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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ARHGAP6 | 395 | Rho GTPase activating protein 6 | X | rhoGAPX-1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19960375 | 2010 | Cell line : - Source : Department of Pathology in the First Hospital of Changsha, P. R. China Sample Type : Formalin-fixed paraffin-embedded tumor and normal adjacent tissue No. of Sample : 150 Stage : - | Immunocytochemistry, Affinity Chromatography, ELISA, Western Blotting, Matrix Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS), RT-PCR | Up-regulation | - | The RhoGAP6 isoform 1 variant might serve as a biomarker for the development and progression of CRC. We confirmed that the expression levels of this variant were elevated in aberrant cells and tissues |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Rho GTPase activating proteins |
| Description | This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Chromosome | X |
| Location | Xp22.3 |
| Start | 11137543 |
| End | 11665701 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 528159 |
| OMIM ID | 300118 |
| HGNC ID | HGNC:676 |
| Unigene ID | Hs.435291 |
| Ensembl ID | ENSG00000047648 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_013427.2 |
|---|---|
| Exon | join(1..1461,410995..411154,468706..468777,476718..476974, 479271..479466,483584..483639,486250..486400, 487454..487602,496018..496197,509076..509173, 521454..521722,523389..523469,526172..528159) | mRNA Sequence | Download Select all |
| Length | 3943 |
CDS Information
| Location | join(874..1461,410995..411154,468706..468777, 476718..476974,479271..479466,483584..483639, 486250..486400,487454..487602,496018..496197, 509076..509173,521454..521722,523389..523469, 526172..526839) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS14140.1 |
Protein Information
| Protein ID | NP_001274171.1 |
|---|---|
| Protein Name | Rho GTPase activating protein 6 |
| Molecular Wt. (Da) | 87386 |
| Protein Sequence | Download Select all |
| Length | 794 |
| Uniprot ID | P09681 |
| Ensembl Protein ID | ENSP00000350005 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 772 |
| S | Phosphorylation | 569 |
| S | Phosphorylation | 663 |
| S | Phosphorylation | 673 |
| S | Phosphorylation | 663 |
| S | Phosphorylation | 673 |
| S | Phosphorylation | 695 |
| S | Phosphorylation | 705 |
| S | Phosphorylation | 460 |
| S | Phosphorylation | 470 |
| S | Phosphorylation | 264 |
| S | Phosphorylation | 296 |
| S | Phosphorylation | 264 |
| S | Phosphorylation | 296 |
| S | Phosphorylation | 61 |
| S | Phosphorylation | 939 |
| S | Phosphorylation | 736 |
| S | Phosphorylation | 928 |
| S | Phosphorylation | 725 |
| S | Phosphorylation | 754 |
| S | Phosphorylation | 551 |
| S | Phosphorylation | 777 |
| S | Phosphorylation | 574 |
| S | Phosphorylation | 667 |
| S | Phosphorylation | 667 |
| S | Phosphorylation | 699 |
| S | Phosphorylation | 464 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04376 | 402-608 | RhoGAP_ARHGAP6 |
| cl02570 | 402-608 | RhoGAP superfamily |
| smart00324 | 408-598 | RhoGAP |
| pfam00620 | 411-570 | RhoGAP |
| cd00159 | 411-597 | RhoGAP |
| cd04391 | 410-612 | RhoGAP_ARHGAP18 |
| cd04397 | 386-608 | RhoGAP_fLRG1 |
| cd04385 | 410-598 | RhoGAP_ARAP |
| cd04404 | 404-602 | RhoGAP-p50rhoGAP |
| cd04395 | 410-562 | RhoGAP_ARHGAP21 |
| cd04375 | 410-608 | RhoGAP_DLC1 |
| cd04377 | 408-580 | RhoGAP_myosin_IX |
| cd04393 | 410-564 | RhoGAP_FAM13A1a |
| cd04398 | 410-602 | RhoGAP_fRGD1 |
| cd04394 | 405-605 | RhoGAP-ARHGAP11A |
| cd04386 | 408-602 | RhoGAP_nadrin |
| cd04402 | 410-602 | RhoGAP_ARHGAP20 |
| cd04396 | 406-563 | RhoGAP_fSAC7_BAG7 |
| cd04403 | 410-569 | RhoGAP_ARHGAP27_15_12_9 |
| cd04390 | 408-602 | RhoGAP_ARHGAP22_24_25 |
| cd04372 | 409-602 | RhoGAP_chimaerin |
| cd04378 | 410-577 | RhoGAP_GMIP_PARG1 |
| cd04392 | 421-612 | RhoGAP_ARHGAP19 |
| cd04400 | 408-562 | RhoGAP_fBEM3 |
| cd04382 | 410-607 | RhoGAP_MgcRacGAP |
| cd04407 | 410-580 | RhoGAP_myosin_IXB |
| cd04384 | 410-574 | RhoGAP_CdGAP |
| cd04408 | 409-570 | RhoGAP_GMIP |
| cd04383 | 410-564 | RhoGAP_srGAP |
| cd04379 | 408-596 | RhoGAP_SYD1 |
| cd04381 | 409-562 | RhoGap_RalBP1 |
| cd04406 | 408-590 | RhoGAP_myosin_IXA |
| cd04387 | 409-571 | RhoGAP_Bcr |
| cd04374 | 414-597 | RhoGAP_Graf |
| cd04409 | 410-577 | RhoGAP_PARG1 |
| cd04373 | 408-574 | RhoGAP_p190 |
| cd04389 | 407-563 | RhoGAP_KIAA1688 |
| cd04380 | 398-569 | RhoGAP_OCRL1 |
| cd04388 | 421-606 | RhoGAP_p85 |
| cd04405 | 475-530 | RhoGAP_BRCC3-like |
| cd04399 | 408-519 | RhoGAP_fRGD2 |
| PHA03247 | 60-173 | PHA03247 |
Ontology Information
| HPRD ID | 1313 |
|---|---|
| Molecular Class | GTPase activating protein |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.