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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
LMO1 4004 LIM domain only 1 (rhombotin 1)  11TTG1, RHOM1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24845030   2014Cell line : -

Source : Chinese patients

Sample Type : CRC Tumor

No. of Sample : 182

Stage : -

real time RT-PCR and immunohistochemistryUp-regulation--


Gene Details



NC_000011.9 (8245851..8290182, complement)

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Gene Type protein coding
Gene Family -
Description This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2012]  
Chromosome 11
Location 11p15
Start 8245851  
End 8290182  
Strand -  
Gene Sequence

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Length 44332  
OMIM ID 186921   
HGNC ID HGNC:6641   
Unigene ID Hs.654426   
Ensembl ID ENSG00000166407   
PharmGKB ID PA30407   

mRNA Information


mRNA ID NM_001270428.1
Exon join(1..209,38132..38345,41536..41661,43915..44332)  
mRNA Sequence

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Length 983  



CDS Information


   
Location188..655
CDS Sequence

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CCDS ID CCDS44534.1



Protein Information


      
Protein IDNP_001257357.1
Protein NameLIM domain only 1 (rhombotin 1)
Molecular Wt. (Da)0
Protein Sequence

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Length 155  
Uniprot IDP32119
Ensembl Protein ID ENSP00000301522  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                            
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2625GATA3572NP_001002295.1in vitro9020185   
4066LYL11046NP_005574.2in vivo7957052   
4807NHLH11212NP_005589.1in vitro;in vivo;yeast 2-hybrid10603358   
6887TAL21735NP_005412.1in vivo7957052   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0938824-78  LIM1_LMO1_LMO3
cl0247524-78  LIM superfamily
cd0938988-142  LIM2_LMO1_LMO3
cl0247588-142  LIM superfamily
cd0939088-142  LIM2_dLMO
cd0938424-79  LIM1_LMO2
cd0938624-78  LIM1_LMO4
cd0937788-142  LIM2_Lhx2_Lhx9
cd0938788-141  LIM2_LMO4
cd0836824-78  LIM
cd0937688-142  LIM2_Lhx3_Lhx4
pfam0041224-82  LIM
cd0938588-141  LIM2_LMO2
cd0937888-142  LIM2_Lmx1a_Lmx1b
cd0937988-142  LIM2_AWH
cd0947588-142  LIM2_Lhx9
smart0013288-141  LIM
pfam0041288-143  LIM
cd0937488-142  LIM2_Isl
cd0947188-142  LIM2_Isl2
cd0947488-142  LIM2_Lhx2
cd0937588-142  LIM2_Lhx1_Lhx5
cd0937324-78  LIM1_AWH
cd0946724-78  LIM1_Lhx3b
cd0937124-78  LIM1_Lmx1b
cd0836888-142  LIM
cd0946624-78  LIM1_Lhx3a
cd0947288-142  LIM2_Lhx3b
cd0947388-142  LIM2_Lhx4
cd0936924-78  LIM1_Lhx2_Lhx9
cd0946824-78  LIM1_Lhx4
cd0937024-78  LIM1_Lmx1a
smart0013224-77  LIM
cd0936724-78  LIM1_Lhx1_Lhx5
cd0938388-142  LIM2_Lhx7_Lhx8
cd0938288-142  LIM2_Lhx6
cd0946924-78  LIM1_Lhx2
cd0936424-78  LIM1_LIMK
cd0936624-78  LIM1_Isl
cd0936824-60  LIM1_Lhx3_Lhx4
cd0938124-79  LIM1_Lhx7_Lhx8
cd0947024-78  LIM1_Lhx9
cd0938024-78  LIM1_Lhx6
cd0932924-78  LIM3_abLIM
cd0939188-142  LIM1_Lrg1p_like
cd0935324-80  LIM2_Zyxin
cd0946224-78  LIM1_LIMK1
cd0933724-78  LIM2_Paxillin_like
cd0936124-62  LIM1_Enigma_like
cd0939624-55  LIM_DA1
cd0933824-78  LIM3_Paxillin_like
cd0946324-78  LIM1_LIMK2
cd0941024-54  LIM3_Leupaxin
cd09392104-142  LIM2_Lrg1p_like
cd0939124-54  LIM1_Lrg1p_like
cd0933888-142  LIM3_Paxillin_like
cd0932724-78  LIM1_abLIM
cd09327101-142  LIM1_abLIM
cd0937288-142  LIM2_FBLP-1
cd0933088-136  LIM4_abLIM
cd0940724-78  LIM2_Paxillin
cd0945324-62  LIM1_ENH


Ontology Information


   
HPRD ID3421
Molecular ClassTranscription factor
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO