Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MMP3 | 4314 | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | 11 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24999605 | 2014 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Microarrays and Taqman RT-PCR, immunohistochemistry | Up-regulation | - | In cases of sporadic colorectal tumors, MMP3 protein expression in the lamina propria itself seems to be highly specific for the detection of tumorous transition. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008] |
| Chromosome | 11 |
| Location | 11q22.3 |
| Start | 102706528 |
| End | 102714342 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 7815 |
| OMIM ID | 185250 |
| HGNC ID | HGNC:7173 |
| Unigene ID | Hs.375129 |
| Ensembl ID | ENSG00000149968 |
| PharmGKB ID | PA30886 |
mRNA Information
| mRNA ID | NM_002422.4 |
|---|---|
| Exon | join(1..170,696..940,1033..1181,1333..1458,3019..3183, 3360..3504,4369..4502,4902..5061,6211..6314,7386..7815) | mRNA Sequence | Download Select all |
| Length | 1906 |
Protein Information
| Protein ID | NP_002413.1 |
|---|---|
| Protein Name | matrix metallopeptidase 3 (stromelysin 1, progelatinase) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 477 |
| Uniprot ID | O15350 |
| Ensembl Protein ID | ENSP00000340740 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1404 | HAPLN1 | 275 | NP_001875.1 | in vitro | 7694569 |
| 1634 | DCN | 501 | NP_001911.1 | in vitro | 9148753 |
| 3486 | IGFBP3 | 899 | NP_001013416.1 | in vitro | 7523391 |
| 5054 | SERPINE1 | 1418 | NP_000593.1 | in vitro | 10967118 |
| 6347 | CCL2 | 1149 | NP_002973.1 | in vitro;in vivo | 121 491 929 558 113 |
| 6354 | CCL7 | 1150 | CAA50405.1 | in vitro;in vivo | 1 214 919 210 947 980 |
| 6355 | CCL8 | 3791 | NP_005614.2 | in vitro | 12149192 |
| 6357 | CCL13 | 3230 | NP_005399.1 | in vitro | 12149192 |
| 6696 | SPP1 | 1325 | NP_001035147.1 | in vitro | 11375993 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Rheumatoid arthritis | hsa05323 |
| TNF signaling pathway | hsa04668 |
| Transcriptional misregulation in cancer | hsa05202 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04278 | 108-264 | ZnMc_MMP |
| cl00064 | 108-264 | ZnMc superfamily |
| cd00094 | 287-477 | HX |
| cl02471 | 287-477 | HX superfamily |
| cd00203 | 114-263 | ZnMc |
| cd04277 | 132-264 | ZnMc_serralysin_like |
| cd04279 | 119-264 | ZnMc_MMP_like_1 |
| smart00120 | 388-435 | HX |
| pfam00045 | 388-433 | Hemopexin |
| cd04268 | 114-263 | ZnMc_MMP_like |
| pfam01471 | 25-87 | PG_binding_1 |
| cl18368 | 25-87 | PG_binding_1 superfamily |
| pfam00045 | 296-338 | Hemopexin |
| pfam00045 | 340-383 | Hemopexin |
| smart00120 | 296-338 | HX |
| smart00120 | 340-383 | HX |
| cd04267 | 178-264 | ZnMc_ADAM_like |
| cd04327 | 108-228 | ZnMc_MMP_like_3 |
| cd04275 | 170-228 | ZnMc_pappalysin_like |
| pfam00413 | 108-264 | Peptidase_M10 |
| smart00235 | 105-265 | ZnMc |
Ontology Information
| HPRD ID | 1840 |
|---|---|
| Molecular Class | Metallo protease |
| Molecular Function | Cytoskeletal protein binding (GO:0008092) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P08254 | DB00786 | Marimastat | SmallMoleculeDrug |