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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25127039 | 2014 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : Population-based cohort of 425 CRC patients Stage : TNM Stage I,II | Bisulfite pyrosequencing | Hypermethylation | - | miR137 and IGFBP3 hypermethylation as promising diagnostic biomarkers in CRC. |
Gene Details
| Gene Type | ncRNA |
|---|---|
| Gene Family | ncRNAs / Micro RNAs |
| Description | microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] |
| Chromosome | 1 |
| Location | 1p21.3 |
| Start | 98511626 |
| End | 98511727 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 102 |
| OMIM ID | 614304 |
| HGNC ID | HGNC:31523 |
| Unigene ID | - |
| Ensembl ID | ENSG00000207958 |
| PharmGKB ID | - |
Protein Information
| Protein ID | |
|---|---|
| Protein Name | microRNA 137 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 0 |
| Uniprot ID | |
| Ensembl Protein ID |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
No STRING Network could be found.
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MicroRNAs in cancer | hsa05206 |
Structure Information
No matching records could be found.
Domain Information
No matching records could be found.
Drug Information
No matching records could be found.