Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MIF | 4282 | Macrophage migration inhibitory factor (glycosylation-inhibiting factor) | 22 | GIF; GLIF; MMIF |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19009023 | 2009 | Cell line : - Source : Department of Pathology of the Second Affiliated Hospital of Guangzhou Medical College, American Type Culture Collection (Manassas, VA, USA). Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry, Cell culture, Cell invasion assay, RT-PCR, Tautomerase activity. | Up-regulation | - | MIF upregulation is associated with increased tumor differentiation, lymph node invasion, and hepatic metastasis, consistent with the intimate involvement of MIF in colorectal carcinogenesis and metastasis. MIF may enhance colorectal tumor growth and invasion through induction of VEGF and MMP-9. These findings suggest that the level of MIF in both serum and colorectal tissue may be a useful marker in the diagnosis of colorectal cancer and its metastasis to the liver. A total of 77 patients (who underwent colorectal cancer diagnosis during the period 2003-2005) participated in this study, 8 with normal intestinal mucosa, 20 with colorectal adenomas, and 49 with colorectal carcinomas. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008] |
| Chromosome | 22 |
| Location | 22q11.23 |
| Start | 23894378 |
| End | 23895222 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 845 |
| OMIM ID | 153620 |
| HGNC ID | HGNC:7097 |
| Unigene ID | Hs.407995 |
| Ensembl ID | ENSG00000099964 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_002415.1 |
|---|---|
| Exon | join(1..205,395..567,663..845) | mRNA Sequence | Download Select all |
| Length | 561 |
CDS Information
| Location | join(98..205,395..567,663..729) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS13819.1 |
Protein Information
| Protein ID | NP_002406.1 |
|---|---|
| Protein Name | Macrophage migration inhibitory factor (glycosylation-inhibiting factor) |
| Molecular Wt. (Da) | 12345 |
| Protein Sequence | Download Select all |
| Length | 115 |
| Uniprot ID | P42772 |
| Ensembl Protein ID | ENSP00000276925 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 37;- |
| K | Acetylation | 78 |
Enzyme Information
| EC | 5.3.2.1 |
|---|---|
| Name | phenylpyruvate tautomerase phenylpyruvic keto-enol isomerase |
| Class | Isomerases; Intramolecular oxidoreductases; Interconverting keto- and enol-groups |
| Sysname | phenylpyruvate keto---enol-isomerase |
| Substrate | keto-phenylpyruvate |
| Product | enol-phenylpyruvate |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 972 | CD74 | 825 | NP_001020330.1 | in vitro;in vivo | 12782713 |
| 4830 | NME1 | 1131 | NP_937818.1 | in vivo | 18815136 |
| 7157 | TP53 | 1859 | NP_000537.3 | in vivo | 18815136 |
| 26003 | GORASP2 | 8303 | NP_056345.3 | yeast 2-hybrid | 16189514 |
| 29888 | STRN4 | 18125 | NP_001034966.1 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Phenylalanine metabolism | hsa00360 |
| Tyrosine metabolism | hsa00350 |
Structure Information
| PDB ID | 1CA7 |
|---|---|
| Resolution | 2.5 |
| Method | X-RAY DIFFRACTION |
| Chains | A,B,C |
| Molecule | PROTEIN (MACROPHAGE MIGRATION INHIBITORY FACTOR) |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam01187 | 2-115 | MIF |
| cl22914 | 2-115 | MIF superfamily |
| PTZ00397 | 1-114 | PTZ00397 |
| PTZ00450 | 32-114 | PTZ00450 |
| COG1942 | Jan-54 | PptA |
| cl00235 | Jan-54 | 4Oxalocrotonate_Tautomerase superfamily |
Ontology Information
| HPRD ID | 2849 |
|---|---|
| Molecular Class | Cytokine |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.