CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
MMP8	4317	matrix metallopeptidase 8 (neutrophil collagenase)	11

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
21918979	2012	Cell line : - Source : - Sample Type : Serum sample No. of Sample : 148 CRC and 83 healthy controls. Stage : -	Immunofluorometric assay	Up-regulation	-	Serum or plasma MMP-8 may prove to be a worthy biomarker for CRC. MMP-8 is involved in the course and progression of CRC influencing the immune response against the tumor and contributing to the resolution of necrosis.

Gene Details

Chromosome 11 - NC_000011.10 (102711795..102724964, complement)
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Gene Type	protein coding
Gene Family
Description	This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.
Chromosome	11
Location	11q21-q22
Start	102711795
End	102724964
Strand	-
Gene Sequence	>gi\|568815587:c102724964-102711795 Homo sapiens chromosome 11, GRCh38.p2 Primary Assembly AGCTGTGAGTGACACATGATGCTGTGAACGTCAGGGTGCTCGCCAGGGAAGGGCCCTACCCAGAGGGACA GAAAGAAAGCCAGGAGGGGTAGAGTTTGAAGAGAAGATCATGTTCTCCCTGAAGACGCTTCCATTTCTGC TCTTACTCCATGTGCAGATTTCCAAGGCCTTTCCTGTATCTTCTAAAGAGAAAAATACAAAAACTGTTCA GGTAAATGAACTATCAGTTAGGTGATGTTTGATTTGCTGATTATTAGGAAATAGTGTGGGTTGTTTTCTC TTGTTAATTAAAACAGCCTGAAAGAAATTATTTGGGTGATTAGTTTGAGATTGAACATCTCCTTTTAGTG ATTTGGAGGGTTCCAAGCTGGTAAGGACTAGGCCTTTTAAAAGCCGGACATGAAAACAAGCTGAATTCTT TAAAGGCTGGGAAAATACTGCTGTAGAGTTACCCCTAGTTGGGAAACTTTTGTAGAAGAAATGGTTTTAT TTATAAAATGGTATCATTTTCTTTCTCATTTACCTAAGGTTTTTCCTTCCAGGATATCTGCAATCAAGTT ACTATATGTCTGGTGCTTCCATACAGGCATTTTCTTTGCCGCCAAAAATTCCAGATATAGAAAATAATGT GAGGATGGTAGATTACAATGAACTAGAAATCAGTACACAGTAAAATCATATTTCCCAGCATCAGATTGTG GACTGTTTATAAACTCTTGGAAGCATTATAAAAGCAGAACCAATAGTTTTTTTCCATTGTTTCACAGTCT GAAAGTGAACCCAAATTTTTAAGAAACACAAGGGAATTCTGTCACAAATCTCTCATGCACAGTTTTCTTA GCATTATAGTTTGGAGAAAGCATTATTATTATTAAGAGGTTATCTCTTAATTGTAACCCCCGGGTTAATG TAAAGTCCATTGAGTGCTTATTCTATGCAAGGCAACTGCTACACATTTCACAAATATCTCATTTAATCCT CACAAGAACCTTATTGGAGCATTATTATTTTCATTTCAGAGACAAAAATATCTTAAATCAGATAAATAAT GTGGCCAAGTGCTCACAGTTAATTCATGGCAGAGTTAAGATTTGAACCCAGGCCTGTCTGATTCCAAAGC GTGTGATCTGGTCAGTGTCACCTACTGCTGTGGTTAGAGTGTGTCCCTTGAATTTATGTGTTAAAGATTT AGTAGCCCATGTGACAGTGGGTCCTTTAAGAAGTACTTAGGTCATTAAGAAAGATTAATGACACTCTTGT GTGACTGGATTAATTTTTGCTGGAGTGGGTTCTGGCTCTTGCAGAACTGGATTAGTAATTAATAGAATGG GTATTATAAAGAGGGGCTGCCCTTTGTGTTTTGCCCCTTTTCACACATGCTTGCTCCCCTTTTGTTTCTC TGCCATGTTATGACACAGCACAAGGCCATCTCAGAAGCCAACCAGATGCAGCCACCTGATCTTGGACTTC CCAGCCTCCAGAATTGTGAGAGAAAATCAGCCCCTTTTATGTATAAGTTACCCAGCTTCAGATATTCTGT TATAGCAACAGAAAATGGACTAAGACACTGACAAGGTGCCAGGTGTTCACAGGCAGCATGAGGTCTAGTT AGGTTACATTTCACTGTGTATGAAGAAACTTTTAAGCCAAACTTAAAATAGGTAATTTTTAGGCTAAACT CTTTGGATTTTGACTAAATTTAACACTTCCAAAGAGTTACTTTGGTGAATAAAATGCTAATATCAATGAT ATTGCTGTTCCCCTAAAAGATATTTGAAATTATTTTGAAATTATCAGTTCTCATTTGAGAGGCAACATGG TGAGTTAAAATCTGAATCATCACTTGGAAAATTCCTTAATTCTCTGTGCTTCTGTTTGTTCAGCAGAATA AATAAGCCTTTTCTACAGTAGTGAAGAGGATAAAAAAGAGGAACTGCACTGATGCAACAAATACCTCAAG AGAAGTCAATTAATGTTAGTCCTAATTTTTTTGTAAAAACAAGAAGACAGTCTCCTGACTGTAGAGTAGC ACTTTGCCTGTGTGATGTGATCCTCATCCCTTATGAGACACCCTTTTTTATGCATAACCATTAACTGGAG CACTGAGTGGAGGAACTGTTCTTTCTAAAAAGAGTTGTTCTCTCAAAGCCAACCTACAAATTAATTTGTG TTATTGTTCCTGTGGCTGTCAAGTTATCAGACCTCTGTAGTAACTTAGAAAGGGTTGCAAAATGACCAGA GAACTGGAGGTCCTTTCACAGCAAGACCCCTATGTGCTTGTCTTTGTCCAGGACTACCTGGAAAAGTTCT ACCAATTACCAAGCAACCAGTATCAGTCTACAAGGAAGAATGGCACTAATGTGATCGTTGAAAAGCTTAA AGAAATGCAGCGATTTTTTGGGTTGAATGTGACGGGGAAGCCAAATGAGGAAACTCTGGACATGATGAAA AAGCCTCGCTGTGGAGTGCCTGACAGTGGTGGTTTTATGTTAACCCCAGGAAACCCCAAGTGGGAACGCA CTAACTTGACCTACAGGTGATATCTCTAGGGTTTCAGGATACACTCATTTATCCAGTATGGACTGGGCTC TTATATGACAGACACTGTTCTTGGGATACACTAGGAACAAGTAGATAAATATCCCTGCCTTTGAAGAGTG TGAGTAGTGAATGAATATGAGAATGAAAATGTTGAGATACCGTGGGTTCTTTCCACTCCAAGGCTTCCCG TTTTAGTCTTCCTTCTCCAACAATCTAAAGAGGACTACCAGCAATGTTAGGCTGTCTCTCTAAGCACTTA CTTTAGGACCCAACAAAGGCTTAATCATTGCTGGAGAGAGTCAAGTCCCTCCTTTCATACATCTTAATAA TAATAATAATATCTAATATTTGTGGAATATTATTACTATTTGACAAGTAATGAACTAAATGCTTTATATG TATTTAATCCCCACGGCAGCCCTATGAGAGGGATACTATATTAGTATCCTCATTTTATGAATAGGAAACT GAGGTTTAAAGACATGTATTAACTTGTTCAGAACCCACATCTGTCCTCCACCCTGAGACCTGCACTCCCT CCTTATCCTCTCCAGTGGTAGCACACCATGATGCAACTCACTTCAAAACAGAACAACTCATCAGTTGATG GACTACTGTTCTAAATAACATTTAACTCTTCATACATCCTCTCATTTTGAAGGATTCGAAACTATACCCC ACAGCTGTCAGAGGCTGAGGTAGAAAGAGCTATCAAGGATGCCTTTGAACTCTGGAGTGTTGCATCACCT CTCATCTTCACCAGGATCTCACAGGGAGAGGCAGATATCAACATTGCTTTTTACCAAAGAGGTAGGTACA AAGCAGTCATGCTCAGTTTTGCTTTCTTTGGCTAACCTGAAACTTGGCAAGGATCTAATACAAATGTTCT TATTTCAGATCACGGTGACAATTCTCCATTTGATGGACCCAATGGAATCCTTGCTCATGCCTTTCAGCCA GGCCAAGGTATTGGAGGAGATGCTCATTTTGATGCCGAAGAAACATGGACCAACACCTCCGCAAGTAAGT TAATCAAGATTATGTCCACACACAGCTTCTGAATTAACCTTTTACAGATTAGAATACACACACACACACA CACACAATAAAGGTAACATAATATTTCAAACTCACAAAAAGTGATCATTTGAAATTTTTGCTACCTCATG ATACTAAGTCAATTTGGGATTTTTTTAAAAAAAGAAAGAAAAAGACATGCTGAATCTGATTACTGACCTT ACTTCTTAGGTCAGAGATCAGAAAATACAGACTACGGCCAAATCCTGCCTGACCCCTGTCTGTATAAATA AAGTTTTATTGAAACAGGGCCACATTTATTTGTTTCTATATCATAAATGGCTGCTTTCACTCTACAATGG CAAGCTGAGTAATTGCAACATGGATCATTTGGCTTACAAAGCCTAAAATATTTGCTATCTGGTTCTTTAC AGATACTGCTTTAGAATATCTTTATTTTAATATTCCCAAATTTAGTGATGTTTGAAAAGAGCCTATTTTT CCATTTTTGGAAATTCATTTAGAAATTATAATTTCTATAATTAGAAATTAGCCTATTTTTCCATTTTTTG GAAATTCATTTAGAAATTATAATTTCTATAATTAGAAATTAGTCTATTGAGAAAAGAACAGACACCTTCC CTCTCATCTAGTTAGTTCATCTCCTTGGAGCTCTTCTTCAGTGGTATGCTTCTGTACAGCAAGCCACTCC TTTCAGGAGAAGGCTCCTATTAAGAAGGACTGGGCTGCTTGAAGGGAAGAAATGAGGCTGAGGACAGGTA TACCCAGACCATGTGGTACTTCACAAAATATGGGGTAACAATATGCCAGAGAGCACTTTTAGAAAATAAT CAGAAAGGCACCTTTTACCTTTGCTTGGCACCTGTTCCTCCTGCCATTTTCTCAACATGGGTATGTTACG AGGGTCTATTCTACCTAAGTCCATATGCTAGGAGCTGTGTGTAGCCAAAGATAGGTAATAACCCTCAGCT CCTCTCCATTCCCTGTTGCCCTCCTCACTAGTTCGGATGATCATTACCTCTTACCTGAACGAATGATCTA GATTCCTAACTGGACTCTCCATCTCCAGTATGTGCTCCCTCTAATTTTTCCTACCATTGCAGCAGGGTTT GTTTTTGGAAGCCCATCTTGGATCACATCACTCTCATGCTTAAAAGTTTCAATGTTTACACATTCTGCAC CAAATAAGGTCCAAATACTTCCACTTGGTATTGAAGGCTCTTGGTGCTTGTTCATCCTTGTCTTTCTTGG CTTGTCTTCTTATTTCACGTATTCCATTCACATCGGGCTAACACCCACATTGTACATTCACTGTTTCTAG GTCACACCCTATGCTTTTCATCTTCCTCACATTTGCTTGAATTGCTTCCTCTCCCTGAAATACTCTTCCC ATGCCCCACGCACCACCTTTTAAAATCTCTCTCATCTTGCCATGCTATGTATGTCAAAGGCCACCTTCTG TCTTGCCTTGTCCTGGAAATGAGAACTTCCTCTGCAGAATTCTGACAGCTTTTGTATCTCCTTCTCTGTC ATCACTCACTGTGTGCTTTCAAGTTGTTTGCACACATCTCTCCTCTTCTAGACTATGCACTCCCTGTAGA GCAGAGAACCACAACAAATTGCCCACAGTTCCTTTCACGGTATTCCAAGCATTCAAAGATATTTTTCTGA AATGCACTCATGAATGCATAATTAAAAGGATGTGATGATAAGAAACAATTCTTAGAGCATGGGTAGAATT TTAGCAGGCTAATTATCAACAGGAAGTTGAACATTGCAGTAAGAGCATGGATCTTGCCATTATACCTGGG TTTGACCCCAATCTGTCACTTACTAGTTGAGGGACCAAGTACCAGCTATTCAAAATCTATGGGCATCAGT CACTTTACTATAAAAATATTGTTAATAAAACTTCAGAAAAATGTTATGAGGATTGCATAACATTAGATTG CCTAGTATGTTGTAGGTACTCTACAATTATGGCTTTTTTTAAAAGTAGGCATATACAAAAATGCATCAGT GTGTTTGTGAGGCAGCATGTAGACTGGCTGGACTGAAGGATTCATGTTAAAAGGCAAGCACTCAAATATC TGCTGGAGCCAAGTGGAGGAGGTCTTGAAGGCCAGGCAAAAGAGGTTGGGCTTTATTTGATAGGAAGTGA GATCCTGGGAAGGTTTTAAGTCTCCAGTTGTGAACGGCACTATGCTCATGGAAGTTAAAACATGGAGAAA GAGAGCAATAAGGGTAGGATTTGTCTCTCTCCAGTAGAGAATTCCTAGAGCATCTTAGAAAGCTCAGAAA CAGAGAAGAGCTGGTGCTAAGCTGTGGGTGATGAGGGAGCCAACATGAGCCAGCCCTCCATCTGAGGCTG CTCCACTGCTGGGCTGGCTTCTCTTCTAACTACTTGCTCACAGGGACTCTACTCGTGAGGCTGAGTGTCT GGGACAGTGGAGATGGTGATTGTGGGAATGCAAGAGAAGAGGGGTTCCCAAAGTCATGACGGCTCTGCCA TTACTTCTCCAAGTCTCAGATGCACATTTGTAAAATGTGAGAATTGGAATAAATGCAGCTTTTCTGGGTT CTAAGAGTTTATAAGAAGTTCATACTCACCTAGTCGCCATCTATGACCACTATCTTGATTCTTCTCAATG TCCACTTTCTCAGGTATCTGAAAGAAAGATGAAAAAGACAGCCATGGGAAGGGCTATTTCCCTGAGCAGT TTTGACTTGGAGGTTGCATTCCTTGAGATCATGTTTCTGCCACCCTGGGATCCACACTGAGCTGTTTACC ACCCGTGTTTGCATTTCAGATTACAACTTGTTTCTTGTTGCTGCTCATGAATTTGGCCATTCTTTGGGGC TCGCTCACTCCTCTGACCCTGGTGCCTTGATGTATCCCAACTATGCTTTCAGGGAAACCAGCAACTACTC ACTCCCTCAAGATGACATCGATGGCATTCAGGCCATCTATGGTAAGGTCTTCTCAAGAGAGTCATAGTAC ATGGTAGGACCTGGGAATAGGCGAACACTCCCAGAATCTGAATATCTCTTCCTTTGCACTTCTGCAGTTT CCATAAAACTGAACTCTGAATTTCCCCAGTAATAAAGCATTAACAAAGAAGGTGTGAGGGACTGAGCCTC TATTGCTGCCCTAAAAGAAAAAAAGTTTAAGAAGAAATGCACTACAGTGCTTCCCAGTTATTGTCTTTGG ATGGTGGGGATTTTTTTCTTCTTTTTTAGGCTTTCCAAATTTCCAATTTTAAATTTTTTTTGGGGGGGGG GATGGAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGACGCGATCTTGGCTCACTGCAACCTCTGCCT CCCAAGTTCAAGCAATTCTCCTGCCTCAGCCTCTCAAGTAGCTGAGATTACAGATGCCCACCACCACACT TGGCTAATTTTTGTATTTTCAGTAGAGAGGTGATTTCACCACAATGACCAGGCTGGTCTTGAACTCCTGA CCTCGAGTGATCTGCCCACCTCAGCCTCCCAAAATGCTGGGATTACAGGCGTGAGCCATTGCACCTGGCC CCAATTTTAAATATTCTAAAAAGACATGACTATTCTTTTTCCTACAGCAATCCTGCTCCCAGATGTATCT ATCAAAGAAATTCTCATGTAGATCCATAAGGGGACATGTACAAATCATGCCAAAGATGTTCACTGCAGTC TTGTTTGTGGTAATGGAAGTTGGAAGACACCTGGGAGTCTATTAGGAGAAGACTATACAGATAAAATGTG GTAGCTGCACACCATGAAGTGATGTGCAGCAGTGAGAAACATGGTACTAGATGCACATATGGCAACAGTA CAGATGGGTCTTTAAAACTTGGTACTTTGTGAAAAAGAAACAGAATGAGATATATTGCACAATGTATTAA TTAAATTACACAATATATAAGTCTATGTAAATTTAAAATGTATATAAACAAAGCAAGGCATTTTTCAAGA AGAAGAAAGGGAATGGTAGTGGAGTATGGAGAGAAAAAAAGAAACTTTTTTAAGGCATCACTGATACATT TCAAGGATAAGTATAGGGGCCTTTTGCCATATTGCCTGGATAAGACCATTACATCTCTCTTCACGCTTGC CCTTCTGTTCCCTAGTTGGCTGTGAATAAAAACAAGAAACCAATAAGGGATTTACTGCTCTCTAAAAAAG TGTGGAATGGAATGGAATAGTGGATTGGAGTGAAATATAATTGAATGGAGTGGAACAGAGTGGAGTGGAA TTGGGGAAAGCCCTTTTCTGTCTCTGGTGGGACAGCACTATAAAATCAAGCAAGCATGCCAGGGTGCCAC AACCAGGGAACTTTTTTGTGATTGCAGATATTTCAGAAATGTTGAGCCTATCCTAACTGCCTCTATTCCC CAATTTCTTCCTCCTGCCCACCCCAACAACACCCCTTTATTTTGTTCACCAATGTTTTTATCTTAACTAT TATTATAGCCTTTCATTCCACAGTGAGAAAACACATGAAAATTCAAATACTTATAGAAAAAATATTGCTA AAATTTGACTTAGGTGTATGCTATAGCGTAAAAGACTAATATCATTCTTTCCTGAAAGTGGATTTTGGTG AGGAGAGAGGCAATAGATACTGAGTGACCAAAAAAGCAGAAAGAGGAACTGAAAAGTCAGAGAAGAATTA GTTTAGAATTTAAAAGGGAAGGAAGGAGCATAGAATTCAAATTTCTTTACTTCACAGCTTGACCTGGAAC TTACCCTGAAAACCATCATTACTCTTATTAAAGAAACAAAAACTTTAAAAGGATGAAATATACAATTACT TTAATACTTTATGGTATAGTCTGGTAGCACTTACCTTCACATGAAGACCCTTCACCTTTCTGAGAAGTCT CTGATGTACCCAAGAGTCACACCGGACTTACTCTCATAAGAAAGACCTTTTTTTTTTTTTTTTTTTTTTT TCCAGGACTTTCAAGCAACCCTATCCAACCTACTGGACCAAGCACACCCAAACCCTGTGACCCCAGTTTG ACATTTGATGCTATCACCACACTCCGTGGAGAAATACTTTTCTTTAAAGACAGGTATAAAATTGAAATAT TTCTTCCTTTGATTCCTCTTACTGACATACCTTAAAACTGGATTCAAATTAAGTCACACGTTAGTCACCT TTTCCTTGAATTCTATACTTGTGCTTCTCATCGGAATTTTTTATAGGTTCTGGGGCACCACTAGGATTAT CATAGCCCCCTGAGCTTAACTTTATCATCTTCGTCTTTTAAAGACTATTTGTACCATTTTTGTGTCTATA CTGAATTTATGCAATTGAGTATTTTCTGGGTAACTCAAGACATCCAGGAGAAAAAAAAAACATGAAAACA TTCACAAACATTCAGATGCCTTTGGTGATGTAAACAGACATGGGCTACAGCTGCTTGGGAACCCCATAGC TGAAACACCAAAGCACCATCCAGTTCCATCCAAAATCAGTCAAGTAAATGGAACCTGCGCTTAGCTAGCT GTGCAGCAAATCATCAAACTGAGCGAAATTTTTATTTGTCCATTGGCTATTTTGTGAGTGTGCAATCACA GGCTGAGGGTACATGCTGTTGCTTTTATCAATATGTTCACAGCATTTACTGGGAGCAATAATGAAAGATG CTACAAAGTAAGATTTTTCAATGTCCAAGGCAGGACAATGCCAAATGTAATCAAATAAGATCACTCCCAT AACCTTCCCTGAAAGCTGTGAAGTACTTGCCAGATGGACAATATCACTATAAAGCTTCGCCATATGCTGG TCACTGTGCTAGGAACTTTGCATTCGTTCGATTGTTATATTCTCCCAGCAATCCTACAAGGACCATCACT AGCCTAAAAGTCACAGGAACTGCCTACTTAGACTGTTATGTATAAGTGTGTGTGTGTGTTTCCTTATGTT CCGTTAGGTACTTCTGGAGAAGGCATCCTCAGCTACAAAGAGTCGAAATGAATTTTATTTCTCTATTCTG GCCATCCCTTCCAACTGGTATACAGGCTGCTTATGAAGATTTTGACAGAGACCTCATTTTCCTATTTAAA GGTAACTTCCTAAAGTTTTCATCTTATGTTAGTTCTGCCTGAAGGGAGGGGGCAGGACTTCTTTGTGGTC CCTTTCAGGTTCATGGTGAGCTAATGACAGCATTAAGCTGGCCAGGCTTTTGCCAGAAGACTAGGGTTGG GCCCCATCAGGACCACTAACTACTGTGTGAACCTGAGTGGGTTATTTGCTTTTCAGCCCTCAGTTTTCTC ACCAACAAAATGAGACCACACTAGACTGTCGTTAGCATTCTTTCATCCTCATCCCAGATACAATTCTCTA AGACTCCTCAAGCTGTAATTTGGTTTCTGCATAAAAGTCACACAAACTAAGGCATCCAATTGTGGGGCCT TGAATGTCTTGCTCAGAAGTTTTTATTTTTTATAGGCTCTGGGGAACCATTAAGGCTCTCACAGCCCCCC TGAACTTAACTTTATCATCTTCATCTTTTAAAGACTATTTGTTCCATTTTCATATCTATGTGCAAGACCA AGAAGTGGTATATATATATATATATATATATATATATATATATATATATATAATTTTGTAAAAATGGAAA AGTCGTATTTAACACTTAACCTGAATCATTGACAGGCAACCAATACTGGGCTCTGAGTGGCTATGATATT CTGCAAGGTTATCCCAAGGATATATCAAACTATGGCTTCCCCAGCAGCGTCCAAGCAATTGACGCAGCTG TTTTCTACAGAAGTAAAACATACTTCTTTGTAAATGACCAATTCTGGAGGTAACGTAAACTATTTTTTCA ATTATAGGTTGAAATCTGTGTTTCTCTACCCTGCTTACAAACCTTCAAGCATTTCAAGGTTTAAAACAAT CTAGATAGTCTCTAATAGGTTTTACCGAGAATATATTCTTTTTTACAGGATGATTGATGTTACCATGGCT TTTGAAATTTTTCATTTCTATAAAATTAAAATGTCTATGCAATAGTATTGAGGATTCTGCATCAAGAAAC AAAGAAAACCTTAACAAAGCACTAGGGTGAGATACAAAGAAAGATTTAAGCTAATTCTCACTTATGAGTT CAACTCAGACATATGCAAGCAAATGTTATCCAGATAGCCTGCAGAATTTGGTTCCCAAGTTGAACCTATT ATGTATGTTTATATATCTATATACACACACAAGGGAGTTATACTATATACCAATTAAGTAAAAGCCTTGA AAATATAAGCTTACTTTGGGTAATAACAGTGTGTCAGCCATCAAGCCTGTTTTAGAATTAATGATAACCA TATGTTTTATAAATGTGTACCCTTAGGTAGAGAAATTAACCATTCTTAATCCTAGTAAACAGGGCATTGT GAGAACTGAATGAAAAAATATGTGTGAGGAGACTTTGTAAATTATATACAATAAAAAAAATTTTTTTCGT TATATTCTGTATTGGTGTTAAATCGGATAACATTTTGTTTTTACCAGATATGATAACCAAAGACAATTCA TGGAGCCAGGTTATCCCAAAAGCATATCAGGTGCCTTTCCAGGAATAGAGAGTAAAGTTGATGCAGTTTT CCAGCAAGAACGTAAGTAGGAAAAAAAAACCTAATAAATGTGTTGTTTGTTTGTTTATTATAGAGGAGAC AGGGTCTTACTATGCTGACCAGGTTAGTGTCAAACTCCTGGCCTCAAGCAATCCTCCCACCTCAGCCTCC CAGAGTTCTGGGATTACAGGCATTAGCCACCGCACCTGGTGTTTAAATTTTTTAAATAGCATGTTTGCAT TTGAATGTTATGTTGGAACAGGGGCAGGGTTTTCTAACTGAAGACATCTGAGATATTCTATAAGCTAATT CAATAAATTATCTCTCTTTTTTTATAGATTTCTTCCATGTCTTCAGTGGACCAAGATATTACGCATTTGA TCTTATTGCTCAGAGAGTTACCAGAGTTGCAAGAGGCAATAAATGGCTTAACTGTAGATATGGCTGAAGC AAAATCAAATGTGGCTGTATCCACTTTCAGAATGTTGAAGGGAAGTTCAGCAAGCATTTTCGTTACATTG TGTCCTGCTTATACTTTTCTCAATATTAAGTCATTGTTTCCCATCACTGTATCCATTCTACCTGTCCTCC GTGAAAATATGTTTGGAATATTCCACTATTTGCAGAGGCTTATTCAGTTCTTACACATTCCATCTTACAT TAGTGATTCCATCAAAGAGAAGGAAAGTAAGCCTTTTTGTCACCTCAATATTTACTATTTCAATACTTAC ATATCTGACTTCTAGGATTTATTGTTATATTACTTGCCTATCTGACTTCATACATCCCTCAGTTTCTTAA AATGTCCTATGTATATCTTCTACATGCAATTTAGAACTAGATTTTGGTTAGAAGTAAGGATTATAAACAA CCTAGACAGTACCCTTGGCCTTTACAGAAAATATGGTGCTGTTTTCTACCCTTGGAAAGAAATGTAGATG ATATGTTTCGTGGGTTGAATTGTGTCCCCCATAAAAGATATGTTGAAGTTCTAACCCCAGGTACCCATGA ATGTGAGCTTACCAGGGTCTTTGCAGATGTAATTAGTTAAGTTAAGGTGAGATCACACTGAATTAGGGTG GGCTCTAAATCCATTATGACTGTTGTTCTTATAAGAAGAAGAGAGGCATAGTCACCTAGGGGAGGAGGCC GTATGAAGACAGAGGCAGAGATTGGAGTGACGCATCTCCAAGCCAAGGAATTCCAAGGACTGTAAGCCAC CAGTAGAAGCTTTGAAGAGGCAAGGAAGGATTCCCTCCAATAGCCTTCAAGTGTGACCCTGCTGACACCT GCAGAATTCGGACTTCTATCCTCCAAAACCGTGAGGGAATAAATTTCCTTTGTTTTAAGCCACCAACTTT GCAATACTTTGTTACAGCAACCCTAGACATGAGGTACTAGACACAGTACATCTACACATATGAAAATGAA TCAACACAGAATGCAGAAGTAGAACCCTTGCTAAGGACTACTGGGCATCTTCCCAGGACAGCAGCCAAAA GAGAACCACCACTTCCTCTCCTGCCTCCTCCTTGCTCTCTCCTAGAGTCCAAACCCAAATGGGCCAGTTG GATCTGATGTTCGTCAGTTCTTTACTTCTATTTCCTGGGGTACTCAGGAGGGCACACACTATAGATAACT TGGGTTAGCTGCATAAAATTCAATGTCTCATTAAGTTGCATTAAACTGAGCTTAGATGTGTAAGTTTGCT AACGGATGGGTTTTTTTGTTAAGAACTATAGGATTTATGGGACCAAGTCTAGCGAGTCCAGATATCAAAA TCATTATAATGTTATATTTGCTGTTATTAGAATATAATATAGCTTATTATACAATAAATATGTAGACTGT AAAATATATTTCTCACTAGTACCTCCTATTTTCTTTCTCTGTTGAAGTTTTTAAATCCCACAGATAATTA AATTGGCACCTTTATGCTTGTTCAAAAATTAAAATAATCTATTAAATAAGTTCAAATTAAAGATTTTTAC TTCAAATGAC Download Select all
Length	13170
OMIM ID	120355
HGNC ID	HGNC:7175
Unigene ID	Hs.161839
Ensembl ID	ENSG00000118113
PharmGKB ID	-

mRNA Information

mRNA ID	NM_002424.2
Exon	join(11..211,2292..2536,3203..3351,3439..3564,6390..6551, 8546..8663,9528..9661,10256..10409,11108..11211, 11508..13170)
mRNA Sequence	>4317 GACACATGATGCTGTGAACGTCAGGGTGCTCGCCAGGGAAGGGCCCTACCCAGAGGGACAGAAA GAAAGCCAGGAGGGGTAGAGTTTGAAGAGAAGATCATGTTCTCCCTGAAGACGCTTCCATTTCT GCTCTTACTCCATGTGCAGATTTCCAAGGCCTTTCCTGTATCTTCTAAAGAGAAAAATACAAAA ACTGTTCAGCAGAATAAATAAGCCTTTTCTACAGTAGTGAAGAGGATAAAAAAGAGGAACTGCA CTGATGCAACAAATACCTCAAGAGAAGTCAATTAATGACTACCTGGAAAAGTTCTACCAATTAC CAAGCAACCAGTATCAGTCTACAAGGAAGAATGGCACTAATGTGATCGTTGAAAAGCTTAAAGA AATGCAGCGATTTTTTGGGTTGAATGTGACGGGGAAGCCAAATGAGGAAACTCTGGACATGATG AAAAAGCCTCGCTGTGGAGTGCCTGACAGTGGTGGTTTTATGTTAACCCCAGGAAACCCCAAGT GGGAACGCACTAACTTGACCTACAGGATTCGAAACTATACCCCACAGCTGTCAGAGGCTGAGGT AGAAAGAGCTATCAAGGATGCCTTTGAACTCTGGAGTGTTGCATCACCTCTCATCTTCACCAGG ATCTCACAGGGAGAGGCAGATATCAACATTGCTTTTTACCAAAGAGATCACGGTGACAATTCTC CATTTGATGGACCCAATGGAATCCTTGCTCATGCCTTTCAGCCAGGCCAAGGTATTGGAGGAGA TGCTCATTTTGATGCCGAAGAAACATGGACCAACACCTCCGCAAATTACAACTTGTTTCTTGTT GCTGCTCATGAATTTGGCCATTCTTTGGGGCTCGCTCACTCCTCTGACCCTGGTGCCTTGATGT ATCCCAACTATGCTTTCAGGGAAACCAGCAACTACTCACTCCCTCAAGATGACATCGATGGCAT TCAGGCCATCTATGGACTTTCAAGCAACCCTATCCAACCTACTGGACCAAGCACACCCAAACCC TGTGACCCCAGTTTGACATTTGATGCTATCACCACACTCCGTGGAGAAATACTTTTCTTTAAAG ACAGGTACTTCTGGAGAAGGCATCCTCAGCTACAAAGAGTCGAAATGAATTTTATTTCTCTATT CTGGCCATCCCTTCCAACTGGTATACAGGCTGCTTATGAAGATTTTGACAGAGACCTCATTTTC CTATTTAAAGGCAACCAATACTGGGCTCTGAGTGGCTATGATATTCTGCAAGGTTATCCCAAGG ATATATCAAACTATGGCTTCCCCAGCAGCGTCCAAGCAATTGACGCAGCTGTTTTCTACAGAAG TAAAACATACTTCTTTGTAAATGACCAATTCTGGAGATATGATAACCAAAGACAATTCATGGAG CCAGGTTATCCCAAAAGCATATCAGGTGCCTTTCCAGGAATAGAGAGTAAAGTTGATGCAGTTT TCCAGCAAGAACATTTCTTCCATGTCTTCAGTGGACCAAGATATTACGCATTTGATCTTATTGC TCAGAGAGTTACCAGAGTTGCAAGAGGCAATAAATGGCTTAACTGTAGATATGGCTGAAGCAAA ATCAAATGTGGCTGTATCCACTTTCAGAATGTTGAAGGGAAGTTCAGCAAGCATTTTCGTTACA TTGTGTCCTGCTTATACTTTTCTCAATATTAAGTCATTGTTTCCCATCACTGTATCCATTCTAC CTGTCCTCCGTGAAAATATGTTTGGAATATTCCACTATTTGCAGAGGCTTATTCAGTTCTTACA CATTCCATCTTACATTAGTGATTCCATCAAAGAGAAGGAAAGTAAGCCTTTTTGTCACCTCAAT ATTTACTATTTCAATACTTACATATCTGACTTCTAGGATTTATTGTTATATTACTTGCCTATCT GACTTCATACATCCCTCAGTTTCTTAAAATGTCCTATGTATATCTTCTACATGCAATTTAGAAC TAGATTTTGGTTAGAAGTAAGGATTATAAACAACCTAGACAGTACCCTTGGCCTTTACAGAAAA TATGGTGCTGTTTTCTACCCTTGGAAAGAAATGTAGATGATATGTTTCGTGGGTTGAATTGTGT CCCCCATAAAAGATATGTTGAAGTTCTAACCCCAGGTACCCATGAATGTGAGCTTACCAGGGTC TTTGCAGATGTAATTAGTTAAGTTAAGGTGAGATCACACTGAATTAGGGTGGGCTCTAAATCCA TTATGACTGTTGTTCTTATAAGAAGAAGAGAGGCATAGTCACCTAGGGGAGGAGGCCGTATGAA GACAGAGGCAGAGATTGGAGTGACGCATCTCCAAGCCAAGGAATTCCAAGGACTGTAAGCCACC AGTAGAAGCTTTGAAGAGGCAAGGAAGGATTCCCTCCAATAGCCTTCAAGTGTGACCCTGCTGA CACCTGCAGAATTCGGACTTCTATCCTCCAAAACCGTGAGGGAATAAATTTCCTTTGTTTTAAG CCACCAACTTTGCAATACTTTGTTACAGCAACCCTAGACATGAGGTACTAGACACAGTACATCT ACACATATGAAAATGAATCAACACAGAATGCAGAAGTAGAACCCTTGCTAAGGACTACTGGGCA TCTTCCCAGGACAGCAGCCAAAAGAGAACCACCACTTCCTCTCCTGCCTCCTCCTTGCTCTCTC CTAGAGTCCAAACCCAAATGGGCCAGTTGGATCTGATGTTCGTCAGTTCTTTACTTCTATTTCC TGGGGTACTCAGGAGGGCACACACTATAGATAACTTGGGTTAGCTGCATAAAATTCAATGTCTC ATTAAGTTGCATTAAACTGAGCTTAGATGTGTAAGTTTGCTAACGGATGGGTTTTTTTGTTAAG AACTATAGGATTTATGGGACCAAGTCTAGCGAGTCCAGATATCAAAATCATTATAATGTTATAT TTGCTGTTATTAGAATATAATATAGCTTATTATACAATAAATATGTAGACTGTAAAATATATTT CTCACTAGTACCTCCTATTTTCTTTCTCTGTTGAAGTTTTTAAATCCCACAGATAATTAAATTG GCACCTTTATGCTTGTTCAAAAATTAAAATAATCTATTAAATAAGTTCAAATTAAAGATTTTTA CTTCAAATGAC Download Select all
Length	3147

CDS Information

Location	join(110..211,2292..2536,3203..3351,3439..3564,6390..6551, 8546..8663,9528..9661,10256..10409,11108..11211, 11508..11617)
CDS Sequence	>lcl\|NM_001304441.1_cds_NP_001291370.1_1 [gene=MMP8] [protein=neutrophil collagenase isoform 2] [protein_id=NP_001291370.1] [location=260..1594] ATGCAACAAATACCTCAAGAGAAGTCAATTAATGACTACCTGGAAAAGTTCTACCAATTACCAAGCAACC AGTATCAGTCTACAAGGAAGAATGGCACTAATGTGATCGTTGAAAAGCTTAAAGAAATGCAGCGATTTTT TGGGTTGAATGTGACGGGGAAGCCAAATGAGGAAACTCTGGACATGATGAAAAAGCCTCGCTGTGGAGTG CCTGACAGTGGTGGTTTTATGTTAACCCCAGGAAACCCCAAGTGGGAACGCACTAACTTGACCTACAGGA TTCGAAACTATACCCCACAGCTGTCAGAGGCTGAGGTAGAAAGAGCTATCAAGGATGCCTTTGAACTCTG GAGTGTTGCATCACCTCTCATCTTCACCAGGATCTCACAGGGAGAGGCAGATATCAACATTGCTTTTTAC CAAAGAGATCACGGTGACAATTCTCCATTTGATGGACCCAATGGAATCCTTGCTCATGCCTTTCAGCCAG GCCAAGGTATTGGAGGAGATGCTCATTTTGATGCCGAAGAAACATGGACCAACACCTCCGCAAATTACAA CTTGTTTCTTGTTGCTGCTCATGAATTTGGCCATTCTTTGGGGCTCGCTCACTCCTCTGACCCTGGTGCC TTGATGTATCCCAACTATGCTTTCAGGGAAACCAGCAACTACTCACTCCCTCAAGATGACATCGATGGCA TTCAGGCCATCTATGGACTTTCAAGCAACCCTATCCAACCTACTGGACCAAGCACACCCAAACCCTGTGA CCCCAGTTTGACATTTGATGCTATCACCACACTCCGTGGAGAAATACTTTTCTTTAAAGACAGGTACTTC TGGAGAAGGCATCCTCAGCTACAAAGAGTCGAAATGAATTTTATTTCTCTATTCTGGCCATCCCTTCCAA CTGGTATACAGGCTGCTTATGAAGATTTTGACAGAGACCTCATTTTCCTATTTAAAGGCAACCAATACTG GGCTCTGAGTGGCTATGATATTCTGCAAGGTTATCCCAAGGATATATCAAACTATGGCTTCCCCAGCAGC GTCCAAGCAATTGACGCAGCTGTTTTCTACAGAAGTAAAACATACTTCTTTGTAAATGACCAATTCTGGA GATATGATAACCAAAGACAATTCATGGAGCCAGGTTATCCCAAAAGCATATCAGGTGCCTTTCCAGGAAT AGAGAGTAAAGTTGATGCAGTTTTCCAGCAAGAACATTTCTTCCATGTCTTCAGTGGACCAAGATATTAC GCATTTGATCTTATTGCTCAGAGAGTTACCAGAGTTGCAAGAGGCAATAAATGGCTTAACTGTAGATATG GCTGA Download Select all
CCDS ID	CCDS8320.1

Protein Information

Protein ID	NP_002415.1
Protein Name	matrix metallopeptidase 8 (neutrophil collagenase)
Molecular Wt. (Da)	51131
Protein Sequence	>4317 MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLK EMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAE VERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGG DAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDG IQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISL FWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYR SKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLI AQRVTRVARGNKWLNCRYG Download Select all
Length	467
Uniprot ID	P17693
Ensembl Protein ID	ENSP00000353472

Post-translational Modification Information (Source : HPRD)

No matching records could be found.

Enzyme Information

EC	3.4.24.34
Name	neutrophil collagenase matrix metalloproteinase 8 PMNL collagenase MMP-8
Class	Hydrolases; Acting on peptide bonds (peptidases); Metalloendopeptidases
Sysname
Substrate
Product
Reaction (IUBMB)

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
6347	CCL2	1149	NP_002973.1	in vitro;in vivo	121 491 929 558 113

Pathway Information

No matching records could be found.

Structure Information

PDB ID	1A85
Resolution	2
Method	X-RAY DIFFRACTION
Chains	A
Molecule	MMP-8
Model	View

Domain Information

ID	Location	Description
cd04278	107-262	ZnMc_MMP
cl00064	107-262	ZnMc superfamily
cd00094	276-464	HX
cl02471	276-464	HX superfamily
cd04279	132-262	ZnMc_MMP_like_1
cd04277	120-262	ZnMc_serralysin_like
cd00203	118-261	ZnMc
pfam01471	29-86	PG_binding_1
cl18368	29-86	PG_binding_1 superfamily
smart00120	377-422	HX
pfam00045	377-422	Hemopexin
cd04268	113-261	ZnMc_MMP_like
pfam00045	285-326	Hemopexin
pfam00045	329-372	Hemopexin
smart00120	329-372	HX
smart00120	285-326	HX
cd04327	125-227	ZnMc_MMP_like_3
pfam13688	143-251	Reprolysin_5
cd04275	154-227	ZnMc_pappalysin_like
cd11375	207-253	Peptidase_M54
pfam00413	107-262	Peptidase_M10
smart00235	104-262	ZnMc

Ontology Information

HPRD ID	2580
Molecular Class	Metallo protease
Molecular Function	Transferase activity (GO:0016740)
Biological Process	Metabolism (GO:0008152); Energy pathways (GO:0006091)

SNP Information

View SNP Geneview Report

Drug Information

Uniprot ID DrugBank ID Name Type
P22894 DB00786 Marimastat SmallMoleculeDrug

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO