Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22090062 | 2012 | Cell line : - Source : - Sample Type : Visceral adipose tissue No. of Sample : - Stage : - | real-timeRT- PCR | Down-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008] |
| Chromosome | 8 |
| Location | 8p22 |
| Start | 19796582 |
| End | 19824770 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 28189 |
| OMIM ID | 609708 |
| HGNC ID | HGNC:6677 |
| Unigene ID | Hs.180878 |
| Ensembl ID | ENSG00000175445 |
| PharmGKB ID | PA232 |
mRNA Information
| mRNA ID | NM_000237.2 |
|---|---|
| Exon | join(1..458,9110..9270,12699..12878,14240..14351, 15050..15283,16771..17013,20190..20310,21831..22013, 23045..23149,26240..28189) | mRNA Sequence | Download Select all |
| Length | 3747 |
Protein Information
| Protein ID | NP_000228.1 |
|---|---|
| Protein Name | lipoprotein lipase |
| Molecular Wt. (Da) | 78103 |
| Protein Sequence | Download Select all |
| Length | 475 |
| Uniprot ID | P54274 |
| Ensembl Protein ID | ENSP00000276602 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 196 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 811 | CALR | 169 | NP_004334.1 | in vivo | 12740382 |
| 1071 | CETP | 325 | NP_000069.2 | in vivo | 9374130 |
| 4035 | LRP1 | 138 | NP_002323.2 | in vitro;in vivo | 128 147 375 106 947 000 000 |
| 5775 | PTPN4 | 1471 | NP_002821.1 | yeast 2-hybrid | 16169070 |
| 6142 | RPL18A | 16045 | NP_000971.1 | yeast 2-hybrid | 16169070 |
| 7436 | VLDLR | 1895 | NP_003374.3 | in vitro | 7592875 |
| 10980 | COPS6 | 16735 | NP_006824.2 | yeast 2-hybrid | 16169070 |
| 51631 | LUC7L2 | 17456 | NP_057103.2 | yeast 2-hybrid | 16169070 |
| 57562 | KIAA1377 | 17212 | NP_065853.2 | yeast 2-hybrid | 16169070 |
| 65264 | UBE2Z | 8589 | NP_075567.2 | yeast 2-hybrid | 16169070 |
| 84164 | ASCC2 | 16515 | NP_115580.2 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Alzheimer's disease | hsa05010 |
| Glycerolipid metabolism | hsa00561 |
| PPAR signaling pathway | hsa03320 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00707 | 37-334 | Pancreat_lipase_like |
| cl21494 | 37-334 | Esterase_lipase superfamily |
| cd01758 | 341-465 | PLAT_LPL |
| cl00011 | 341-465 | PLAT superfamily |
| pfam00151 | 31-338 | Lipase |
| cd01755 | 341-465 | PLAT_lipase |
| cd00741 | 127-271 | Lipase |
| pfam01477 | 343-463 | PLAT |
| smart00308 | 341-452 | LH2 |
| cd00113 | 342-452 | PLAT |
| cd01759 | 343-451 | PLAT_PL |
| TIGR03230 | 33-473 | lipo_lipase |
| pfam12697 | 76-195 | Abhydrolase_6 |
| COG0596 | 77-197 | MhpC |
| pfam12695 | 75-165 | Abhydrolase_5 |
Ontology Information
| HPRD ID | 139 |
|---|---|
| Molecular Class | Enzyme: Lipase |
| Molecular Function | Ligand-dependent nuclear receptor activity (GO:0004879) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P06858 | DB05269 | AST-120 | SmallMoleculeDrug |
| P06858 | DB06439 | Tyloxapol | SmallMoleculeDrug |