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General Information

• Evidence
• Gene
• mRNA
• CDS
• Protein
• PTM
• Enzyme
• PPi
• Pathway
• Structural
• Domain
• Ontology
• SNP
• Drug
• External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
21621406	2011	Cell line : HT29, SW480 Source : - Sample Type : - No. of Sample : - Stage : -	MSI Analysis,Tissue Microarrays, immunohistochemistry	Down-regulation	-	Low expression of LMNA is associated with an increased disease recurrence in stage II and III colon cancer patients.
18714339	2008	Cell line : - Source : Kennemer Gasthuis hospital in Haarlem, The Netherlands. Sample Type : CRC Tumor No. of Sample : 454 Stage : TNM Stage II, III	Cox proportional hazard ratio method,Flow cytometry, cell migration assays,Immunohistochemistry,Indirect immunofluorescence, confocal microscopy	Up-regulation	-	Expression of A-type lamins increases the risk of death from CRC because its presence gives rise to increased invasiveness and potentially a more stem cell-like phenotype.

Gene Details

NC_000001.10 (156052369..156109880)
View Larger Image   

Gene Type	protein coding
Gene Family	Intermediate filaments type V, lamins
Description	The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
Chromosome	1
Location	1q22
Start	156052369
End	156109880
Strand	+
Gene Sequence	Download   Select all
Length	57512
OMIM ID	150330
HGNC ID	HGNC:6636
Unigene ID	Hs.594444
Ensembl ID	ENSG00000160789
PharmGKB ID	PA231

mRNA Information

mRNA ID	NM_001282625.1
Exon	join(1..118,403..639,7926..8037,32168..32729,48072..48228, 51858..51983,52260..52430,52642..52767,53356..53576, 53669..53891,54376..54483,54568..54687,55109..55321)
mRNA Sequence	Download   Select all
Length	2501

CDS Information

   

Location	674..2392
CDS Sequence	Download   Select all
CCDS ID	CCDS1129.1

Protein Information

      

Protein ID	NP_001269554.1
Protein Name	lamin A/C
Molecular Wt. (Da)	66277
Protein Sequence	Download   Select all
Length	572
Uniprot ID	Q13569
Ensembl Protein ID	ENSP00000376611

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	390
S	Phosphorylation	392
C	Methylation	689
S	Phosphorylation	390
S	Phosphorylation	392
Y	Proteolytic Cleavage	646
S	Phosphorylation	390
S	Phosphorylation	392
Y	Proteolytic Cleavage	616
S	Phosphorylation	390
S	Phosphorylation	392
T	Phosphorylation	19
S	Phosphorylation	22
S	Phosphorylation	392
T	Phosphorylation	19
S	Phosphorylation	22
S	Phosphorylation	392
T	Phosphorylation	19
S	Phosphorylation	22
S	Phosphorylation	392
T	Phosphorylation	19
S	Phosphorylation	22
S	Phosphorylation	392
D	Proteolytic Cleavage	230
D	Proteolytic Cleavage	230
D	Proteolytic Cleavage	230
D	Proteolytic Cleavage	230
T	Phosphorylation	19
S	Phosphorylation	403
S	Phosphorylation	404
S	Phosphorylation	525
T	Phosphorylation	19
S	Phosphorylation	403
S	Phosphorylation	404
S	Phosphorylation	525
T	Phosphorylation	19
S	Phosphorylation	403
S	Phosphorylation	404
S	Phosphorylation	525
T	Phosphorylation	19
S	Phosphorylation	403
S	Phosphorylation	404
S	Phosphorylation	525
D	Proteolytic Cleavage	230
D	Proteolytic Cleavage	230
D	Proteolytic Cleavage	230
D	Proteolytic Cleavage	230
S	Phosphorylation	622
S	Phosphorylation	652
S	Phosphorylation	423
S	Phosphorylation	423
S	Phosphorylation	423
S	Phosphorylation	423
S	Phosphorylation	407
S	Phosphorylation	407
S	Phosphorylation	407
S	Phosphorylation	407
T	Phosphorylation	409
T	Phosphorylation	409
T	Phosphorylation	409
T	Phosphorylation	409
S	Phosphorylation	406
S	Phosphorylation	406
S	Phosphorylation	406
S	Phosphorylation	406
S	Phosphorylation	390;-
S	Phosphorylation	390;-
S	Phosphorylation	390;-
S	Phosphorylation	390;-
S	Phosphorylation	392;-
S	Phosphorylation	392;-
S	Phosphorylation	392;-
S	Phosphorylation	392;-
S	Phosphorylation	22;-
S	Phosphorylation	22;-
S	Phosphorylation	22;-
S	Phosphorylation	22;-
S	Phosphorylation	628;-
S	Phosphorylation	598;-
S	Phosphorylation	652;-
S	Phosphorylation	622;-
T	Phosphorylation	19;-
T	Phosphorylation	19;-
T	Phosphorylation	19;-
T	Phosphorylation	19;-
S	Phosphorylation	632;-
S	Phosphorylation	602;-
S	Phosphorylation	395;-
S	Phosphorylation	395;-
S	Phosphorylation	395;-
S	Phosphorylation	395;-
T	Phosphorylation	10;-
T	Phosphorylation	10;-
T	Phosphorylation	10;-
T	Phosphorylation	10;-
T	Phosphorylation	24;-
T	Phosphorylation	24;-
T	Phosphorylation	24;-
T	Phosphorylation	24;-
S	Phosphorylation	94;-
S	Phosphorylation	94;-
S	Phosphorylation	94;-
S	Phosphorylation	94;-
S	Phosphorylation	616;-
S	Phosphorylation	618;-
S	Phosphorylation	612;-
S	Phosphorylation	613;-
S	Phosphorylation	586;-
S	Phosphorylation	588;-
S	Phosphorylation	582;-
S	Phosphorylation	583;-
S	Phosphorylation	619;-
S	Phosphorylation	589;-
T	Phosphorylation	643;-
T	Phosphorylation	613;-
S	Phosphorylation	636;-
S	Phosphorylation	606;-
S	Phosphorylation	414;-
S	Phosphorylation	414;-
S	Phosphorylation	414;-
S	Phosphorylation	414;-
T	Phosphorylation	416;-
T	Phosphorylation	416;-
T	Phosphorylation	416;-
T	Phosphorylation	416;-
T	Phosphorylation	424;-
T	Phosphorylation	424;-
T	Phosphorylation	424;-
T	Phosphorylation	424;-
S	Phosphorylation	277;-
S	Phosphorylation	277;-
S	Phosphorylation	277;-
S	Phosphorylation	277;-
S	Phosphorylation	282;-
S	Phosphorylation	282;-
S	Phosphorylation	282;-
S	Phosphorylation	282;-
T	Phosphorylation	394;-
T	Phosphorylation	394;-
T	Phosphorylation	394;-
T	Phosphorylation	394;-
S	Phosphorylation	426;-
S	Phosphorylation	426;-
S	Phosphorylation	426;-
S	Phosphorylation	426;-
S	Phosphorylation	12
S	Phosphorylation	12
S	Phosphorylation	12
S	Phosphorylation	12
S	Phosphorylation	18
S	Phosphorylation	18
S	Phosphorylation	18
S	Phosphorylation	18
S	Phosphorylation	301
S	Phosphorylation	301
S	Phosphorylation	301
S	Phosphorylation	301
S	Phosphorylation	398
S	Phosphorylation	398
S	Phosphorylation	398
S	Phosphorylation	398
S	Phosphorylation	458
S	Phosphorylation	458
S	Phosphorylation	458
S	Phosphorylation	458
S	Phosphorylation	570
S	Phosphorylation	615
S	Phosphorylation	585
S	Phosphorylation	17
S	Phosphorylation	17
S	Phosphorylation	17
S	Phosphorylation	17
K	Acetylation	378
K	Acetylation	378
K	Acetylation	378
K	Acetylation	378
K	Acetylation	450
K	Acetylation	450
K	Acetylation	450
K	Acetylation	450
K	Acetylation	270
K	Acetylation	270
K	Acetylation	270
K	Acetylation	270
K	Acetylation	108
K	Acetylation	108
K	Acetylation	108
K	Acetylation	108
K	Acetylation	97
K	Acetylation	97
K	Acetylation	97
K	Acetylation	97
K	Acetylation	311
K	Acetylation	311
K	Acetylation	311
K	Acetylation	311
K	Acetylation	114
K	Acetylation	114
K	Acetylation	114
K	Acetylation	114
S	Phosphorylation	71
S	Phosphorylation	71
S	Phosphorylation	71
S	Phosphorylation	71
S	Phosphorylation	51
S	Phosphorylation	51
S	Phosphorylation	51
S	Phosphorylation	51
S	Phosphorylation	66
S	Phosphorylation	66
S	Phosphorylation	66
S	Phosphorylation	66
S	Phosphorylation	533
S	Phosphorylation	533
S	Phosphorylation	533
T	Phosphorylation	534
T	Phosphorylation	534
T	Phosphorylation	534
S	Phosphorylation	568
S	Glycosylation	612
S	Glycosylation	582
T	Glycosylation	643
T	Glycosylation	613
T	Phosphorylation	3
T	Phosphorylation	3
T	Phosphorylation	3
T	Phosphorylation	3
T	Phosphorylation	64
T	Phosphorylation	64
T	Phosphorylation	64
T	Phosphorylation	64
S	Phosphorylation	107
S	Phosphorylation	107
S	Phosphorylation	107
S	Phosphorylation	107
S	Phosphorylation	212
S	Phosphorylation	212
S	Phosphorylation	212
S	Phosphorylation	212
S	Phosphorylation	428
S	Phosphorylation	428
S	Phosphorylation	428
S	Phosphorylation	428
S	Phosphorylation	429
S	Phosphorylation	429
S	Phosphorylation	429
S	Phosphorylation	429
S	Phosphorylation	431
S	Phosphorylation	431
S	Phosphorylation	431
S	Phosphorylation	431
S	Phosphorylation	463
S	Phosphorylation	463
S	Phosphorylation	463
S	Phosphorylation	463
T	Phosphorylation	505
T	Phosphorylation	505
T	Phosphorylation	505
T	Phosphorylation	505
S	Phosphorylation	625
S	Phosphorylation	595

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING)      View   

                                                                                                                                       

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
60	ACTB	32	NP_001092.1	in vitro	9563518
1950	EGF	578	NP_001954.2	in vitro;in vivo;yeast 2-hybrid	16248985
2316	FLNA	2060	NP_001104026.1	yeast 2-hybrid	16248985
4088	SMAD3	4380	NP_005893.1	in vitro	15527767
5093	PCBP1	3128	NP_006187.2	in vitro;in vivo;yeast 2-hybrid	16248985
7329	UBE2I	9045	NP_003336.1	in vitro;in vivo;yeast 2-hybrid	16248985
7703	PCGF2	10621	NP_009075.1	in vitro;in vivo;yeast 2-hybrid	16248985
64949	MRPS26	17595	NP_110438.1	yeast 2-hybrid	16248985
201294	UNC13D	10598	NP_954712.1	yeast 2-hybrid	16248985

Pathway Information

                  

Pathway Name	Pathway ID
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	hsa05412
Dilated cardiomyopathy	hsa05414
Hypertrophic cardiomyopathy (HCM)	hsa05410

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
pfam00932	433-548	LTD
cl20210	433-548	LTD superfamily
smart00935	302-363	OmpH
cl21485	302-363	OmpH superfamily
smart00935	170-263	OmpH
cl21485	170-263	OmpH superfamily
pfam05384	32-148	DegS
cl20073	32-148	DegS superfamily
PRK10920	284-352	PRK10920
cl19375	284-352	HemX superfamily
TIGR03495	267-342	phage_LysB
cl20064	267-342	phage_LysB superfamily
pfam03961	297-376	DUF342
cl19219	297-376	DUF342 superfamily
pfam03938	301-364	OmpH
pfam00038	30-386	Filament
TIGR02168	10-362	SMC_prok_B
COG1196	51-391	Smc
COG1196	73-390	Smc
TIGR02168	32-361	SMC_prok_B
TIGR02169	31-334	SMC_prok_A
COG1196	32-324	Smc
COG1196	32-331	Smc
TIGR02169	29-362	SMC_prok_A
TIGR02169	73-381	SMC_prok_A
TIGR02168	110-447	SMC_prok_B
PRK02224	28-390	PRK02224
TIGR02168	6-266	SMC_prok_B
COG0419	24-388	SbcC
pfam01576	24-383	Myosin_tail_1
COG1196	27-246	Smc
PRK03918	59-389	PRK03918
TIGR02168	5-311	SMC_prok_B
PRK02224	24-355	PRK02224
COG0419	86-388	SbcC
COG0419	30-388	SbcC
pfam12128	59-407	DUF3584
pfam12128	33-389	DUF3584
COG4942	126-356	EnvC
COG0419	24-354	SbcC
PRK03918	25-387	PRK03918
pfam07888	92-364	CALCOCO1
TIGR03007	134-355	pepcterm_ChnLen
TIGR02680	20-359	TIGR02680
pfam05622	29-372	HOOK
pfam05911	24-198	DUF869
pfam10174	82-381	Cast
PRK11281	131-366	PRK11281
pfam01576	62-385	Myosin_tail_1
PRK02224	85-362	PRK02224
TIGR03185	46-380	DNA_S_dndD
COG4942	78-344	EnvC
PRK03918	32-325	PRK03918
pfam12128	79-354	DUF3584
COG4942	71-352	EnvC
pfam05483	52-403	SCP-1
pfam06160	29-355	EzrA
pfam13514	25-387	AAA_27
COG4372	84-278	COG4372
COG4372	227-388	COG4372
pfam01576	135-389	Myosin_tail_1
pfam13514	24-397	AAA_27
PRK05771	33-307	PRK05771
pfam01576	78-372	Myosin_tail_1
COG1579	233-373	COG1579
PTZ00121	78-341	PTZ00121
TIGR00618	25-389	sbcc
COG3883	136-355	CwlO1
PRK12705	57-212	PRK12705
pfam09731	49-321	Mitofilin
TIGR01843	167-361	type_I_hlyD
TIGR00606	21-387	rad50
TIGR02168	162-457	SMC_prok_B
pfam05622	28-324	HOOK
TIGR04523	29-341	Mplasa_alph_rch
PTZ00121	78-462	PTZ00121
COG4372	146-367	COG4372
COG1579	77-229	COG1579
PRK04863	78-404	mukB
pfam02463	105-404	SMC_N
pfam13514	7-377	AAA_27
TIGR04523	93-388	Mplasa_alph_rch
TIGR02680	95-382	TIGR02680
PRK09039	69-199	PRK09039
pfam05483	63-385	SCP-1
pfam02463	28-283	SMC_N
PTZ00121	53-472	PTZ00121
TIGR04211	88-188	SH3_and_anchor
TIGR04320	124-205	Surf_Exclu_PgrA
COG1579	104-279	COG1579
pfam05667	27-225	DUF812
pfam10174	32-348	Cast
PRK04863	28-387	mukB
TIGR03346	183-387	chaperone_ClpB
pfam12128	29-329	DUF3584
TIGR04523	90-326	Mplasa_alph_rch
pfam05667	114-335	DUF812
pfam04111	256-388	APG6
PRK09039	298-364	PRK09039
TIGR01843	123-314	type_I_hlyD
TIGR03007	238-393	pepcterm_ChnLen
pfam06160	93-326	EzrA
TIGR04523	26-390	Mplasa_alph_rch
TIGR01843	84-298	type_I_hlyD
pfam13514	32-359	AAA_27
COG0249	77-204	MutS
pfam15070	30-375	GOLGA2L5
PRK10929	257-425	PRK10929
pfam10168	176-348	Nup88
pfam05557	47-364	MAD
pfam09730	29-353	BicD
pfam08614	184-364	ATG16
COG1340	88-347	COG1340
TIGR04211	240-336	SH3_and_anchor
pfam10174	105-337	Cast
COG0497	89-323	RecN
PRK12704	78-194	PRK12704
TIGR00618	97-385	sbcc
PRK00286	235-353	xseA
TIGR03007	38-202	pepcterm_ChnLen
pfam06818	105-267	Fez1
pfam13166	164-326	AAA_13
pfam01496	41-265	V_ATPase_I
PRK11281	30-364	PRK11281
COG1570	233-348	XseA
PRK04778	29-313	PRK04778
PLN02939	29-217	PLN02939
pfam04582	3-177	Reo_sigmaC

Ontology Information

   

HPRD ID	2763
Molecular Class	Structural protein
Molecular Function	Peroxidase activity (GO:0004601)
Biological Process	Metabolism (GO:0008152); Energy pathways (GO:0006091)

SNP Information

View SNP Geneview Report   

Drug Information

No matching records could be found.

External Links

                                 

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO