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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| LDHB | 3945 | Lactate dehydrogenase B | 12 | LDH-B; LDH-H; LDHBD; TRG-5 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18978174 | 2009 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Microarray, RT-PCR and Immunohistochemistry | Unknown | - | The LDH expression profile differs between the invasive phenotypes. |
| 6948128 | 1982 | Cell line : 6 Cancer Cell line Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | - |
| 22991145 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Utilizing a fluorogenic derivatization-liquid chromatography-tandem mass spectrometry (FD-LC-MS/MS) | Up-regulation | - | Upregulation of LDHB and downregulation of GAPDH suggest the existence of a specific nonglycolytic energy production pathway in metastatic colorectal cancer cells. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes an enzyme which catalyzes the reversible conversion of lactate and pyruvate, and NAD and NADH, in the glycolytic pathway. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on the X chromosome and on chromosome. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2010] |
| Chromosome | 12 |
| Location | 12p12.2-p1 |
| Start | 21635341 |
| End | 21657971 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 22631 |
| OMIM ID | 150100 |
| HGNC ID | HGNC:6541 |
| Unigene ID | Hs.446149 |
| Ensembl ID | ENSG00000111716 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_002300.6 |
|---|---|
| Exon | join(117..221,3295..3429,10956..11073,13864..14037, 15847..16020,19502..19619,20778..20901,22263..22631) | mRNA Sequence | Download Select all |
| Length | 1317 |
CDS Information
| Location | join(3301..3429,10956..11073,13864..14037,15847..16020, 19502..19619,20778..20901,22263..22430) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS8691.1 |
Protein Information
| Protein ID | NP_001167568.1 |
|---|---|
| Protein Name | Lactate dehydrogenase B |
| Molecular Wt. (Da) | 36507 |
| Protein Sequence | Download Select all |
| Length | 334 |
| Uniprot ID | P30307 |
| Ensembl Protein ID | ENSP00000321656 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 240;- |
| Y | Phosphorylation | 240;- |
| K | Acetylation | 7 |
| K | Acetylation | 119 |
| K | Acetylation | 319 |
| K | Acetylation | 329 |
| K | Acetylation | 58 |
| S | Phosphorylation | 44 |
Enzyme Information
| EC | 1.1.1.27 |
|---|---|
| Name | L-lactate dehydrogenase lactic acid dehydrogenase L(+)-nLDH L-(+)-lactate dehydrogenase L-lactic dehydrogenase L-lactic acid dehydrogenase lactate dehydrogenase lactate dehydrogenase NAD+-dependent lactic dehydrogenase NAD+-lactate dehydrogenase |
| Class | Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor |
| Sysname | (S)-lactate:NAD+ oxidoreductase |
| Substrate | (S)-lactate [CPD:C00186]; NAD+ |
| Product | pyruvate [CPD:C00022]; NADH [CPD:C00004]; H+ |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cysteine and methionine metabolism | hsa00270 |
| Glucagon signaling pathway | hsa04922 |
| Glycolysis / Gluconeogenesis | hsa00010 |
| Metabolic pathways | hsa01100 |
| Propanoate metabolism | hsa00640 |
| Pyruvate metabolism | hsa00620 |
Structure Information
| PDB ID | 1I0Z |
|---|---|
| Resolution | 2.1 |
| Method | X-RAY DIFFRACTION |
| Chains | A,B |
| Molecule | L-LACTATE DEHYDROGENASE H CHAIN |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05293 | 20-330 | LDH_1 |
| cl21454 | 20-330 | NADB_Rossmann superfamily |
| cd00300 | 24-329 | LDH_like |
| cd05292 | 22-331 | LDH_2 |
| cd05291 | 22-330 | HicDH_like |
| cd00650 | 24-329 | LDH_MDH_like |
| cd01339 | 24-324 | LDH-like_MDH |
| cd05290 | 23-324 | LDH_3 |
| pfam00056 | 22-161 | Ldh_1_N |
| cd05294 | 23-324 | LDH-like_MDH_nadp |
| pfam02866 | 165-334 | Ldh_1_C |
| cl15765 | 165-334 | Ldh_1_C superfamily |
| cd00704 | 48-324 | MDH |
| cd01337 | 23-185 | MDH_glyoxysomal_mitochondrial |
| cd01336 | 23-194 | MDH_cytoplasmic_cytosolic |
| PLN02602 | 4-332 | PLN02602 |
| TIGR01771 | 26-326 | L-LDH-NAD |
| PRK00066 | 22-331 | ldh |
| COG0039 | 22-334 | Mdh |
| PRK06223 | 22-324 | PRK06223 |
| TIGR01763 | 23-331 | MalateDH_bact |
| PTZ00117 | 23-334 | PTZ00117 |
| PTZ00082 | 19-320 | PTZ00082 |
| TIGR01759 | 23-324 | MalateDH-SF1 |
| TIGR01772 | 23-324 | MDH_euk_gproteo |
| TIGR01756 | 57-331 | LDH_protist |
| TIGR01758 | 23-247 | MDH_euk_cyt |
| PTZ00325 | 23-199 | PTZ00325 |
| COG1486 | 98-183 | CelF |
| PLN00106 | 92-194 | PLN00106 |
| PRK05086 | 23-214 | PRK05086 |
Ontology Information
| HPRD ID | 227 |
|---|---|
| Molecular Class | Enzyme: Dehydrogenase |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.