Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ARHGDIA | 396 | Rho GDP dissociation inhibitor (GDI) alpha | 17 | GDIA1; NPHS8; RHOGDI; RHOGDI-1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18651761 | 2008 | Cell line : - Source : Nanfang Hospital tumor tissue bank Sample Type : CRC tumor and Normal tissue No. of Sample : 150 Stage : - | Immunohistochemistry, western Blotting, In Vitro Cell Growth Assay, Wound Healing Assay | Up-regulation | - | RhoGDI was up-regulated in CRC, especially in metastatic CRC, and that high RhoGDI expression related to poorer clinical outcome. The functional investigation suggested that overexpression of RhoGDI stimulated tumor cell growth and migration in vitro. |
| 20812987 | 2010 | Cell line : - Source : Nanfang Hospital tumour tissue bank. Sample Type : CRC tumor and Normal tissue No. of Sample : 150 Stage : - | 2-D Gelelectrophoresis, and mass spectrometry,Western blotting, Immunohistochemistry | Up-regulation | - | This gene differentially expressed in between normal colorectal tissue and colorectal cancer tissue experiment done by 2-D Gel eclectrophotesis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Aplysia Ras-related homologs (ARHs), also called Rho genes, belong to the RAS gene superfamily encoding small guanine nucleotide exchange (GTP/GDP) factors. The ARH proteins may be kept in the inactive, GDP-bound state by interaction with GDP dissociation inhibitors, such as ARHGDIA (Leffers et al., 1993 [PubMed 8262133]).[supplied by OMIM, Jan 2009] |
| Chromosome | 17 |
| Location | 17q25.3 |
| Start | 81867719 |
| End | 81871406 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 3688 |
| OMIM ID | 601925 |
| HGNC ID | HGNC:678 |
| Unigene ID | Hs.159161 |
| Ensembl ID | ENSG00000141522 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001185078.2 |
|---|---|
| Exon | join(1..109,1450..1666,1782..1865,2001..2077,2171..2234, 2464..3688) | mRNA Sequence | Download Select all |
| Length | 1824 |
CDS Information
| Location | join(1477..1666,1782..1865,2001..2077,2171..2234, 2332..2351,2464..3042) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_001288169.1 |
|---|---|
| Protein Name | Rho GDP dissociation inhibitor (GDI) alpha |
| Molecular Wt. (Da) | 25700 |
| Protein Sequence | Download Select all |
| Length | 235 |
| Uniprot ID | P02771 |
| Ensembl Protein ID | ENSP00000379138 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Acetylation | 127 |
| K | Acetylation | 141 |
| K | Acetylation | 105 |
| K | Acetylation | 178 |
| S | Phosphorylation | 34 |
| S | Phosphorylation | 24 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 387 | RHOA | 1323 | NP_001655.1 | in vitro;in vivo | 10489445 |
| 998 | CDC42 | 309 | NP_001782.1 | in vitro;in vivo | 1 067 681 611 149 920 |
| 1027 | CDKN1B | 2867 | NP_004055.1 | yeast 2-hybrid | 16169070 |
| 3728 | JUP | 1414 | NP_002221.1 | yeast 2-hybrid | 16169070 |
| 5880 | RAC2 | 3628 | NP_002863.1 | in vitro | 11513578 |
| 5962 | RDX | 1534 | NP_002897.1 | in vitro;in vivo | 92 873 519 681 826 |
| 6457 | SH3GL3 | 4528 | NP_003018.3 | yeast 2-hybrid | 16169070 |
| 6484 | ST3GAL4 | 84 | NP_006269.1 | yeast 2-hybrid | 16169070 |
| 7409 | VAV1 | 1284 | NP_005419.2 | in vitro | 10664460 |
| 23327 | NEDD4L | 5903 | NP_001138439.1 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Neurotrophin signaling pathway | hsa04722 |
| Vasopressin-regulated water reabsorption | hsa04962 |
Structure Information
| PDB ID | 1CC0 |
|---|---|
| Resolution | 5 |
| Method | X-RAY DIFFRACTION |
| Chains | A,C |
| Molecule | transforming protein rhoA |
| Model | View |
Ontology Information
| HPRD ID | 74 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.