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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MAD2L1 | 4085 | MAD2 mitotic arrest deficient-like 1 (yeast) | 4 | MAD2, HSMAD2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26183163 | 2015 | Cell line : - Source : - Sample Type : Population based case-control study No. of Sample : 710 CRC cases and 735 controls Stage : - | Meta analysis | Polymorhpism | - | The study emphasized that MAD1L1 Arg558His and MAD2L1 Leu84Met can significantly interact with smoking to enhance CRC risk. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008] |
| Chromosome | 4 |
| Location | 4q27 |
| Start | 120980577 |
| End | 120988013 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 7437 |
| OMIM ID | 601467 |
| HGNC ID | HGNC:6763 |
| Unigene ID | Hs.591697 |
| Ensembl ID | ENSG00000164109 |
| PharmGKB ID | PA30521 |
mRNA Information
| mRNA ID | NM_002358.3 |
|---|---|
| Exon | join(1..197,1041..1187,4764..4884,5882..5985,6569..7437) | mRNA Sequence | Download Select all |
| Length | 1453 |
Protein Information
| Protein ID | NP_002349.1 |
|---|---|
| Protein Name | MAD2 mitotic arrest deficient-like 1 (yeast) |
| Molecular Wt. (Da) | 34211 |
| Protein Sequence | Download Select all |
| Length | 205 |
| Uniprot ID | Q03403 |
| Ensembl Protein ID | ENSP00000291526 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 170 |
| S | Phosphorylation | 178 |
| S | Phosphorylation | 195 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 996 | CDC27 | 304 | NP_001107563.1 | in vivo | 9736712 |
| 1439 | CSF2RB | 739 | NP_000386.1 | in vitro;in vivo | 11551900 |
| 3643 | INSR | 975 | NP_000199.2 | in vitro;in vivo;yeast 2-hybrid | 9092546 |
| 4153 | MBL2 | 1107 | NP_000233.1 | in vitro;in vivo | 11804586 |
| 10459 | MAD2L2 | 7246 | NP_006332.3 | in vitro | 10660610 |
| 29882 | ANAPC2 | 7367 | NP_037498.1 | in vivo | 9637688 |
| 81628 | TSC22D4 | 18231 | NP_112197.1 | yeast 2-hybrid | 16189514 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell cycle | hsa04110 |
| HTLV-I infection | hsa05166 |
| Oocyte meiosis | hsa04114 |
| Progesterone-mediated oocyte maturation | hsa04914 |
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 1812 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Auxiliary transport protein activity (GO:0015457) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.