
mRNA Sequence

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Length 10666  



CDS Information


   
Location242..10243
CDS Sequence

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CCDS ID CCDS11880.1



Protein Information


      
Protein IDNP_937762.2
Protein Namelaminin, alpha 3
Molecular Wt. (Da)0
Protein Sequence

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Length 3333  
Uniprot IDP20366
Ensembl Protein ID ENSP00000321106  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation1441
TPhosphorylation3050

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                          
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
649BMP1209NP_006120.1in vitro;in vivo10806203   
3914LAMB31032NP_000219.2in vitro7775432   
5327PLAT1419NP_000921.1in vitro10956663   
5340PLG1417NP_000292.1in vitro10956663   
6383SDC2803NP_002989.2in vitro11373281   
79939SLC35E115373NP_079157.3yeast 2-hybrid16169070   


Pathway Information


                                                
Pathway Name Pathway ID
Amoebiasis hsa05146
ECM-receptor interaction hsa04512
Focal adhesion hsa04510
Metabolic pathways hsa01100
Pathways in cancer hsa05200
PI3K-Akt signaling pathway hsa04151
Small cell lung cancer hsa05222
Toxoplasmosis hsa05145


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd001103158-3309  LamG
cl228613158-3309  LamG superfamily
cd001102994-3134  LamG
cl228612994-3134  LamG superfamily
cd001102602-2742  LamG
cl228612602-2742  LamG superfamily
cd001102769-2901  LamG
cl228612769-2901  LamG superfamily
cd000551265-1307  EGF_Lam
cl228751265-1307  EGF_Lam superfamily
cd00055535-577  EGF_Lam
cl22875535-577  EGF_Lam superfamily
cd000551356-1401  EGF_Lam
cl228751356-1401  EGF_Lam superfamily
cd000551404-1454  EGF_Lam
cl228751404-1454  EGF_Lam superfamily
cd000551686-1732  EGF_Lam
cl228751686-1732  EGF_Lam superfamily
cd001102390-2568  LamG
cl228612390-2568  LamG superfamily
cd00055425-465  EGF_Lam
cl22875425-465  EGF_Lam superfamily
cd00055491-531  EGF_Lam
cl22875491-531  EGF_Lam superfamily
cd000551733-1785  EGF_Lam
cl228751733-1785  EGF_Lam superfamily
cd00055631-682  EGF_Lam
cl22875631-682  EGF_Lam superfamily
cd00055299-344  EGF_Lam
cl22875299-344  EGF_Lam superfamily
cd00055684-727  EGF_Lam
cl22875684-727  EGF_Lam superfamily
cd00055355-423  EGF_Lam
cl22875355-423  EGF_Lam superfamily
cd00055586-628  EGF_Lam
cl22875586-628  EGF_Lam superfamily
smart0013646-297  LamNT
cl0280646-297  Laminin_N superfamily
pfam0005547-297  Laminin_N
pfam060092288-2416  Laminin_II
cl055152288-2416  Laminin_II superfamily
smart002811514-1641  LamB
cl025481514-1641  Laminin_B superfamily
smart002823181-3310  LamG
pfam022103186-3311  Laminin_G_2
smart002823011-3136  LamG
pfam022103016-3136  Laminin_G_2
smart002822621-2742  LamG
pfam022102626-2742  Laminin_G_2
pfam000543018-3138  Laminin_G_1
pfam022102797-2901  Laminin_G_2
pfam000531266-1314  Laminin_EGF
smart002822794-2903  LamG
pfam000543186-3313  Laminin_G_1
smart001801266-1307  EGF_Lam
pfam000531356-1407  Laminin_EGF
smart00180536-579  EGF_Lam
smart002822435-2570  LamG
smart001801356-1402  EGF_Lam
pfam000521518-1652  Laminin_B
pfam000531734-1784  Laminin_EGF
pfam00053491-538  Laminin_EGF
pfam00053536-583  Laminin_EGF
pfam000531405-1453  Laminin_EGF
pfam133853017-3138  Laminin_G_3
smart00180491-533  EGF_Lam
pfam000531687-1734  Laminin_EGF
smart00180426-466  EGF_Lam
smart001801405-1447  EGF_Lam
smart001801734-1777  EGF_Lam
pfam00053426-465  Laminin_EGF
pfam000542626-2742  Laminin_G_1
smart001801687-1729  EGF_Lam
smart00180631-671  EGF_Lam
pfam00053631-681  Laminin_EGF
pfam022102432-2563  Laminin_G_2
pfam00053585-628  Laminin_EGF
cd137692092-2256  ApoLp-III_like
cl215092092-2256  ApoLp-III_like superfamily
pfam00053356-423  Laminin_EGF
smart00180684-722  EGF_Lam
cd134061694-1786  TNFRSF4
cl228551694-1786  TNFRSF superfamily
pfam133853157-3287  Laminin_G_3
pfam00053684-722  Laminin_EGF
smart00180356-423  EGF_Lam
cd134161665-1788  TNFRSF16
cl228551665-1788  TNFRSF superfamily
smart00180586-628  EGF_Lam
pfam039382091-2210  OmpH
cl214852091-2210  OmpH superfamily
pfam127182026-2161  Tropomyosin_1
cl228572026-2161  Tropomyosin_1 superfamily
smart00180299-339  EGF_Lam
smart009352091-2187  OmpH
smart002103172-3308  TSPN
pfam00053299-345  Laminin_EGF
cd105751665-1786  TNFRSF6B
pfam119852057-2161  DUF3486
cl204402057-2161  DUF3486 superfamily
pfam074642017-2160  ApoLp-III
cl215092017-2160  ApoLp-III_like superfamily
pfam060081845-2105  Laminin_I
pfam060082062-2339  Laminin_I
COG04191838-2441  SbcC
TIGR045231838-2341  Mplasa_alph_rch
COG11961856-2386  Smc
COG11961829-2360  Smc
COG04191830-2389  SbcC
TIGR045231836-2378  Mplasa_alph_rch
TIGR021681871-2159  SMC_prok_B
TIGR045231831-2387  Mplasa_alph_rch
pfam055571809-2381  MAD
TIGR021681838-2382  SMC_prok_B
TIGR021681831-2161  SMC_prok_B
COG11961978-2276  Smc
pfam055571841-2361  MAD
TIGR021691856-2154  SMC_prok_A
TIGR021681836-2383  SMC_prok_B
pfam015761830-2355  Myosin_tail_1
pfam101741828-2330  Cast
PRK039181856-2352  PRK03918
TIGR006061838-2354  rad50
PRK022241841-2180  PRK02224
pfam054831798-2267  SCP-1
COG11962024-2410  Smc
TIGR021691838-2161  SMC_prok_A
PRK039181838-2158  PRK03918
PRK039181948-2161  PRK03918
pfam121281832-2412  DUF3584
TIGR021682028-2376  SMC_prok_B
TIGR021692098-2388  SMC_prok_A
COG13402099-2411  COG1340
TIGR006181799-2253  sbcc
pfam078881886-2160  CALCOCO1
TIGR016121856-2387  235kDa-fam
PRK022241838-2375  PRK02224
pfam015761839-2176  Myosin_tail_1
pfam101741886-2386  Cast
COG04191915-2383  SbcC
PRK022241808-2076  PRK02224
PRK011561869-2390  PRK01156
pfam121281863-2161  DUF3584
pfam000381844-2072  Filament
COG08402008-2388  Tar
COG13401887-2238  COG1340
TIGR006061883-2393  rad50
COG30961966-2182  MukB
pfam135141829-2388  AAA_27
COG38831912-2163  CwlO1
pfam154501822-2159  DUF4631
COG43721847-2161  COG4372
pfam068731658-1828  SerH
pfam127951858-2042  MscS_porin
pfam121281841-2182  DUF3584
COG32061930-2246  GumC
pfam015761864-2387  Myosin_tail_1
pfam097311832-2175  Mitofilin
PTZ004401881-2368  PTZ00440
pfam015762032-2411  Myosin_tail_1
TIGR021682032-2410  SMC_prok_B
TIGR016121858-2386  235kDa-fam
pfam078881817-2161  CALCOCO1
PRK048631965-2170  mukB
PRK022242026-2382  PRK02224
TIGR018431876-2042  type_I_hlyD
pfam135141866-2186  AAA_27
COG49421992-2180  EnvC
COG51852100-2355  HEC1
TIGR006341969-2276  recN
PTZ004401856-2373  PTZ00440
pfam079262053-2161  TPR_MLP1_2
pfam138511828-1941  GAS
COG07112066-2183  AtpF
pfam083171971-2161  Spc7
COG04971983-2160  RecN
TIGR042112081-2164  SH3_and_anchor
TIGR006181987-2382  sbcc
pfam057011838-2260  WEMBL
PTZ001211971-2264  PTZ00121


Ontology Information


   
HPRD ID1208
Molecular ClassExtracellular matrix protein
Molecular FunctionG-protein coupled receptor activity (GO:0004930)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO