Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MMP12 | 4321 | matrix metallopeptidase 12 (macrophage elastase) | 11 | HME |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23898086 | 2013 | Cell line : - Source : From southeastern Sweden who underwent surgical resection for primary colorectal adenocarcinomas at the Department of Surgery, Ryhov County Hospital, J�nk�ping, Sweden Sample Type : Blood samples No. of Sample : 385 Stage : - | TaqMan RT-PCR | Polymorhpism | - | -82AG (rs2276109) polymorphism of the MMP12 gene reflects clinical outcome of patients with CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play a role in aneurysm formation and mutations in this gene are associated with lung function and chronic obstructive pulmonary disease (COPD). This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016] |
| Chromosome | 11 |
| Location | 11q22.3 |
| Start | 102733464 |
| End | 102745764 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 12301 |
| OMIM ID | 601046 |
| HGNC ID | HGNC:7158 |
| Unigene ID | Hs.1695 |
| Ensembl ID | - |
| PharmGKB ID | PA30870 |
mRNA Information
| mRNA ID | NM_002426.5 |
|---|---|
| Exon | join(1..199,1923..2170,3083..3231,3316..3441,6966..7127, 7642..7765,8587..8720,9100..9259,10783..10889, 11835..12302) | mRNA Sequence | Download Select all |
| Length | 1881 |
Protein Information
| Protein ID | NP_002417.2 |
|---|---|
| Protein Name | matrix metallopeptidase 12 (macrophage elastase) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 470 |
| Uniprot ID | P09493 |
| Ensembl Protein ID | ENSP00000267996 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
No STRING Network could be found.
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2161 | F12 | 1992 | NP_000496.2 | in vivo | 10930399 |
| 4018 | LPA | 1063 | NP_005568.2 | in vitro | 10187779 |
| 5329 | PLAUR | 1421 | NP_002650.1 | in vitro;in vivo | 12195704 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00094 | 279-470 | HX |
| cl02471 | 279-470 | HX superfamily |
| cd04278 | 109-263 | ZnMc_MMP |
| cl00064 | 109-263 | ZnMc superfamily |
| cd04279 | 133-263 | ZnMc_MMP_like_1 |
| cd04277 | 133-263 | ZnMc_serralysin_like |
| cd00203 | 113-262 | ZnMc |
| cd04268 | 114-262 | ZnMc_MMP_like |
| smart00120 | 380-427 | HX |
| pfam01471 | 28-87 | PG_binding_1 |
| cl18368 | 28-87 | PG_binding_1 superfamily |
| pfam00045 | 380-427 | Hemopexin |
| pfam00045 | 332-375 | Hemopexin |
| smart00120 | 332-376 | HX |
| smart00120 | 288-330 | HX |
| pfam00045 | 288-330 | Hemopexin |
| cd11375 | 215-239 | Peptidase_M54 |
| PRK13267 | 216-245 | PRK13267 |
| pfam00045 | 429-469 | Hemopexin |
| smart00120 | 429-469 | HX |
| COG1913 | 216-238 | COG1913 |
| pfam13688 | 98-228 | Reprolysin_5 |
| COG5549 | 209-265 | COG5549 |
| cd04327 | 133-228 | ZnMc_MMP_like_3 |
| pfam13582 | 181-229 | Reprolysin_3 |
| pfam00413 | 109-263 | Peptidase_M10 |
| smart00235 | 105-263 | ZnMc |
Ontology Information
| HPRD ID | 1860 |
|---|---|
| Molecular Class | Metallo protease |
| Molecular Function | Heat shock protein activity (GO:0003773) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P39900 | DB00551 | Acetohydroxamic Acid | SmallMoleculeDrug |
| P39900 | DB00786 | Marimastat | SmallMoleculeDrug |