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General Information
- Evidence
- Gene
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22125836 | 2011 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 80 Stage : TNM Stage I-IV | Immunohistochemistry | Down-regulation | - | The expression of FOXO4 was significantly decreased or deleted in colorectal cancer, indicating that FOXO4 may function as a tumor suppressor in the development and progression of colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Forkhead boxes |
| Description | This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010] |
| Chromosome | X |
| Location | Xq13.1 |
| Start | 70315999 |
| End | 70323384 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 7386 |
| OMIM ID | 300033 |
| HGNC ID | HGNC:7139 |
| Unigene ID | Hs.584654 |
| Ensembl ID | ENSG00000184481 |
| PharmGKB ID | PA162388882 |
mRNA Information
| mRNA ID | NM_005938.3 |
|---|---|
| Exon | join(1..833,4536..5592,5929..7386 | mRNA Sequence | Download Select all |
| Length | 3365 |
Protein Information
| Protein ID | NP_005929.2 |
|---|---|
| Protein Name | forkhead box O4 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 505 |
| Uniprot ID | P01375 |
| Ensembl Protein ID | ENSP00000365290 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 197 |
| S | Phosphorylation | 262 |
| T | Phosphorylation | 451 |
| T | Phosphorylation | 455 |
| T | Phosphorylation | 32 |
| T | Phosphorylation | 32 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2099 | ESR1 | 589 | NP_000116.2 | in vitro | 11435445 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| FoxO signaling pathway | hsa04068 |
| Ras signaling pathway | hsa04014 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00059 | 101-181 | FH |
| cl00061 | 101-181 | FH superfamily |
| smart00339 | 101-183 | FH |
| pfam00250 | 104-193 | Fork_head |
| COG5025 | 98-232 | COG5025 |
| COG5025 | 105-182 | COG5025 |
| pfam05887 | Apr-83 | Trypan_PARP |
| PHA03247 | 18-100 | PHA03247 |
Ontology Information
| HPRD ID | 535 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | DNA topoisomerase activity (GO:0003916) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.