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General Information
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26194111 | 2015 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Down-regulation | - | Decreased expression of 15-LOX-1 may lead to the development of colitis-associated colorectal cancer and colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. [provided by RefSeq, Nov 2015] |
| Chromosome | 5 |
| Location | 5q23.3-q31 |
| Start | 121398890 |
| End | 121414206 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 15317 |
| OMIM ID | 153455 |
| HGNC ID | HGNC:6664 |
| Unigene ID | Hs.102267 |
| Ensembl ID | ENSG00000113083 |
| PharmGKB ID | PA30427 |
mRNA Information
| mRNA ID | NM_002317.6 |
|---|---|
| Exon | join(1..1006,1360..1468,2820..2957,4192..4348,7772..7867, 8193..8308,11612..15166) | mRNA Sequence | Download Select all |
| Length | 5332 |
Protein Information
| Protein ID | NP_002308.2 |
|---|---|
| Protein Name | lysyl oxidase |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 417 |
| Uniprot ID | P28347 |
| Ensembl Protein ID | ENSP00000334754 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| E | Proteolytic Cleavage | 34 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1805 | DPT | 510 | NP_001928.2 | in vivo | 8082810 |
| 2006 | ELN | 556 | NP_000492.2 | in vivo | 6912069 |
| 3009 | HIST1H1B | 821 | NP_005313.1 | in vitro | 12686141 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam01186 | 213-417 | Lysyl_oxidase |
| cl03127 | 213-417 | Lysyl_oxidase superfamily |
Ontology Information
| HPRD ID | 2975 |
|---|---|
| Molecular Class | Enzyme: Oxidase |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.