Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| NR3C2 | 4306 | nuclear receptor subfamily 3 group C member 2  | 4 | MR; MCR; MLR; NR3C2VIT  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24516561    | 2014 | Cell line : - Source : Brest University Hospital Sample Type : CRC tumor and normal tissue No. of Sample : 55 CRAs, 25 CRCs and 27 colorectal normal mucosae Stage : - | Whole-Genome Microarray,Gene Expression Analysis,Gene Set Enrichment Analysis,Alternative Splicing Analysis,RT-PCR | Altered splicing | - | CFH, CRYAB, DPT, FBLN1, ITIH5, NR3C2, SLIT3 and TIMP1 showed altered pre-mRNA splicing in CRAs. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Nuclear hormone receptors |
| Description | This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]   |
| Chromosome | 4 |
| Location | 4q31.1 |
| Start | 148999915   |
| End | 149365850   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 365936   |
| OMIM ID | 600983    |
| HGNC ID | HGNC:7979    |
| Unigene ID | Hs.163924    |
| Ensembl ID | ENSG00000151623    |
| PharmGKB ID | PA242    |
mRNA Information
| mRNA ID | ?NM_000901.4 |
|---|---|
| Exon |   | mRNA Sequence |    Download   Select all |
| Length |   |
CDS Information
| Location | |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS3772.1 |    
Protein Information
| Protein ID | |
|---|---|
| Protein Name | nuclear receptor subfamily 3 group C member 2 |
| Molecular Wt. (Da) | 186415 |
| Protein Sequence |    Download   Select all |
| Length | 0   |
| Uniprot ID | P21580 |    
| Ensembl Protein ID | ENSP00000237289   |    
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 58 |    ACTA1 |    30 |    NP_001091.1 |    in vitro |    8612804    |
| 71 |    ACTG1 |    17 |    NP_001605.1 |    in vitro |    8612804    |
| 367 |    AR |    2437 |    NP_000035.2 |    yeast 2-hybrid |    12644298    |
| 2908 |    NR3C1 |    679 |    NP_001019265.1 |    in vitro;in vivo |    11154266    |
| 3320 |    HSP90AA1 |    777 |    NP_001017963.2 |    in vitro |    9392437    |
| 5629 |    PROX1 |    3330 |    NP_002754.2 |    yeast 2-hybrid |    15604093    |
| 8805 |    TRIM24 |    4556 |    NP_056989.2 |    in vitro |    911   527   411   518   808    |
| 10401 |    PIAS3 |    9068 |    NP_006090.2 |    in vitro;in vivo;yeast 2-hybrid |    15171715    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Aldosterone-regulated sodium reabsorption |    hsa04960 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07075 | 737-984  | NR_LBD_MR |
| cl11397 | 737-984  | NR_LBD superfamily |
| cd07172 | 599-673  | NR_DBD_GR_PR |
| cl02596 | 599-673  | NR_DBD_like superfamily |
| cd06947 | 737-982  | NR_LBD_GR_Like |
| cd07076 | 739-984  | NR_LBD_GR |
| cd07074 | 739-984  | NR_LBD_PR |
| cd07073 | 741-982  | NR_LBD_AR |
| cd06930 | 766-934  | NR_LBD_F2 |
| cd06963 | 603-673  | NR_DBD_GR_like |
| cd06157 | 767-934  | NR_LBD |
| cd07173 | 599-673  | NR_DBD_AR |
| cd06916 | 603-673  | NR_DBD_like |
| pfam00105 | 601-670  | zf-C4 |
| smart00430 | 775-934  | HOLI |
| pfam00104 | 748-943  | Hormone_recep |
| cd07068 | 739-880  | NR_LBD_ER_like |
| smart00399 | 602-669  | ZnF_C4 |
| cd06960 | 603-672  | NR_DBD_HNF4A |
| cd07171 | 598-673  | NR_DBD_ER |
| cd07167 | 603-672  | NR_DBD_Lrh-1_like |
| cd06949 | 734-967  | NR_LBD_ER |
| cd06961 | 603-668  | NR_DBD_TR |
| cd07155 | 603-668  | NR_DBD_ER_like |
| cd07170 | 599-668  | NR_DBD_ERR |
| cd06946 | 739-877  | NR_LBD_ERR |
| cd06969 | 601-668  | NR_DBD_NGFI-B |
| cd07168 | 596-672  | NR_DBD_DHR4_like |
| cd07164 | 603-669  | NR_DBD_PNR_like_1 |
| cd07169 | 601-672  | NR_DBD_GCNF_like |
| cd07154 | 603-672  | NR_DBD_PNR_like |
| cd06967 | 598-668  | NR_DBD_TR2_like |
| cd07156 | 603-668  | NR_DBD_VDR_like |
| cd06964 | 598-668  | NR_DBD_RAR |
| cd06957 | 603-672  | NR_DBD_PNR_like_2 |
| cd06970 | 599-672  | NR_DBD_PNR |
| cd06956 | 602-668  | NR_DBD_RXR |
| cd07163 | 603-669  | NR_DBD_TLX |
| cd06959 | 603-668  | NR_DBD_EcR_like |
| cd06968 | 603-668  | NR_DBD_ROR |
| cd06958 | 603-668  | NR_DBD_COUP_TF |
| cd06966 | 601-669  | NR_DBD_CAR |
| cd07165 | 603-669  | NR_DBD_DmE78_like |
| cd07160 | 600-668  | NR_DBD_LXR |
| cd07162 | 602-668  | NR_DBD_PXR |
| cd07179 | 603-668  | 2DBD_NR_DBD2 |
| cd07161 | 601-668  | NR_DBD_EcR |
| cd06955 | 601-668  | NR_DBD_VDR |
| cd06962 | 601-668  | NR_DBD_FXR |
| cd07158 | 603-672  | NR_DBD_Ppar_like |
| cd07166 | 602-672  | NR_DBD_REV_ERB |
| cd07157 | 601-671  | 2DBD_NR_DBD1 |
| cd06965 | 603-668  | NR_DBD_Ppar |
| cd06943 | 759-928  | NR_LBD_RXR_like |
| cd06929 | 777-936  | NR_LBD_F1 |
| cd06953 | 741-940  | NR_LBD_DHR4_like |
| cd06942 | 779-952  | NR_LBD_Sex_1_like |
| cd06940 | 779-934  | NR_LBD_REV_ERB |
| cd06945 | 754-969  | NR_LBD_Nurr1_like |
| cd06935 | 747-934  | NR_LBD_TR |
| cd06954 | 753-963  | NR_LBD_LXR |
| cd07070 | 757-879  | NR_LBD_SF-1 |
| cd06937 | 760-970  | NR_LBD_RAR |
| cd06933 | 751-896  | NR_LBD_VDR |
| cd06931 | 718-896  | NR_LBD_HNF4_like |
| cd06948 | 772-944  | NR_LBD_COUP-TF |
| cd06941 | 780-963  | NR_LBD_DmE78_like |
| cd07348 | 782-969  | NR_LBD_NGFI-B |
| cd06950 | 728-814  | NR_LBD_Tlx_PNR_like |
| cd06939 | 777-963  | NR_LBD_ROR_like |
| cd07072 | 778-969  | NR_LBD_DHR38_like |
| cd06938 | 776-943  | NR_LBD_EcR |
| cd07071 | 783-969  | NR_LBD_Nurr1 |
| cd06952 | 781-928  | NR_LBD_TR2_like |
| cd06936 | 760-906  | NR_LBD_Fxr |
| cd06934 | 777-879  | NR_LBD_PXR_like |
| cd06932 | 779-934  | NR_LBD_PPAR |
| cd06944 | 764-880  | NR_LBD_Ftz-F1_like |
Ontology Information
| HPRD ID | 536 |    
|---|---|
| Molecular Class | Not Available |
| Molecular Function | DNA topoisomerase activity (GO:0003916) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)   |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P08235 | DB00393 | Nimodipine | SmallMoleculeDrug |
| P08235 | DB00396 | Progesterone | SmallMoleculeDrug |
| P08235 | DB00421 | Spironolactone | SmallMoleculeDrug |
| P08235 | DB00588 | Fluticasone Propionate | SmallMoleculeDrug |
| P08235 | DB00687 | Fludrocortisone | SmallMoleculeDrug |
| P08235 | DB00700 | Eplerenone | SmallMoleculeDrug |
| P08235 | DB01023 | Felodipine | SmallMoleculeDrug |
| P08235 | DB01395 | Drospirenone | SmallMoleculeDrug |
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
