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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
LAMB1 3912 laminin, beta 1  7- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25257191   2015Cell line : -

Source : Korean

Sample Type : CRC Tumor

No. of Sample : 139

Stage : TNM stage I-IV

SSCP, DNA sequencing,ImmunohistochemistryMutation--


Gene Details



NC_000007.13 (107564244..107643804, complement)

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Gene Type protein coding
Gene Family Laminins
Description Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis. [provided by RefSeq, Aug 2011]  
Chromosome 7
Location 7q22
Start 107564244  
End 107643804  
Strand -  
Gene Sequence

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Length 79561  
OMIM ID 150240   
HGNC ID HGNC:6486   
Unigene ID Hs.650585   
Ensembl ID ENSG00000091136   
PharmGKB ID PA30275   

mRNA Information


mRNA ID NM_002291.2
Exon join(1..249,389..511,1627..1802,4868..5003,8400..8473, 16997..17185,17275..17338,22549..22751,25193..25313, 27483..27671,27947..28126,28262..28374,30289..30368, 38673..38808,40297..40455,41684..41811,42031..42154, 42711..42915,43526..43669,43880..44111,47730..47893, 49606..49830,51137..51351,52038..52134,63002..63371, 66083..66267,67704..67945,70983..71186,71860..72004, 73741..73948,74155..74296,77001..77177,78971..79130, 79273..79559)  
mRNA Sequence

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Length 5866  



CDS Information


   
Location336..5696
CDS Sequence

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CCDS ID CCDS5750.1



Protein Information


      
Protein ID NP_002282.2
Protein Namelaminin, beta 1
Molecular Wt. (Da)0
Protein Sequence

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Length 1786  
Uniprot IDP25103
Ensembl Protein ID ENSP00000303522  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation1280
TPhosphorylation1281
TPhosphorylation242
TPhosphorylation939
YPhosphorylation950
SPhosphorylation953
NGlycosylation1279
SPhosphorylation1735
SPhosphorylation154

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                            
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
43ACHE10NP_056646.1in vitro;in vivo;yeast 2-hybrid15474030   
1291COL6A1370NP_001839.2in vivo10407855   
8328GFI1B5088NP_004179.3yeast 2-hybrid16713569   
127002ATXN7L212506NP_699171.3yeast 2-hybrid16713569   


Pathway Information


                                          
Pathway Name Pathway ID
Amoebiasis hsa05146
ECM-receptor interaction hsa04512
Focal adhesion hsa04510
Pathways in cancer hsa05200
PI3K-Akt signaling pathway hsa04151
Small cell lung cancer hsa05222
Toxoplasmosis hsa05145


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00055772-819  EGF_Lam
cl22875772-819  EGF_Lam superfamily
cd00055820-863  EGF_Lam
cl22875820-863  EGF_Lam superfamily
cd00055457-508  EGF_Lam
cl22875457-508  EGF_Lam superfamily
cd000551131-1180  EGF_Lam
cl228751131-1180  EGF_Lam superfamily
cd000551083-1126  EGF_Lam
cl228751083-1126  EGF_Lam superfamily
cd00055509-548  EGF_Lam
cl22875509-548  EGF_Lam superfamily
cd00055866-911  EGF_Lam
cl22875866-911  EGF_Lam superfamily
cd000551028-1081  EGF_Lam
cl228751028-1081  EGF_Lam superfamily
cd00055397-456  EGF_Lam
cl22875397-456  EGF_Lam superfamily
cd00055975-1026  EGF_Lam
cl22875975-1026  EGF_Lam superfamily
cd00055335-387  EGF_Lam
cl22875335-387  EGF_Lam superfamily
cd00055271-323  EGF_Lam
cl22875271-323  EGF_Lam superfamily
cd00055916-974  EGF_Lam
cl22875916-974  EGF_Lam superfamily
pfam0005535-269  Laminin_N
cl0280635-269  Laminin_N superfamily
smart0013629-269  LamNT
pfam00053821-869  Laminin_EGF
smart00180773-818  EGF_Lam
pfam00053773-821  Laminin_EGF
pfam000531084-1132  Laminin_EGF
pfam000531132-1171  Laminin_EGF
smart00180821-864  EGF_Lam
pfam00053398-455  Laminin_EGF
pfam00053458-512  Laminin_EGF
smart001801132-1176  EGF_Lam
pfam000531028-1082  Laminin_EGF
smart001801084-1129  EGF_Lam
smart00180510-554  EGF_Lam
pfam00053867-914  Laminin_EGF
smart00180458-501  EGF_Lam
smart001801028-1081  EGF_Lam
pfam00053510-548  Laminin_EGF
smart00180398-455  EGF_Lam
pfam00053976-1021  Laminin_EGF
pfam00053917-973  Laminin_EGF
smart00180867-906  EGF_Lam
pfam010441446-1781  Vinculin
cl202131446-1781  Vinculin superfamily
smart009351693-1780  OmpH
cl214851693-1780  OmpH superfamily
pfam00053335-386  Laminin_EGF
COG13821649-1766  GimC
cl091111649-1766  Prefoldin superfamily
PRK039471531-1664  PRK03947
cd137691474-1634  ApoLp-III_like
cl215091474-1634  ApoLp-III_like superfamily
pfam149321623-1777  HAUS-augmin3
cl224001623-1777  HAUS-augmin3 superfamily
smart00180976-1019  EGF_Lam
PRK073531684-1778  PRK07353
cl214781684-1778  Mt_ATP-synt_B superfamily
COG28251685-1781  HlpA
smart00180335-388  EGF_Lam
TIGR025681627-1767  LcrE
cl154541627-1767  HrpJ superfamily
PRK144711564-1680  PRK14471
pfam00053271-326  Laminin_EGF
pfam051031646-1748  DivIVA
cl195171646-1748  DivIVA superfamily
COG17301533-1669  GIM5
pfam044021588-1729  SIMPL
cl010771588-1729  SIMPL superfamily
pfam134761614-1776  AAA_23
cl214551614-1776  P-loop_NTPase superfamily
pfam064281680-1752  Sec2p
cl057641680-1752  Sec2p superfamily
cd076481579-1713  F-BAR_FCHO
cl120131579-1713  BAR superfamily
pfam086471666-1761  BRE1
cl073161666-1761  BRE1 superfamily
smart00180917-966  EGF_Lam
cd008901607-1731  Prefoldin
pfam031791573-1680  V-ATPase_G
cl039221573-1680  V-ATPase_G superfamily
smart009351710-1780  OmpH
cd073071216-1327  BAR
cl120131216-1327  BAR superfamily
pfam039381710-1780  OmpH
pfam053351581-1727  DUF745
cl225361581-1727  DUF745 superfamily
pfam127181463-1660  Tropomyosin_1
cl228571463-1660  Tropomyosin_1 superfamily
COG13401452-1778  COG1340
PTZ001211224-1778  PTZ00121
COG11961202-1776  Smc
TIGR021681216-1776  SMC_prok_B
COG11961459-1783  Smc
COG11961216-1777  Smc
PRK039181189-1727  PRK03918
PRK022241285-1775  PRK02224
TIGR021691190-1779  SMC_prok_A
COG04191224-1775  SbcC
COG11961442-1780  Smc
COG04191224-1778  SbcC
PRK039181223-1782  PRK03918
COG11961457-1775  Smc
COG04191457-1780  SbcC
TIGR021681220-1779  SMC_prok_B
TIGR021681189-1777  SMC_prok_B
TIGR021691454-1776  SMC_prok_A
TIGR021691229-1771  SMC_prok_A
TIGR021681489-1777  SMC_prok_B
COG11961217-1780  Smc
PTZ001211467-1778  PTZ00121
PRK039181217-1783  PRK03918
PTZ001211437-1780  PTZ00121
PTZ001211457-1767  PTZ00121
TIGR006181199-1771  sbcc
TIGR006061223-1764  rad50
pfam054831208-1775  SCP-1
TIGR021691217-1777  SMC_prok_A
COG11961229-1663  Smc
TIGR045231457-1777  Mplasa_alph_rch
pfam101741199-1780  Cast
PRK022241217-1773  PRK02224
pfam054831190-1667  SCP-1
TIGR045231221-1750  Mplasa_alph_rch
smart002831456-1691  MA
pfam015761447-1780  Myosin_tail_1
pfam015761228-1771  Myosin_tail_1
COG04191190-1781  SbcC
TIGR045231476-1778  Mplasa_alph_rch
pfam101741248-1778  Cast
COG11961362-1691  Smc
COG38831584-1780  CwlO1
pfam135141191-1768  AAA_27
COG04191593-1784  SbcC
COG13401442-1711  COG1340
pfam015761538-1776  Myosin_tail_1
TIGR045231244-1773  Mplasa_alph_rch
PRK039181545-1776  PRK03918
TIGR021681251-1777  SMC_prok_B
TIGR045231483-1780  Mplasa_alph_rch
pfam071111235-1774  HCR
pfam040941271-1780  DUF390
pfam057011444-1778  WEMBL
COG11961190-1507  Smc
pfam054831240-1760  SCP-1
pfam015761452-1775  Myosin_tail_1
pfam121281218-1778  DUF3584
pfam071111283-1786  HCR
COG43721539-1770  COG4372
COG18421571-1751  PspA
COG49421581-1778  EnvC
COG08401449-1708  Tar
pfam002611588-1773  Tropomyosin
pfam015761201-1762  Myosin_tail_1
TIGR006181178-1774  sbcc
COG49421452-1727  EnvC
pfam135141440-1747  AAA_27
COG22681449-1767  YqiK
pfam024631297-1727  SMC_N
pfam097311568-1780  Mitofilin
COG43721447-1741  COG4372
TIGR021681453-1778  SMC_prok_B
TIGR031851447-1743  DNA_S_dndD
pfam056221457-1757  HOOK
pfam138681457-1760  Trichoplein
pfam040121547-1767  PspA_IM30
COG38831435-1733  CwlO1
pfam135141434-1769  AAA_27
TIGR006061250-1786  rad50
COG49421442-1670  EnvC
pfam101741476-1778  Cast
PRK022241449-1776  PRK02224
pfam054831589-1778  SCP-1
pfam097311432-1774  Mitofilin
COG43721564-1773  COG4372
TIGR006061244-1778  rad50
PRK022241546-1777  PRK02224
pfam059111222-1748  DUF869
PRK047781453-1725  PRK04778
PTZ003411473-1714  PTZ00341
TIGR045231610-1784  Mplasa_alph_rch
COG07111565-1707  AtpF
pfam002611485-1696  Tropomyosin
pfam057011457-1744  WEMBL
pfam097301471-1777  BicD
COG18421593-1780  PspA
COG13401192-1382  COG1340
PTZ001211192-1760  PTZ00121
COG30961442-1752  MukB
COG32061505-1778  GumC
TIGR027941517-1743  tolA_full
COG24331595-1766  COG2433
pfam121281453-1771  DUF3584
pfam071111537-1780  HCR
pfam040121592-1779  PspA_IM30
PTZ004401458-1756  PTZ00440
pfam042861459-1775  DUF445
PTZ004401220-1710  PTZ00440
pfam052621515-1716  Borrelia_P83
pfam055571461-1775  MAD
pfam060081539-1779  Laminin_I
pfam060081491-1696  Laminin_I
TIGR018431512-1741  type_I_hlyD
COG44871552-1762  COG4487
PRK124721564-1710  PRK12472
PRK055631447-1730  PRK05563
pfam097261254-1749  Macoilin
TIGR021691202-1394  SMC_prok_A
pfam052621576-1729  Borrelia_P83
pfam056671547-1778  DUF812
COG38531474-1669  TelA
PRK001061569-1737  PRK00106
COG30641561-1762  TolA
COG04971592-1771  RecN
TIGR033191569-1733  RNase_Y
PRK127041570-1733  PRK12704
pfam007691539-1761  ERM
PRK095101539-1743  tolA
pfam024631567-1783  SMC_N
PTZ004401476-1778  PTZ00440
pfam040121437-1668  PspA_IM30
COG35991537-1732  DivIVA
pfam135141431-1768  AAA_27
PTZ001211595-1769  PTZ00121
pfam084291458-1768  PLU-1
pfam121281441-1742  DUF3584
pfam004301540-1664  ATP-synt_B
TIGR026801498-1769  TIGR02680
COG44771446-1762  EzrA
PTZ001211574-1769  PTZ00121
pfam102341493-1659  Cluap1
TIGR026801443-1670  TIGR02680
PRK001061439-1630  PRK00106
TIGR021691569-1778  SMC_prok_A
pfam049121443-1780  Dynamitin
TIGR026801216-1578  TIGR02680
pfam139491437-1716  ALIX_LYPXL_bnd
pfam078881438-1777  CALCOCO1
pfam120721569-1761  DUF3552
pfam154501442-1775  DUF4631
PRK127041644-1772  PRK12704
PRK112811581-1778  PRK11281
COG18421450-1667  PspA
TIGR031851430-1651  DNA_S_dndD
TIGR026801515-1766  TIGR02680
PRK001061630-1764  PRK00106
pfam079261518-1632  TPR_MLP1_2
CHL000941442-1556  dnaK
TIGR031851491-1777  DNA_S_dndD
COG43721217-1382  COG4372
pfam127951575-1778  MscS_porin
TIGR029261575-1665  AhaH
PRK048631456-1778  mukB
COG30641518-1726  TolA
TIGR006341597-1777  recN
PLN032291457-1767  PLN03229
COG17501530-1756  COG1750
pfam067051561-1768  SF-assemblin
TIGR033191463-1662  RNase_Y
PLN029391466-1765  PLN02939
COG47171456-1766  YhaN
pfam127951452-1667  MscS_porin
PHA025621547-1779  46
TIGR021681201-1390  SMC_prok_B
pfam120721462-1685  DUF3552
pfam028411646-1777  GBP_C
COG13901454-1579  NtpE
PTZ004401469-1778  PTZ00440
COG47171538-1778  YhaN
COG35991442-1642  DivIVA
PRK127051602-1781  PRK12705
COG15791647-1783  COG1579
PHA025621473-1619  46
pfam083171459-1582  Spc7
PRK004091688-1773  PRK00409
PRK047781538-1777  PRK04778
COG22681454-1697  YqiK
pfam156191696-1771  Lebercilin
PRK127051559-1719  PRK12705
pfam000151228-1386  MCPsignal
pfam061601538-1777  EzrA
PRK022921540-1698  PRK02292
PRK127041461-1672  PRK12704
pfam153461650-1779  ARGLU
pfam079261593-1704  TPR_MLP1_2
pfam097281541-1784  Taxilin
TIGR033461522-1733  chaperone_ClpB
smart007871459-1579  Spc7
pfam061601480-1656  EzrA
smart007871648-1777  Spc7
COG50221455-1715  COG5022
COG06991217-1389  CrfC
pfam139491560-1777  ALIX_LYPXL_bnd
pfam041561271-1388  IncA
smart002831229-1386  MA
COG12931490-1778  YloA
pfam153461545-1661  ARGLU
COG13901589-1716  NtpE
pfam041561636-1742  IncA
TIGR018431644-1777  type_I_hlyD
pfam138511648-1780  GAS
TIGR033191652-1780  RNase_Y
pfam000381669-1775  Filament


Ontology Information


   
HPRD ID2850
Molecular ClassExtracellular matrix protein
Molecular FunctionTranscription regulator activity (GO:0030528)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO