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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
MAPT 4137 Microtubule-associated protein tau  17TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
17848589   2007Cell line : -

Source : Tumor Bank Network established at the Centro Nacional de Investigaciones Oncologicas (CNIO).

Sample Type : -

No. of Sample : -

Stage : -

Antibody Microarrays,Protein Labeling and Microarray Assay,Tissue Microarray Design and ImmunohistochemistryUp-regulation1.683-


Gene Details



Chromosome: 17; NC_000017.10 (43971748..44105700)

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Gene Type protein coding
Gene Family -
Description This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]  
Chromosome 17
Location 17q21.1
Start 45894382  
End 46028334  
Strand -  
Gene Sequence

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Length 133953  
OMIM ID 157140   
HGNC ID HGNC:6893   
Unigene ID Hs.101174    
Ensembl ID ENSG00000186868   
PharmGKB ID -   

mRNA Information


mRNA ID NM_001123066.3
Exon join(1..305,67940..68089,77478..77564,80004..80090, 83994..84059,88797..89549,92659..92714,95497..95694, 97079..97205,99543..99596,102018..102283,115929..116021, 119862..119943,124237..124349,129575..133953)  
mRNA Sequence

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Length 5544  



CDS Information


   
Locationjoin(67957..68089,77478..77564,80004..80090,83994..84059, 88485..89549,92659..92714,95497..95694,97079..97205, 102018..102283,115929..116021,119862..119943, 124237..124349,129575..129790)
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_058519.3
Protein NameMicrotubule-associated protein tau
Molecular Wt. (Da)78797
Protein Sequence

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Length 758  
Uniprot IDP38936
Ensembl Protein ID ENSP00000244741  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation123
SPhosphorylation527
SPhosphorylation555
TPhosphorylation720
SPhosphorylation729
SPhosphorylation733
SPhosphorylation739
TPhosphorylation123
SPhosphorylation210
SPhosphorylation238
TPhosphorylation403
SPhosphorylation412
SPhosphorylation416
SPhosphorylation422
SPhosphorylation152
SPhosphorylation180
TPhosphorylation345
SPhosphorylation354
SPhosphorylation355
SPhosphorylation358
SPhosphorylation364
TPhosphorylation65
SPhosphorylation152
SPhosphorylation180
TPhosphorylation314
SPhosphorylation323
SPhosphorylation327
SPhosphorylation333
TPhosphorylation65
SDephosphorylation235
SDephosphorylation396
SPhosphorylation519
TPhosphorylation522
TPhosphorylation529
SPhosphorylation531
TPhosphorylation534
TPhosphorylation548
SPhosphorylation552
TPhosphorylation690
SPhosphorylation713
SPhosphorylation721
SPhosphorylation202
TPhosphorylation205
TPhosphorylation212
SPhosphorylation214
TPhosphorylation217
TPhosphorylation231
SPhosphorylation235
TPhosphorylation373
SPhosphorylation396
SPhosphorylation404
SPhosphorylation144
TPhosphorylation147
TPhosphorylation154
TPhosphorylation159
TPhosphorylation173
SPhosphorylation177
TPhosphorylation315
SPhosphorylation338
SPhosphorylation346
SPhosphorylation144
TPhosphorylation147
TPhosphorylation154
SPhosphorylation156
TPhosphorylation159
TPhosphorylation173
SPhosphorylation177
TPhosphorylation284
SPhosphorylation307
SPhosphorylation315
DProteolytic Cleavage738
SPhosphorylation554
SPhosphorylation579
SPhosphorylation237
SPhosphorylation262
SPhosphorylation179
SPhosphorylation204
SPhosphorylation179
SPhosphorylation204
SDephosphorylation519
SDephosphorylation202
SDephosphorylation144
SDephosphorylation144
TPhosphorylation492
TPhosphorylation498
SPhosphorylation519
TPhosphorylation175
TPhosphorylation217
SPhosphorylation202
TPhosphorylation117
TPhosphorylation123
SPhosphorylation144
TPhosphorylation117
TPhosphorylation123
SPhosphorylation144
SPhosphorylation579
SPhosphorylation673
SPhosphorylation262
SPhosphorylation356
SPhosphorylation204
SPhosphorylation298
SPhosphorylation204
SPhosphorylation267
TPhosphorylation529
TPhosphorylation212
TPhosphorylation154
TPhosphorylation154
DProteolytic Cleavage738
SDephosphorylation515
SDephosphorylation516
SDephosphorylation519
SDephosphorylation198
SDephosphorylation199
SDephosphorylation202
SDephosphorylation140
SDephosphorylation141
SDephosphorylation144
SDephosphorylation140
SDephosphorylation141
SDephosphorylation144
SPhosphorylation531
SPhosphorylation575
SPhosphorylation637
SPhosphorylation669
SPhosphorylation214
SPhosphorylation258
SPhosphorylation320
SPhosphorylation352
TPhosphorylation147
SPhosphorylation200
SPhosphorylation262
SPhosphorylation294
SPhosphorylation156
SPhosphorylation200
SPhosphorylation231
SPhosphorylation263
DProteolytic Cleavage738
SPhosphorylation512
SPhosphorylation515
SPhosphorylation516
TPhosphorylation529
SPhosphorylation531
TPhosphorylation548
SPhosphorylation579
SPhosphorylation673
SPhosphorylation726
SPhosphorylation195
SPhosphorylation198
SPhosphorylation199
TPhosphorylation212
SPhosphorylation214
TPhosphorylation231
SPhosphorylation262
SPhosphorylation356
SPhosphorylation409
SPhosphorylation137
SPhosphorylation140
SPhosphorylation141
TPhosphorylation147
TPhosphorylation154
TPhosphorylation173
SPhosphorylation204
SPhosphorylation298
SPhosphorylation351
SPhosphorylation137
SPhosphorylation140
SPhosphorylation141
TPhosphorylation154
SPhosphorylation156
TPhosphorylation173
SPhosphorylation204
SPhosphorylation267
SPhosphorylation320
SDephosphorylation515
SDephosphorylation516
SDephosphorylation519
SDephosphorylation198
SDephosphorylation199
SDephosphorylation140
SDephosphorylation141
SDephosphorylation140
SDephosphorylation141
DProteolytic Cleavage738
DProteolytic Cleavage738
TPhosphorylation498
SPhosphorylation519
TPhosphorylation522
TPhosphorylation548
SPhosphorylation637
TPhosphorylation181
SPhosphorylation202
TPhosphorylation205
TPhosphorylation231
SPhosphorylation320
TPhosphorylation123
SPhosphorylation144
TPhosphorylation147
TPhosphorylation173
SPhosphorylation262
TPhosphorylation123
SPhosphorylation144
TPhosphorylation147
TPhosphorylation173
SPhosphorylation231
SPhosphorylation46
TPhosphorylation498
SPhosphorylation501
TPhosphorylation50
SPhosphorylation512
SPhosphorylation515
SPhosphorylation516
SPhosphorylation519
TPhosphorylation522
SPhosphorylation525
TPhosphorylation529
TPhosphorylation534
TPhosphorylation548
SPhosphorylation579
SPhosphorylation713
SPhosphorylation717
SPhosphorylation721
SPhosphorylation730
TPhosphorylation181
SPhosphorylation202
SPhosphorylation195
SPhosphorylation198
SPhosphorylation199
SPhosphorylation202
TPhosphorylation205
SPhosphorylation208
TPhosphorylation212
TPhosphorylation217
TPhosphorylation231
SPhosphorylation262
SPhosphorylation396
SPhosphorylation400
SPhosphorylation404
SPhosphorylation413
SPhosphorylation199
TPhosphorylation181
TPhosphorylation123
SPhosphorylation126
SPhosphorylation137
SPhosphorylation140
SPhosphorylation141
SPhosphorylation144
TPhosphorylation147
SPhosphorylation150
TPhosphorylation154
TPhosphorylation159
TPhosphorylation173
SPhosphorylation204
SPhosphorylation338
SPhosphorylation342
SPhosphorylation346
TPhosphorylation123
SPhosphorylation126
SPhosphorylation137
SPhosphorylation140
SPhosphorylation141
SPhosphorylation144
TPhosphorylation147
SPhosphorylation150
TPhosphorylation154
TPhosphorylation159
TPhosphorylation173
SPhosphorylation204
SPhosphorylation307
SPhosphorylation311
SPhosphorylation315
SPhosphorylation324
SPhosphorylation641
SPhosphorylation324
SPhosphorylation266
SPhosphorylation235
SPhosphorylation579
SPhosphorylation673
SPhosphorylation262
SPhosphorylation356
SPhosphorylation204
SPhosphorylation298
SPhosphorylation204
SPhosphorylation267
SPhosphorylation579
SPhosphorylation610
SPhosphorylation622
SPhosphorylation641
SPhosphorylation673
SPhosphorylation262
SPhosphorylation293
SPhosphorylation305
SPhosphorylation324
SPhosphorylation356
SPhosphorylation204
SPhosphorylation235
SPhosphorylation247
SPhosphorylation266
SPhosphorylation298
SPhosphorylation204
SPhosphorylation235
SPhosphorylation267
SDephosphorylation519
SDephosphorylation202
SDephosphorylation144
SDephosphorylation144
SPhosphorylation519
SPhosphorylation202
SPhosphorylation144
SPhosphorylation144
TPhosphorylation470
TPhosphorylation153
TPhosphorylation95
TPhosphorylation95
SPhosphorylation156
YPhosphorylation711
YPhosphorylation394
YPhosphorylation336
YPhosphorylation305
DProteolytic Cleavage421
DProteolytic Cleavage421
DProteolytic Cleavage421
DProteolytic Cleavage421
DProteolytic Cleavage421
DProteolytic Cleavage363
DProteolytic Cleavage363
DProteolytic Cleavage363
DProteolytic Cleavage363
DProteolytic Cleavage363
DProteolytic Cleavage332
DProteolytic Cleavage332
DProteolytic Cleavage332
DProteolytic Cleavage332
DProteolytic Cleavage332
SPhosphorylation262
SPhosphorylation214
TPhosphorylation212
TPhosphorylation580
TPhosphorylation263
TPhosphorylation205
TPhosphorylation205
SPhosphorylation131
TPhosphorylation135
SPhosphorylation73
TPhosphorylation77
SPhosphorylation73
TPhosphorylation77
SPhosphorylation46
TPhosphorylation50
SPhosphorylation558
SPhosphorylation241
SPhosphorylation183
SPhosphorylation183

Enzyme Information


   
EC2.5.1.34
Name4-dimethylallyltryptophan synthase
dimethylallylpyrophosphate:L-tryptophan dimethylallyltransferase
dimethylallyltryptophan synthetase
dimethylallylpyrophosphate:tryptophan dimethylallyl transferase
DMAT synthetase
4-(gamma,gamma-dimethylallyl)tryptophan synthase
tryptophan dimethylallyltransferase
ClassTransferases; Transferring alkyl or aryl groups, other than methyl groups; Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysnamedimethylallyl-diphosphate:L-tryptophan 4-dimethylallyltransferase  
Substratedimethylallyl diphosphate [CPD:C00235]; L-tryptophan  
Productdiphosphate [CPD:C00013]; 4-(3-methylbut-2-enyl)-L-tryptophan [CPD:C04290]  
Reaction (IUBMB)



PPi Information


(Click to view network : Source STRING)      View   

                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
60ACTB32NP_001092.1in vitro6304075   
801CALM1241NP_008819.1in vitro2123288   
2534FYN655NP_002028.1in vitro;in vivo1   182   609   916   014   710   
3312HSPA87205NP_006588.1in vitro14612456   
5663PSEN187NP_000012.1in vivo9689133   


Pathway Information


            
Pathway Name Pathway ID
Alzheimer's disease hsa05010
MAPK signaling pathway hsa04010


Structure Information


PDB ID1I8H
Resolution-
Methodsolution NMR
Chains A  
Molecule MICROTUBULE-ASSOCIATED PROTEIN TAU  
Model View



Domain Information




ID Location Description
pfam00418592-622  Tubulin-binding
cl02863592-622  Tubulin-binding superfamily
pfam00418623-653  Tubulin-binding
cl02863623-653  Tubulin-binding superfamily
pfam00418560-591  Tubulin-binding
cl02863560-591  Tubulin-binding superfamily
pfam00418654-685  Tubulin-binding
cl02863654-685  Tubulin-binding superfamily
PHA03247142-570  PHA03247
PHA03247138-568  PHA03247
PTZ00449314-587  PTZ00449
pfam05109252-572  Herpes_BLLF1
PHA03307202-588  PHA03307
PHA03307332-579  PHA03307
PRK07764231-569  PRK07764
PHA03378275-568  PHA03378
PHA03307227-569  PHA03307
PHA0330781-536  PHA03307


Ontology Information


   
HPRD ID2542
Molecular ClassStructural protein
Molecular FunctionKinase regulator activity (GO:0019207)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P10636DB01229PaclitaxelSmallMoleculeDrug
P10636DB01248DocetaxelSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO