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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19367279 | 2009 | Cell line : - Source : Oncologic Hospital of Athens �Saint Savvas. Sample Type : CRC tumor No. of Sample : 122 Stage : - | Immunofluorometric ELISA measurement of kallikreins | Down-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Kallikreins |
| Description | This gene encodes a member of the kallikrein subfamily of serine proteases that have diverse physiological functions such as regulation of blood pressure and desquamation. The altered expression of this gene is implicated in the progression of different cancers including breast and prostate tumors. The encoded protein is a precursor that is proteolytically processed to generate the functional enzyme. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015] |
| Chromosome | 19 |
| Location | 19q13.3-q1 |
| Start | 51581154 |
| End | 51587502 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 6349 |
| OMIM ID | 606135 |
| HGNC ID | HGNC:6362 |
| Unigene ID | Hs.283925 |
| Ensembl ID | ENSG00000129437 |
| PharmGKB ID | PA30151 |
Protein Information
| Protein ID | NP_001298111.1 |
|---|---|
| Protein Name | kallikrein-related peptidase 14 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 267 |
| Uniprot ID | Q9NR28 |
| Ensembl Protein ID | ENSP00000267169 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00190 | 41-263 | Tryp_SPc |
| cl21584 | 41-263 | Tryp_SPc superfamily |
| smart00020 | 40-260 | Tryp_SPc |
| pfam00089 | 41-260 | Trypsin |
| COG5640 | 17-264 | COG5640 |
Ontology Information
| HPRD ID | 10426 |
|---|---|
| Molecular Class | Serine protease |
| Molecular Function | Translation regulator activity (GO:0045182) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.