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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26419959 | 2015 | Cell line : - Source : Nurses' Health Study and the Health Professionals Follow-up Study Sample Type : Population based Case control study No. of Sample : 538 rectal and colon cancer cases Stage : - | real time RT-PCR, tissue microarray immunohistochemistry and computer-assisted image analysis | Up-regulation | - | MIR21 as a potential target for immunotherapy and prevention in colorectal cancer. |
Gene Details
| Gene Type | ncRNA |
|---|---|
| Gene Family | ncRNAs / Micro RNAs |
| Description | microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] |
| Chromosome | 17 |
| Location | 17q23.1 |
| Start | 57918627 |
| End | 57918698 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 72 |
| OMIM ID | 611020 |
| HGNC ID | HGNC:31586 |
| Unigene ID | - |
| Ensembl ID | ENSG00000199004 |
| PharmGKB ID | - |
Protein Information
| Protein ID | |
|---|---|
| Protein Name | microRNA 21 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 0 |
| Uniprot ID | |
| Ensembl Protein ID |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
No STRING Network could be found.
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MicroRNAs in cancer | hsa05206 |
| Proteoglycans in cancer | hsa05205 |
Structure Information
No matching records could be found.
Domain Information
No matching records could be found.
Drug Information
No matching records could be found.