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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
LGALS3 3958 Lectin, galactoside-binding, soluble, 3  14L31; GAL3; MAC2; CBP35; GALBP; GALIG; LGALS2 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20089989   2010Cell line : -

Source : VU University Medical Center, Amsterdam, The Netherlands.

Sample Type : CRC tumor and normal tissue

No. of Sample : -

Stage : -

Biochemical isolation to nano-LC-MS/MS analysis Down-regulation-This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue.


Gene Details



Chromosome: 14; NC_000014.8 (55595935..55612148)

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Gene Type protein coding
Gene Family Lectins, galactoside-binding
Description This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]  
Chromosome 14
Location 14q22.3
Start 55129217  
End 55145430  
Strand +  
Gene Sequence

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Length 16214  
OMIM ID 153619   
HGNC ID HGNC:6563   
Unigene ID Hs.531081    
Ensembl ID ENSG00000131981   
PharmGKB ID -   

mRNA Information


mRNA ID NM_002306.3
Exon join(1..84,8154..8175,8829..9152,11059..11147, 13368..13533,15900..16214)  
mRNA Sequence

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Length 1017  



CDS Information


   
Location join(8158..8175,8829..9152,11059..11147,13368..13456, 16096..16178)
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_002297.2
Protein NameLectin, galactoside-binding, soluble, 3
Molecular Wt. (Da)26021
Protein Sequence

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Length 250  
Uniprot IDP60953
Ensembl Protein ID ENSP00000314458  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation12
SPhosphorylation6
SPhosphorylation12
SPhosphorylation6
SPhosphorylation12
SPhosphorylation6
TPhosphorylation133

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2006ELN556NP_000492.2in vitro;in vivo10536372   
2212FCGR2A906NP_001129691.1in vitro10704522   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00070117-244  GLECT
cl00071117-244  GLECT superfamily
smart00908123-244  Gal-bind_lectin
smart00276118-248  GLECT
pfam00337117-247  Gal-bind_lectin
pfam0208418-105  Bindin
cl2292018-105  Bindin superfamily
PHA0318575-113  PHA03185
cl1923675-113  PHA03185 superfamily
pfam0854936-92  SWI-SNF_Ssr4
cl0945436-92  SWI-SNF_Ssr4 superfamily
pfam0854945-104  SWI-SNF_Ssr4
pfam1034929-95  WWbp
cl2289229-95  DAZAP2 superfamily
cd0622622-81  M14_CPT_like
cl1139322-81  Peptidase_M14_like superfamily
PRK077649-113  PRK07764
PRK0776412-114  PRK07764
PHA0337816-129  PHA03378
PRK0776427-113  PRK07764
PHA0337817-139  PHA03378
PHA0324715-128  PHA03247
PRK0776413-113  PRK07764
pfam0315720-113  Glutenin_hmw
PRK1495923-113  PRK14959
PHA0337817-150  PHA03378
pfam0960624-106  Med15
PRK1495137-111  PRK14951
PHA0324717-128  PHA03247
PRK077644-139  PRK07764
PHA0324742-125  PHA03247
PRK0776410-113  PRK07764
PRK140869-113  dnaA
PRK1232313-123  PRK12323
PRK1232312-123  PRK12323
PHA0324737-129  PHA03247
PRK0700310-113  PRK07003
PRK1495910-113  PRK14959
PRK0776417-113  PRK07764
PRK0911147-117  PRK09111
PRK1232329-129  PRK12323
PRK0776419-113  PRK07764
PRK1496538-106  PRK14965
PRK1495116-131  PRK14951
PRK1227037-117  kgd
pfam0977029-128  PAT1
PHA0324717-140  PHA03247
PRK149632-110  PRK14963
PRK0776431-128  PRK07764
pfam1494435-107  TCRP1
PRK0700329-111  PRK07003
TIGR0162827-123  PABP-1234
pfam0315729-112  Glutenin_hmw
pfam12004Jul-97  DUF3498
PRK0776412-114  PRK07764
PRK0911120-91  PRK09111
PRK1496524-112  PRK14965
PRK1232330-113  PRK12323
PRK1227019-111  kgd
pfam0465213-110  DUF605
pfam0977019-95  PAT1
PRK1232319-129  PRK12323
pfam0315713-111  Glutenin_hmw
pfam0551817-113  Totivirus_coat
PRK0911148-119  PRK09111
PRK1232331-113  PRK12323
PRK0776429-113  PRK07764
PRK1243828-92  PRK12438
PRK1232313-148  PRK12323
PRK1227027-114  kgd
PRK1227023-111  kgd
PRK1280048-101  fliF
PRK1495119-129  PRK14951
PHA0268249-121  PHA02682
PRK077648-113  PRK07764
PHA0268247-123  PHA02682
pfam0977019-125  PAT1


Ontology Information


   
HPRD ID4304
Molecular ClassTranscription regulatory protein
Molecular FunctionCell adhesion molecule activity (GO:0005194)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO