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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
LIG4 3981 ligase IV, DNA, ATP-dependent  13- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24282031   2014Cell line : HCT116

Source : Department of Pathology, Hong Kong University (HKU).

Sample Type : CRC tumor and normal tissues

No. of Sample : 16

Stage : Duke Stage A-D

MCIp and CGI microarray,Cell culture, 5-aza-dC and siRNA treatment,Quantitative DNA methylation,Clonal bisulfite sequencing,real time RT-PCR,Western blotting,End-joining assayHypermethylation- Hypermethylation of the LIG4 promoter is a new mechanism to control ligase IV expression. It may represent a new epigenetic marker for CRC independent of known markers.


Gene Details



NC_000013.10 (108859790..108870716, complement)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]  
Chromosome 13
Location 13q33-q34
Start 108859790  
End 108870716  
Strand -  
Gene Sequence

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Length 10927  
OMIM ID 601837   
HGNC ID HGNC:6601   
Unigene ID Hs.166091   
Ensembl ID ENSG00000174405   
PharmGKB ID PA30375   

mRNA Information


mRNA ID NM_001098268.1
Exon join(1..207,7073..10927)  
mRNA Sequence

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Length 4077  



CDS Information


   
Location236..2971
CDS Sequence

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CCDS ID CCDS9508.1



Protein Information


      
Protein IDNP_001091738.1
Protein Nameligase IV, DNA, ATP-dependent
Molecular Wt. (Da)72101
Protein Sequence

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Length 911  
Uniprot IDQ99081
Ensembl Protein ID ENSP00000267811  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation650
TPhosphorylation650

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
10592SMC29277NP_006435.2in vitro;in vivo;yeast 2-hybrid12589063   


Pathway Information


      
Pathway Name Pathway ID
Non-homologous end-joining hsa03450


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd07903235-455  Adenylation_DNA_ligase_IV
cl12015235-455  Adenylation_DNA_ligase_like superfamily
cd07968459-596  OBF_DNA_ligase_IV
cl08424459-596  OBF_DNA_ligase_family superfamily
cd00027661-731  BRCT
cl00038661-731  BRCT superfamily
cd00027830-899  BRCT
cl00038830-899  BRCT superfamily
cd07898246-453  Adenylation_DNA_ligase
pfam01068248-451  DNA_ligase_A_M
cd07893460-593  OBF_DNA_ligase
pfam0467514-209  DNA_ligase_A_N
cl2027214-209  DNA_ligase_A_N superfamily
cd07900238-454  Adenylation_DNA_ligase_I_Euk
cd07901242-453  Adenylation_DNA_ligase_Arch_LigB
cd07902234-454  Adenylation_DNA_ligase_III
cd07906246-451  Adenylation_DNA_ligase_LigD_LigC
cd07969460-595  OBF_DNA_ligase_I
pfam04679476-588  DNA_ligase_A_C
cd07972462-601  OBF_DNA_ligase_Arch_LigB
pfam11411749-784  DNA_ligase_IV
cl12940749-784  DNA_ligase_IV superfamily
cd08039256-454  Adenylation_DNA_ligase_Fungal
cd06846247-452  Adenylation_DNA_ligase_like
cd07967460-597  OBF_DNA_ligase_III
cd07896246-452  Adenylation_kDNA_ligase_like
pfam00533656-730  BRCT
smart00292656-730  BRCT
cd07905246-453  Adenylation_DNA_ligase_LigC
cd07897268-452  Adenylation_DNA_ligase_Bac1
pfam00533829-898  BRCT
cd08040460-585  OBF_DNA_ligase_family
smart00292845-898  BRCT
TIGR0057481-602  dnl1
PRK0110915-588  PRK01109
COG1793183-602  CDC9
PLN0311314-588  PLN03113
PRK03180142-597  ligB
PRK07636248-468  ligB
PRK09632242-535  PRK09632
TIGR02779271-593  NHEJ_ligase_lig
PHA02587127-588  30
PRK09633271-459  ligD
TIGR04120246-602  DNA_lig_bact
PRK05972270-535  ligD
PRK09247249-602  PRK09247
TIGR02776292-609  NHEJ_ligase_prk
PHA00454424-473  PHA00454
PRK09125381-535  PRK09125


Ontology Information


   
HPRD ID6026
Molecular ClassDNA ligase
Molecular FunctionTranscription regulator activity (GO:0030528)
Biological ProcessTranscription (GO:0006350); Cell migration (GO:0016477); Ribosome biogenesis and assembly (GO:0042254)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO