Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| LIF | 3976 | leukemia inhibitory factor | 22 | CDF, DIA, HILDA |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25323535 | 2014 | Cell line : HCT116,RKO,DLD 1 Source : - Sample Type : - No. of Sample : - Stage : - | Western blotting,Immunofluorescence,Taqman real-time RT- PCR,Cell sorting,,Immunohystochemistry | Up-regulation | - | LIF�is a novel negative regulator of p53, overexpression of�LIF�is an important mechanism for the attenuation of p53, which promotes chemoresistance in CRCs. |
| 25726527 | 2015 | Cell line : RKO, HCT116 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Taqman real timeRT- PCR,Western-blotting, ELISA,Chromating immunoprecepetation assay | Up-regulation | - | Hypoxia induces LIF expression in human cancer cells mainly through HIF-2?, which could be an important underlying mechanism for LIF overexpression in human cancers. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012] |
| Chromosome | 22 |
| Location | 22q12.2 |
| Start | 30636436 |
| End | 30642840 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 6405 |
| OMIM ID | 159540 |
| HGNC ID | HGNC:6596 |
| Unigene ID | Hs.2250 |
| Ensembl ID | ENSG00000128342 |
| PharmGKB ID | PA30370 |
mRNA Information
| mRNA ID | NM_001257135.1 |
|---|---|
| Exon | join(11073..11247,13863..17477) | mRNA Sequence | Download Select all |
| Length | 3808 |
Protein Information
| Protein ID | NP_001244064.1 |
|---|---|
| Protein Name | leukemia inhibitory factor |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 88 |
| Uniprot ID | Q9NQB0 |
| Ensembl Protein ID | ENSP00000344823 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3572 | IL6ST | 2824 | NP_002175.2 | in vivo | 12707269 |
| 3977 | LIFR | 1048 | NP_002301.1 | in vitro | 1 260 100 916 051 220 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cytokine-cytokine receptor interaction | hsa04060 |
| Jak-STAT signaling pathway | hsa04630 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
| TNF signaling pathway | hsa04668 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00080 | 34-191 | LIF_OSM |
| cl21565 | 34-191 | CNTF superfamily |
| pfam01291 | 43-202 | LIF_OSM |
Ontology Information
| HPRD ID | 2725 |
|---|---|
| Molecular Class | Cytokine |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.