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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
LAMC1 3915 laminin, gamma 1 (formerly LAMB2)  1- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24737748   2014Cell line : -

Source : -

Sample Type : Population based case control study

No. of Sample : 14 037 CRC and 15 937 controls

Stage : -

Meta analysisMutation-rs3217810 intronic in CCND2 (12p13.32; OR = 1.19, P = 2.16 � 10(-10)) and rs10911251 near LAMC1 significantly associated with CRC.


Gene Details



NC_000001.10 (182992572..183114727)

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Gene Type protein coding
Gene Family Laminins
Description Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis. [provided by RefSeq, Aug 2011]  
Chromosome 1
Location 1q31
Start 182992572  
End 183114727  
Strand +  
Gene Sequence

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Length 122156  
OMIM ID 150290   
HGNC ID HGNC:6492   
Unigene ID Hs.609663   
Ensembl ID ENSG00000135862   
PharmGKB ID PA30280   

mRNA Information


mRNA ID NM_002293.3
Exon join(1..675,79869..80173,84817..84947,87029..87195, 91072..91260,92061..92178,93118..93216,93308..93444, 93861..93983,94075..94264,94575..94687,98264..98485, 98604..98792,101172..101417,101938..102091,102661..102803, 103767..103945,105135..105291,106885..107090, 107840..107919,108941..109078,109947..110091, 111201..111350,111583..111697,112927..113126, 114210..114368,116945..117044,119075..122133)  
mRNA Sequence

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Length 7889  



CDS Information


   
Location258..5087
CDS Sequence

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CCDS ID CCDS1351.1



Protein Information


      
Protein IDNP_002284.3
Protein Namelaminin, gamma 1 (formerly LAMB2)
Molecular Wt. (Da)19692
Protein Sequence

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Length 1609  
Uniprot IDQ01995
Ensembl Protein ID ENSP00000278968  



Post-translational Modification Information (Source : HPRD)


Residue Type site
NGlycosylation650
SPhosphorylation159
TPhosphorylation166
SPhosphorylation179
SPhosphorylation181
TPhosphorylation185
SPhosphorylation187
SPhosphorylation664
YPhosphorylation667
SPhosphorylation675

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                            
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
4811NID1574NP_002499.2in vivo9733643   
23557SNAPIN6111NP_036569.1yeast 2-hybrid16169070   
51019CCDC5313031NP_057137.1yeast 2-hybrid16169070   
55729ATF7IP9811NP_060649.3yeast 2-hybrid15231748   


Pathway Information


                                                
Pathway Name Pathway ID
Amoebiasis hsa05146
ECM-receptor interaction hsa04512
Focal adhesion hsa04510
Pathways in cancer hsa05200
PI3K-Akt signaling pathway hsa04151
Prion diseases hsa05020
Small cell lung cancer hsa05222
Toxoplasmosis hsa05145


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00055934-981  EGF_Lam
cl22875934-981  EGF_Lam superfamily
cd00055444-493  EGF_Lam
cl22875444-493  EGF_Lam superfamily
cd00055724-771  EGF_Lam
cl22875724-771  EGF_Lam superfamily
cd00055883-933  EGF_Lam
cl22875883-933  EGF_Lam superfamily
cd00055397-443  EGF_Lam
cl22875397-443  EGF_Lam superfamily
cd00055982-1029  EGF_Lam
cl22875982-1029  EGF_Lam superfamily
cd00055828-876  EGF_Lam
cl22875828-876  EGF_Lam superfamily
cd00055285-330  EGF_Lam
cl22875285-330  EGF_Lam superfamily
cd00055772-820  EGF_Lam
cl22875772-820  EGF_Lam superfamily
cd00055341-389  EGF_Lam
cl22875341-389  EGF_Lam superfamily
pfam0005550-284  Laminin_N
cl0280650-284  Laminin_N superfamily
smart0013644-284  LamNT
pfam00052558-688  Laminin_B
cl02548558-688  Laminin_B superfamily
smart00281553-678  LamB
smart00180935-980  EGF_Lam
pfam00053445-492  Laminin_EGF
pfam00053935-983  Laminin_EGF
pfam00053398-445  Laminin_EGF
pfam00053724-763  Laminin_EGF
smart00180445-492  EGF_Lam
smart00180398-442  EGF_Lam
pfam00053884-932  Laminin_EGF
smart00180724-765  EGF_Lam
smart00180884-932  EGF_Lam
smart00180983-1028  EGF_Lam
pfam00053983-1031  Laminin_EGF
pfam00053828-875  Laminin_EGF
pfam127181287-1434  Tropomyosin_1
cl228571287-1434  Tropomyosin_1 superfamily
cd001761446-1596  SPEC
cl024881446-1596  SPEC superfamily
pfam110681444-1583  YlqD
cl126301444-1583  YlqD superfamily
smart00180828-872  EGF_Lam
pfam00053342-396  Laminin_EGF
pfam074641361-1475  ApoLp-III
cl215091361-1475  ApoLp-III_like superfamily
pfam00053286-328  Laminin_EGF
cd113861123-1255  MCP_signal
cl215471123-1255  MCP_signal superfamily
cd092361180-1336  V_AnPalA_UmRIM20_like
cl146541180-1336  V_Alix_like superfamily
TIGR024731222-1335  flagell_FliJ
cl214771222-1335  FliJ superfamily
smart003971072-1155  t_SNARE
cl228561072-1155  SNARE superfamily
pfam104731462-1573  CENP-F_leu_zip
cl228581462-1573  CENP-F_leu_zip superfamily
smart00180286-328  EGF_Lam
cd092371428-1596  V_ScBro1_like
cl146541428-1596  V_Alix_like superfamily
cd001761049-1254  SPEC
cl024881049-1254  SPEC superfamily
pfam103681124-1267  YkyA
cl215091124-1267  ApoLp-III_like superfamily
cd096061073-1158  M3B_PepF_1
cl148131073-1158  GluZincin superfamily
smart00180342-388  EGF_Lam
pfam127181417-1570  Tropomyosin_1
cl228571417-1570  Tropomyosin_1 superfamily
smart002831091-1302  MA
pfam060081206-1480  Laminin_I
COG04191049-1596  SbcC
COG11961038-1596  Smc
pfam054831040-1594  SCP-1
COG11961036-1553  Smc
COG04191071-1591  SbcC
COG04191048-1582  SbcC
COG11961035-1596  Smc
COG04191068-1594  SbcC
TIGR021681181-1597  SMC_prok_B
PRK039181072-1594  PRK03918
COG11961069-1486  Smc
TIGR021681036-1596  SMC_prok_B
PRK039181073-1590  PRK03918
PTZ001211058-1594  PTZ00121
TIGR045231039-1595  Mplasa_alph_rch
TIGR045231072-1590  Mplasa_alph_rch
TIGR021681046-1515  SMC_prok_B
pfam054831090-1596  SCP-1
TIGR021691036-1596  SMC_prok_A
TIGR045231075-1560  Mplasa_alph_rch
TIGR021681035-1590  SMC_prok_B
COG08401049-1326  Tar
pfam015761104-1596  Myosin_tail_1
COG11961039-1327  Smc
pfam015761081-1596  Myosin_tail_1
TIGR021691041-1596  SMC_prok_A
pfam135141039-1529  AAA_27
pfam135141085-1582  AAA_27
pfam101741042-1608  Cast
TIGR021691136-1528  SMC_prok_A
pfam121281041-1577  DUF3584
TIGR021691229-1591  SMC_prok_A
COG22681142-1438  YqiK
TIGR021691294-1596  SMC_prok_A
TIGR021681074-1522  SMC_prok_B
COG07111394-1489  AtpF
PTZ001211069-1591  PTZ00121
pfam120721375-1581  DUF3552
PRK127041373-1581  PRK12704
TIGR006181200-1571  sbcc
PRK039181030-1456  PRK03918
COG11961385-1596  Smc
TIGR006061027-1589  rad50
TIGR045231288-1598  Mplasa_alph_rch
TIGR016121049-1608  235kDa-fam
pfam101741072-1509  Cast
COG18421368-1573  PspA
pfam015761075-1513  Myosin_tail_1
COG38831384-1591  CwlO1
pfam040121394-1571  PspA_IM30
COG43721373-1577  COG4372
PRK073521393-1485  PRK07352
COG43721107-1337  COG4372
TIGR006181042-1585  sbcc
pfam127951216-1485  MscS_porin
PRK022241039-1477  PRK02224
pfam052621371-1609  Borrelia_P83
PTZ004401037-1592  PTZ00440
pfam015761231-1598  Myosin_tail_1
PRK011561078-1596  PRK01156
COG47171050-1590  YhaN
PTZ004401050-1585  PTZ00440
pfam060081282-1542  Laminin_I
pfam052621063-1312  Borrelia_P83
COG52711118-1595  MDN1
PRK022241040-1438  PRK02224
pfam055571077-1564  MAD
pfam135141047-1477  AAA_27
pfam007691375-1568  ERM
COG30961074-1327  MukB
pfam002611116-1308  Tropomyosin
PRK022241181-1596  PRK02224
PRK048631072-1536  mukB
COG44771046-1431  EzrA
pfam061601140-1594  EzrA
pfam121281028-1585  DUF3584
pfam127951296-1563  MscS_porin
COG08401360-1588  Tar
COG52811179-1577  COG5281
PTZ004401122-1581  PTZ00440
TIGR016121038-1589  235kDa-fam
COG13401043-1331  COG1340
COG30961048-1312  MukB
COG08401084-1471  Tar
pfam138681072-1333  Trichoplein
TIGR016121367-1589  235kDa-fam
PRK039181448-1598  PRK03918
pfam071111051-1605  HCR
pfam101741181-1596  Cast
pfam024631282-1584  SMC_N
PTZ004401073-1586  PTZ00440
COG13401452-1608  COG1340
TIGR031851178-1579  DNA_S_dndD
TIGR033191406-1585  RNase_Y
pfam127951040-1277  MscS_porin
TIGR006181048-1321  sbcc
pfam004301366-1470  ATP-synt_B
PRK022241358-1590  PRK02224
COG30641237-1502  TolA
TIGR042111387-1490  SH3_and_anchor
COG13401270-1570  COG1340
PHA025621280-1504  46
COG52811089-1530  COG5281
pfam058021394-1595  EspB
COG43721189-1457  COG4372
COG38831358-1572  CwlO1
TIGR006061067-1598  rad50
PHA025621043-1306  46
pfam057011182-1594  WEMBL
PRK095101229-1457  tolA
pfam131661438-1590  AAA_13
TIGR016121040-1591  235kDa-fam
COG18421098-1333  PspA
TIGR043201458-1581  Surf_Exclu_PgrA
pfam097281279-1596  Taxilin
pfam056671362-1596  DUF812
pfam056671072-1289  DUF812
PRK127051185-1332  PRK12705
COG35991229-1451  DivIVA
smart002831372-1582  MA
TIGR026801143-1488  TIGR02680
COG51851054-1472  HEC1
PRK047781142-1591  PRK04778
COG18421180-1449  PspA
COG35991294-1470  DivIVA
pfam03302687-999  VSP
TIGR016121195-1589  235kDa-fam
COG13401358-1594  COG1340
PRK011561038-1458  PRK01156
PTZ001211063-1309  PTZ00121
smart002831160-1438  MA
pfam056221034-1336  HOOK
pfam056671069-1301  DUF812
TIGR021691039-1326  SMC_prok_A
COG49421223-1489  EnvC
PRK022241051-1285  PRK02224
pfam056221049-1513  HOOK
COG44871085-1599  COG4487
pfam052621434-1599  Borrelia_P83
pfam131661095-1337  AAA_13
pfam139491357-1564  ALIX_LYPXL_bnd
pfam055571232-1602  MAD
COG04971357-1575  RecN
TIGR011441394-1484  ATP_synt_b
pfam004301394-1482  ATP-synt_B
smart002831357-1527  MA
TIGR026801356-1507  TIGR02680
PTZ004401067-1608  PTZ00440
PRK022241038-1346  PRK02224
COG30641068-1274  TolA
pfam121281101-1587  DUF3584
pfam083171497-1594  Spc7
PRK109291361-1549  PRK10929
COG32061102-1314  GumC
COG35991359-1584  DivIVA
pfam083171229-1375  Spc7
PRK039181365-1608  PRK03918
COG38531128-1506  TelA
pfam054831044-1478  SCP-1
COG13401357-1590  COG1340
PRK011561241-1599  PRK01156
TIGR043201361-1469  Surf_Exclu_PgrA
pfam057011050-1240  WEMBL
PTZ004401097-1596  PTZ00440
pfam057011074-1552  WEMBL
COG32641409-1579  MscK
PTZ001211069-1337  PTZ00121
PRK004091394-1595  PRK00409
PRK050351131-1440  PRK05035
COG13901228-1328  NtpE
PTZ004401277-1599  PTZ00440
pfam119321411-1580  DUF3450
COG13901458-1574  NtpE
pfam131661287-1596  AAA_13
TIGR043201391-1524  Surf_Exclu_PgrA
COG15791386-1590  COG1579
COG47171035-1330  YhaN
PLN031881035-1309  PLN03188
COG32641098-1267  MscK
pfam057011069-1479  WEMBL
pfam060081102-1372  Laminin_I
COG08401358-1589  Tar
pfam052621247-1447  Borrelia_P83
PRK077351305-1507  PRK07735
PRK127041075-1274  PRK12704
COG44771094-1478  EzrA
TIGR027941237-1502  tolA_full


Ontology Information


   
HPRD ID3780
Molecular ClassExtracellular matrix protein
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO