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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| EPCAM | 4072 | Tumor-associated calcium signal transducer 1 | 2 | ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20606680 | 2010 | Cell line : - Source : Institute of Pathology,University Hospital of Basel, Switzerland; the Institute of Clinical Pathology, Basel Switzerland; and the Institute of Pathology, Stadtspital Triemli, Zurich, Switzerland. Sample Type : - No. of Sample : - Stage : - | Tissue microarray, immunohistochemistry, Tumour invasion assay. | Down-regulation | - | Loss, rather than overexpression, of membranous CD44s, CD166, and EpCAM is linked to tumour progression. Archival paraffin-embedded material from 1420 patients with primary, pre-operatively untreated colorectal cancer were retrieved. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules |
| Description | This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008] |
| Chromosome | 2 |
| Location | 2p21 |
| Start | 47369148 |
| End | 47387028 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 17881 |
| OMIM ID | 185535 |
| HGNC ID | HGNC:11529 |
| Unigene ID | Hs.542050 |
| Ensembl ID | ENSG00000119888 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_002354.2 |
|---|---|
| Exon | join(1..434,4316..4423,4661..4901,6087..6152,7867..7930, 9806..9907,10622..10822,16019..16063,17425..17881) | mRNA Sequence | Download Select all |
| Length | 1731 |
CDS Information
| Location | join(359..434,4316..4423,4661..4901,6087..6152,7867..7930, 9806..9907,10622..10822,16019..16063,17425..17466) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS1833.1 |
Protein Information
| Protein ID | NP_002345.2 |
|---|---|
| Protein Name | Tumor-associated calcium signal transducer 1 |
| Molecular Wt. (Da) | 32734 |
| Protein Sequence | Download Select all |
| Length | 314 |
| Uniprot ID | Q12864 |
| Ensembl Protein ID | ENSP00000027335 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| C | Disulfide Bridge | 110;116 |
| N | Glycosylation | 111 |
| C | Disulfide Bridge | 118;135 |
| C | Disulfide Bridge | 27;46 |
| C | Disulfide Bridge | 29;59 |
| C | Disulfide Bridge | 38;48 |
| C | Disulfide Bridge | 66;99 |
| N | Glycosylation | 74 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1366 | CLDN7 | 7633 | NP_001298.3 | in vitro | 16054130 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00191 | 65-125 | TY |
| cl00150 | 65-125 | TY superfamily |
| pfam00086 | 66-135 | Thyroglobulin_1 |
| smart00211 | 97-125 | TY |
Ontology Information
| HPRD ID | 447 |
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Kinase activity (GO:0016301) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.