Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MAPT | 4137 | Microtubule-associated protein tau  | 17 | TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17848589    | 2007 | Cell line : - Source : Tumor Bank Network established at the Centro Nacional de Investigaciones Oncologicas (CNIO). Sample Type : - No. of Sample : - Stage : - | Antibody Microarrays,Protein Labeling and Microarray Assay,Tissue Microarray Design and Immunohistochemistry | Up-regulation | 1.683 | - |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]   |
| Chromosome | 17 |
| Location | 17q21.1 |
| Start | 45894382   |
| End | 46028334   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 133953   |
| OMIM ID | 157140    |
| HGNC ID | HGNC:6893    |
| Unigene ID | Hs.101174     |
| Ensembl ID | ENSG00000186868    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_001123066.3 |
|---|---|
| Exon | join(1..305,67940..68089,77478..77564,80004..80090, 83994..84059,88797..89549,92659..92714,95497..95694, 97079..97205,99543..99596,102018..102283,115929..116021, 119862..119943,124237..124349,129575..133953)   | mRNA Sequence |    Download   Select all |
| Length | 5544   |
CDS Information
| Location | join(67957..68089,77478..77564,80004..80090,83994..84059, 88485..89549,92659..92714,95497..95694,97079..97205, 102018..102283,115929..116021,119862..119943, 124237..124349,129575..129790) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | - |    
Protein Information
| Protein ID | NP_058519.3 |
|---|---|
| Protein Name | Microtubule-associated protein tau |
| Molecular Wt. (Da) | 78797 |
| Protein Sequence |    Download   Select all |
| Length | 758   |
| Uniprot ID | P38936 |    
| Ensembl Protein ID | ENSP00000244741   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 123 |
| S | Phosphorylation | 527 |
| S | Phosphorylation | 555 |
| T | Phosphorylation | 720 |
| S | Phosphorylation | 729 |
| S | Phosphorylation | 733 |
| S | Phosphorylation | 739 |
| T | Phosphorylation | 123 |
| S | Phosphorylation | 210 |
| S | Phosphorylation | 238 |
| T | Phosphorylation | 403 |
| S | Phosphorylation | 412 |
| S | Phosphorylation | 416 |
| S | Phosphorylation | 422 |
| S | Phosphorylation | 152 |
| S | Phosphorylation | 180 |
| T | Phosphorylation | 345 |
| S | Phosphorylation | 354 |
| S | Phosphorylation | 355 |
| S | Phosphorylation | 358 |
| S | Phosphorylation | 364 |
| T | Phosphorylation | 65 |
| S | Phosphorylation | 152 |
| S | Phosphorylation | 180 |
| T | Phosphorylation | 314 |
| S | Phosphorylation | 323 |
| S | Phosphorylation | 327 |
| S | Phosphorylation | 333 |
| T | Phosphorylation | 65 |
| S | Dephosphorylation | 235 |
| S | Dephosphorylation | 396 |
| S | Phosphorylation | 519 |
| T | Phosphorylation | 522 |
| T | Phosphorylation | 529 |
| S | Phosphorylation | 531 |
| T | Phosphorylation | 534 |
| T | Phosphorylation | 548 |
| S | Phosphorylation | 552 |
| T | Phosphorylation | 690 |
| S | Phosphorylation | 713 |
| S | Phosphorylation | 721 |
| S | Phosphorylation | 202 |
| T | Phosphorylation | 205 |
| T | Phosphorylation | 212 |
| S | Phosphorylation | 214 |
| T | Phosphorylation | 217 |
| T | Phosphorylation | 231 |
| S | Phosphorylation | 235 |
| T | Phosphorylation | 373 |
| S | Phosphorylation | 396 |
| S | Phosphorylation | 404 |
| S | Phosphorylation | 144 |
| T | Phosphorylation | 147 |
| T | Phosphorylation | 154 |
| T | Phosphorylation | 159 |
| T | Phosphorylation | 173 |
| S | Phosphorylation | 177 |
| T | Phosphorylation | 315 |
| S | Phosphorylation | 338 |
| S | Phosphorylation | 346 |
| S | Phosphorylation | 144 |
| T | Phosphorylation | 147 |
| T | Phosphorylation | 154 |
| S | Phosphorylation | 156 |
| T | Phosphorylation | 159 |
| T | Phosphorylation | 173 |
| S | Phosphorylation | 177 |
| T | Phosphorylation | 284 |
| S | Phosphorylation | 307 |
| S | Phosphorylation | 315 |
| D | Proteolytic Cleavage | 738 |
| S | Phosphorylation | 554 |
| S | Phosphorylation | 579 |
| S | Phosphorylation | 237 |
| S | Phosphorylation | 262 |
| S | Phosphorylation | 179 |
| S | Phosphorylation | 204 |
| S | Phosphorylation | 179 |
| S | Phosphorylation | 204 |
| S | Dephosphorylation | 519 |
| S | Dephosphorylation | 202 |
| S | Dephosphorylation | 144 |
| S | Dephosphorylation | 144 |
| T | Phosphorylation | 492 |
| T | Phosphorylation | 498 |
| S | Phosphorylation | 519 |
| T | Phosphorylation | 175 |
| T | Phosphorylation | 217 |
| S | Phosphorylation | 202 |
| T | Phosphorylation | 117 |
| T | Phosphorylation | 123 |
| S | Phosphorylation | 144 |
| T | Phosphorylation | 117 |
| T | Phosphorylation | 123 |
| S | Phosphorylation | 144 |
| S | Phosphorylation | 579 |
| S | Phosphorylation | 673 |
| S | Phosphorylation | 262 |
| S | Phosphorylation | 356 |
| S | Phosphorylation | 204 |
| S | Phosphorylation | 298 |
| S | Phosphorylation | 204 |
| S | Phosphorylation | 267 |
| T | Phosphorylation | 529 |
| T | Phosphorylation | 212 |
| T | Phosphorylation | 154 |
| T | Phosphorylation | 154 |
| D | Proteolytic Cleavage | 738 |
| S | Dephosphorylation | 515 |
| S | Dephosphorylation | 516 |
| S | Dephosphorylation | 519 |
| S | Dephosphorylation | 198 |
| S | Dephosphorylation | 199 |
| S | Dephosphorylation | 202 |
| S | Dephosphorylation | 140 |
| S | Dephosphorylation | 141 |
| S | Dephosphorylation | 144 |
| S | Dephosphorylation | 140 |
| S | Dephosphorylation | 141 |
| S | Dephosphorylation | 144 |
| S | Phosphorylation | 531 |
| S | Phosphorylation | 575 |
| S | Phosphorylation | 637 |
| S | Phosphorylation | 669 |
| S | Phosphorylation | 214 |
| S | Phosphorylation | 258 |
| S | Phosphorylation | 320 |
| S | Phosphorylation | 352 |
| T | Phosphorylation | 147 |
| S | Phosphorylation | 200 |
| S | Phosphorylation | 262 |
| S | Phosphorylation | 294 |
| S | Phosphorylation | 156 |
| S | Phosphorylation | 200 |
| S | Phosphorylation | 231 |
| S | Phosphorylation | 263 |
| D | Proteolytic Cleavage | 738 |
| S | Phosphorylation | 512 |
| S | Phosphorylation | 515 |
| S | Phosphorylation | 516 |
| T | Phosphorylation | 529 |
| S | Phosphorylation | 531 |
| T | Phosphorylation | 548 |
| S | Phosphorylation | 579 |
| S | Phosphorylation | 673 |
| S | Phosphorylation | 726 |
| S | Phosphorylation | 195 |
| S | Phosphorylation | 198 |
| S | Phosphorylation | 199 |
| T | Phosphorylation | 212 |
| S | Phosphorylation | 214 |
| T | Phosphorylation | 231 |
| S | Phosphorylation | 262 |
| S | Phosphorylation | 356 |
| S | Phosphorylation | 409 |
| S | Phosphorylation | 137 |
| S | Phosphorylation | 140 |
| S | Phosphorylation | 141 |
| T | Phosphorylation | 147 |
| T | Phosphorylation | 154 |
| T | Phosphorylation | 173 |
| S | Phosphorylation | 204 |
| S | Phosphorylation | 298 |
| S | Phosphorylation | 351 |
| S | Phosphorylation | 137 |
| S | Phosphorylation | 140 |
| S | Phosphorylation | 141 |
| T | Phosphorylation | 154 |
| S | Phosphorylation | 156 |
| T | Phosphorylation | 173 |
| S | Phosphorylation | 204 |
| S | Phosphorylation | 267 |
| S | Phosphorylation | 320 |
| S | Dephosphorylation | 515 |
| S | Dephosphorylation | 516 |
| S | Dephosphorylation | 519 |
| S | Dephosphorylation | 198 |
| S | Dephosphorylation | 199 |
| S | Dephosphorylation | 140 |
| S | Dephosphorylation | 141 |
| S | Dephosphorylation | 140 |
| S | Dephosphorylation | 141 |
| D | Proteolytic Cleavage | 738 |
| D | Proteolytic Cleavage | 738 |
| T | Phosphorylation | 498 |
| S | Phosphorylation | 519 |
| T | Phosphorylation | 522 |
| T | Phosphorylation | 548 |
| S | Phosphorylation | 637 |
| T | Phosphorylation | 181 |
| S | Phosphorylation | 202 |
| T | Phosphorylation | 205 |
| T | Phosphorylation | 231 |
| S | Phosphorylation | 320 |
| T | Phosphorylation | 123 |
| S | Phosphorylation | 144 |
| T | Phosphorylation | 147 |
| T | Phosphorylation | 173 |
| S | Phosphorylation | 262 |
| T | Phosphorylation | 123 |
| S | Phosphorylation | 144 |
| T | Phosphorylation | 147 |
| T | Phosphorylation | 173 |
| S | Phosphorylation | 231 |
| S | Phosphorylation | 46 |
| T | Phosphorylation | 498 |
| S | Phosphorylation | 501 |
| T | Phosphorylation | 50 |
| S | Phosphorylation | 512 |
| S | Phosphorylation | 515 |
| S | Phosphorylation | 516 |
| S | Phosphorylation | 519 |
| T | Phosphorylation | 522 |
| S | Phosphorylation | 525 |
| T | Phosphorylation | 529 |
| T | Phosphorylation | 534 |
| T | Phosphorylation | 548 |
| S | Phosphorylation | 579 |
| S | Phosphorylation | 713 |
| S | Phosphorylation | 717 |
| S | Phosphorylation | 721 |
| S | Phosphorylation | 730 |
| T | Phosphorylation | 181 |
| S | Phosphorylation | 202 |
| S | Phosphorylation | 195 |
| S | Phosphorylation | 198 |
| S | Phosphorylation | 199 |
| S | Phosphorylation | 202 |
| T | Phosphorylation | 205 |
| S | Phosphorylation | 208 |
| T | Phosphorylation | 212 |
| T | Phosphorylation | 217 |
| T | Phosphorylation | 231 |
| S | Phosphorylation | 262 |
| S | Phosphorylation | 396 |
| S | Phosphorylation | 400 |
| S | Phosphorylation | 404 |
| S | Phosphorylation | 413 |
| S | Phosphorylation | 199 |
| T | Phosphorylation | 181 |
| T | Phosphorylation | 123 |
| S | Phosphorylation | 126 |
| S | Phosphorylation | 137 |
| S | Phosphorylation | 140 |
| S | Phosphorylation | 141 |
| S | Phosphorylation | 144 |
| T | Phosphorylation | 147 |
| S | Phosphorylation | 150 |
| T | Phosphorylation | 154 |
| T | Phosphorylation | 159 |
| T | Phosphorylation | 173 |
| S | Phosphorylation | 204 |
| S | Phosphorylation | 338 |
| S | Phosphorylation | 342 |
| S | Phosphorylation | 346 |
| T | Phosphorylation | 123 |
| S | Phosphorylation | 126 |
| S | Phosphorylation | 137 |
| S | Phosphorylation | 140 |
| S | Phosphorylation | 141 |
| S | Phosphorylation | 144 |
| T | Phosphorylation | 147 |
| S | Phosphorylation | 150 |
| T | Phosphorylation | 154 |
| T | Phosphorylation | 159 |
| T | Phosphorylation | 173 |
| S | Phosphorylation | 204 |
| S | Phosphorylation | 307 |
| S | Phosphorylation | 311 |
| S | Phosphorylation | 315 |
| S | Phosphorylation | 324 |
| S | Phosphorylation | 641 |
| S | Phosphorylation | 324 |
| S | Phosphorylation | 266 |
| S | Phosphorylation | 235 |
| S | Phosphorylation | 579 |
| S | Phosphorylation | 673 |
| S | Phosphorylation | 262 |
| S | Phosphorylation | 356 |
| S | Phosphorylation | 204 |
| S | Phosphorylation | 298 |
| S | Phosphorylation | 204 |
| S | Phosphorylation | 267 |
| S | Phosphorylation | 579 |
| S | Phosphorylation | 610 |
| S | Phosphorylation | 622 |
| S | Phosphorylation | 641 |
| S | Phosphorylation | 673 |
| S | Phosphorylation | 262 |
| S | Phosphorylation | 293 |
| S | Phosphorylation | 305 |
| S | Phosphorylation | 324 |
| S | Phosphorylation | 356 |
| S | Phosphorylation | 204 |
| S | Phosphorylation | 235 |
| S | Phosphorylation | 247 |
| S | Phosphorylation | 266 |
| S | Phosphorylation | 298 |
| S | Phosphorylation | 204 |
| S | Phosphorylation | 235 |
| S | Phosphorylation | 267 |
| S | Dephosphorylation | 519 |
| S | Dephosphorylation | 202 |
| S | Dephosphorylation | 144 |
| S | Dephosphorylation | 144 |
| S | Phosphorylation | 519 |
| S | Phosphorylation | 202 |
| S | Phosphorylation | 144 |
| S | Phosphorylation | 144 |
| T | Phosphorylation | 470 |
| T | Phosphorylation | 153 |
| T | Phosphorylation | 95 |
| T | Phosphorylation | 95 |
| S | Phosphorylation | 156 |
| Y | Phosphorylation | 711 |
| Y | Phosphorylation | 394 |
| Y | Phosphorylation | 336 |
| Y | Phosphorylation | 305 |
| D | Proteolytic Cleavage | 421 |
| D | Proteolytic Cleavage | 421 |
| D | Proteolytic Cleavage | 421 |
| D | Proteolytic Cleavage | 421 |
| D | Proteolytic Cleavage | 421 |
| D | Proteolytic Cleavage | 363 |
| D | Proteolytic Cleavage | 363 |
| D | Proteolytic Cleavage | 363 |
| D | Proteolytic Cleavage | 363 |
| D | Proteolytic Cleavage | 363 |
| D | Proteolytic Cleavage | 332 |
| D | Proteolytic Cleavage | 332 |
| D | Proteolytic Cleavage | 332 |
| D | Proteolytic Cleavage | 332 |
| D | Proteolytic Cleavage | 332 |
| S | Phosphorylation | 262 |
| S | Phosphorylation | 214 |
| T | Phosphorylation | 212 |
| T | Phosphorylation | 580 |
| T | Phosphorylation | 263 |
| T | Phosphorylation | 205 |
| T | Phosphorylation | 205 |
| S | Phosphorylation | 131 |
| T | Phosphorylation | 135 |
| S | Phosphorylation | 73 |
| T | Phosphorylation | 77 |
| S | Phosphorylation | 73 |
| T | Phosphorylation | 77 |
| S | Phosphorylation | 46 |
| T | Phosphorylation | 50 |
| S | Phosphorylation | 558 |
| S | Phosphorylation | 241 |
| S | Phosphorylation | 183 |
| S | Phosphorylation | 183 |
Enzyme Information
| EC | 2.5.1.34 |    
|---|---|
| Name | 4-dimethylallyltryptophan synthase dimethylallylpyrophosphate:L-tryptophan dimethylallyltransferase dimethylallyltryptophan synthetase dimethylallylpyrophosphate:tryptophan dimethylallyl transferase DMAT synthetase 4-(gamma,gamma-dimethylallyl)tryptophan synthase tryptophan dimethylallyltransferase |
| Class | Transferases; Transferring alkyl or aryl groups, other than methyl groups; Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date) |
| Sysname | dimethylallyl-diphosphate:L-tryptophan 4-dimethylallyltransferase   |
| Substrate | dimethylallyl diphosphate [CPD:C00235]; L-tryptophan   |
| Product | diphosphate [CPD:C00013]; 4-(3-methylbut-2-enyl)-L-tryptophan [CPD:C04290]   |
| Reaction (IUBMB) | ![]() |
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 60 |    ACTB |    32 |    NP_001092.1 |    in vitro |    6304075    |
| 801 |    CALM1 |    241 |    NP_008819.1 |    in vitro |    2123288    |
| 2534 |    FYN |    655 |    NP_002028.1 |    in vitro;in vivo |    1   182   609   916   014   710    |
| 3312 |    HSPA8 |    7205 |    NP_006588.1 |    in vitro |    14612456    |
| 5663 |    PSEN1 |    87 |    NP_000012.1 |    in vivo |    9689133    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Alzheimer's disease |    hsa05010 |    
| MAPK signaling pathway |    hsa04010 |    
Structure Information
| PDB ID | 1I8H |
|---|---|
| Resolution | - |
| Method | solution NMR |
| Chains | A   |
| Molecule | MICROTUBULE-ASSOCIATED PROTEIN TAU   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00418 | 592-622  | Tubulin-binding |
| cl02863 | 592-622  | Tubulin-binding superfamily |
| pfam00418 | 623-653  | Tubulin-binding |
| cl02863 | 623-653  | Tubulin-binding superfamily |
| pfam00418 | 560-591  | Tubulin-binding |
| cl02863 | 560-591  | Tubulin-binding superfamily |
| pfam00418 | 654-685  | Tubulin-binding |
| cl02863 | 654-685  | Tubulin-binding superfamily |
| PHA03247 | 142-570  | PHA03247 |
| PHA03247 | 138-568  | PHA03247 |
| PTZ00449 | 314-587  | PTZ00449 |
| pfam05109 | 252-572  | Herpes_BLLF1 |
| PHA03307 | 202-588  | PHA03307 |
| PHA03307 | 332-579  | PHA03307 |
| PRK07764 | 231-569  | PRK07764 |
| PHA03378 | 275-568  | PHA03378 |
| PHA03307 | 227-569  | PHA03307 |
| PHA03307 | 81-536  | PHA03307 |
Ontology Information
| HPRD ID | 2542 |    
|---|---|
| Molecular Class | Structural protein |
| Molecular Function | Kinase regulator activity (GO:0019207) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P10636 | DB01229 | Paclitaxel | SmallMoleculeDrug |
| P10636 | DB01248 | Docetaxel | SmallMoleculeDrug |
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    

