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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MMP15 | 4324 | matrix metallopeptidase 15 (membrane-inserted) | 16 | MT2-MMP, MTMMP2, SMCP-2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22576687 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : - Stage : - | Confocal analysis, western blotting , immunofluorescence analysis and real time RT-PCR | Up-regulation | - | MMP-15 and 19, in colorectal cancer may lead to a re-evaluation of the use of MMP inhibitors and suggests the need of integrated translational studies on MMP . |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein may play a role in cancer progression. [provided by RefSeq, Jan 2016] |
| Chromosome | 16 |
| Location | 16q13 |
| Start | 58059282 |
| End | 58080805 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 21524 |
| OMIM ID | 602261 |
| HGNC ID | HGNC:7161 |
| Unigene ID | Hs.80343 |
| Ensembl ID | ENSG00000102996 |
| PharmGKB ID | PA30873 |
mRNA Information
| mRNA ID | NM_002428.3 |
|---|---|
| Exon | join(1..1135,12095..12243,12889..13017,14498..14805, 15160..15321,16240..16493,16854..16992,17833..17983, 18135..18250,19630..21524) | mRNA Sequence | Download Select all |
| Length | 4268 |
Protein Information
| Protein ID | NP_002419.1 |
|---|---|
| Protein Name | matrix metallopeptidase 15 (membrane-inserted) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 669 |
| Uniprot ID | P12270 |
| Ensembl Protein ID | ENSP00000356448 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 589 |
| S | Phosphorylation | 67 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4035 | LRP1 | 138 | NP_002323.2 | in vitro | 14645246 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04278 | 138-304 | ZnMc_MMP |
| cl00064 | 138-304 | ZnMc superfamily |
| cd00094 | 367-559 | HX |
| cl02471 | 367-559 | HX superfamily |
| cd04279 | 157-304 | ZnMc_MMP_like_1 |
| cd04277 | 162-304 | ZnMc_serralysin_like |
| cd00203 | 162-303 | ZnMc |
| pfam11857 | 644-669 | DUF3377 |
| cl13321 | 644-669 | DUF3377 superfamily |
| pfam00045 | 419-462 | Hemopexin |
| smart00120 | 419-462 | HX |
| pfam00045 | 374-416 | Hemopexin |
| pfam01471 | 53-106 | PG_binding_1 |
| cl18368 | 53-106 | PG_binding_1 superfamily |
| pfam00045 | 466-511 | Hemopexin |
| cd04268 | 162-271 | ZnMc_MMP_like |
| smart00120 | 466-511 | HX |
| smart00120 | 522-558 | HX |
| pfam00045 | 522-558 | Hemopexin |
| smart00120 | 374-417 | HX |
| COG1913 | 257-287 | COG1913 |
| cd11375 | 256-279 | Peptidase_M54 |
| cd04327 | 162-269 | ZnMc_MMP_like_3 |
| COG5549 | 162-306 | COG5549 |
| PRK13267 | 257-277 | PRK13267 |
| cd04269 | 249-280 | ZnMc_adamalysin_II_like |
| pfam07998 | 239-287 | Peptidase_M54 |
| pfam00413 | 138-304 | Peptidase_M10 |
| smart00235 | 137-304 | ZnMc |
Ontology Information
| HPRD ID | 3833 |
|---|---|
| Molecular Class | Metallo protease |
| Molecular Function | Signal transducer activity (GO:0004871) |
| Biological Process | Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P51511 | DB00786 | Marimastat | SmallMoleculeDrug |