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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MAGEA3 | 4102 | melanoma antigen family A, 3 | X | HYPD, HIP8, MGC14613, CT1.3 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17007017 | 2006 | Cell line : SNU 1 , SNU 6 Source : Korean Cell Line Bank (KCLB; Seoul, Korea) or the American Type Culture Collection (ATCC; Manassas, VA, USA) Sample Type : CRC tumor and normal tissue No. of Sample : 88 Stage : - | RT-PCR and methylation-specific PCR, sequencing analysis, sodium bisulfite modification | Hypomethylation/Up-regulation | - | The promoter hypomethylation of MAGE genes up-regulates its expression in colorectal carcinomas. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008] |
| Chromosome | X |
| Location | Xq28 |
| Start | 151934652 |
| End | 151938250 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 3599 |
| OMIM ID | 300174 |
| HGNC ID | HGNC:6801 |
| Unigene ID | Hs.417816 |
| Ensembl ID | ENSG00000221867 |
| PharmGKB ID | PA30547 |
mRNA Information
| mRNA ID | XM_005274676.2 |
|---|---|
| Exon | join(1..98,1827..1956,2037..3616) | mRNA Sequence | Download Select all |
| Length | 1808 |
Protein Information
| Protein ID | XP_005274733.1 |
|---|---|
| Protein Name | melanoma antigen family A, 3 |
| Molecular Wt. (Da) | 43530 |
| Protein Sequence | Download Select all |
| Length | 314 |
| Uniprot ID | P10646 |
| Ensembl Protein ID | ENSP00000233156 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam01454 | 116-286 | MAGE |
| cl03220 | 116-286 | MAGE superfamily |
| pfam12440 | Mar-98 | MAGE_N |
| cl13827 | Mar-98 | MAGE_N superfamily |
Ontology Information
| HPRD ID | 1821 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Receptor binding (GO:0005102) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.