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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
NR3C2 4306 nuclear receptor subfamily 3 group C member 2  4MR; MCR; MLR; NR3C2VIT 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24516561   2014Cell line : -

Source : Brest University Hospital

Sample Type : CRC tumor and normal tissue

No. of Sample : 55 CRAs, 25 CRCs and 27 colorectal normal mucosae

Stage : -

Whole-Genome Microarray,Gene Expression Analysis,Gene Set Enrichment Analysis,Alternative Splicing Analysis,RT-PCRAltered splicing-CFH, CRYAB, DPT, FBLN1, ITIH5, NR3C2, SLIT3 and TIMP1 showed altered pre-mRNA splicing in CRAs.


Gene Details



NC_000004.11 (148999915..149365850, complement)

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Gene Type protein coding
Gene Family Nuclear hormone receptors
Description This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]  
Chromosome 4
Location 4q31.1
Start 148999915  
End 149365850  
Strand -  
Gene Sequence

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Length 365936  
OMIM ID 600983   
HGNC ID HGNC:7979   
Unigene ID Hs.163924   
Ensembl ID ENSG00000151623   
PharmGKB ID PA242   

mRNA Information


mRNA ID ?NM_000901.4
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS3772.1



Protein Information


      
Protein ID
Protein Namenuclear receptor subfamily 3 group C member 2
Molecular Wt. (Da)186415
Protein Sequence

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Length 0  
Uniprot IDP21580
Ensembl Protein ID ENSP00000237289  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                        
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
58ACTA130NP_001091.1in vitro8612804   
71ACTG117NP_001605.1in vitro8612804   
367AR2437NP_000035.2yeast 2-hybrid12644298   
2908NR3C1679NP_001019265.1in vitro;in vivo11154266   
3320HSP90AA1777NP_001017963.2in vitro9392437   
5629PROX13330NP_002754.2yeast 2-hybrid15604093   
8805TRIM244556NP_056989.2in vitro911   527   411   518   808   
10401PIAS39068NP_006090.2in vitro;in vivo;yeast 2-hybrid15171715   


Pathway Information


      
Pathway Name Pathway ID
Aldosterone-regulated sodium reabsorption hsa04960


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd07075737-984  NR_LBD_MR
cl11397737-984  NR_LBD superfamily
cd07172599-673  NR_DBD_GR_PR
cl02596599-673  NR_DBD_like superfamily
cd06947737-982  NR_LBD_GR_Like
cd07076739-984  NR_LBD_GR
cd07074739-984  NR_LBD_PR
cd07073741-982  NR_LBD_AR
cd06930766-934  NR_LBD_F2
cd06963603-673  NR_DBD_GR_like
cd06157767-934  NR_LBD
cd07173599-673  NR_DBD_AR
cd06916603-673  NR_DBD_like
pfam00105601-670  zf-C4
smart00430775-934  HOLI
pfam00104748-943  Hormone_recep
cd07068739-880  NR_LBD_ER_like
smart00399602-669  ZnF_C4
cd06960603-672  NR_DBD_HNF4A
cd07171598-673  NR_DBD_ER
cd07167603-672  NR_DBD_Lrh-1_like
cd06949734-967  NR_LBD_ER
cd06961603-668  NR_DBD_TR
cd07155603-668  NR_DBD_ER_like
cd07170599-668  NR_DBD_ERR
cd06946739-877  NR_LBD_ERR
cd06969601-668  NR_DBD_NGFI-B
cd07168596-672  NR_DBD_DHR4_like
cd07164603-669  NR_DBD_PNR_like_1
cd07169601-672  NR_DBD_GCNF_like
cd07154603-672  NR_DBD_PNR_like
cd06967598-668  NR_DBD_TR2_like
cd07156603-668  NR_DBD_VDR_like
cd06964598-668  NR_DBD_RAR
cd06957603-672  NR_DBD_PNR_like_2
cd06970599-672  NR_DBD_PNR
cd06956602-668  NR_DBD_RXR
cd07163603-669  NR_DBD_TLX
cd06959603-668  NR_DBD_EcR_like
cd06968603-668  NR_DBD_ROR
cd06958603-668  NR_DBD_COUP_TF
cd06966601-669  NR_DBD_CAR
cd07165603-669  NR_DBD_DmE78_like
cd07160600-668  NR_DBD_LXR
cd07162602-668  NR_DBD_PXR
cd07179603-668  2DBD_NR_DBD2
cd07161601-668  NR_DBD_EcR
cd06955601-668  NR_DBD_VDR
cd06962601-668  NR_DBD_FXR
cd07158603-672  NR_DBD_Ppar_like
cd07166602-672  NR_DBD_REV_ERB
cd07157601-671  2DBD_NR_DBD1
cd06965603-668  NR_DBD_Ppar
cd06943759-928  NR_LBD_RXR_like
cd06929777-936  NR_LBD_F1
cd06953741-940  NR_LBD_DHR4_like
cd06942779-952  NR_LBD_Sex_1_like
cd06940779-934  NR_LBD_REV_ERB
cd06945754-969  NR_LBD_Nurr1_like
cd06935747-934  NR_LBD_TR
cd06954753-963  NR_LBD_LXR
cd07070757-879  NR_LBD_SF-1
cd06937760-970  NR_LBD_RAR
cd06933751-896  NR_LBD_VDR
cd06931718-896  NR_LBD_HNF4_like
cd06948772-944  NR_LBD_COUP-TF
cd06941780-963  NR_LBD_DmE78_like
cd07348782-969  NR_LBD_NGFI-B
cd06950728-814  NR_LBD_Tlx_PNR_like
cd06939777-963  NR_LBD_ROR_like
cd07072778-969  NR_LBD_DHR38_like
cd06938776-943  NR_LBD_EcR
cd07071783-969  NR_LBD_Nurr1
cd06952781-928  NR_LBD_TR2_like
cd06936760-906  NR_LBD_Fxr
cd06934777-879  NR_LBD_PXR_like
cd06932779-934  NR_LBD_PPAR
cd06944764-880  NR_LBD_Ftz-F1_like


Ontology Information


   
HPRD ID536
Molecular ClassNot Available
Molecular FunctionDNA topoisomerase activity (GO:0003916)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P08235DB00393NimodipineSmallMoleculeDrug
P08235DB00396ProgesteroneSmallMoleculeDrug
P08235DB00421SpironolactoneSmallMoleculeDrug
P08235DB00588Fluticasone PropionateSmallMoleculeDrug
P08235DB00687FludrocortisoneSmallMoleculeDrug
P08235DB00700EplerenoneSmallMoleculeDrug
P08235DB01023FelodipineSmallMoleculeDrug
P08235DB01395DrospirenoneSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO