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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CD46 4179 CD46 molecule, complement regulatory protein  1TRA2.10, MGC26544, TLX 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24978917   2014Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : -

Stage : -

Immunohistochemistry,Tissue microarrays Up-regulation-CD46, CD55, and CD59 are up-regulated in colon cancer


Gene Details



NC_000001.10 (207925383..207968861)

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Gene Type protein coding
Gene Family CD molecules, "Complement system"
Description The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]  
Chromosome 1
Location 1q32
Start 207925383  
End 207968861  
Strand +  
Gene Sequence

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Length 43479  
OMIM ID 120920   
HGNC ID HGNC:6953   
Unigene ID Hs.510402   
Ensembl ID ENSG00000117335   
PharmGKB ID PA30700   

mRNA Information


mRNA ID NM_002389.4
Exon join(1..272,4977..5165,5503..5605,7602..7687,9212..9409, 14976..15158,15570..15614,15742..15786,18284..18325, 31255..31293,33034..33069,33582..33645,38216..38308, 41482..43479)  
mRNA Sequence

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Length 3402  



CDS Information


   
Location176..1354
CDS Sequence

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CCDS ID CCDS1479.1



Protein Information


      
Protein IDNP_002380.3
Protein NameCD46 molecule, complement regulatory protein
Molecular Wt. (Da)44744
Protein Sequence

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Length 392  
Uniprot IDQ03167
Ensembl Protein ID ENSP00000212355  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation339
YPhosphorylation338
YPhosphorylation324
YPhosphorylation368
YPhosphorylation324
YPhosphorylation368
YPhosphorylation354
YPhosphorylation353
YPhosphorylation354
YPhosphorylation353
YPhosphorylation339
YPhosphorylation338
YPhosphorylation340;-
YPhosphorylation343;-
YPhosphorylation384;-
YPhosphorylation387;-
YPhosphorylation370;-
YPhosphorylation373;-
YPhosphorylation369;-
YPhosphorylation372;-
YPhosphorylation355;-
YPhosphorylation358;-
YPhosphorylation354;-
YPhosphorylation357;-

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
0C4B402NP_000583.2in vitro1717583   
718C3400NP_000055.2in vitro1717583   


Pathway Information


            
Pathway Name Pathway ID
Complement and coagulation cascades hsa04610
Measles hsa05162


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0003399-158  CCP
cl0004399-158  CCP superfamily
cd00033228-283  CCP
cl00043228-283  CCP superfamily
cd00033162-224  CCP
cl00043162-224  CCP superfamily
cd0003335-88  CCP
cl0004335-88  CCP superfamily
smart0003299-157  CCP
smart00032231-283  CCP
pfam00084228-283  Sushi
smart00032162-223  CCP
pfam00084162-223  Sushi
pfam0008499-157  Sushi
smart0003235-88  CCP
PHA0292754-285  PHA02927
PHA0263999-288  PHA02639
PHA02817157-285  PHA02817
PHA02831114-285  PHA02831
PHA0292785-290  PHA02927
PHA0281729-159  PHA02817


Ontology Information


   
HPRD ID2836
Molecular ClassCell surface receptor
Molecular FunctionExtracellular matrix structural constituent (GO:0005201)
Biological ProcessCell growth and/or maintenance (GO:0008151)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO