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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 11248420 | 2001 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 80 Stage : Dukes A,B, C,D | Northern blotting | Down-regulation | - | Reduced expression of MGP may be used to distinguish the normal colorectal cells from malignant cells. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is secreted and likely acts as an inhibitor of bone formation. The encoded protein is found in the organic matrix of bone and cartilage. Defects in this gene are a cause of Keutel syndrome (KS). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] |
| Chromosome | 12 |
| Location | 12p12.3 |
| Start | 15034115 |
| End | 15038853 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 4739 |
| OMIM ID | 154870 |
| HGNC ID | HGNC:7060 |
| Unigene ID | Hs.365706 |
| Ensembl ID | ENSG00000111341 |
| PharmGKB ID | PA30790 |
mRNA Information
| mRNA ID | NM_000900.3 |
|---|---|
| Exon | join(1..189,1675..1707,2873..2948,3640..4739) | mRNA Sequence | Download Select all |
| Length | 1398 |
Protein Information
| Protein ID | NP_000891.2 |
|---|---|
| Protein Name | matrix Gla protein |
| Molecular Wt. (Da) | 17468 |
| Protein Sequence | Download Select all |
| Length | 103 |
| Uniprot ID | P43699 |
| Ensembl Protein ID | ENSP00000346879 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 22 |
| S | Phosphorylation | 25 |
| S | Phosphorylation | 28 |
Enzyme Information
No matching records could be found.
PPi Information
No STRING Network could be found.
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 650 | BMP2 | 206 | NP_001191.1 | in vitro | 11741887 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00069 | 32-96 | GLA |
| cl02449 | 32-96 | Gla superfamily |
| pfam00594 | 56-97 | Gla |
Ontology Information
| HPRD ID | 4325 |
|---|---|
| Molecular Class | Extracellular matrix protein |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.