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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MGST1 | 4257 | microsomal glutathione S-transferase 1 | 12 | MGST-I |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23314968 | 2012 | Cell line : - Source : Teaching hospital Makassar Sample Type : Case-control study, CRC tumour samples and peripheral blood No. of Sample : 35 CRC and 61 control Stage : - | DNA resequencing ,PCR-RFLP | Polymorhpism | - | MGST1 gene polymorphisms as one of environment gene may contribute to CRC risk in younger age. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Glutathione S-transferases / Microsomal |
| Description | The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012] |
| Chromosome | 12 |
| Location | 12p12.3-p1 |
| Start | 16500076 |
| End | 16530123 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 30048 |
| OMIM ID | 138330 |
| HGNC ID | HGNC:7061 |
| Unigene ID | Hs.389700 |
| Ensembl ID | ENSG00000008394 |
| PharmGKB ID | PA30791 |
mRNA Information
| mRNA ID | NM_145792.2 |
|---|---|
| Exon | join(1..43,7090..7237,10464..10558,16654..17269) | mRNA Sequence | Download Select all |
| Length | 919 |
Protein Information
| Protein ID | NP_665735.1 |
|---|---|
| Protein Name | microsomal glutathione S-transferase 1 |
| Molecular Wt. (Da) | 14280 |
| Protein Sequence | Download Select all |
| Length | 155 |
| Uniprot ID | Q04726 |
| Ensembl Protein ID | ENSP00000319233 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemical carcinogenesis | hsa05204 |
| Drug metabolism - cytochrome P450 | hsa00982 |
| Glutathione metabolism | hsa00480 |
| Metabolism of xenobiotics by cytochrome P450 | hsa00980 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam01124 | 19-149 | MAPEG |
| cl09190 | 19-149 | MAPEG superfamily |
| COG3686 | 14-144 | COG3686 |
Ontology Information
| HPRD ID | 4326 |
|---|---|
| Molecular Class | Enzyme: Glutathione transferase |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P10620 | DB00143 | Glutathione | SmallMoleculeDrug |