Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ARHGDIB 397 Rho GDP dissociation inhibitor (GDI) beta  12Ly-GDI, RhoGDI2 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20706620   2010Cell line : -

Source : Tokyo Medical and Dental University Hospital Faculty of Medicine (Tokyo, Japan).

Sample Type : Fresh-frozen CRC tissue

No. of Sample : 70

Stage : -

Affymetrix Gene Chip, comprehensive CNA analysisAmplification-ARHGDIB has been reported as a metastasis-related gene, and data also showed copy number increases of this gene in cases with metastasis.


Gene Details



NC_000012.11 (15094949..15114562, complement)

View Larger Image
   
Gene Type protein coding
Gene Family Endogenous ligands
Description Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]  
Chromosome 12
Location 12p12.3
Start 15094949  
End 15114562  
Strand -  
Gene Sequence

   Download   Select all

Length 19614  
OMIM ID 602843   
HGNC ID HGNC:679   
Unigene ID Hs.504877   
Ensembl ID -   
PharmGKB ID PA24964   

mRNA Information


mRNA ID XM_011520665.1
Exon join(368..475,10905..11097,11744..11827,13680..13756, 16790..16853,18908..19614)  
mRNA Sequence

   Download   Select all

Length 1233  



CDS Information


   
Location121..726
CDS Sequence

   Download   Select all

CCDS ID CCDS8671.1



Protein Information


      
Protein IDXP_011518967.1
Protein NameRho GDP dissociation inhibitor (GDI) beta
Molecular Wt. (Da)22857
Protein Sequence

   Download   Select all

Length 201  
Uniprot IDP14174
Ensembl Protein ID ENSP00000215754  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation24;-
YPhosphorylation24;-
YPhosphorylation24;-
KAcetylation124
KAcetylation175
KAcetylation40
KAcetylation102
KAcetylation25
KAcetylation47
KAcetylation21
KAcetylation30

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                         
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
387RHOA1323NP_001655.1in vivo9799233   
399RHOH3616NP_004301.1in vitro;in vivo;yeast 2-hybrid1   136   884   811   809   800   
998CDC42309NP_001782.1in vivo9799233   
5879RAC13627NP_061485.1in vivo9799233   
5880RAC23628NP_002863.1in vitro10655614   
7409VAV11284NP_005419.2in vitro;in vivo;yeast 2-hybrid10664460   
7430EZR475NP_003370.2in vitro9287351   


Pathway Information


            
Pathway Name Pathway ID
Neurotrophin signaling pathway hsa04722
Vasopressin-regulated water reabsorption hsa04962


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam021151-198  Rho_GDI
cl034541-198  Rho_GDI superfamily


Ontology Information


   
HPRD ID1138
Molecular ClassAdapter molecule
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO