Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ARHGDIB | 397 | Rho GDP dissociation inhibitor (GDI) beta  | 12 | Ly-GDI, RhoGDI2  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20706620    | 2010 | Cell line : - Source : Tokyo Medical and Dental University Hospital Faculty of Medicine (Tokyo, Japan). Sample Type : Fresh-frozen CRC tissue No. of Sample : 70 Stage : - | Affymetrix Gene Chip, comprehensive CNA analysis | Amplification | - | ARHGDIB has been reported as a metastasis-related gene, and data also showed copy number increases of this gene in cases with metastasis. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]   |
| Chromosome | 12 |
| Location | 12p12.3 |
| Start | 15094949   |
| End | 15114562   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 19614   |
| OMIM ID | 602843    |
| HGNC ID | HGNC:679    |
| Unigene ID | Hs.504877    |
| Ensembl ID | -    |
| PharmGKB ID | PA24964    |
mRNA Information
| mRNA ID | XM_011520665.1 |
|---|---|
| Exon | join(368..475,10905..11097,11744..11827,13680..13756, 16790..16853,18908..19614)   | mRNA Sequence |    Download   Select all |
| Length | 1233   |
CDS Information
| Location | 121..726 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS8671.1 |    
Protein Information
| Protein ID | XP_011518967.1 |
|---|---|
| Protein Name | Rho GDP dissociation inhibitor (GDI) beta |
| Molecular Wt. (Da) | 22857 |
| Protein Sequence |    Download   Select all |
| Length | 201   |
| Uniprot ID | P14174 |    
| Ensembl Protein ID | ENSP00000215754   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 24;- |
| Y | Phosphorylation | 24;- |
| Y | Phosphorylation | 24;- |
| K | Acetylation | 124 |
| K | Acetylation | 175 |
| K | Acetylation | 40 |
| K | Acetylation | 102 |
| K | Acetylation | 25 |
| K | Acetylation | 47 |
| K | Acetylation | 21 |
| K | Acetylation | 30 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 387 |    RHOA |    1323 |    NP_001655.1 |    in vivo |    9799233    |
| 399 |    RHOH |    3616 |    NP_004301.1 |    in vitro;in vivo;yeast 2-hybrid |    1   136   884   811   809   800    |
| 998 |    CDC42 |    309 |    NP_001782.1 |    in vivo |    9799233    |
| 5879 |    RAC1 |    3627 |    NP_061485.1 |    in vivo |    9799233    |
| 5880 |    RAC2 |    3628 |    NP_002863.1 |    in vitro |    10655614    |
| 7409 |    VAV1 |    1284 |    NP_005419.2 |    in vitro;in vivo;yeast 2-hybrid |    10664460    |
| 7430 |    EZR |    475 |    NP_003370.2 |    in vitro |    9287351    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Neurotrophin signaling pathway |    hsa04722 |    
| Vasopressin-regulated water reabsorption |    hsa04962 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam02115 | 1-198  | Rho_GDI |
| cl03454 | 1-198  | Rho_GDI superfamily |
Ontology Information
| HPRD ID | 1138 |    
|---|---|
| Molecular Class | Adapter molecule |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
