CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
MMP2	4313	matrix metallopeptidase 2	16	CLG4; MONA; CLG4A; MMP-2; TBE-1; MMP-II

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
23801889	2013	Cell line : - Source : China Medical University Hospital, Taiwan Sample Type : CRC Tumor No. of Sample : 282 Stage : -	Genotyping, Kaplan-Meier analysis, Cox regression model, survival tree analysis	Polymorhpism	-	MMP2 might be potential predictors of distant metastasis-free survival after curative surgery.
24289619	2013	Cell line : - Source : Saudi population King Khalid University Hospital in Riyadh, KSA. Sample Type : CRC Tumor and adjecent normal tissue No. of Sample : 12 Stage : -	TaqMan allele discrimination assays and DNA sequencing,PCR, and sequencing,real-time RT-PCR,Genotyping	Polymorhpism	10 Fold	The MMP-2 C-1306T SNP in the promoter region was associated with CRC in our Saudi population and the MMP-2 gene expression level was found to be 10 times higher in CRC patients.
24998576	2014	Cell line : - Source : Saudi population, King Khalid University Hospital Riydh Kingdom of Saudi Arabia. Sample Type : CRC Tumor and adjecent normal tissue No. of Sample : 250 Stage : -	PCR sequencing, real time RT-PCR	Polymorhpism	-	risk associated with the SNPs, including genes for COX-2 (A/G transition at +202) and MMP-2 (C/T transition at-1306), with colorectal cancer in 125 patients and 125 healthy controls.

Gene Details

NC_000016.9 (55513081..55540586)
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Gene Type	protein coding
Gene Family	Matrix metallopeptidases
Description	This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Chromosome	16
Location	16q12.2
Start	55513081
End	55540586
Strand	+
Gene Sequence	>gi\|568815582:55478830-55506691 Homo sapiens chromosome 16, GRCh38.p2 Primary Assembly GTGCAGGGTGTCCTAGCCAAGCCGGCGTCCCTCCTAGTAGTACCGCTGCTCTCTAACCTCAGGACGTCAA GGGCCTAGAGCGACAGATGTTTCCCAGCAGGGGGTTCTGAGGCTGTGCGCCCAGATCGCGAGAGAGGCAA GTGGGGTGACGAGGTCGTGCACTGAGGGTGGACGTAGAGGCCAGGAGTAGCAGGCGGCCGGGGAAAAGAG GTGGAGAAAGGAAAAAAGAGGAGAAAAGTGGAGGAGGGCGAGTAGGGGGGTGGGGCAGAGAGGGGCGGGC CCGAGTGCGCCCCCCGCCCCCAGCCCCGCTCTGCCAGCTCCCTCCCAGCCCAGCCGGCTACATCTGGCGG CTGCCCTCCCTTGTTTCCGCTGCATCCAGACTTCCTCAGGCGGTGGCTGGAGGCTGCGCATCTGGGGCTT TAAACATACAAAGGGATTGCCAGGACCTGCGGCGGCGGCGGCGGCGGCGGGGGCTGGGGCGCGGGGGCCG GACCATGAGCCGCTGAGCCGGGCAAACCCCAGGCCACCGAGCCAGCGGACCCTCGGAGCGCAGCCCTGCG CCGCGGAGCAGGCTCCAACCAGGCGGCGAGGCGGCCACACGCACCGAGCCAGCGACCCCCGGGCGACGCG CGGGGCCAGGGAGCGCTACGATGGAGGCGCTAATGGCCCGGGGCGCGCTCACGGGTCCCCTGAGGGCGCT CTGTCTCCTGGGCTGCCTGCTGAGCCACGCCGCCGCCGCGCCGTCGCCCATCATCAAGTTCCCCGGCGAT GTCGCCCCCAAAACGGACAAAGAGTTGGCAGTGGTGAGTTGCTGCGCTGGCCTCAAGGAACCACGTTTAG ACAAACTTCGGAGGCAAAGGATGGGGGTGTCTCTCCCCCTGCCCTCGGCGGTGGGCACACAGCGTGGGGG AGGGGCTTCGGTAAACAGCTTGGGGGGTCTTTGGCAAGCTATTGGAGTGATCTCTTGCAAACGGTGGGGG ATCTTTTGTAAGCAAAGAAAACCTTTGATAAACAATTTGGCAACCTTCAGCATACAGCAGTGGGGCGAAA AACAAGCCAGAGAGTGGGAGAGGGGTGACCTGGCAAACTACTGGAAAGGGACTCTTATGTAAATAGCGGG GACATCCTCTAGTATCTGGGACATTTGGCGGGGGGGGGGGGCGGTCTTTGTAAACAACTTTTGGACACAT CTGGGCAGTTGCTAAGGGCTCTTGCCAAGCGTCTAGGTAAGCCTTTGGCAAACAGCTACAGGGGTCGTTT TTGCTAATGTAGGACTTTGGGAACGGTGCTCTGGCACACAATTTGGGTAAACTTATGCGCGCATAAGGAT GGGAGGGAGCTTGGTCAAAGCGGGGCTTGGCAAATTTCTAGGAACCTTCGGCACAGATCCGGAGAGGGAC CTTTAAACAAACAGCTCGAGGGGGCCATTTGGGAAGTGATTGGGGCAGGAGGGAAGCAGAGAGCGCATCT TTTTTCTCCTGGCTTAATGGACAAATTGGTCAAGGGCTGGGCCTCGGAAAGTTTCCTCGAACTTCTCCAA AGGGTCGGAGAAAAGAAGGAGAGAGCTGGCCCGGCAGGAGGGAGGAGGAGTGGGGCAGGCGCTGGAGGGC CCGGCGCGTGGGGCGGGGGCGGACTGCGCTCCGCTCGGGTCGGAGAGCGGCCAGAGAGCCCTCCTTCCTG GCTGGGCTCCCAAACCGCGGTTCAGATGTTGTCTTGTGAGCGTGCGCGCGCCTGGCTGGAGGGGCACTGA GCCTGGCCGCAGTGTTGCGTAAGTAGGGCCTGAGGAGAGAGGCAGGCCAGGGACCCATCAAGATGTCCTT TCCAGTCCAGGGGATATCTGCTCCCTTGTTGCTTCAGCCACCCTGCCCTCCAGCCTCCCCCTCAACCTGT CCGGGAGAAGACGCCCATGCCCTCTGGTCACCCTAGGAACTCCTTCAGGAGGTGACAACTACCCTCTCCC AACTCTCACCCTTCCAAACAGCTAGGTCTCAGCCCCCTCTGGATAGATGGGTTGGGAAACCTCCATACAT TTTTAGAGGGCTACTTTTTTCAAGGATCTGGAGCTGGCTGGCATAATGATGTGGCTGTTGGGTGGGGGTG AGAGTGGAGCTTTGGGACAATGACAAAGCTACTTGGTTTCCTACACCTTTTCCAGCCAATGGGTCACAGG ATGAACCCCTAAATTGGGGTTCAGCCTGGGGGCCACATGGGTTCTTGGCTTGCACAGGAAGGAATTCAAG AGCGAGCCAACAGAGTAAAGTGAAAACAAATTTATTAAGAAGGTAAAGGAATAAAAGGGTGATTATTCCA TAGACAGAGCAGGGAATGGGCTGCTGGACTGAGTATACATATGGTTATTTCTTGATTATATGCTAAACAA GGGGTGGATTATTTAAGAGTTTTCCAGAAAAAGGGTGGGGAGTTCCTGGAACCGAGGGTTTCTCTCCCTT TTAGACCATATAGGGTAACTTCTCAATGTTGCTATGGCATTTATAAACTGTCACAGCGCTGGTGGGAGTG TCTAATGTATTTAACATGCTAATACATTATAATTAGCATATAATGAGCAGTGAGGACGACTAGAGGTCAC TTTCATTGCAGTCTTGGTTTGGGTGGGCTTTCTCCAGCTTCTTTACTGCATCCTGTTTTATCATAGGGGT CTTTGTGACCCGAACTGTATATGGTGAAATCAGTCCTACCAACCTCCTGTCTCATTCTGTGACTAAGAAT GCATGCCTGCCCTCCTGGGAATGAAGCACAGCAGGTCTCAGCCTCATCTTACCCAGCCCCCCACTCAAGA TGGAGGTGCCTGGTTTGAACACCTCTGACAAATGGAAGTCTGTGTTGTCCAGAGGCAATGCAGTGGGGGC TTAAGAAGATAACTCTGGACTTAGACCGCTTGGCTTCAAATCAAAGAGTGCATGAACCAACCAGCTGGCC TAGTGATGATGTTAGGCAAGTGACTTCTCAGTTTCTTCATCTGCAAACTGGGAAATTTCCTATCTCAGGG TTAAAAGAGAGGTAATCTTAGGTGCTTACCTAGCACATGGTAAGTACTCAATAAGCACTAGCCATTATTC TATTATATTATTATTATTGTTATGTCCTCCATTTCCCCTTTCCTAACTACTTCCAACAAGGCTAGGACCG TTGTCAGAAGATCTCCTGGCTCCTTTCAACATTCTAACACAGTACTTATCACATACTTCATTTTGTTTTA TTTGGGATCTATCAGCCTCCCTGCTAGGATTTGAACCTTAGAGACAGAATTGTCTATCTTTTTCACCTGT TTTTCCTCAGCAGTAGCACTGGGCTTGGTACATGGTAGGTATTAAAAAGTATTTGTTGAATAAATAAATG AGTCGGTTGCTCCCTGAACCTCTGCAGGGACCTGCTCAGTTTGGGCCTCAGTTTGGGCAGGGCCAGTTGT ATGACTCATGAAGGACAGGACTACTTTCTTTTTGCAAATGGCTGATTCAGGATTTAAACCCAGGTCTGTC TACTGCCAGAGCCCATGCACATAGTCCTTGAATCTCTTTAGAAGAAAACAGGAGGAAAAAAGTCCCCAAG TCACCAGCCGCAAGGTAGATAAATGAGTTGATAGAGGTAAAGGAAGGATGCTGGAGTATAATGATTCCAT ATCACAGCCTCTGGAGCCAGATTGCTTTGTCCCAAATCCAGATCTACCATTTGTGAACTGTGTGATCGTA AGCAAGTTTCTTAACCTCTCTGTGCTTCAGTTTCCTCCTCTGTATAATAGGGTTAGTATATCTACATTAC AGAGTTTTGAGCATTAAATGAGTTAACATATTCTGACTTTAGTGCCTGGACATATAGTCAGCACCCAGCA CCAACAAGTGGTAGCCATGCTCTCTATAGCTGTATGTCCTGTCGCTCAACTAATGGGTGACCGTGCTGGT TTGGGAACCCAGTACTCCACCCAGTGCTCTGGGACCCCTGGCTTATTTCCTGTCTGGACTATGGCACTGG GTTGGGGGGCTGATTGCTACAGCCTGCTTTGGTCAGTACTGTGCCATCCTAATGTGGCTAATTGCCTTGG GGGTGTGCATTTCTTTCAGCAATACCTGAACACCTTCTATGGCTGCCCCAAGGAGAGCTGCAACCTGTTT GTGCTGAAGGACACACTAAAGAAGATGCAGAAGTTCTTTGGACTGCCCCAGACAGGTGATCTTGACCAGA ATACCATCGAGACCATGCGGAAGCCACGCTGCGGCAACCCAGATGTGGCCAACTACAACTTCTTCCCTCG CAAGCCCAAGTGGGACAAGAACCAGATCACATACAGGTGCCGGGGCAGGGCTTGGGGAGGCAGGGCCATG GGGCTGAGGGACACGAGTCTCCTTGACCCATGCATTCTCTCCACTCAGGGGATCCATGAGGTGTCTTTTG TGAAGGCTTGACATCTTAGGGAGTTTCAATACACAGTTCTTAGAAAATGAAGTCAGACAGACTTGAGTTT CATACTTGCTGGCCATGAGACATTGGGTTACTTTTCAGTGCTGTGAATGTTGGCTTTCCAATCTACAAAA TGGGGCTTAAAAAATGCCCTTATATGGTATGTTGGGGAACTAAGCTAGGCTGAACTAATACAAACGGCTT CTATGATTTTTGACACAGAGCAAGAGTGTAGTAATGCTAGTCATTGTTATTGTTTTTAGATGAGGTCATT GGGATGGGCAGAAGGAACGTGATGATTGGTAGCTAATTGGGTTTAGCAGCCCAATTGGGTTATAACTGGT TGCTAATTGGGCCAAGAGCTGTGCTCTGTATGGGTGGTGCTGGGTTCCAATGGTGGGATCTTTGCCCTGT GCCCCATAATGCACTACTTATGGCCCTCCCCCACCAGCCAGAAGTGACAGATGGAACTCCTGAGCTGGGG CCTAAAAATGTTGGCTGGCCTGGGACTCCCTGGGTCTTCAAGGCATTCTGGGAGGGTTGTCCTTGGCAGT GAGCCCTGCCCAGCCTACACACACATACACGCAGGCACATGCTCACATATACATACACATACCTGTGCAC CCTTCCCGTGCTTGTGCATATACTTGTATGTTCACATACACACACACACTCAAACTTTTTCATACATCTG TGCACACACACATACTTGCATATACATACACTTATGCACATGCATACACACTCACATGCAGTTCTACCAC CTCCAGGATCATTGGCTACACACCTGATCTGGACCCAGAGACAGTGGATGATGCCTTTGCTCGTGCCTTC CAAGTCTGGAGCGATGTGACCCCACTGCGGTTTTCTCGAATCCATGATGGAGAGGCAGACATCATGATCA ACTTTGGCCGCTGGGGTAGGCAGAAGATGGGGCAGAAGAGGGGCCAGCAGGGATCAGTGTTGAGACGAGG GGGTGAGATGGACATTAGAGGGGCGTGGGGATCCTAAGGGCGGCTTAGATAGGACAGTAGATGGTGTGGG CCCTGGGGGTGGTTTAGATGGGGGCAGCACAACACGGAGTGGACACTGGAGAGCCACGTTGACATGGGGG CAGATGGTGTGTTGTGGTATAACCTGGAGGCCGTCTAAACCCGAAGCAAGTGGTCTACTGTGCTGTCCAA TATGGCAGCCATTAGGCAGAATATACATGGCTGTTTAAATTTAAATTAGTTAAAAATTTTAAATTAGTTT CCTGGTCACACTGGGCACATTTTAAGTGCTCAAAAGACACAGGAGGCTAGTGACTATTGATTTTGGACAG CACAGACAAAGAATATTCCTCTTAATCACAGAAAGCTCTGTTGGATGATGCTGGTAGACACTGAGGAACT GTAGATATATGAGAGTGGTTTGGAAACAGTGGAGCAGTGTAGACACTAGAGGAAGGGTCGTAGAACCTGG GGCCAGGTGGCCATGTGAGTTTATGGTGTGAACACTGCCAGTAGCACAGACATAAAGGTATGTGGTATAG ACACTGAGTGGTAAGTGATGAAGGTAAAGAGCAGGGGAAACAATGTAGACAAGTGGGTGGGTGGTACAGG CCTTGGTGACAAGGTGGGCATGAGGATTCATGTTGCAGATATTGGTGATAGTGTGACATGAAGGCAGGAT TGTGGTTAAGAGGGCAGTATTGACAGGATGGAGGATGGCATAGACACTGGGGATGATGAAGATGGGGTGA GGACACTAGTGTGGTAATGTGGGTATGTGGTACATATAGTGTCATGGTGGTAGAGTAGACAATGGAGGTA GAGGGTATGGATACTGGGAGTCATGTAAACCTGGGAGAGCAGTGTAGACCATAGGATGGTAACAACCAGG TCAGCAGATCTCTACTGAGCTCCTGTTGACAGTCCTGGATAACCCCACTGGGACAAGGGAAGGGGACAGA TGCTGGGTGGGCTGACAGGCTCCACATGTAGATGGGGTGTGGAGGGGTTTCAGGGTCTAGGTGGCACAGC TAGACGCTAAGACCCAGTGTGTGTTTCAGAGCATGGCGATGGATACCCCTTTGACGGTAAGGACGGACTC CTGGCTCATGCCTTCGCCCCAGGCACTGGTGTTGGGGGAGACTCCCATTTTGATGACGATGAGCTATGGA CCTTGGGAGAAGGCCAAGGTGAGAAAGGGGCCCTCTGCATGCCCCAGACCTTCTCTCCTGTCCTCTCTCC ACTCCATTTGCTTGGACCAGAGAGGTGGGAGGGGAGGAAAGTCACACATCTGGGTGAGTCAGAATCTTGG TCTCCAAAGAAGGCCTGGAGAAGTCCAACCTCCCCCTTCCATGTCACTCTTTAGTGGTCCGTGTGAAGTA TGGGAACGCCGATGGGGAGTACTGCAAGTTCCCCTTCTTGTTCAATGGCAAGGAGTACAACAGCTGCACT GATACCGGCCGCAGCGATGGCTTCCTCTGGTGCTCCACCACCTACAACTTTGAGAAGGATGGCAAGTACG GCTTCTGTCCCCATGAAGGTGAGCATCCACTCTAGTCCCCAAGACTTTCCACCCCAAGCCTCCAGCTTCC CGGGCTCCCCAGTGTGCTCTTCCCTCCACACTCTCCAGGACTGGCTGCCACTGCCAGTTAATGAGCATCC CTCCAACGTCCTTCACTCAGTTCCCCCCCATCCTGATCTGAGCCATTGCTGTTTCTCTCCCACCAGTACC ATGATGAACGTAGTACTCTAATTAAATCAAGTTGATTTTTTTTAAGTTTCACCATTAGCAATCATTTAGG AAGTCACAGATTTGATTTGCTAATTATTTATTTCTAATATATATTGGAGTGAACTTAGAACTATTACAAT GCCCAGTGGTTCTCTCTAGAACCAGTCTTTACACTTCAGTCAAGATTGATACTTCAAGGGCATGAGGAAA GGCTTGCTGGTAGCTGGAAACCTAGCAGTGTGATAGGGAGGCAGGACTCAGACCAGGGCTGGACTCAACC TGGTTTGCGTACTCCAACTGAGGAATTTCAGCTATTGCTCCTGCCTTGGTCCTGATGCTGCCTCTGCTAA TGCGTGTGTGTGTGTGTGTGTGTGTGCCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG TCTGGGCACGGGGGCTATACTATCTGCCTCTCTTGGGCACTGTCTTTTTCTGCCTCCTGTCTAGCTTGTG TCTGCATCTCTGTGTCTTGATAAAGACTTTAGGCTTGACTCAGTATTTGTGTTTGTGTGCTTGTCAGTGC CTGAGATGCAACATTTCAGAGATTTTGAAGCCACATGGGGGAAATCTTTTAAAATGGGGTACAGATATTG ACATACACACTCAATCCTTTTTAAAAATATCCTTGACACACTTAATAGTCATAAATCACAAAAAGACAAT GTAACTTCATACTCTATGAAGTCATCATATTTGATAATTCTGCAGATTGAAAGCCCAGAAAACCTGGCGA AAATGGAAAAAAGTCTAAAAATTTTTAACACTATCTTCTTTCCCATGTCACAAAGACTCTATAGTCTACA TAGACTAAAGACTGTCTTTTTGTCTGTAATTTTATGTCTGTGAATCTCCCTAACCCCACTGTAACTGAAA ACTAAGCACCAACCATCTTGACAGAATGAAAGAAACAAAGAGCTAGTTAATTCCCTTCCTGTTTATGCTT TTACTACCAGAGCTAAACTTTATATTAAGTAAGAGTTTAAGCCATTCACCATTAATAAGTCAGACATTTT GAAATAAAAATATTTTTTGTATCTTGCGTTTCCCGGTAGGGATTACATGTGGCGTTAACCCTTCCCTGTG TCACCCCTCTGATAGGAACAGAAAGCTTTGGTGATAGTTAGATGTGGAAACAGCTGTATTTCATAAATTT GGGAAGGGTTATTCCCTGCATTGGACATTAGCCATTTACTTTGTGCTTAGCCAGATGCAAGTACGCACAA CACGCACGTGTCTGGGTCTCGAGGCAGAGATTGTTGTTACTCAGCCCCTGCTGATGGCTGAGTCAGTGTC TGATTCTTGCCATCCTTGTCAGGGGAATTTGGGAGGAGACAGGGGCTTCCTGGGTGGTAGAAATGAGAGG TCAGAGGCAGGGGGCTGGCATTGGTCGAAGTTAACGCTTTGCCTTTCTCAACTCTGAGGCCACTAAGGTA TCTGGACTCAGTCTTGCCTTTTCTCTAGGTGCCATTGTTTCTGGCATTGCAGGACAAGGTCTTTTGGTAG AGAGGGGAGTGGTGAGGATACAGGGCCTCGAGTTCTGTGGTGGGAGGCCAGGGACTGGGCTCCATTCCGG CCATGGTGGAGTTAACGGGGGCTGGTGAGGTCACCTCTGGCGCCGTTGTGCACAGATGGTCCTTGTTATG GACTTGTGGTTTTGCTGGTTGGCAATTCCAGAGACACCATTTTTTAGCTTTGGGTGGATGAGGGGAGGAT GGGGAGAATCCAAGACAGACAGGCCAGGCTCTGAACCCCACTCCCTCCCCCAACTCTCCATTTATGGCCC CTGTCTTGAAGATGTCAAAGTAGGAGCCCAGAGTGTTTAGTAAAAGGGACCTGAAGGCACCACCTCCCTC TCCCTCCCTCCTCCTCTTCATTCTTTCTCTCCTTCCTACAGAGACTGCAACAAGGCCATCCAGGAAGGGG CCTGGGGTTGACAGGAGGTAAAGCAAGCTTTCTGTGTATGCGTGTGCACGCACACACACATATATGAGAG TGACAGACTAAGCAAGAGAGATTGAGATTAGTGTGTTTTGTAGTTTTTAGTTACAACCTTCATTCACTTC TTTCATTTCTGTGACCATGAGCAGTTTGAGAACCATCTTTGTCCTAGCCTTGATTTCTCCACCTATCAAA TGGAGAGAGATTCTCGTGGTCCTGCCTGCCATGACTGATATATTCATGTCATACATCATTATTACATGAA ATTTGCATGGTACAGGTGTGGACCAGGCAGAATGGACAGTGCCCTTGGGGCTGAGGCAGGGTTCTAGAAG CCCTTGCTGTGTGCCAGGTGTCAATCATTTTGTTGTTGGGTGGTCCACAAGGTCCCACGGGAGGGATTGG GATAACCAGGGAAGCAGGGGTTCTCTCTGGGAGCTCAGAGAAGCAGCTCCTTACCAACCAGTAGAGATGT TTTCTTAATATTTTAACAATGCATCAACTTCACTGGTGTGAACCGGCAGGTGGGCAGCCAGCCAGCCCTG TGCCCATGGAAGCATGTCTCATTCACATCCTTCCCTCTCTCCCCCACCCTTAGCCCTGTTCACCATGGGC GGCAACGCTGAAGGACAGCCCTGCAAGTTTCCATTCCGCTTCCAGGGCACATCCTATGACAGCTGCACCA CTGAGGGCCGCACGGATGGCTACCGCTGGTGCGGCACCACTGAGGACTACGACCGCGACAAGAAGTATGG CTTCTGCCCTGAGACCGGTGGGTGCCACTCCCTCTCCCTCCCTCAGGGCCCAGCACCTGCTGTCTGACAA AAAAAAAACCCATAAGACTCCGAGTGCCCACCTCCTTTCCCCAAGACAGGGGTGCTAAGACATCTGTGCG AATGACATCCACACCAAGATGTCCGTGTAGCTAGTCAGGATACTTGTCACCTGGTATGGCCTGGGCACTG AAATCAGAACAGACATTGGGCATCAACAGTTGAATTGGTGACACTTAAATGTCAGGCCTGCTCAGGATCC TCTGACCGACCTGCATCCCTTTTCTCTCAGGCTCTCTGGCAGAGACTTCTCTCTCCTCCTCTCTGACCCT GCAATCTCTCTTCCCTGCCTTTCCTGGTCTGTATCTCCACCTTTTAGTCTGTTTTTTATTAAGAGCTCCG TGCTTTCCTCCCTGTCTCCTTCCTGCCCTCCTCTCTATCCCTCCCTCCTTTCCTTCTTCCCTTCCTCCAA CAGGAATTTACTGAGCGCCTGCTTTGTGCAGCATACACAGAGGTTGGTCTCTGCAAAGCCCTGCCCAAGG GGGCTCACAGCTGAGGGGCATGTGCTGGTGCCATCAGCTTCATCCAACTCCCTTTGCCCCTAGCCCATCT GCCCCCTTCCATGGGAGGCTCATTAGAACTCTGGAATCTGGCTTCCTGGGTTTGAATTGCAGCTCTGATA CTTCCTAGCAGTGTTGGCTTAGGGAAATTTCATCATCTCTCTGATCTATTTCCCATCCATGAAACGCGGT GCTATTCAGTCCCTCCTGCACAAGGCTGTTGTCAGGGGTGGGTGAGATGAGTCTAAAGATACAGTGCCTG GGACTGAGTCTAACTTAGGTGTGGTTCATTAAGGTCAGCGTCATGTCATTGCTTCCTGGTGGTAGCCTCA GACTCTTTGCTGCGCCTTGACCCGTATCCCTAACCCCACAGCCATGTCCACTGTTGGTGGGAACTCAGAA GGTGCCCCCTGTGTCTTCCCCTTCACTTTCCTGGGCAACAAATATGAGAGCTGCACCAGCGCCGGCCGCA GTGACGGAAAGATGTGGTGTGCGACCACAGCCAACTACGATGATGACCGCAAGTGGGGCTTCTGCCCTGA CCAAGGTACGAGGCCCTGGTCATTGGACAGAGACCCTGGACATTGCCCTTGCCCCTAAACTTGCTCCAAA AACCTTCCTGAGACCTCACCCACTTCAAGCATAGACACTGCCCCCCAGACACCCACCTACCCAGACCCGC CCACCTGGGCTGAGACAATGCCCATCTCTGGTGGAGCCAAGGTCCCTGCTTAGATCCTGCCCATCCAGGT GGAGGCACAGCCTCCAAAATCAGACCCTGGTAGACCAGATGCTGCTACTCACCTCCTGGGTAAGAACTGG CCTTCCTGAGGGGTCACTGCTCTTGTCTTCCCCTTCAGCCACCCTCCAGGCGGGCTTGTGACTACCAAAA TTGGCTGAATTCTGAGCACAGATTACCAGAGAGACAATTCTCCTAAGAGACATTCCCACTGCACAAAGAG GTGCCTTCAAGGAGCTGGTAGGCAGTAGAAGAAAGGAAAAAAGGAAGAGCCTCATGCTTGATCTGACACC ATGGTCCACGCAGCCCTGGGGGAGCCCCCAGAGCCCTCTCTCCCCCATCAGTCAGCACCATCTGTTACCA GGGTGTAAATGGTGGGTCCTCGTCAGTCCTGGGTGCTGAGGATGGAGCTGACTGGGACAGCTCTCTGCCC CCTAGGACTCACAAGCTCAGGGGAGAGAGTGACCAGGAGACAGCTTGTGACCTTACTATGTGCTCAGTGC AGTGAGCAGGGTGCTTGGGGCCCTGTGCCCAATCTAGGCTACAGAGCCCAGGGTTGCAGGGTTGCTTAAA GCTCCCTGATGGCCCATAATGGCCAGGTCAGTGGGCAGGTCCAGGGCCTGTCAGAATTAGGCAAGCCTGT CTTTATGTTGCTTTCATTCTTTTTAATCATCATGAGATGGAACTTGGCAGATGTCAGTGGACAGAGGCTG GCCAAAGGAGGTTTTCTTATCCCCTGCTAAATTCCTTGCTAGGACACAGTCTGATTTTACCAGCTTAAAG GTGGGATTCTCCACCTTCCTGAGTGGTTCAAGTATCCAGAGCTCAGTGGCTCACCCAGGGTGAATATTAT AGTCTCCTGGGGCTGCCATGACAAAGTGCCACAAACTGATGGCTTGAAACAAACCCCATGTATTCTTTCA TGCTTCTGGAGGCTGGAAGTCTAAAATCACGGCGTCAGTAAGGCCATGTTCCCTCTGAAGGATGCGTCAC TCCAGTCTATGCCTCTGTCATGACATGGATGGCCTTCTTCCCCCTCTGCTTGCCTCTCCTCCTTTTTTTT TTTTTTGAGACGGAGTCTTGCTCTTGCCCAGCTGGAGTGCAGTGGCATGATCTCGGCTCACTGCAACCTC TGCCTCCTGGGTTCAAGTGATTCTCCTGCCTATTTCCAAATAAGTTCACATTCACAGGTCCCTAGGGTTA AGACTTGGGCAAATCTTTTCTGGGGGGACGCATTTAACCACAACAGGGTGTGACACAGGTTTTGCTCGCT GGCTGTGGCTCAGCCTGTGCAACCACGCTAAGTGTGAAAGGTTTTTACTGCTTTCACCTGGGCAGAAATG GTGGCAACATGGGGCCAGCCTATCCCCACTCTTCTTACCTCTTCAGAGAGGCTGAGGAGCTGGGTTTGTA GAGCTCATCTTTTATAGAGAGACATAAAAAGCCAGGAAGCAGGATTTTAAAATGAATGGGGTTTTAAGTA GAAAATTCGCAGATACTACTTGTTCTGTTCCTTTATAGCACACCTGTCCTGATACTGACTTGGAAAGAGA CAAGAAGACTTTGGCTGACCCCACTTGGAAACAATAGGCACTAATCCCAAAATTGTGTATTGATCCCAGA ATTCTCAGGAAAAGAAAAAAAAAATCAATACATGCCGCTTCCAGGGTTCTCAGCCTTACTGTGGGGCTGT CCTCAAAAGTCTGCATCACTGGGTCAGGTCTTGACTTCTCTCTCATCTCTCTTCCTGTCTTTCAACCCTC TCTCCTCCCTGCAACCCTCAGGGTACAGCCTGTTCCTCGTGGCAGCCCACGAGTTTGGCCACGCCATGGG GCTGGAGCACTCCCAAGACCCTGGGGCCCTGATGGCACCCATTTACACCTACACCAAGAACTTCCGTCTG TCCCAGGATGACATCAAGGGCATTCAGGAGCTCTATGGTAAACCTCCGGGCGGGGGTTGGGGGTGGAGGG TGAGGAGGGGGGAGGTCATGTAGCCTGGGATGGAGGCCCAGGGGGTGGGACCAGCAAGATCTCATCCAGC CAGGAGTGCTGGAGACGAGGGCAGGAAATGGGAGTGTTGACCTGGTCTTGGGAAGGCAGAGCAGCTCTCC AAGGGGATACTTGGATAACTCTTCCCTATCCGAACAATGCTAATATCCATGTCACTCTTAGCGCTCCATT TCTGGGTTTCTCCCATTTTCTAGGTGAGTAAGGTCACCTGGTGCAAGGTTACACAGGTTTGAGCAACCCA GTGGAGTTTAGAATCCAGGAGAATAGCCAAGTACAGGACAGAATTTTCCATCATGTGGAATGACCTTAAC AATACGGGGGTGGAAGTTTCTAGTTTTCATAATAAGCTTTGATTTTTAGTATGTAGTAGAAACAGAACAA CCAGTGCCTTAAGCCAATTATTTATTTATTTATTTATTTATTTATTTATTTATTTATTTATTTATTGTTG GTTCTTACAGTGAGGCTAGAGTTTAAAAAGTCAGTTCATTTTTAAAAAATATTTAATGGTCCAGGTGATA TCTGAGCCAGGCCAAAATAGTGAAAGTGGTGCTTGAGTGATGAAGTTTGGGGACTGCTAGACTCAGGAAA AAGCCCAAGGTCTGCCGTGAGGGGTGCTGGGTTCAAATGTGGCCTCTGCCCTTCACTAGCTGCAAGATAT TGTGTAAGTCTTTATACCTCTTTGGACTCAGTTTCCTCATCTCTAAAATAATTGCTTATCATGAAAAGTG CCATACTGTCAGTTCTGGACACACCAGCGGCCCCCTGACCGCCCTGACTCTTGTGGGCATAAGAATCTGA GCTTTGGGTTTGAATCCTTGGGCAAGTCACTCAACTTTTCTGGGCCTCAGTTTCCTCACCTGTGAAATGG TGCAATCATGATACCCCACTCCCAGGGCTATAGAGAGGACTGATTTGGGTGATGTCAGTAAAAAGCATAT ATAAAGTACAAAGGGCCCCAGGACTCCCCAAGTCCAGGCATCTTCTTGTTACCTTACGGAGCTTACACTA AGGCCAGAAGGCGATTTCTTCTGACTCTTAGATGGTTGGGTGGGCACCCCTGGGGGCTCACCCTAGTGGG GAGAACCTCTGGAGCTGCAGAGAGTCTAAGGTCAGGTGTTCTCCCCAGGGGCCTCTCCTGACATTGACCT TGGCACCGGCCCCACCCCCACGCTGGGCCCTGTCACTCCTGAGATCTGCAAACAGGACATTGTATTTGAT GGCATCGCTCAGATCCGTGGTGAGATCTTCTTCTTCAAGGACCGGTGAGTGCAGGAGCTTGCTTCTTGTC CTCCTTGTCTCCTGTCCTCTGCTCTTATACCATTATTCTTTTCCCTCACTCTTCGCTGAAGACTCCGCCA AATGCTTCCCAGAATGACCTGAATTAGGCAGTTTCTGCTGTGTATCAAACAACCTCCAGGTTTCAGTGGA TTTGCACCCAAGCATTTTGTTTGCTCTCTCATAGTCTGTGGGTCTACTAGTTATCTTGACTTTCAGCTAC AGTTTGGGTTCAGGTGTGCTCTGCCTGTTGTTCTCATGGGATTAGCAGCTACTCATGGCAGATGACAGGG TGCAAGAGGCCAAACTGAACTACACAAGCTCATTTAAAGCCTCCACTCACATCTTGTCTGAGAATATTCC ACTGCCTGAAATAAGTCACATGGCCAATCCCAAGACCTACCCTAGAGGGTAGTACTGCAAAGTCACATGG AAATGCATATGAATGCATAATCCTAAAATCAAAATGGAGGGAAGAATTGGGAACCATAATTCAGTCTACC ACAGGCCTTCTAGAATGGCGTTGCCCTCAAATGGCCAAATTACTCTGTGTATGGGTGGTGAGTGACTGCA GAGTAGAAAGAGGTGGTATTCTTCATGCTATAGATAAAGATCACCACTCAGTTGACTAAAGACTGAGGTT TACCCTAATGCCCTAGTTCCCTGGAGAATGGCAGGCAGTATCTAGGACCTCATTAAAGGGTCTGTCCTTC CATTCTTCTATCATCCATCCATCTACCCATCCATCCATCCATACCTATATCTTTCCATCCATCATCCATC CAGCCAGCCAGCCATCTATTATCCATTATTTATGATCCAGCCATCCATTATTCATTATTCATCCATTTAT TCATTCATAGAGTATAGTAGTTGAGAAAATGGACTCTGAAGCCAGATTCTCTGGGTTAGAATTCTGTAAC TGCTACTTACTGGTTATGTAATCATAGACAAGTTAATTAAGTATCTTCTTTGTACCTTGGTTTCCTCATT TATAAAATGGGGCTAATATTCCAACCTATCTCCTAGGGCTGTTGTAAGGATTAGATGAACTTAGTGCTGA GAACAAAAACAATGCCTGACACAGAGTAAGTGTATTCATATTAGCTATTGTTATTGACAAATAATTGTTT GGCATCTACTGTGCCAAATACTTTGCTAGGCTTTAGTAGCTGGAGGAGGAAGAATGATGTTCTCGGGACA GTGGGGTGGGGGGCTGCTAGATCAGTGTTCTCAAAGACAGGCGCATGGGCCTCCTATAACAGAACCATCT AGAGTGTGGGTATTAAAAGGTGGGTTTTCTGCCCCAGCTTCAGACCCTCCTGACTGGAACTCTGGGGCTA GGCCCCAGGAATCTGCGTTTTAGCAAATTCTCCCAGTGATTCTGATGCACATTAAAGTTTGTGCATCACA AGTCCAGTTTGAGAAATAGGCATGGAGAACTGACATGGCAAGATGAAAGAAAAGTGATCGCAGAGGTGTT AGGTGCTTTTGTGAGCACGTCCCAGTCAAGGAAGGCTTCACAGATGCAGCAGCATTTGAGCAGAGCCTTC AAAGGAGAAGCAAGAATCTGATGGGGGTGACAAGTTAGGAGGTTCTTTGAGACAGAGGGACCTGCAGAGC CAAGCCATAGTGATGTGAAAGTTTCTGGATTAGCCAGTGAGAATCTGGTGAGGCTAGAAGATGTTCCATA AACTTTCAGGAAGAGTTTCCTCTACTCTAGGCACTGGGCCAAATTCTGGGGTGCAGATGCCTTGCCCTTC ACAGGGTCTGCTGGCCAATGGGGAAATGGCAAGAATGCAATGAGAGATGAGACTTAGAATGTAGTGAGAA ATCAGGTCCCGTCAGGCCTCGAATGCCCAAATCAGGATATATAACAGCAGATGTCAGCACTGCTCTGCAG TTCCCATTGTAAGGATCTGGCAATGTGCTTCATCTGGAGCTCCTCCCACTAAGAAAGCCCTGACCACACA TGCAGATCTCAGATGTGTGGGGCCTAGGAAAGGATGCAGAGCCCAGACCCAGGCTGGAGCCATCCCTGGC CTACCACATCACAGTTTTCTTTCAAAAGGAACGTGATGAGTGTTTAATGGGTTTATTTGATTAACCAGTA AATATTAAACTTCAACCATGAGCAAAAATTGCTGCTAGGCACTGGTGAGGGTGGGGGTCATGAAGGACAG TATTGCAGGGTGATTAAACTCAGACTTTGGAGTCAGATCTGGATATGAATCTTGGTAATAACTAATTTAT TTAGTCATTGATGTAGTGATAACTAAGTAATTTGAATCCTAACCTCTCTGAGCTTCATTTGCTAAATAAA AATTGTGACACCTTCCTACGCTAGGATGTTTTTCTGCAAATAACAGAGACCATCCCTCTGCAAACTCAAT CCAGCCTAAACAGTAGAGAGAAATTGCTTTCATTTGGTACAAAGTCCAGGGGTAGAGCTGCCTGCAGGGG CAGAGAGAGGGTCAGTGACTTGATGTCTTTGTCCACTGCTAGCCTCTGCACTTACTTCATCCTAAGGCCG GTTCTACCTCATGGTCACAAGAAGGTTACCAGTGGCAGTTGGGGCTCTAATCCCTGCCCTCTCCCAGGAA GCGAGAGAGAAAGAGACACGCACAGATACACACACACAGACCCCCAGATGTGAAATACAAGTCTGTGTGT TCCGTCTTTACACCACTGTAAGTCATATGGCAACTGCTGAATCAGTAACAGTGCTAGGGAATGCTAAACT CTGATTGGCTTAGACCAGTAGTTCTCAAACCTTGGCATGCGTTAGAATCATCTGGAAGGCTTGTTAAAAC ACAGATTCTGGGCCCCAAGCCCAGAGATTCTTATCTGTAGATCTCTGTAAGGACCCAATCATTTGCATTT CTAATGAGTTCTCAGGTGACGCAGATGCTGCTGGTCAGGAGACTGCACTTTGAGAACCAGTGGCTTATAC CAATCAGTATCTACCCCTAGAATGGGGGTAGGGGACACAGGGTCAGAGGAGGTGAAGGCTGGATCATAAA TGTGGAGTTTTGTGAAGAAGGATGGTGGGGAAATAGATAATTAATGCTAGGTAGACCATCCAGAGTGCAT GCTGTCTTAAAAGATTGTGGGGATTAAATTACAAGGCACATAAATAAAGCACATGGCATTTAGTAGGACC CTCAATAAATGATAACTCTTACTCTTGACAAAGTACACAAATTCATTTCATTTTAATTCAGGAAATACTT GAGTGTCATCAGCTCCTGCCCCAATTGGCCTCTAATCAAATAGGAGAGTTAAGACAAACAGACACTACTG TTCCAGGCACTCAGAGTTGATGATTTTGAGAGGCTTAGAGAGGGAAAACACAATATGGATGGAGGTAGTC AGGGAAGGCTTCCTGGAGGAGGTAGAGGGAGAGAACAGGGTAGGAGGATGTTTCTCAGCTCCAGCAGATT GCAGACAGGAACTCTGCCCGTTCTCCAGTCCTTCTCCAACCTTCCTTTGATCCTGCCTCCCACTCCCATC ATGGAATCATCTCTGGGATGTTTCTGGGTGGGTTTGGGGGTGTGTGTGGTTCGAGCTGCAGGGTGACTGA AGATGTGGTTTCCTGTGCCCCCTTGCCTCCTGCCAGGTTCATTTGGCGGACTGTGACGCCACGTGACAAG CCCATGGGGCCCCTGCTGGTGGCCACATTCTGGCCTGAGCTCCCGGAAAAGATTGATGCGGTATACGAGG CCCCACAGGAGGAGAAGGCTGTGTTCTTTGCAGGTGTGTGGGAAGCACCCTTCCTTGGCCCTCAGCTCCA CAGGGCTCTGCACCAGGGCTCCTGGGTGTCCCAGGCTCACTCCCCCTCTCAAACCACAGTTCCTATGCAC CCGTGGGTGCTCCCTTTCCTTTATGGATTCATTCTTTCAACATTATTTCCTGAAGTGCGCAGCTCCTCTG GGAGATTGGTTCCGACACCCAACATCAGATAGCATTAACCCTCAGTGTACACATTTCATTTTCTTAATTC TTTTCAATCCGTCTCATTTCTTTTCTAGAAGAAAAAAAGTCTCAGTTTAGTGCTGGTGTGTCCCTAACGC CTTTGTAGTGATACAGTCTTTGGCAGGTAACAGTTTTAGTTCGAATGTTTTAAAGAATATTTGTTTTCAT TTTTACTTTTAGACATAAATTGGTTTTAACAGAGGCAGTTAGTTATAATAGTGTGGAGTTTCAAATCAGG ACAGAAACGGATTATTCAGTAACTGATATTTTGACAGTCAAAAAACATTTTTTAATAAATTTATTTTTAA AGATTTCAAAATGAATTCACTGAAAGCAGAATGTTAAGTAAATAATAGTACAGGGAGCCCCTAGAAGTGG TAGAAATCATCAAGGTGAGGTCTGTATGGCTAAGGTTTACTCATTTAACATTTATTGGAGCATTTCCATG CGCTGGGCTTTGCCATACCCTGGGGATACAAGCTCTGCCTTCGCGATGCTCACAAACCACTCAGGGAGAC AGACAGCTGGGCTCTTATGAGGGGTAAAGAAGGATTTAGGAGGTCCCTGTCCTGGTCTGAGGTGGGATCC TAGAGAAGATAAAGGCTCAGCCAAGACTATTGTCTCCACCACCTGGCTCCCACCTCCCCCAATCCACCGT AATCATGGGTCCCGGAGAGGACAACTGCTGGCTCCTAGGGCACCTTTTTGCAAATTAGCAAAAGGTGCCT CTTTATGACAGCAAGGCCCTTAGAGTGCACGACTTGGTGAGCAGAGTGTGAGCTGGATTTATCCCCCAAC TCATGTCCTTGACCAGGCACCTTCTGTAATTGACTTCTAAAGCCCTCTGTGTGAGCCCTGATTCTGGGCA CTGCAACCAGGAGTGAGCAGGAAGTTGCACTCTGTTGGGAATGGCTGCAGTGGGGCCCGTGGACAGACAG ATGATGGGAGGAACAGGCTGGCCTAGGGCATGTCAGCACCAGCCAACACACCCTTTGCTTCCACCCCAGG GAATGAATACTGGATCTACTCAGCCAGCACCCTGGAGCGAGGGTACCCCAAGCCACTGACCAGCCTGGGA CTGCCCCCTGATGTCCAGCGAGTGGATGCCGCCTTTAACTGGAGCAAAAACAAGAAGACATACATCTTTG CTGGAGACAAATTCTGGAGGTAAGGGAGGGCGGTGGGTAGGACAGCAGCACAGTTGGCTGCGAGAGACAG AGAAGCCGCCCTGAGGCTTCAAGCCTCCTGGGCTGAGTTCAGAGGTTGGTGGGCTCTGGATGCCCTCTCT CTGGTATCTAACCTCTTTGGTCTCTGGCACCTCTGAGATGTTGCCAAAGGTGAACCATTCTTGTACACAT TGCTGATATAATTCTGGTGGAATATCCTTTCTCTTTGCAGAATTCTTTTGATTGGCCCATGTCTGGTCTG GACCCTCACATTTTGAAATGACTCACTGAAGAAGGGGGTAATAAAAATAAAGATAATAACTGCTCCTATT GACACTATGTGTCAGAGACTGTCCCAAGGGTTCTATGGGATAGGAATTATTATTCCTCCCATTTTACAGA TGAGGAAACCTGGGTTCAGAAAGGTTAGGTAACCGTGGCTGGGCACAGTGGCTCACGCCTGTAATCCCAG CACTTTGGGAGGCCAAGATGGGTGGATCACTTGAGCTCAGGAGTTCCAGATCAGCCTGGCCACATGGTGA AACCCCATCTCTACTAAAAATGCAAAAAAATTAGCTGGACATGGTGGTGCATGCCTGCAATCCCAGCTAC TAGGGAGACTGAGGCAGGGGAATCACTTAAACCTGGAAGACAGAAGTTGCAGTGAGCTGAGATCATGCCA CTGCACTCCAGCCTGGGCAACAGAGTGAGACTCCAACTCAAAAAAAAAAAAAAGAAAAAAGAAAGGTTAA GTAACCAGCTTGGAGTCACATAGCCAGGTAGGGACAGGTTGGGATTTGAACCCTGGCATTCTGTCTCCTG GGAAAACATGTTAGTCTTCACTCTTCACTACTATTCTATACCCGAGATGGTGGAATGGGGGTTCCAAGAG ATGGGGGAACATGAAGGCAGTGGACAAAATATGAAGAAGACTTAGAGATGGGTGCACCAGTCATCCATAG AAGCCAGCATCCAAATCAGACCCCATGGAAGGAGCAGGTGCCCTGTGTCATGCTCACAGCAGGCCCGTGG CTGTGGGTGCAGGTTGGCAGGGGAACAATTTGGAAGCAGATGGTTCTGTGCTCCAGGTTATCTACAGGAA AGGGTCCAGTTCTGAGGGGCTATAGTCATGACCAGGGAACCTAATATCCAGGAGTGGCTGGTGAGAGGTA GCCCAAACCTCAGGAGTTTGACTGTAATTCTTCACACTTTCTAGAAAAGGAAACGGAGGTCCAAAGAAAT TAAATAACTTGTTCAAGCTATAGAGATATGTGTATTTGCACAAAGCCAGGATTATAGCTACTTCTCTTGT ATTCTAACTGAGTACCCCCTCCACTATACCTGCCAGTCCATTTGATTAGTGAGGAAAGAGTGGTCGGGGC ACAAAGACTTGTGGTGTGTCTTTCCATCCCCTCCCTCCTGGTATCCCCACATTCCTTCCATGGCTGCCAC TGCATCTGGGCCCTACCCAAGAATTTTAGAGGGCACTTCCTGAGGCCTTTGTCTGCCATCCCCAAAACAA TCCCGCTTACTTCCTAAGGCCTCTGTCTTCTCCCCCTTCCCTCCTCCCCACTACTCTGCCCCCCAGCTGC CCTGCATTCAGAAACTCTTTATATCCCAGGCCTGCCCATGTCAGGGTGGAATTCCAGACATATTGCTAAG ACACTTAGCAACCTAAGCTGATTGATATCTCAAGCCTCAAGAAAGAAAACAGTCAGGCAGGAAACCACAG AGCAGGCTTTCCACCCACCAGCTCCAGACACTAGCCCCAGACAGTGTGCACGCACACGCACACACACACA CGCGTACTGCGAATGGCATCTCAGCATTGTAGGAGCCCTGAATCTCCAAGTCTTAGAATTGTGGCTGGTG AGCCGCACAGACTCACAGAAACGTGAATCTTAGAATCCTAAAGCCCTGAAGTTTTCAAATTATGGTGTTG GAAGAACTTTTTAAATCACTTTTCCATGCACTGTATCTATGTAAACATGCAAAAACAGACCTGTTCCTAG CATATAGGAACATGATTGTGTGCGCATGTGCGCATACACACACACACACACACACACACACACACACACA CACACACACAGGCATGGAGGTTGTGGCAGTGCCTTGCTGGATTTCCAGGCAGAGTTATTTGCCTCCCAGT CCTTTTCCACACAAGCCCACCTCCCAAAGCCAGAGCCAGGACAGACAGCGTGCTCTACAGAGGAACCACC CTGAGACTTCCTGAAAAGGGACAGAGCTGAAGGGCCTATCAGAAGCTCTGGGCTGGCTTCCAAAGGAGAC AGATCTCTATTCCAAGAGAAGTGGTGAATGAGCTTGTGACACTGGCCCTGCCGTGGAGTCTGCAGAGGCC CCAGAGGCATCTTTGCTGGAGAAGGAGAGAGAGCCCCAGAGTGACAGAGGCTGAGCAGCTGTCTTCAGCA TGCCAAGAAGAGCTCAGGCCCTGCTTGTAGAAGCTTTCACTAAGCCACAAATATATGTTCCACATCTGCT GTGTGCCAGGCACTTAGCTAGCTGCTGGAGAGACGGGGGTCAAAAAATCATCACACCCTGCCCTCATGTA GTTTATAGTAGAATGAGGGAAAATTATGTAAACACATTTGAATCAGATAATGATGGCTCTCAGTATGGGG CCTCTACCATAGCCCAGCCTGAGGCTATGCAGGTCACCTATATTTCTCAGTTGAGGTAGATACTGTTAGC TCCTTTTCCCAAGTGTGGAAACTGAGGCTAAAGTGGCTCAAGGAAAAGCTGGGACACAAATATCTGTGTT CTTAACACCTGCTATACATGGCAACTTCTACAGCTGCAGAGAAGTACCACATCTTCTGACACCACAGTGC TTGTATTCTTTCTGGATGAAAAGAACTTGGAAGCAAACTAATTCTCTTATCTGAGACTCAGTTTCCTCAT CTGTAAAATGGGCTTGACTTCTGCCATCCCCACCTTCTGTGGGTAGAATGAGAAAGAAATGAGGGCCAGT TCAAGTGTGGGACACACATCTCCAAACTATCCTAACGCTAGGGAATGTAGTTTGAGGGCTCAGTGGAGGT GCCTTGGATGGGAGTGTTGGGATTTTGAGCTAGGGAACTTGGTTTTGGTGACCCAGGGCATGAGGAAGCA TGCCAGGTTTTGTAAGAATGAGTTTTATGCTGCACCTGGGATTAAGGAAGGCGTTAGTTCTTCGGGGTGA TGGCTGAGGGAGAAGTCCCTTTGAGGGAGAAGTCTCCTCTAGAAGGGAGCATATAGGGAAAGCTGCTGTT GGGGTCCAGGGTGGAGGTGGTCAAGGCTGGCTGCAGAAAGGAAGGGAGCCCCCTAGGAGGCACTGTGGAG CAAAAGGTGGCTGCTACCAGGATGGGATGCGAACACAGATTCATCTAGAAACAGCTCCACTTGGGCAAGA CTTGTTTACTAGGATATCCATAGCTCCCATAGTGGGAGCTCAGTAAATATTTATGGAATAATGAAGTGGA GAGGCAAAGGAATCAACATGACAGCAGCATTTAAAAAGTTCTCCAAAAATCTTAAAAGACAGAAGGATTG CTAGCCAGGGAGAAGAACATACTAACCGATGCCCAAAGTATTTACCTGAATTAAAGGCGGGGCCCAGGAT TGCTGCCGCCGGAACTGAGGTGGCATGTGGCCCACCCTGTGACTAACAGGCCTTGGACTTACACGTACCT TCCACCTTGCATTGTAACCTCACTGCCCCAGCCATGGTCATCTCCCAGGGCAGGGACTGTCATCTCCCTG TGGCAGATGAAGAAGCAGCAATTTTTCCAAGCCATGAAGTGAAAGAATGATGGGGCAGATTCCCATCCCT GGGCTTCTAGTTTAGCACTCCTCGGATTACAGCAGGGATTTGTTTGTAAGGGAGCTAACATTTCTTAAGT ACCTACTAAATATTTATGAGACATGGGGATAGAGGCTCTGCATGTGCTGTTTTATTTAATGCATGCATTA AATTAAATACACTAAATTAGACACAACCCCATTTTACAGCTGGTAAAACTGTAGCTGTATGGAAAGTGGT TAACACACTGTTTGGCATGTAGTAAGTGCTTTATAAATGTTAGCAGTAATCATGAGATTGTTTTTATGGG GTCATCCAAAGTCATATAATTAAAAGTGGTAGATCTGAGGCTCAGACTCAGGTCTGATTCCATGCCCTTC CTTCCACTGCAGCTGGCTGCTTCCCTGAAGGGCTAGGTCCAGTTTCCGAGGCCTATCCAGGAGCCATCAG CTGGGTGCTCCCATCCAGGCCAGGGGGGAAGTGTCCTTTAGAGAGGCCCTGCTGGTTCACTGTGTCTGTT TCTTTACAGATACAATGAGGTGAAGAAGAAAATGGATCCTGGCTTCCCCAAGCTCATCGCAGATGCCTGG AATGCCATCCCCGATAACCTGGATGCCGTCGTGGACCTGCAGGGCGGCGGTGAGCCACCCAGGACTGTCT CCGCTTTCTAGGACTCCCCGCCCCTAGCCAGGGCCCAGCTCCTTGCAAATACACACTTCTTTATTGTGCA GGGCAGGCAGGCAGGCGGCGCCCAGGAAAACAAATCAACTCCTTCATCCTAGTGCTGGGAAGGTTTCCAG ATCCCTGACCTCTGCTCCTTGGCCTGGCTCCAGGCAGTAAGACCCAGAAAGACTTCTCACAGCTGCAGGG CCTGGAGCCAGGGCAGGGGAGGGCGGAAGGCCTGGGCCAGGGGAGAAGGAACATGGGCTCTGTGCCGTGG ATTCATTCTGGGGTTTGATCCAGGCCCATTTGCGTTTTGCAGGAGGCCTGTGACCACCTCCCATTAGCAG AAGGATGGCTCCATTTGAGACAAGGCAAACTTTGTCATGCTCTGTTGCTCATGTGGCAAAGATCCTCCAC TCAACCAGTTTGCCCCTGGCCCCCTGCTGATTAAAACACAACCAGTAGCAGCGAGGGATAGAATTTGGAG TTTGAAAATCATACTCTTGAGGAGGCATCTGTGAGCTTTCTAGGGTCCTGGAAATGGGTCCAGTTTGGCT TTTTTTAGAGGAGATTTCAACTAAATTCCACAGATTTTTTTTTTTTTGAGCACCTACTGTATGCTAAGCA CAGGCCCTGACCTCCAGTAGCTGAAGGTCTTACATGTCCAAGAAAATGCAGTGTACAATCAGATGCTAGA TTAGGAGTTATCTTCAAGAATAAACATCTATTGAGCACCTACTACATGCTAGCATATTAATAGTAAATGA GATTATGTATGTCAGGAGTCACAAACTCCAACAGCTCCATGTGTCAGGCAGGTAGCACAAATGAGTAAAG CAGGCAGGGGCAGACAGTGGGGAACTGTGGAGTCTGTGCGGAATCAGAGCACATGCCTCATTTACAGGAG ACACTTTCTTCTCACCTTCAGATAATTATTGGCGGGCAAGATTAGGGGCCTAGGCAGCTGCCATGGTTCA CACCTGTCATCCCAGCACTCTGGGAGGCCAAGGCAGGAGAACTGCTTGAGCGCAGGAGTTTGAGACCAGC CTGGGCAACATAGTGAGACTCTATCTCTACAAAAAAATTTTAAAAAACATTAGCTACACATGACGGCGCA TACCTGTAGTCCCAGCTACTGGGGAGGGTGAGCAGAGAGGATCGCTTGAGCCCAGGAGTTTAAGGCTGCA GTGAGCCGTGTTCATGCCGCTGCATTCCAGACTGGGTGACAGAGTGAGACCTGGTCTCAAAAAAAAAGAA TGGGGCCTGGTGTTGTTAGATATTCTATATTAGATATTCTAGTTTTTTTAAAGGAAGCCAGAAATCTGTA CTTCTGTGTGACTTTTTGGATGTTTACATGTTGGCAAGTTATTCAGATTTAAAGACAAAACAAAACAAAC TTGTGAGAGTCAAATAAAACCCATCTGTGGGCCTGACAGGACTGGATATATCCTGTTTTGCCACCTCTGG TACATGGAATGTGCTTAGTTTGATGCTTGTGTTAAGTGGAGTTATTGTTTTTAATAATAGCATATGTTAT CTGACTTAATGCTCACTGCAAGCCCTAGAAGGTTGATAATCTTTATCCTCATCTTAGAGATGAGCAAACA GGGAATAAAAGAGCTTATTTCACAGCCATTTCCCTTCTTCCACTCCCAGAGGGGGCTCTTCTGGGCTTTT GTTGTGTTTTGGTTTTGTTTTTGTTTTCTTTTCTTCAATCAGCTCAGATTGAAACAATTGAATTTTTTTT TTTTTTTTTTTGAGACAGAGTCTCCCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTTGGCTCACT GCAAGCTCCGCCTACTGGGTTCACACCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGC CTACCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGAGGTTTCACCATGTTAGCCAGGATGG TCTTGATCTCCTGACTTCGTGATCTGCCCGTCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCA CCGCGCCCCGCCACAGTTGAGTTTTTTTTTTGGCGGGGGGACAAGGTCTTGCTCTATCACCCAGGCTAGA GGCACAATCATAGCTCACTGCAGCCTCGAACTCCTGGGCTTAAGCGACCCTCCCACGTCAGCCTCCTAAG TAGCTTGGACTACAGGAATGTACCACTATACCCAGCTAATTTAAATATGTTTTTCGTAGAAATGGGGGTC TCTCTATGCTGCCCAAGCTGGTCTCGAACTCCTGGGCTCAAGCAATCCTCCTGCCTCAGCCTTTCAAAGC TCTCTTCTCGTTTAAAAGCTTCTTCCCTATGCCAGGCAGAAATTCAAAGTTCCCAGGAACCTTCTGTGTG CCAGAATGTCAGGATAAGGGGGTCACGGTCTCTTCTTTCTCTATCCCAGGTCACAGCTACTTCTTCAAGG GTGCCTATTACCTGAAGCTGGAGAACCAAAGTCTGAAGAGCGTGAAGTTTGGAAGCATCAAATCCGACTG GCTAGGCTGCTGAGCTGGCCCTGGCTCCCACAGGCCCTTCCTCTCCACTGCCTTCGATACACCGGGCCTG GAGAACTAGAGAAGGACCCGGAGGGGCCTGGCAGCCGTGCCTTCAGCTCTACAGCTAATCAGCATTCTCA CTCCTACCTGGTAATTTAAGATTCCAGAGAGTGGCTCCTCCCGGTGCCCAAGAATAGATGCTGACTGTAC TCCTCCCAGGCGCCCCTTCCCCCTCCAATCCCACCAACCCTCAGAGCCACCCCTAAAGAGATACTTTGAT ATTTTCAACGCAGCCCTGCTTTGGGCTGCCCTGGTGCTGCCACACTTCAGGCTCTTCTCCTTTCACAACC TTCTGTGGCTCACAGAACCCTTGGAGCCAATGGAGACTGTCTCAAGAGGGCACTGGTGGCCCGACAGCCT GGCACAGGGCAGTGGGACAGGGCATGGCCAGGTGGCCACTCCAGACCCCTGGCTTTTCACTGCTGGCTGC CTTAGAACCTTTCTTACATTAGCAGTTTGCTTTGTATGCACTTTGTTTTTTTCTTTGGGTCTTGTTTTTT TTTTCCACTTAGAAATTGCATTTCCTGACAGAAGGACTCAGGTTGTCTGAAGTCACTGCACAGTGCATCT CAGCCCACATAGTGATGGTTCCCCTGTTCACTCTACTTAGCATGTCCCTACCGAGTCTCTTCTCCACTGG ATGGAGGAAAACCAAGCCGTGGCTTCCCGCTCAGCCCTCCCTGCCCCTCCCTTCAACCATTCCCCATGGG AAATGTCAACAAGTATGAATAAAGACACCTACTGAGTGGCCGTGTTTGCCATCTGTTTTAGCAGAGCCTA GACAAGGGCCACAGACCCAGCCAGAAGCGGAAACTTAAAAAGTCCGAATCTCTGCTCCCTGCAGGGCACA GGTGATGGTGTCTGCTGGAAAGGTCAGAGCTTCCAAAGTAAACAGCAAGAGAACCTCAGGGAGAGTAAGC TCTAGTCCCTCTGTCCTGTAGAAAGAGCCCTGAAGAATCAGCAATTTTGTTGCTTTATTGTGGCATCTGT TCGAGGTTTGCTTCCTCTTTAAGTCTGTTTCTTCATTAGCAATCATATCAGTTTTAATGCTACTACTAAC AATGAACAGTAACAATAATATCCCCCTCAATTAATAGAGTGCTTTCTATGTGCAAGGCACTTTTCACGTG TCACCTATTTTAACCTTTCCAACCACATAAATAAAAAAGGCCATTATTAGTTGAATCTTATTGATGAAGA GA Download Select all
Length	27506
OMIM ID	120360
HGNC ID	HGNC:7166
Unigene ID	Hs.513617
Ensembl ID	ENSG00000087245
PharmGKB ID	PA30877

mRNA Information

mRNA ID	?NM_001127891.2
Exon
mRNA Sequence	>gi\|700274110\|ref\|NM_001302508.1\| Homo sapiens matrix metallopeptidase 2 (MMP2), transcript variant 3, mRNA GTGCAGGGTGTCCTAGCCAAGCCGGCGTCCCTCCTAGTAGTACCGCTGCTCTCTAACCTCAGGACGTCAA GGGCCTAGAGCGACAGATGTTTCCCAGCAGGGGGTTCTGAGGCTGTGCGCCCAGATCGCGAGAGAGCAAT ACCTGAACACCTTCTATGGCTGCCCCAAGGAGAGCTGCAACCTGTTTGTGCTGAAGGACACACTAAAGAA GATGCAGAAGTTCTTTGGACTGCCCCAGACAGGTGATCTTGACCAGAATACCATCGAGACCATGCGGAAG CCACGCTGCGGCAACCCAGATGTGGCCAACTACAACTTCTTCCCTCGCAAGCCCAAGTGGGACAAGAACC AGATCACATACAGGATCATTGGCTACACACCTGATCTGGACCCAGAGACAGTGGATGATGCCTTTGCTCG TGCCTTCCAAGTCTGGAGCGATGTGACCCCACTGCGGTTTTCTCGAATCCATGATGGAGAGGCAGACATC ATGATCAACTTTGGCCGCTGGGAGCATGGCGATGGATACCCCTTTGACGGTAAGGACGGACTCCTGGCTC ATGCCTTCGCCCCAGGCACTGGTGTTGGGGGAGACTCCCATTTTGATGACGATGAGCTATGGACCTTGGG AGAAGGCCAAGTGGTCCGTGTGAAGTATGGGAACGCCGATGGGGAGTACTGCAAGTTCCCCTTCTTGTTC AATGGCAAGGAGTACAACAGCTGCACTGATACCGGCCGCAGCGATGGCTTCCTCTGGTGCTCCACCACCT ACAACTTTGAGAAGGATGGCAAGTACGGCTTCTGTCCCCATGAAGCCCTGTTCACCATGGGCGGCAACGC TGAAGGACAGCCCTGCAAGTTTCCATTCCGCTTCCAGGGCACATCCTATGACAGCTGCACCACTGAGGGC CGCACGGATGGCTACCGCTGGTGCGGCACCACTGAGGACTACGACCGCGACAAGAAGTATGGCTTCTGCC CTGAGACCGCCATGTCCACTGTTGGTGGGAACTCAGAAGGTGCCCCCTGTGTCTTCCCCTTCACTTTCCT GGGCAACAAATATGAGAGCTGCACCAGCGCCGGCCGCAGTGACGGAAAGATGTGGTGTGCGACCACAGCC AACTACGATGATGACCGCAAGTGGGGCTTCTGCCCTGACCAAGGGTACAGCCTGTTCCTCGTGGCAGCCC ACGAGTTTGGCCACGCCATGGGGCTGGAGCACTCCCAAGACCCTGGGGCCCTGATGGCACCCATTTACAC CTACACCAAGAACTTCCGTCTGTCCCAGGATGACATCAAGGGCATTCAGGAGCTCTATGGGGCCTCTCCT GACATTGACCTTGGCACCGGCCCCACCCCCACGCTGGGCCCTGTCACTCCTGAGATCTGCAAACAGGACA TTGTATTTGATGGCATCGCTCAGATCCGTGGTGAGATCTTCTTCTTCAAGGACCGGTTCATTTGGCGGAC TGTGACGCCACGTGACAAGCCCATGGGGCCCCTGCTGGTGGCCACATTCTGGCCTGAGCTCCCGGAAAAG ATTGATGCGGTATACGAGGCCCCACAGGAGGAGAAGGCTGTGTTCTTTGCAGGGAATGAATACTGGATCT ACTCAGCCAGCACCCTGGAGCGAGGGTACCCCAAGCCACTGACCAGCCTGGGACTGCCCCCTGATGTCCA GCGAGTGGATGCCGCCTTTAACTGGAGCAAAAACAAGAAGACATACATCTTTGCTGGAGACAAATTCTGG AGATACAATGAGGTGAAGAAGAAAATGGATCCTGGCTTCCCCAAGCTCATCGCAGATGCCTGGAATGCCA TCCCCGATAACCTGGATGCCGTCGTGGACCTGCAGGGCGGCGGTCACAGCTACTTCTTCAAGGGTGCCTA TTACCTGAAGCTGGAGAACCAAAGTCTGAAGAGCGTGAAGTTTGGAAGCATCAAATCCGACTGGCTAGGC TGCTGAGCTGGCCCTGGCTCCCACAGGCCCTTCCTCTCCACTGCCTTCGATACACCGGGCCTGGAGAACT AGAGAAGGACCCGGAGGGGCCTGGCAGCCGTGCCTTCAGCTCTACAGCTAATCAGCATTCTCACTCCTAC CTGGTAATTTAAGATTCCAGAGAGTGGCTCCTCCCGGTGCCCAAGAATAGATGCTGACTGTACTCCTCCC AGGCGCCCCTTCCCCCTCCAATCCCACCAACCCTCAGAGCCACCCCTAAAGAGATACTTTGATATTTTCA ACGCAGCCCTGCTTTGGGCTGCCCTGGTGCTGCCACACTTCAGGCTCTTCTCCTTTCACAACCTTCTGTG GCTCACAGAACCCTTGGAGCCAATGGAGACTGTCTCAAGAGGGCACTGGTGGCCCGACAGCCTGGCACAG GGCAGTGGGACAGGGCATGGCCAGGTGGCCACTCCAGACCCCTGGCTTTTCACTGCTGGCTGCCTTAGAA CCTTTCTTACATTAGCAGTTTGCTTTGTATGCACTTTGTTTTTTTCTTTGGGTCTTGTTTTTTTTTTCCA CTTAGAAATTGCATTTCCTGACAGAAGGACTCAGGTTGTCTGAAGTCACTGCACAGTGCATCTCAGCCCA CATAGTGATGGTTCCCCTGTTCACTCTACTTAGCATGTCCCTACCGAGTCTCTTCTCCACTGGATGGAGG AAAACCAAGCCGTGGCTTCCCGCTCAGCCCTCCCTGCCCCTCCCTTCAACCATTCCCCATGGGAAATGTC AACAAGTATGAATAAAGACACCTACTGAGTGGCCGTGTTTGCCATCTGTTTTAGCAGAGCCTAGACAAGG GCCACAGACCCAGCCAGAAGCGGAAACTTAAAAAGTCCGAATCTCTGCTCCCTGCAGGGCACAGGTGATG GTGTCTGCTGGAAAGGTCAGAGCTTCCAAAGTAAACAGCAAGAGAACCTCAGGGAGAGTAAGCTCTAGTC CCTCTGTCCTGTAGAAAGAGCCCTGAAGAATCAGCAATTTTGTTGCTTTATTGTGGCATCTGTTCGAGGT TTGCTTCCTCTTTAAGTCTGTTTCTTCATTAGCAATCATATCAGTTTTAATGCTACTACTAACAATGAAC AGTAACAATAATATCCCCCTCAATTAATAGAGTGCTTTCTATGTGCAAGGCACTTTTCACGTGTCACCTA TTTTAACCTTTCCAACCACATAAATAAAAAAGGCCATTATTAGTTGAATCTTATTGATGAAGAGAAAAAA AAAAAAAAAA Download Select all
Length

CDS Information

Location
CDS Sequence	>lcl\|NM_001302508.1_cds_NP_001289437.1_1 [gene=MMP2] [protein=72 kDa type IV collagenase isoform 3] [protein_id=NP_001289437.1] [location=212..1966] ATGCAGAAGTTCTTTGGACTGCCCCAGACAGGTGATCTTGACCAGAATACCATCGAGACCATGCGGAAGC CACGCTGCGGCAACCCAGATGTGGCCAACTACAACTTCTTCCCTCGCAAGCCCAAGTGGGACAAGAACCA GATCACATACAGGATCATTGGCTACACACCTGATCTGGACCCAGAGACAGTGGATGATGCCTTTGCTCGT GCCTTCCAAGTCTGGAGCGATGTGACCCCACTGCGGTTTTCTCGAATCCATGATGGAGAGGCAGACATCA TGATCAACTTTGGCCGCTGGGAGCATGGCGATGGATACCCCTTTGACGGTAAGGACGGACTCCTGGCTCA TGCCTTCGCCCCAGGCACTGGTGTTGGGGGAGACTCCCATTTTGATGACGATGAGCTATGGACCTTGGGA GAAGGCCAAGTGGTCCGTGTGAAGTATGGGAACGCCGATGGGGAGTACTGCAAGTTCCCCTTCTTGTTCA ATGGCAAGGAGTACAACAGCTGCACTGATACCGGCCGCAGCGATGGCTTCCTCTGGTGCTCCACCACCTA CAACTTTGAGAAGGATGGCAAGTACGGCTTCTGTCCCCATGAAGCCCTGTTCACCATGGGCGGCAACGCT GAAGGACAGCCCTGCAAGTTTCCATTCCGCTTCCAGGGCACATCCTATGACAGCTGCACCACTGAGGGCC GCACGGATGGCTACCGCTGGTGCGGCACCACTGAGGACTACGACCGCGACAAGAAGTATGGCTTCTGCCC TGAGACCGCCATGTCCACTGTTGGTGGGAACTCAGAAGGTGCCCCCTGTGTCTTCCCCTTCACTTTCCTG GGCAACAAATATGAGAGCTGCACCAGCGCCGGCCGCAGTGACGGAAAGATGTGGTGTGCGACCACAGCCA ACTACGATGATGACCGCAAGTGGGGCTTCTGCCCTGACCAAGGGTACAGCCTGTTCCTCGTGGCAGCCCA CGAGTTTGGCCACGCCATGGGGCTGGAGCACTCCCAAGACCCTGGGGCCCTGATGGCACCCATTTACACC TACACCAAGAACTTCCGTCTGTCCCAGGATGACATCAAGGGCATTCAGGAGCTCTATGGGGCCTCTCCTG ACATTGACCTTGGCACCGGCCCCACCCCCACGCTGGGCCCTGTCACTCCTGAGATCTGCAAACAGGACAT TGTATTTGATGGCATCGCTCAGATCCGTGGTGAGATCTTCTTCTTCAAGGACCGGTTCATTTGGCGGACT GTGACGCCACGTGACAAGCCCATGGGGCCCCTGCTGGTGGCCACATTCTGGCCTGAGCTCCCGGAAAAGA TTGATGCGGTATACGAGGCCCCACAGGAGGAGAAGGCTGTGTTCTTTGCAGGGAATGAATACTGGATCTA CTCAGCCAGCACCCTGGAGCGAGGGTACCCCAAGCCACTGACCAGCCTGGGACTGCCCCCTGATGTCCAG CGAGTGGATGCCGCCTTTAACTGGAGCAAAAACAAGAAGACATACATCTTTGCTGGAGACAAATTCTGGA GATACAATGAGGTGAAGAAGAAAATGGATCCTGGCTTCCCCAAGCTCATCGCAGATGCCTGGAATGCCAT CCCCGATAACCTGGATGCCGTCGTGGACCTGCAGGGCGGCGGTCACAGCTACTTCTTCAAGGGTGCCTAT TACCTGAAGCTGGAGAACCAAAGTCTGAAGAGCGTGAAGTTTGGAAGCATCAAATCCGACTGGCTAGGCT GCTGA Download Select all
CCDS ID	CCDS10752.1

Protein Information

Protein ID
Protein Name	matrix metallopeptidase 2
Molecular Wt. (Da)	0
Protein Sequence	>lcl\|NM_001302508.1_prot_NP_001289437.1_1 [gene=MMP2] [protein=72 kDa type IV collagenase isoform 3] [protein_id=NP_001289437.1] [location=212..1966] MQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFAR AFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLG EGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNA EGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFL GNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYT YTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRT VTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQ RVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAY YLKLENQSLKSVKFGSIKSDWLGC Download Select all
Length	0
Uniprot ID	P04637
Ensembl Protein ID	ENSP00000269305

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
N	Proteolytic Cleavage	66
N	Proteolytic Cleavage	109
N	Proteolytic Cleavage	66
T	Phosphorylation	364

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
2	A2M	72	NP_000005.2	in vitro	9344465
1277	COL1A1	362	NP_000079.2	in vitro	11368514
1293	COL6A3	371	NP_004360.2	in vitro	8862926
1294	COL7A1	358	NP_000085.1	in vivo	10652000
1404	HAPLN1	275	NP_001875.1	in vitro	7694569
1634	DCN	501	NP_001911.1	in vitro	9148753
2048	EPHB2	2997	NP_004433.2	in vitro	18713744
2260	FGFR1	634	NP_000595.1	in vitro;in vivo	8692946
3486	IGFBP3	899	NP_001013416.1	in vitro	7523391
3553	IL1B	985	NP_000567.1	in vitro	8663297
3814	KISS1	4475	NP_002247.3	in vitro;in vivo	12879005
3958	LGALS3	1090	NP_002297.2	in vitro	7947821
5858	PZP	7178	NP_002855.2	in vitro	9344465
6354	CCL7	1150	CAA50405.1	in vitro;in vivo;yeast 2-hybrid	1 094 798 912 149 190
63827	BCAN	2644	NP_068767.3	in vitro	10986281
80781	COL18A1	382	NP_569711.2	in vitro;in vivo	12023034

Pathway Information

Pathway Name	Pathway ID
AGE-RAGE signaling pathway in diabetic complications	hsa04933
Bladder cancer	hsa05219
Estrogen signaling pathway	hsa04915
GnRH signaling pathway	hsa04912
Leukocyte transendothelial migration	hsa04670
Pathways in cancer	hsa05200
Proteoglycans in cancer	hsa05205

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd00094	466-660	HX
cl02471	466-660	HX superfamily
cd04278	118-446	ZnMc_MMP
cl00064	118-446	ZnMc superfamily
cd00062	343-390	FN2
cl09951	343-390	FN2 superfamily
cd00062	285-332	FN2
cl09951	285-332	FN2 superfamily
cd00062	227-274	FN2
cl09951	227-274	FN2 superfamily
smart00059	342-390	FN2
smart00059	284-332	FN2
smart00059	226-274	FN2
pfam00040	349-390	fn2
pfam00040	233-274	fn2
pfam00040	291-332	fn2
smart00120	568-614	HX
pfam00045	568-614	Hemopexin
cd04279	387-446	ZnMc_MMP_like_1
cd00203	394-445	ZnMc
pfam01471	52-97	PG_binding_1
cl18368	52-97	PG_binding_1 superfamily
pfam00045	475-517	Hemopexin
pfam00045	520-563	Hemopexin
cd04277	364-446	ZnMc_serralysin_like
smart00120	520-563	HX
cd04268	400-445	ZnMc_MMP_like
smart00120	475-517	HX
cd04267	399-446	ZnMc_ADAM_like
cd00203	124-222	ZnMc
cd04268	121-201	ZnMc_MMP_like
pfam00413	118-446	Peptidase_M10
smart00235	115-218	ZnMc

Ontology Information

HPRD ID	1839
Molecular Class	Not Available
Molecular Function	Cytoskeletal protein binding (GO:0008092)
Biological Process	Cell growth and/or maintenance (GO:0008151)

SNP Information

View SNP Geneview Report

Drug Information

Uniprot ID DrugBank ID Name Type
P08253 DB00786 Marimastat SmallMoleculeDrug
P08253 DB01197 Captopril SmallMoleculeDrug

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

Uniprot ID	DrugBank ID	Name	Type
P08253	DB00786	Marimastat	SmallMoleculeDrug
P08253	DB01197	Captopril	SmallMoleculeDrug

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO