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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 1282489 | 2003 | Cell line : - Source : Indonesia Sample Type : CRC tumor No. of Sample : 29 Stage : - | Immunohistochemistry,methylation-specific PCR, in situ hybridization | Up-regulation | - | CpG methylation of the E-cad promoter and significant MeCP2 expression cooperatively and epigenetically regulate E-cad expression in colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015] |
| Chromosome | X |
| Location | Xq28 |
| Start | 153287025 |
| End | 153363188 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 76164 |
| OMIM ID | 300005 |
| HGNC ID | HGNC:6990 |
| Unigene ID | Hs.200716 |
| Ensembl ID | ENSG00000169057 |
| PharmGKB ID | PA30729 |
mRNA Information
| mRNA ID | XM_005274668.2 |
|---|---|
| Exon | 73148..75919 | mRNA Sequence | Download Select all |
| Length | 8251 |
Protein Information
| Protein ID | XP_005274725.1 |
|---|---|
| Protein Name | methyl CpG binding protein 2 |
| Molecular Wt. (Da) | 44744 |
| Protein Sequence | Download Select all |
| Length | 708 |
| Uniprot ID | P35443 |
| Ensembl Protein ID | ENSP00000339730 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 80 |
| S | Phosphorylation | 78 |
| S | Phosphorylation | 116 |
| Y | Phosphorylation | 120 |
| S | Phosphorylation | 149 |
| S | Phosphorylation | 426 |
| S | Phosphorylation | 229 |
| K | Acetylation | 449 |
| T | Phosphorylation | 160 |
| S | Phosphorylation | 216 |
| T | Phosphorylation | 228 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3146 | HMGB1 | 1228 | NP_002119.1 | in vitro | 11748221 |
| 6497 | SKI | 1271 | NP_003027.1 | in vitro;in vivo | 11441023 |
| 6595 | SMARCA2 | 2483 | NP_003061.3 | in vitro;in vivo | 15696166 |
| 6598 | SMARCB1 | 3364 | NP_003064.2 | in vitro;in vivo | 1569166 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01396 | 94-168 | MeCP2_MBD |
| cl00110 | 94-168 | MBD superfamily |
| smart00391 | 92-169 | MBD |
| pfam01429 | 91-165 | MBD |
| cd00122 | 94-157 | MBD |
Ontology Information
| HPRD ID | 1784 |
|---|---|
| Molecular Class | DNA binding protein |
| Molecular Function | Extracellular matrix structural constituent (GO:0005201) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.