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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TRPM1 | 4308 | transient receptor potential cation channel, subfamily M, member 1 | 15 | LTRPC1, CSNB1C |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23563852 | 2013 | Cell line : SW1116-M, SW1116-S5 Source : - Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry, Flow cytometer, invasion assay, Cell proliferation assay | Up-regulation | 2 Fold | Sixteen of these, including E-cadherins, MTSS1, TRAIL and TRPM1, were up-regulated. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Voltage-gated ion channels / Transient receptor potential cation channels |
| Description | This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011] |
| Chromosome | 15 |
| Location | 15q13.3 |
| Start | 31293264 |
| End | 31453476 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 160213 |
| OMIM ID | 603576 |
| HGNC ID | HGNC:7146 |
| Unigene ID | Hs.155942 |
| Ensembl ID | ENSG00000134160 |
| PharmGKB ID | PA35496 |
mRNA Information
| mRNA ID | NM_001252020.1 |
|---|---|
| Exon | join(1..368,84290..84369,91048..91243,93182..93395, 94087..94211,95027..95198,97982..98156,98572..98695, 99760..99832,100630..100730,110692..110865,111765..111899, 113335..113385,114023..114163,115041..115070, 119031..119323,120928..121156,123108..123230, 123432..123563,125600..125728,128334..128585, 130117..130291,131883..131903,132798..132942, 134157..134359,135003..135135,158204..160213) | mRNA Sequence | Download Select all |
| Length | 6022 |
Protein Information
| Protein ID | NP_001238949.1 |
|---|---|
| Protein Name | transient receptor potential cation channel, subfamily M, member 1 |
| Molecular Wt. (Da) | 85383 |
| Protein Sequence | Download Select all |
| Length | 1642 |
| Uniprot ID | P22105 |
| Ensembl Protein ID | ENSP00000364393 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 424;- |
| T | Phosphorylation | 423;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00520 | 862-1074 | Ion_trans |
| TIGR00870 | 712-1110 | trp |
| PRK12704 | 1149-1248 | PRK12704 |
| COG1196 | 1129-1252 | Smc |
| TIGR02169 | 1123-1282 | SMC_prok_A |
Ontology Information
| HPRD ID | 1859 |
|---|---|
| Molecular Class | Intracellular ligand gated channel |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219); Apoptosis (GO:0006915) |
Drug Information
No matching records could be found.