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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| RPSA | 3921 | Ribosomal protein SA | 3 | SA; LBP; LRP; p40; 67LR; lamR; 37LRP; LAMBR; LAMR1; LRP/LR; LBP/p40; NEM/1CHD4 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis | Up-regulation | - | This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| Chromosome | 3 |
| Location | 3p22.2 |
| Start | 39406689 |
| End | 39412542 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 5854 |
| OMIM ID | 150370 |
| HGNC ID | HGNC:6502 |
| Unigene ID | Hs.449909 |
| Ensembl ID | ENSG00000168028 |
| PharmGKB ID | PA30287 |
mRNA Information
| mRNA ID | NM_001304288.1 |
|---|---|
| Exon | join(1..76,933..1098,1918..2051,4066..4311,4961..5089, 5208..5373,5586..5854) | mRNA Sequence | Download Select all |
| Length | 1155 |
CDS Information
| Location | join(966..1098,1918..2051,4066..4311,4961..5089, 5208..5373,5586..5680) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_002286.2 |
|---|---|
| Protein Name | Ribosomal protein SA |
| Molecular Wt. (Da) | 32723 |
| Protein Sequence | Download Select all |
| Length | 295 |
| Uniprot ID | Q12834 |
| Ensembl Protein ID | ENSP00000308450 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 139;- |
| Y | Phosphorylation | 139;- |
| S | Phosphorylation | 43;- |
| S | Phosphorylation | 43;- |
| Y | Phosphorylation | 139;- |
| Y | Phosphorylation | 139;- |
| S | Acetylation | 2 |
| S | Acetylation | 2 |
| T | Phosphorylation | 241 |
| T | Phosphorylation | 241 |
| K | Acetylation | 52 |
| K | Acetylation | 52 |
| T | Phosphorylation | 125 |
| T | Phosphorylation | 125 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3655 | ITGA6 | 945 | NP_001073286.1 | in vivo | 10477615 |
| 6227 | RPS21 | 1605 | NP_001015.1 | in vitro;yeast 2-hybrid | 1 007 919 416 189 510 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Ribosome | hsa03010 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01425 | 18-184 | RPS2 |
| cl00315 | 18-184 | RPS2 superfamily |
| TIGR01012 | 10-206 | uS2_euk_arch |
| PRK04020 | 10-200 | rps2P |
| COG0052 | 10-217 | RpsB |
| pfam00318 | 19-186 | Ribosomal_S2 |
| TIGR01011 | 7-187 | rpsB_bact |
| PRK05299 | 7-221 | rpsB |
| cd10170 | Mar-63 | HSP70_NBD |
| cl17037 | Mar-63 | NBD_sugar-kinase_HSP70_actin superfamily |
| PTZ00254 | 1-250 | PTZ00254 |
Ontology Information
| HPRD ID | 1146 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Protein tyrosine/serine/threonine phosphatase activity (GO:0008138) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.