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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| LYN | 4067 | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog  | 8 | JTK8; p53Lyn; p56Lyn  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19359472    | 2009 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Microarray analysis | Amplification | - | - |
| 20077526    | 2010 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Gene-annotation enrichment analysis of DAVID, Geneclip and Immunohistochemistry | Up-regulation | - | Individual expression of LYN, MAP4K4, and MID1 was closely correlated with lymph node metastasis and overall survival in CRC patients. SW480 cells were used. |
| 22731636    | 2012 | Cell line : SW 480, SW 620 Source : Sample Type : CRC tumor and normal tissue No. of Sample : 202 primary CRC patients Stage : TNM Stage I-III | RT-PCR, Western blotting, Co-immunoprecipitation, Immunofluorescence assay | Up-regulation | - | Lyn is involved in CD24-induced ERK1/2 activation in CRC. Expression of CD24 and Lyn was positively correlated with tumor grade, stage, lymph node and distant metastasis. |
| 22968445    | 2012 | Cell line : - Source : Department of Pathology of Wrocaw Medical University. Sample Type : - No. of Sample : - Stage : - | Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation. | Up-regulation | - | - |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | SH2 domain containing |
| Description | This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]   |
| Chromosome | 8 |
| Location | 8q13 |
| Start | 55878463   |
| End | 56012447   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 133985   |
| OMIM ID | 165120    |
| HGNC ID | HGNC:6735    |
| Unigene ID | Hs.491767    |
| Ensembl ID | ENSG00000254087    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | XM_011517530.1 |
|---|---|
| Exon | join(8..1641,67986..68031,69156..69261,71997..72095, 72219..72322,73504..73653,75370..75522,88253..88435, 91255..91331,119884..120037,120956..121087,121189..121301)   | mRNA Sequence |    Download   Select all |
| Length | 4158   |
CDS Information
| Location | join(1000..1641,67986..68031,69156..69261,71997..72095, 72219..72322,73504..73653,75370..75522,88253..88435, 91255..91331,119884..120037,120956..121087,131446..131648) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | - |    
Protein Information
| Protein ID | NP_001104567.1 |
|---|---|
| Protein Name | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog |
| Molecular Wt. (Da) | 55902 |
| Protein Sequence |    Download   Select all |
| Length | 491   |
| Uniprot ID | P55290 |    
| Ensembl Protein ID | ENSP00000268613   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 397 |
| Y | Dephosphorylation | 397 |
| Y | Phosphorylation | 508 |
| D | Proteolytic Cleavage | 18 |
| Y | Phosphorylation | 508 |
| Y | Dephosphorylation | 397 |
| Y | Dephosphorylation | 508 |
| S | Phosphorylation | 13;- |
| Y | Phosphorylation | 193;- |
| Y | Phosphorylation | 194;- |
| Y | Phosphorylation | 473;- |
| Y | Phosphorylation | 501;- |
| S | Phosphorylation | 11;- |
| S | Phosphorylation | 228 |
| T | Phosphorylation | 489 |
| T | Phosphorylation | 504 |
| Y | Phosphorylation | 32 |
| Y | Phosphorylation | 316 |
| Y | Phosphorylation | 492 |
| S | Phosphorylation | 246 |
| Y | Phosphorylation | 306 |
Enzyme Information
| EC | 2.7.10.2 |    
|---|---|
| Name | non-specific protein-tyrosine kinase ABL ABL1 ABL2 ABLL ACK1 ACK2 AGMX1 ARG ATK ATP:protein-tyrosine O-phosphotransferase (ambiguous) BLK Bmk BMX BRK Bruton's tyrosine kinase Bsk BTK BTKL CAKb Cdgip CHK CSK CTK CYL cytoplasmic protein tyrosine kinase EMT ETK Fadk FAK FAK2 FER Fert1/2 FES FGR focal adhesion kinase FPS FRK FYN HCK HCTK HYL IMD1 ITK IYK JAK1 JAK2 JAK3 Janus kinase 1 Janus kinase 2 Janus kinase 3 JTK1 JTK9 L-JAK LCK LSK LYN MATK Ntk p60c-src protein tyrosine kinase PKB protein-tyrosine kinase (ambiguous) PSCTK PSCTK1 PSCTK2 PSCTK4 PSCTK5 PTK2 PTK2B PTK6 PYK2 RAFTK RAK Rlk Sik SLK SRC SRC2 SRK SRM SRMS STD SYK SYN Tck TEC TNK1 Tsk TXK TYK2 TYK3 YES1 YK2 ZAP70 |
| Class | Transferases; Transferring phosphorus-containing groups; Protein-tyrosine kinases |
| Sysname | ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)   |
| Substrate | ATP [CPD:C00002]; [protein]-L-tyrosine   |
| Product | ADP [CPD:C00008]; [protein]-L-tyrosine phosphate   |
| Reaction (IUBMB) | ![]() |
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 60 |    ACTB |    32 |    NP_001092.1 |    in vivo |    10403844    |
| 695 |    BTK |    2248 |    NP_000052.1 |    in vitro;in vivo |    8   058   772   112   262   820   000   000   000   000   000   000   000    |
| 840 |    CASP7 |    3457 |    NP_203124.1 |    in vitro |    12586738    |
| 842 |    CASP9 |    3756 |    NP_001220.2 |    in vitro |    12586738    |
| 930 |    CD19 |    113 |    NP_001761.3 |    in vitro;in vivo |    7   589   101   756   817   510   000   000    |
| 933 |    CD22 |    114 |    NP_001762.2 |    in vitro |    8647200    |
| 973 |    CD79A |    203 |    NP_001774.1 |    in vitro;in vivo |    9531288    |
| 974 |    CD79B |    922 |    NP_001035022.1 |    in vitro;in vivo |    9531288    |
| 983 |    CDK1 |    302 |    NP_001777.1 |    in vitro;in vivo |    89   103   368   051   175   800   000   000   000   000    |
| 1017 |    CDK2 |    310 |    NP_001789.2 |    in vitro;in vivo |    104   323   138   806   683    |
| 1027 |    CDKN1B |    2867 |    NP_004055.1 |    in vitro;in vivo |    17254966    |
| 1399 |    CRKL |    3596 |    NP_005198.1 |    in vivo |    11443118    |
| 1436 |    CSF1R |    1269 |    NP_005202.2 |    in vivo |    7636265    |
| 1438 |    CSF2RA |    2381 |    NP_006131.2 |    in vivo |    8943427    |
| 1439 |    CSF2RB |    739 |    NP_000386.1 |    in vitro;in vivo |    99   734   067   636   265    |
| 1441 |    CSF3R |    737 |    NP_724781.1 |    in vitro |    8197119    |
| 1460 |    CSNK2B |    278 |    NP_001311.3 |    yeast 2-hybrid |    14667819    |
| 1493 |    CTLA4 |    474 |    NP_005205.2 |    in vitro;in vivo |    9712716    |
| 1796 |    DOK1 |    4228 |    NP_001372.1 |    in vitro;in vivo |    1   182   590   811   071   630    |
| 2057 |    EPOR |    587 |    NP_000112.1 |    in vitro |    9573010    |
| 2204 |    FCAR |    914 |    NP_001991.1 |    in vivo |    9427690    |
| 2206 |    MS4A2 |    915 |    NP_000130.1 |    in vivo |    7   528   770   761   289   210   000   000    |
| 2207 |    FCER1G |    916 |    NP_004097.1 |    in vivo |    11388899    |
| 2212 |    FCGR2A |    906 |    NP_001129691.1 |    in vitro;in vivo |    8756631    |
| 2213 |    FCGR2B |    6849 |    NP_003992.3 |    in vitro |    8756631    |
| 2348 |    FOLR1 |    638 |    NP_057942.1 |    in vivo |    10633085    |
| 3059 |    HCLS1 |    3199 |    NP_005326.2 |    in vitro;in vivo |    7   682   714   910   482   510   000   000    |
| 3575 |    IL7R |    893 |    NP_002176.2 |    in vivo |    7515933    |
| 3717 |    JAK2 |    993 |    NP_004963.1 |    in vitro |    9573010    |
| 3815 |    KIT |    1287 |    NP_000213.1 |    in vitro;in vivo |    9341198    |
| 4311 |    MME |    392 |    NP_000893.2 |    in vivo |    8943850    |
| 4836 |    NMT1 |    1187 |    NP_066565.1 |    in vitro;in vivo |    11594778    |
| 5335 |    PLCG1 |    1398 |    NP_002651.2 |    in vitro;in vivo |    10   586   033   888   586   800   000   000   000   000   000   000   000   000   000    |
| 5336 |    PLCG2 |    2570 |    AAH11772.1 |    in vitro |    12   181   444   768   205   900   000   000    |
| 5511 |    PPP1R8 |    4028 |    NP_054829.2 |    in vitro |    11104670    |
| 5580 |    PRKCD |    1501 |    NP_006245.2 |    in vitro |    109   459   937   575   560    |
| 6004 |    RGS16 |    3945 |    NP_002919.3 |    in vitro;in vivo |    1   258   887   111   602   600    |
| 6521 |    SLC4A1 |    175 |    NP_000333.1 |    in vitro;in vivo |    199   869   720   650   701   000   000   000   000   000    |
| 6622 |    SNCA |    1227 |    NP_000336.1 |    in vitro;in vivo |    120   967   131   174   462   000   000   000    |
| 6850 |    SYK |    2514 |    NP_003168.2 |    in vitro;in vivo |    78   312   901   153   619   800   000   000   000   000    |
| 7006 |    TEC |    2786 |    NP_003206.2 |    in vitro;in vivo |    86   210   639   446   655    |
| 7314 |    UBB |    6771 |    NP_061828.1 |    in vitro |    11046148    |
| 9046 |    DOK2 |    5411 |    NP_003965.2 |    in vitro;in vivo |    10428862    |
| 11184 |    MAP4K1 |    3583 |    NP_009112.1 |    in vitro |    11514608    |
| 27071 |    DAPP1 |    5773 |    NP_055210.2 |    in vitro |    11524430    |
| 29990 |    PILRB |    8382 |    AAG17224.1 |    in vitro |    10327049    |
| 54923 |    LIME1 |    7904 |    NP_060276.2 |    in vivo |    16249387    |
| 59341 |    TRPV4 |    5667 |    NP_067638.3 |    in vitro;in vivo |    12538589    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| B cell receptor signaling pathway |    hsa04662 |    
| Chemokine signaling pathway |    hsa04062 |    
| Epithelial cell signaling in Helicobacter pylori infection |    hsa05120 |    
| Epstein-Barr virus infection |    hsa05169 |    
| Fc epsilon RI signaling pathway |    hsa04664 |    
| Fc gamma R-mediated phagocytosis |    hsa04666 |    
| Long-term depression |    hsa04730 |    
| NF-kappa B signaling pathway |    hsa04064 |    
| Platelet activation |    hsa04611 |    
| Viral carcinogenesis |    hsa05203 |    
Structure Information
| PDB ID | 1W1F |
|---|---|
| Resolution | - |
| Method | SOLUTION NMR |
| Chains | A   |
| Molecule | TYROSINE-PROTEIN KINASE LYN   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05072 | 239-510  | PTKc_Lyn |
| cl21453 | 239-510  | PKc_like superfamily |
| cd10364 | 125-225  | SH2_Src_Lyn |
| cl15255 | 125-225  | SH2 superfamily |
| cd12004 | 67-122  | SH3_Lyn |
| cl17036 | 67-122  | SH3 superfamily |
| cd05034 | 251-498  | PTKc_Src_like |
| cd05067 | 240-503  | PTKc_Lck_Blk |
| cd05073 | 235-500  | PTKc_Hck |
| cd05068 | 238-502  | PTKc_Frk_like |
| cd14203 | 251-499  | PTKc_Src_Fyn_like |
| cd05069 | 237-509  | PTKc_Yes |
| cd05070 | 237-509  | PTKc_Fyn |
| cd05071 | 237-509  | PTKc_Src |
| cd00192 | 251-498  | PTKc |
| cd05148 | 240-500  | PTKc_Srm_Brk |
| cd05039 | 240-497  | PTKc_Csk_like |
| cd05059 | 246-497  | PTKc_Tec_like |
| cd05052 | 240-501  | PTKc_Abl |
| cd05112 | 243-493  | PTKc_Itk |
| cd05033 | 242-500  | PTKc_EphR |
| cd05041 | 251-498  | PTKc_Fes_like |
| cd05032 | 240-499  | PTKc_InsR_like |
| cd05113 | 242-495  | PTKc_Btk_Bmx |
| cd05060 | 251-501  | PTKc_Syk_like |
| cd05114 | 243-499  | PTKc_Tec_Rlk |
| cd05053 | 239-498  | PTKc_FGFR |
| cd05040 | 251-499  | PTKc_Ack_like |
| cd05082 | 240-499  | PTKc_Csk |
| cd05044 | 251-499  | PTKc_c-ros |
| cd05063 | 241-498  | PTKc_EphR_A2 |
| cd05066 | 247-498  | PTKc_EphR_A |
| cd05055 | 232-499  | PTKc_PDGFR |
| cd05083 | 240-498  | PTKc_Chk |
| cd05085 | 253-497  | PTKc_Fer |
| cd05056 | 240-501  | PTKc_FAK |
| cd05065 | 247-500  | PTKc_EphR_B |
| cd13999 | 253-497  | STKc_MAP3K-like |
| cd05036 | 241-493  | PTKc_ALK_LTK |
| cd05084 | 251-497  | PTKc_Fes |
| cd05048 | 241-490  | PTKc_Ror |
| cd05038 | 243-498  | PTKc_Jak_rpt2 |
| cd05057 | 242-500  | PTKc_EGFR_like |
| cd05051 | 241-493  | PTKc_DDR |
| cd05099 | 234-508  | PTKc_FGFR4 |
| cd05049 | 241-491  | PTKc_Trk |
| cd05045 | 246-498  | PTKc_RET |
| cd05061 | 240-499  | PTKc_InsR |
| cd05106 | 226-491  | PTKc_CSF-1R |
| cd05092 | 242-487  | PTKc_TrkA |
| cd05064 | 241-497  | PTKc_EphR_A10 |
| cd05058 | 253-503  | PTKc_Met_Ron |
| cd09933 | 125-225  | SH2_Src_family |
| cd05098 | 231-507  | PTKc_FGFR1 |
| cd05054 | 240-499  | PTKc_VEGFR |
| cd05050 | 241-490  | PTKc_Musk |
| cd05046 | 242-499  | PTK_CCK4 |
| cd05107 | 232-502  | PTKc_PDGFR_beta |
| cd05035 | 247-499  | PTKc_TAM |
| cd05062 | 240-490  | PTKc_IGF-1R |
| cd05101 | 231-507  | PTKc_FGFR2 |
| cd05075 | 247-498  | PTKc_Axl |
| cd10363 | 125-228  | SH2_Src_HCK |
| cd05116 | 251-501  | PTKc_Syk |
| cd05090 | 241-490  | PTKc_Ror1 |
| cd05100 | 240-504  | PTKc_FGFR3 |
| cd05115 | 253-501  | PTKc_Zap-70 |
| cd14204 | 242-498  | PTKc_Mer |
| cd05047 | 253-490  | PTKc_Tie |
| cd05105 | 232-498  | PTKc_PDGFR_alpha |
| cd05074 | 242-498  | PTKc_Tyro3 |
| cd05043 | 242-503  | PTK_Ryk |
| cd05094 | 242-504  | PTKc_TrkC |
| cd05093 | 242-504  | PTKc_TrkB |
| cd10362 | 125-224  | SH2_Src_Lck |
| cd14205 | 247-499  | PTKc_Jak2_rpt2 |
| cd05089 | 245-490  | PTKc_Tie1 |
| cd05079 | 247-493  | PTKc_Jak1_rpt2 |
| cd05091 | 241-497  | PTKc_Ror2 |
| cd06606 | 246-489  | STKc_MAPKKK |
| cd14014 | 248-489  | STKc_PknB_like |
| cd00180 | 253-493  | PKc |
| cd05104 | 232-490  | PTKc_Kit |
| cd05080 | 247-501  | PTKc_Tyk2_rpt2 |
| cd05097 | 241-497  | PTKc_DDR_like |
| cd05095 | 241-497  | PTKc_DDR2 |
| cd05108 | 248-493  | PTKc_EGFR |
| cd14207 | 240-500  | PTKc_VEGFR1 |
| cd10371 | 125-222  | SH2_Src_Blk |
| cd05102 | 240-500  | PTKc_VEGFR3 |
| cd05096 | 241-497  | PTKc_DDR1 |
| cd05109 | 247-493  | PTKc_HER2 |
| cd05103 | 240-504  | PTKc_VEGFR2 |
| cd05110 | 247-495  | PTKc_HER4 |
| cd05111 | 247-495  | PTK_HER3 |
| cd05081 | 247-498  | PTKc_Jak3_rpt2 |
| cd05088 | 247-490  | PTKc_Tie2 |
| cd13978 | 253-490  | STKc_RIP |
| cd10367 | 125-225  | SH2_Src_Fgr |
| cd05122 | 248-489  | PKc_STE |
| cd06627 | 249-489  | STKc_Cdc7_like |
| cd14066 | 253-500  | STKc_IRAK |
| cd10344 | 114-219  | SH2_SLAP |
| cd14059 | 253-498  | STKc_MAP3K12_13 |
| cd14062 | 253-498  | STKc_Raf |
| cd14151 | 238-490  | STKc_B-Raf |
| cd10418 | 125-222  | SH2_Src_Fyn_isoform_a_like |
| cd10368 | 125-222  | SH2_Src_Fyn |
| cd14150 | 247-490  | STKc_A-Raf |
| cd14061 | 253-490  | STKc_MLK |
| cd14027 | 253-502  | STKc_RIP1 |
| cd10370 | 125-224  | SH2_Src_Src42 |
| cd14058 | 253-501  | STKc_TAK1 |
| cd05087 | 250-489  | PTKc_Aatyk1 |
| cd10365 | 125-222  | SH2_Src_Src |
| cd14149 | 240-498  | STKc_C-Raf |
| cd10366 | 125-222  | SH2_Src_Yes |
| cd14146 | 253-490  | STKc_MLK4 |
| cd10369 | 125-224  | SH2_Src_Frk |
| cd06632 | 253-493  | STKc_MEKK1_plant |
| cd14148 | 253-490  | STKc_MLK2 |
| cd10419 | 127-222  | SH2_Src_Fyn_isoform_b_like |
| cd14060 | 254-498  | STKc_MLTK |
| cd14065 | 253-490  | PKc_LIMK_like |
| cd13992 | 272-490  | PK_GC |
| cd14154 | 253-501  | STKc_LIMK |
| cd14145 | 241-502  | STKc_MLK1 |
| cd06623 | 245-495  | PKc_MAPKK_plant_like |
| cd14147 | 245-490  | STKc_MLK3 |
| cd06625 | 248-489  | STKc_MEKK3_like |
| cd13979 | 245-491  | STKc_Mos |
| cd14009 | 253-452  | STKc_ATG1_ULK_like |
| cd14003 | 248-450  | STKc_AMPK-like |
| pfam00017 | 129-211  | SH2 |
| cd08215 | 248-489  | STKc_Nek |
| cd14221 | 253-500  | STKc_LIMK1 |
| cd14158 | 252-499  | STKc_IRAK4 |
| cd14042 | 263-497  | PK_GC-A_B |
| cd05042 | 251-497  | PTKc_Aatyk |
| cd13997 | 250-493  | PKc_Wee1_like |
| cd05118 | 248-451  | STKc_CMGC |
| cd07830 | 248-489  | STKc_MAK_like |
| cd06612 | 243-489  | STKc_MST1_2 |
| cd14063 | 247-498  | PK_KSR |
| cd07829 | 250-451  | STKc_CDK_like |
| cd14000 | 253-499  | STKc_LRRK |
| smart00252 | 127-217  | SH2 |
| cd05117 | 248-463  | STKc_CAMK |
| cd06609 | 248-493  | STKc_MST3_like |
| cd14206 | 250-494  | PTKc_Aatyk3 |
| cd06628 | 253-493  | STKc_Byr2_like |
| cd14007 | 248-491  | STKc_Aurora |
| cd14098 | 249-489  | STKc_Rad53_Cds1 |
| cd06610 | 248-493  | STKc_OSR1_SPAK |
| cd08529 | 249-495  | STKc_FA2-like |
| cd14162 | 247-494  | STKc_TSSK4-like |
| cd14075 | 248-495  | STKc_NIM1 |
| cd14008 | 253-489  | STKc_LKB1_CaMKK |
| cd14072 | 248-463  | STKc_MARK |
| cd14064 | 253-499  | PKc_TNNI3K |
| cd08225 | 249-489  | STKc_Nek5 |
| cd13985 | 246-488  | STKc_GAK_like |
| cd14156 | 253-499  | PKc_LIMK_like_unk |
| cd06605 | 245-493  | PKc_MAPKK |
| cd05037 | 253-490  | PTK_Jak_rpt1 |
| cd14073 | 249-464  | STKc_NUAK |
| cd14053 | 256-438  | STKc_ACVR2 |
| cd14025 | 251-498  | STKc_RIP4_like |
| cd06629 | 253-489  | STKc_Bck1_like |
| cd14081 | 248-464  | STKc_BRSK1_2 |
| cd08222 | 249-489  | STKc_Nek11 |
| cd06626 | 251-489  | STKc_MEKK4 |
| cd14121 | 252-448  | STKc_ULK3 |
| cd07840 | 253-501  | STKc_CDK9_like |
| cd08530 | 248-493  | STKc_CNK2-like |
| cd14664 | 253-489  | STK_BAK1_like |
| cd06631 | 253-495  | STKc_YSK4 |
| cd14079 | 248-444  | STKc_AMPK_alpha |
| cd14222 | 253-498  | STKc_LIMK2 |
| cd13998 | 254-437  | STKc_TGFbR-like |
| cd06642 | 243-444  | STKc_STK25 |
| cd05123 | 253-487  | STKc_AGC |
| cd08217 | 248-494  | STKc_Nek2 |
| cd06614 | 251-493  | STKc_PAK |
| cd14080 | 249-444  | STKc_TSSK-like |
| cd13996 | 250-489  | STKc_EIF2AK |
| cd14052 | 249-438  | PTKc_Wee1_fungi |
| cd11845 | 67-117  | SH3_Src_like |
| cd14056 | 251-499  | STKc_TGFbR_I |
| cd06641 | 243-489  | STKc_MST3 |
| cd14120 | 253-491  | STKc_ULK1_2-like |
| cd06640 | 243-436  | STKc_MST4 |
| cd14155 | 253-490  | PKc_TESK |
| cd06653 | 248-493  | STKc_MEKK3_like_u1 |
| cd05076 | 271-490  | PTK_Tyk2_rpt1 |
| cd14119 | 253-495  | STKc_LKB1 |
| cd14201 | 253-452  | STKc_ULK2 |
| cd14202 | 253-491  | STKc_ULK1 |
| cd14050 | 250-493  | PKc_Myt1 |
| cd08228 | 248-496  | STKc_Nek6 |
| cd14012 | 293-495  | PK_eIF2AK_GCN2_rpt1 |
| cd13986 | 248-499  | STKc_16 |
| cd07834 | 248-451  | STKc_MAPK |
| cd14078 | 253-444  | STKc_MELK |
| cd06917 | 253-493  | STKc_NAK1_like |
| cd08229 | 230-496  | STKc_Nek7 |
| cd12005 | 67-120  | SH3_Lck |
| cd13982 | 251-489  | STKc_IRE1 |
| cd14068 | 253-495  | STKc_LRRK2 |
| cd06621 | 245-489  | PKc_Pek1_like |
| cd14192 | 253-453  | STKc_MLCK3 |
| cd14084 | 243-434  | STKc_Chk2 |
| cd14161 | 244-463  | STKc_NUAK2 |
| cd07841 | 250-454  | STKc_CDK7 |
| cd14045 | 264-497  | PK_GC_unk |
| cd13983 | 247-489  | STKc_WNK |
| cd05086 | 250-497  | PTKc_Aatyk2 |
| cd07833 | 248-479  | STKc_CDKL |
| cd06652 | 248-493  | STKc_MEKK2 |
| cd06624 | 253-444  | STKc_ASK |
| cd05578 | 254-449  | STKc_Yank1 |
| cd05580 | 245-436  | STKc_PKA_like |
| cd14071 | 251-448  | STKc_SIK |
| cd00173 | 128-211  | SH2 |
| cd08219 | 249-489  | STKc_Nek3 |
| cd14106 | 289-491  | STKc_DRAK |
| cd14010 | 288-444  | STKc_ULK4 |
| cd14137 | 246-453  | STKc_GSK3 |
| cd12009 | 68-120  | SH3_Blk |
| cd14131 | 251-495  | PKc_Mps1 |
| cd05077 | 264-490  | PTK_Jak1_rpt1 |
| cd13993 | 246-494  | STKc_Pat1_like |
| cd07866 | 248-451  | STKc_BUR1 |
| cd14193 | 253-486  | STKc_MLCK4 |
| cd06620 | 245-489  | PKc_Byr1_like |
| cd14006 | 253-434  | STKc_MLCK-like |
| cd14188 | 251-501  | STKc_PLK2 |
| cd14026 | 253-490  | STKc_RIP2 |
| cd08224 | 248-496  | STKc_Nek6_7 |
| cd14105 | 249-459  | STKc_DAPK |
| cd06611 | 243-436  | STKc_SLK_like |
| cd14099 | 248-499  | STKc_PLK |
| cd14103 | 253-453  | STKc_MLCK |
| cd14077 | 249-444  | STKc_Kin1_2 |
| cd14074 | 249-444  | STKc_SNRK |
| cd07836 | 246-453  | STKc_Pho85 |
| cd14663 | 248-464  | STKc_SnRK3 |
| cd07878 | 236-496  | STKc_p38beta |
| cd07877 | 236-451  | STKc_p38alpha |
| cd14198 | 251-489  | STKc_DRAK2 |
| cd05572 | 253-446  | STKc_cGK |
| cd08223 | 249-489  | STKc_Nek4 |
| cd07860 | 250-471  | STKc_CDK2_3 |
| cd14190 | 253-446  | STKc_MLCK2 |
| cd07873 | 247-448  | STKc_PCTAIRE1 |
| cd07870 | 250-450  | STKc_PFTAIRE2 |
| cd14054 | 253-494  | STKc_BMPR2_AMHR2 |
| cd09934 | 122-229  | SH2_Tec_family |
| cd14142 | 245-436  | STKc_ACVR1_ALK1 |
| cd14067 | 287-488  | STKc_LRRK1 |
| cd14144 | 251-436  | STKc_BMPR1 |
| cd06613 | 248-489  | STKc_MAP4K3_like |
| cd09935 | 125-218  | SH2_ABL |
| cd07880 | 236-456  | STKc_p38gamma |
| cd14194 | 253-457  | STKc_DAPK1 |
| cd06651 | 251-438  | STKc_MEKK3 |
| cd07854 | 250-446  | STKc_MAPK4_6 |
| cd05581 | 248-449  | STKc_PDK1 |
| cd14046 | 250-435  | STKc_EIF2AK4_GCN2_rpt2 |
| cd14069 | 248-444  | STKc_Chk1 |
| cd10398 | 124-222  | SH2_Tec_Txk |
| cd05582 | 251-454  | STKc_RSK_N |
| cd06644 | 243-489  | STKc_STK10 |
| cd14195 | 251-457  | STKc_DAPK3 |
| cd14191 | 251-457  | STKc_MLCK1 |
| cd14196 | 290-457  | STKc_DAPK2 |
| cd14197 | 302-489  | STKc_DRAK1 |
| cd14189 | 251-444  | STKc_PLK3 |
| cd07849 | 253-447  | STKc_ERK1_2_like |
| cd14076 | 253-444  | STKc_Kin4 |
| cd07851 | 236-471  | STKc_p38 |
| cd06607 | 251-489  | STKc_TAO |
| cd08218 | 250-489  | STKc_Nek1 |
| cd06618 | 236-493  | PKc_MKK7 |
| cd06645 | 243-493  | STKc_MAP4K3 |
| cd07832 | 248-497  | STKc_CCRK |
| cd05589 | 248-464  | STKc_PKN |
| cd07856 | 251-447  | STKc_Sty1_Hog1 |
| cd14002 | 245-444  | STKc_STK36 |
| cd06608 | 243-493  | STKc_myosinIII_N_like |
| cd14220 | 251-489  | STKc_BMPR1a |
| cd05619 | 245-462  | STKc_nPKC_theta |
| cd09937 | 129-225  | SH2_csk_like |
| cd14132 | 231-512  | STKc_CK2_alpha |
| cd14165 | 253-491  | STKc_TSSK1_2-like |
| cd06617 | 250-494  | PKc_MKK3_6 |
| cd05615 | 253-458  | STKc_cPKC_alpha |
| cd13987 | 253-444  | STKc_SBK1 |
| cd14186 | 245-498  | STKc_PLK4 |
| cd06633 | 243-489  | STKc_TAO3 |
| cd07871 | 247-448  | STKc_PCTAIRE3 |
| cd14116 | 235-458  | STKc_Aurora-A |
| cd05616 | 253-446  | STKc_cPKC_beta |
| cd08220 | 245-438  | STKc_Nek8 |
| cd05620 | 251-446  | STKc_nPKC_delta |
| cd07864 | 249-438  | STKc_CDK12 |
| smart00326 | 64-119  | SH3 |
| cd14004 | 250-493  | STKc_PASK |
| cd14096 | 245-436  | STKc_RCK1-like |
| cd14133 | 248-489  | PKc_DYRK_like |
| cd05078 | 253-490  | PTK_Jak2_rpt1 |
| cd07872 | 247-469  | STKc_PCTAIRE2 |
| pfam00018 | 69-115  | SH3_1 |
| cd14097 | 251-459  | STKc_STK33 |
| cd14219 | 245-490  | STKc_BMPR1b |
| cd14057 | 252-498  | PK_ILK |
| cd14047 | 244-436  | STKc_EIF2AK2_PKR |
| cd13990 | 253-444  | STKc_TLK |
| cd06636 | 236-497  | STKc_MAP4K4_6_N |
| cd06616 | 240-512  | PKc_MKK4 |
| cd07879 | 236-454  | STKc_p38delta |
| cd05579 | 256-488  | STKc_MAST_like |
| cd14185 | 290-476  | STKc_DCKL3 |
| cd06637 | 243-436  | STKc_TNIK |
| cd06622 | 245-493  | PKc_PBS2_like |
| cd14044 | 293-497  | PK_GC-C |
| cd07844 | 247-450  | STKc_PCTAIRE_like |
| cd14043 | 317-506  | PK_GC-2D |
| cd09938 | 129-234  | SH2_N-SH2_Zap70_Syk_like |
| cd06635 | 241-493  | STKc_TAO1 |
| cd06634 | 243-493  | STKc_TAO2 |
| cd07869 | 245-446  | STKc_PFTAIRE1 |
| cd13994 | 271-444  | STKc_HAL4_like |
| cd06643 | 243-436  | STKc_SLK |
| cd07861 | 250-471  | STKc_CDK1_euk |
| cd06638 | 234-497  | STKc_myosinIIIA_N |
| cd14187 | 253-503  | STKc_PLK1 |
| cd06630 | 284-489  | STKc_MEKK1 |
| cd05570 | 251-477  | STKc_PKC |
| cd14082 | 253-434  | STKc_PKD |
| cd06648 | 243-444  | STKc_PAK_II |
| cd05611 | 250-448  | STKc_Rim15_like |
| cd05592 | 251-446  | STKc_nPKC_theta_like |
| cd06659 | 243-501  | STKc_PAK6 |
| cd07845 | 252-451  | STKc_CDK10 |
| cd06619 | 245-489  | PKc_MKK5 |
| cd08221 | 288-493  | STKc_Nek9 |
| cd14114 | 249-446  | STKc_Twitchin_like |
| cd07843 | 245-453  | STKc_CDC2L1 |
| cd14143 | 252-436  | STKc_TGFbR1_ACVR1b_ACVR1c |
| cd07839 | 248-469  | STKc_CDK5 |
| cd14140 | 256-438  | STKc_ACVR2b |
| cd14153 | 253-498  | PK_KSR2 |
| cd07846 | 245-489  | STKc_CDKL2_3 |
| cd08528 | 249-488  | STKc_Nek10 |
| cd07835 | 250-471  | STKc_CDK1_CdkB_like |
| cd14033 | 247-498  | STKc_WNK4 |
| cd14164 | 248-446  | STKc_TSSK6-like |
| cd06646 | 243-436  | STKc_MAP4K5 |
| cd07838 | 248-451  | STKc_CDK4_6_like |
| cd14031 | 247-487  | STKc_WNK3 |
| cd05602 | 248-452  | STKc_SGK1 |
| cd12006 | 67-119  | SH3_Fyn_Yrk |
| cd05612 | 245-448  | STKc_PRKX_like |
| cd12007 | 67-119  | SH3_Yes |
| cd05573 | 249-450  | STKc_ROCK_NDR_like |
| cd10354 | 128-211  | SH2_Cterm_RasGAP |
| cd14017 | 248-498  | STKc_TTBK |
| cd10360 | 129-211  | SH2_Srm |
| cd07862 | 250-472  | STKc_CDK6 |
| cd05590 | 253-456  | STKc_nPKC_eta |
| cd14095 | 290-434  | STKc_DCKL |
| cd09941 | 129-214  | SH2_Grb2_like |
| cd06650 | 241-445  | PKc_MEK1 |
| cd06658 | 243-444  | STKc_PAK5 |
| cd14200 | 289-444  | STKc_CaMKK1 |
| cd13989 | 253-444  | STKc_IKK |
| cd05624 | 241-444  | STKc_MRCK_beta |
| cd07852 | 248-448  | STKc_MAPK15-like |
| cd14135 | 272-451  | STKc_PRP4 |
| cd07858 | 241-447  | STKc_TEY_MAPK |
| cd14104 | 253-483  | STKc_Titin |
| cd14011 | 259-488  | PK_SCY1_like |
| cd14051 | 250-489  | PTKc_Wee1 |
| cd14152 | 247-498  | STKc_KSR1 |
| cd14055 | 251-489  | STKc_TGFbR2_like |
| cd07848 | 253-451  | STKc_CDKL5 |
| cd14093 | 284-434  | STKc_PhKG |
| cd13988 | 253-453  | STKc_TBK1 |
| cd11848 | 67-121  | SH3_SLAP-like |
| cd05603 | 251-476  | STKc_SGK2 |
| cd14113 | 250-444  | STKc_Trio_C |
| cd13975 | 248-502  | PKc_Dusty |
| cd14159 | 253-438  | STKc_IRAK1 |
| cd06647 | 243-444  | STKc_PAK_I |
| cd05610 | 245-396  | STKc_MASTL |
| cd00174 | 67-117  | SH3 |
| cd14091 | 253-460  | STKc_RSK_C |
| cd14175 | 293-459  | STKc_RSK1_C |
| cd14208 | 253-443  | PTK_Jak3_rpt1 |
| cd14086 | 248-444  | STKc_CaMKII |
| cd05623 | 244-444  | STKc_MRCK_alpha |
| cd14118 | 290-444  | STKc_CAMKK |
| cd14092 | 290-459  | STKc_MSK_C |
| cd14166 | 244-460  | STKc_CaMKI_gamma |
| cd10397 | 122-223  | SH2_Tec_Btk |
| cd05587 | 253-446  | STKc_cPKC |
| cd14199 | 248-478  | STKc_CaMKK2 |
| cd07853 | 247-442  | STKc_NLK |
| cd14039 | 253-437  | STKc_IKK_alpha |
| cd05621 | 245-444  | STKc_ROCK2 |
| cd05622 | 245-444  | STKc_ROCK1 |
| cd14184 | 245-489  | STKc_DCKL2 |
| cd07865 | 248-487  | STKc_CDK9 |
| cd14209 | 249-444  | STKc_PKA |
| cd14001 | 289-512  | PKc_TOPK |
| cd14032 | 247-487  | STKc_WNK2_like |
| cd05595 | 251-444  | STKc_PKB_beta |
| cd14036 | 250-488  | STKc_GAK |
| cd07857 | 248-454  | STKc_MPK1 |
| cd06655 | 243-487  | STKc_PAK2 |
| cd14048 | 250-489  | STKc_EIF2AK3_PERK |
| cd14160 | 253-498  | PK_IRAK3 |
| cd06649 | 241-445  | PKc_MEK2 |
| cd05601 | 253-448  | STKc_CRIK |
| cd14176 | 293-459  | STKc_RSK2_C |
| cd14101 | 253-499  | STKc_PIM2 |
| cd06615 | 315-445  | PKc_MEK |
| cd13995 | 256-489  | STKc_MAP3K8 |
| cd14163 | 248-493  | STKc_TSSK3-like |
| cd12011 | 67-121  | SH3_SLAP2 |
| cd14107 | 285-489  | STKc_obscurin_rpt1 |
| cd11772 | 70-119  | SH3_OSTF1 |
| cd07855 | 245-448  | STKc_ERK5 |
| cd09931 | 129-213  | SH2_C-SH2_SHP_like |
| cd11768 | 67-120  | SH3_Tec_like |
| cd14070 | 251-444  | STKc_HUNK |
| cd10341 | 126-214  | SH2_N-SH2_PLC_gamma_like |
| cd06657 | 243-444  | STKc_PAK4 |
| cd14108 | 251-453  | STKc_SPEG_rpt1 |
| cd08216 | 268-431  | PK_STRAD |
| cd14100 | 253-495  | STKc_PIM1 |
| cd14094 | 269-448  | STKc_CASK |
| cd12008 | 69-119  | SH3_Src |
| cd14141 | 256-438  | STKc_ACVR2a |
| cd05574 | 246-449  | STKc_phototropin_like |
| cd06656 | 243-444  | STKc_PAK3 |
| cd14138 | 250-489  | PTKc_Wee1a |
| cd14112 | 270-434  | STKc_Unc-89_rpt2 |
| cd14109 | 286-491  | PK_Unc-89_rpt1 |
| cd06654 | 243-487  | STKc_PAK1 |
| cd07859 | 248-456  | STKc_TDY_MAPK |
| cd14179 | 251-459  | STKc_MSK1_C |
| cd05630 | 253-447  | STKc_GRK6 |
| cd14102 | 253-491  | STKc_PIM3 |
| cd14037 | 244-439  | STKc_NAK_like |
| cd13991 | 244-428  | STKc_NIK |
| cd05604 | 250-452  | STKc_SGK3 |
| cd14111 | 243-455  | STKc_SPEG_rpt2 |
| cd05596 | 240-442  | STKc_ROCK |
| cd06639 | 238-436  | STKc_myosinIIIB_N |
| cd14005 | 248-497  | STKc_PIM |
| cd07847 | 288-451  | STKc_CDKL1_4 |
| cd14167 | 244-491  | STKc_CaMKI_alpha |
| cd10358 | 126-215  | SH2_PTK6_Brk |
| cd07863 | 250-469  | STKc_CDK4 |
| cd11906 | 68-118  | SH3_BTK |
| cd05577 | 253-447  | STKc_GRK |
| cd05598 | 250-451  | STKc_LATS |
| cd07831 | 248-438  | STKc_MOK |
| cd14038 | 252-438  | STKc_IKK_beta |
| cd14117 | 249-451  | STKc_Aurora-B_like |
| cd05632 | 244-447  | STKc_GRK5 |
| cd14180 | 268-459  | STKc_MSK2_C |
| cd14136 | 250-438  | STKc_SRPK |
| cd05631 | 253-447  | STKc_GRK4 |
| cd14177 | 293-459  | STKc_RSK4_C |
| cd05607 | 253-444  | STKc_GRK7 |
| cd05605 | 253-447  | STKc_GRK4_like |
| cd14183 | 245-449  | STKc_DCKL1 |
| cd14169 | 249-444  | STKc_CaMKI_beta |
| cd14178 | 293-459  | STKc_RSK3_C |
| cd05613 | 246-444  | STKc_MSK1_N |
| cd11992 | 69-118  | SH3_Intersectin2_3 |
| cd14030 | 247-487  | STKc_WNK1 |
| cd14041 | 290-444  | STKc_TLK2 |
| cd10348 | 128-218  | SH2_Cterm_shark_like |
| pfam07714 | 247-497  | Pkinase_Tyr |
| smart00221 | 247-497  | STYKc |
| smart00219 | 247-497  | TyrKc |
| smart00220 | 248-491  | S_TKc |
| pfam00069 | 247-493  | Pkinase |
| COG0515 | 248-475  | SPS1 |
| PLN00034 | 250-493  | PLN00034 |
| PTZ00263 | 253-437  | PTZ00263 |
| PLN00009 | 250-471  | PLN00009 |
| PTZ00266 | 248-489  | PTZ00266 |
| PTZ00024 | 251-451  | PTZ00024 |
| PTZ00426 | 245-437  | PTZ00426 |
| PHA03209 | 248-441  | PHA03209 |
| PHA02988 | 264-502  | PHA02988 |
| PRK13184 | 249-444  | pknD |
| PTZ00267 | 290-489  | PTZ00267 |
| TIGR03903 | 269-453  | TOMM_kin_cyc |
Ontology Information
| HPRD ID | 310 |    
|---|---|
| Molecular Class | Enzyme: Tyrosine kinase |
| Molecular Function | Kinase activity (GO:0016301) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)   |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P07948 | DB06616 | Bosutinib | SmallMoleculeDrug |
| P07948 | DB08901 | Ponatinib | SmallMoleculeDrug |
| P07948 | DB09079 | Nintedanib | SmallMoleculeDrug |
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    

